Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PNP
  • Mouse genes Pnp
  • Rat genes Pnp
  • Zfish genes pnp4a,pnp4b,pnp5a,pnp5b,pnp6
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pnp

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0047975	guanosine phosphorylase activity	Pnp	IDA		Mouse	PMID:718989
Molecular Function	GO:0042802	identical protein binding	PNP	IPI	UniProtKB:P00491	Human	PMID:20212140
Molecular Function	GO:0042802	identical protein binding	PNP	IPI	UniProtKB:P00491	Human	PMID:25502805
Molecular Function	GO:0042802	identical protein binding	PNP	IPI	UniProtKB:P00491	Human	PMID:31515488
Molecular Function	GO:0042802	identical protein binding	PNP	IPI	UniProtKB:P00491	Human	PMID:32296183
Molecular Function	GO:0001882	nucleoside binding	PNP	IDA		Human	PMID:9305962
Molecular Function	GO:0042301	phosphate ion binding	PNP	IDA		Human	PMID:18938130
Molecular Function	GO:0005515	protein binding	PNP	IPI	UniProtKB:O14576-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PNP	IPI	UniProtKB:P05067	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PNP	IPI	UniProtKB:P06241	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PNP	IPI	UniProtKB:P14136	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PNP	IPI	UniProtKB:P17612	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PNP	IPI	UniProtKB:P63000	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PNP	IPI	UniProtKB:Q15583	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PNP	IPI	UniProtKB:Q92673	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PNP	IPI	UniProtKB:Q92993-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PNP	IPI	UniProtKB:Q9BXM7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PNP	IPI	UniProtKB:Q9UQM7	Human	PMID:32814053
Molecular Function	GO:0002060	purine nucleobase binding	PNP	IDA		Human	PMID:9305962
Molecular Function	GO:0004731	purine-nucleoside phosphorylase activity	PNP	IDA		Human	PMID:16930574
Molecular Function	GO:0004731	purine-nucleoside phosphorylase activity	PNP	IDA		Human	PMID:16964310
Molecular Function	GO:0004731	purine-nucleoside phosphorylase activity	PNP	IDA		Human	PMID:18938130
Molecular Function	GO:0004731	purine-nucleoside phosphorylase activity	PNP	IDA		Human	PMID:23438750
Molecular Function	GO:0004731	purine-nucleoside phosphorylase activity	PNP	IDA		Human	PMID:3029074
Molecular Function	GO:0004731	purine-nucleoside phosphorylase activity	PNP	IDA		Human	PMID:6771276
Molecular Function	GO:0004731	purine-nucleoside phosphorylase activity	PNP	IDA		Human	PMID:9305962
Molecular Function	GO:0004731	purine-nucleoside phosphorylase activity	Pnp	IMP		Mouse	PMID:11783524
Molecular Function	GO:0004731	purine-nucleoside phosphorylase activity	Pnp	IDA		Mouse	PMID:8064675
Molecular Function	GO:0004731	purine-nucleoside phosphorylase activity	Pnp	IDA		Mouse	PMID:819300
Molecular Function	GO:0004731	purine-nucleoside phosphorylase activity	Pnp	IDA		Mouse	PMID:6771472
Molecular Function	GO:0004731	purine-nucleoside phosphorylase activity	Pnp	IMP	MGI:MGI:3777967	Mouse	PMID:7918681
Molecular Function	GO:0004731	purine-nucleoside phosphorylase activity	Pnp	IMP	MGI:MGI:3777967	Mouse	PMID:1664183
Molecular Function	GO:0004731	purine-nucleoside phosphorylase activity	Pnp	IMP	MGI:MGI:3777967	Mouse	PMID:2516826
Molecular Function	GO:0004731	purine-nucleoside phosphorylase activity	Pnp	IMP	MGI:MGI:3777968	Mouse	PMID:2516826
Molecular Function	GO:0004731	purine-nucleoside phosphorylase activity	Pnp	IMP	MGI:MGI:2386195	Mouse	PMID:10859343
Molecular Function	GO:0004731	purine-nucleoside phosphorylase activity	Pnp	IMP	MGI:MGI:3777975	Mouse	PMID:1781357
Molecular Function	GO:0004731	purine-nucleoside phosphorylase activity	Pnp	IMP	MGI:MGI:3777968	Mouse	PMID:1664183
Molecular Function	GO:0004731	purine-nucleoside phosphorylase activity	Pnp	IDA		Mouse	PMID:3925939
Molecular Function	GO:0004731	purine-nucleoside phosphorylase activity	Pnp	IMP	MGI:MGI:2386195	Mouse	PMID:16964310
Molecular Function	GO:0004731	purine-nucleoside phosphorylase activity	Pnp	IDA		Mouse	PMID:109081
Molecular Function	GO:0004731	purine-nucleoside phosphorylase activity	Pnp	IMP	MGI:MGI:3777968	Mouse	PMID:7918681
Molecular Function	GO:0004731	purine-nucleoside phosphorylase activity	Pnp	IDA		Mouse	PMID:7323947
Molecular Function	GO:0004731	purine-nucleoside phosphorylase activity	Pnp	IMP	MGI:MGI:3777975	Mouse	PMID:1781356
Molecular Function	GO:0004731	purine-nucleoside phosphorylase activity	Pnp	IMP	MGI:MGI:3777968	Mouse	PMID:1781357
Molecular Function	GO:0004731	purine-nucleoside phosphorylase activity	Pnp	IMP	MGI:MGI:3777968	Mouse	PMID:9122228
Molecular Function	GO:0004731	purine-nucleoside phosphorylase activity	Pnp	IMP	MGI:MGI:3777978	Mouse	PMID:1781357
Molecular Function	GO:0004731	purine-nucleoside phosphorylase activity	Pnp	IMP	MGI:MGI:3777976	Mouse	PMID:1781357
Molecular Function	GO:0004731	purine-nucleoside phosphorylase activity	Pnp	IMP	MGI:MGI:3777975	Mouse	PMID:9122228
Molecular Function	GO:0004731	purine-nucleoside phosphorylase activity	Pnp	IMP	MGI:MGI:3777967	Mouse	PMID:9122228
Molecular Function	GO:0004731	purine-nucleoside phosphorylase activity	Pnp	IDA		Mouse	PMID:6407470
Molecular Function	GO:0004731	purine-nucleoside phosphorylase activity	Pnp	IDA		Mouse	PMID:1914521
Molecular Function	GO:0004731	purine-nucleoside phosphorylase activity	Pnp	IDA		Mouse	PMID:1235912
Molecular Function	GO:0004731	purine-nucleoside phosphorylase activity	Pnp	IDA		Mouse	PMID:7918681
Molecular Function	GO:0004731	purine-nucleoside phosphorylase activity	Pnp	IMP	MGI:MGI:3777967	Mouse	PMID:1781357
Molecular Function	GO:0004731	purine-nucleoside phosphorylase activity	Pnp	IDA		Mouse	PMID:204065
Molecular Function	GO:0004731	purine-nucleoside phosphorylase activity	Pnp	IDA		Mouse	PMID:8663040
Molecular Function	GO:0004731	purine-nucleoside phosphorylase activity	Pnp	IDA		Mouse	PMID:1374046
Molecular Function	GO:0004731	purine-nucleoside phosphorylase activity	Pnp	IDA		Mouse	PMID:405970
Molecular Function	GO:0004731	purine-nucleoside phosphorylase activity	Pnp	IDA		Rat	PMID:15532538|RGD:1600264
Molecular Function	GO:0004731	purine-nucleoside phosphorylase activity	Pnp	IDA		Rat	PMID:1834379|RGD:2291865
Cellular Component	GO:0005737	cytoplasm	PNP	IDA		Human	PMID:16930574
Cellular Component	GO:0005737	cytoplasm	PNP	IDA		Human	PMID:3029074
Cellular Component	GO:0005737	cytoplasm	Pnp	IDA		Rat	PMID:2120328|RGD:2291867
Cellular Component	GO:0005829	cytosol	PNP	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	Pnp	IDA		Mouse	PMID:109081
Cellular Component	GO:0005829	cytosol	Pnp	IDA		Mouse	PMID:8064675
Cellular Component	GO:0005829	cytosol	Pnp	IDA		Mouse	PMID:819300
Cellular Component	GO:0005829	cytosol	Pnp	IDA		Mouse	PMID:6407470
Cellular Component	GO:0005829	cytosol	Pnp	IDA		Mouse	PMID:7918681
Cellular Component	GO:0005829	cytosol	Pnp	IDA		Mouse	PMID:3925939
Cellular Component	GO:0070062	extracellular exosome	PNP	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	PNP	HDA		Human	PMID:20458337
Cellular Component	GO:0070062	extracellular exosome	PNP	HDA		Human	PMID:23533145
Cellular Component	GO:0005576	extracellular region	Pnp	IDA		Rat	PMID:15532538|RGD:1600264
Cellular Component	GO:0005634	nucleus	Pnp	IDA		Rat	PMID:2120328|RGD:2291867
Biological Process	GO:0006154	adenosine catabolic process	Pnp	IDA		Mouse	PMID:8064675
Biological Process	GO:0006154	adenosine catabolic process	Pnp	IMP		Mouse	PMID:11783524
Biological Process	GO:0000255	allantoin metabolic process	PNP	IDA		Human	PMID:6771276
Biological Process	GO:0000255	allantoin metabolic process	Pnp	IMP		Mouse	PMID:11783524
Biological Process	GO:0000255	allantoin metabolic process	Pnp	IDA		Mouse	PMID:8064675
Biological Process	GO:0046632	alpha-beta T cell differentiation	Pnp	IMP	MGI:MGI:3777967	Mouse	PMID:9122228
Biological Process	GO:0046632	alpha-beta T cell differentiation	Pnp	IMP	MGI:MGI:2386195	Mouse	PMID:10859343
Biological Process	GO:0046632	alpha-beta T cell differentiation	Pnp	IMP	MGI:MGI:2386195	Mouse	PMID:16964310
Biological Process	GO:0046632	alpha-beta T cell differentiation	Pnp	IMP	MGI:MGI:3777968	Mouse	PMID:9122228
Biological Process	GO:0046632	alpha-beta T cell differentiation	Pnp	IMP	MGI:MGI:3777975	Mouse	PMID:9122228
Biological Process	GO:0043605	amide catabolic process	Pnp	IMP		Mouse	PMID:11783524
Biological Process	GO:0043605	amide catabolic process	Pnp	IDA		Mouse	PMID:8064675
Biological Process	GO:0006196	AMP catabolic process	Pnp	IMP		Mouse	PMID:11783524
Biological Process	GO:0006196	AMP catabolic process	Pnp	IDA		Mouse	PMID:8064675
Biological Process	GO:0044209	AMP salvage	Pnp	IDA		Mouse	PMID:8064675
Biological Process	GO:0008637	apoptotic mitochondrial changes	Pnp	IMP	MGI:MGI:2386195	Mouse	PMID:10859343
Biological Process	GO:0030183	B cell differentiation	Pnp	IMP	MGI:MGI:2386195	Mouse	PMID:10859343
Biological Process	GO:0046059	dAMP catabolic process	PNP	IDA		Human	PMID:6771276
Biological Process	GO:0046059	dAMP catabolic process	Pnp	IMP		Mouse	PMID:11783524
Biological Process	GO:0006157	deoxyadenosine catabolic process	PNP	IDA		Human	PMID:6771276
Biological Process	GO:0006157	deoxyadenosine catabolic process	Pnp	IMP		Mouse	PMID:11783524
Biological Process	GO:0006161	deoxyguanosine catabolic process	Pnp	IMP		Mouse	PMID:11783524
Biological Process	GO:0006161	deoxyguanosine catabolic process	Pnp	IMP	MGI:MGI:2386195	Mouse	PMID:10859343
Biological Process	GO:0006149	deoxyinosine catabolic process	PNP	IDA		Human	PMID:6771276
Biological Process	GO:0006149	deoxyinosine catabolic process	Pnp	IMP		Mouse	PMID:11783524
Biological Process	GO:0006149	deoxyinosine catabolic process	Pnp	IMP	MGI:MGI:2386195	Mouse	PMID:10859343
Biological Process	GO:0046055	dGMP catabolic process	Pnp	IMP		Mouse	PMID:11783524
Biological Process	GO:0046070	dGTP metabolic process	Pnp	IMP	MGI:MGI:3777968	Mouse	PMID:9122228
Biological Process	GO:0046070	dGTP metabolic process	Pnp	IMP	MGI:MGI:3777975	Mouse	PMID:9122228
Biological Process	GO:0046070	dGTP metabolic process	Pnp	IMP	MGI:MGI:2386195	Mouse	PMID:10859343
Biological Process	GO:0006281	DNA repair	Pnp	IMP	MGI:MGI:2386195	Mouse	PMID:10859343
Biological Process	GO:0046038	GMP catabolic process	Pnp	IMP		Mouse	PMID:11783524
Biological Process	GO:0006202	GMP catabolic process to guanine	Pnp	IMP		Mouse	PMID:11783524
Biological Process	GO:0032263	GMP salvage	Pnp	IDA		Mouse	PMID:718989
Biological Process	GO:0006183	GTP biosynthetic process	Pnp	IMP	MGI:MGI:2386195	Mouse	PMID:10859343
Biological Process	GO:0046115	guanosine catabolic process	Pnp	IMP	MGI:MGI:2386195	Mouse	PMID:10859343
Biological Process	GO:0006955	immune response	PNP	IMP		Human	PMID:16930574
Biological Process	GO:0006204	IMP catabolic process	PNP	IDA		Human	PMID:6771276
Biological Process	GO:0006204	IMP catabolic process	Pnp	IMP		Mouse	PMID:11783524
Biological Process	GO:0032264	IMP salvage	Pnp	IDA		Mouse	PMID:819300
Biological Process	GO:0006148	inosine catabolic process	PNP	IDA		Human	PMID:16964310
Biological Process	GO:0006148	inosine catabolic process	PNP	IDA		Human	PMID:23438750
Biological Process	GO:0006148	inosine catabolic process	Pnp	IDA		Mouse	PMID:8064675
Biological Process	GO:0006148	inosine catabolic process	Pnp	IMP		Mouse	PMID:11783524
Biological Process	GO:0006148	inosine catabolic process	Pnp	IMP	MGI:MGI:2386195	Mouse	PMID:16964310
Biological Process	GO:0006148	inosine catabolic process	Pnp	IMP	MGI:MGI:2386195	Mouse	PMID:10859343
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	Pnp	IMP	MGI:MGI:2386195	Mouse	PMID:10859343
Biological Process	GO:0070233	negative regulation of T cell apoptotic process	Pnp	IMP	MGI:MGI:2386195	Mouse	PMID:10859343
Biological Process	GO:0006738	nicotinamide riboside catabolic process	PNP	IDA		Human	PMID:19001417
Biological Process	GO:0006139	nucleobase-containing compound metabolic process	PNP	IDA		Human	PMID:3029074
Biological Process	GO:0009165	nucleotide biosynthetic process	PNP	IGI	UniProtKB:P53915	Human	PMID:19001417
Biological Process	GO:0046638	positive regulation of alpha-beta T cell differentiation	PNP	IDA		Human	PMID:16964310
Biological Process	GO:0046638	positive regulation of alpha-beta T cell differentiation	Pnp	IMP	MGI:MGI:3777975	Mouse	PMID:9122228
Biological Process	GO:0046638	positive regulation of alpha-beta T cell differentiation	Pnp	IMP	MGI:MGI:3777967	Mouse	PMID:9122228
Biological Process	GO:0046638	positive regulation of alpha-beta T cell differentiation	Pnp	IMP	MGI:MGI:2386195	Mouse	PMID:10859343
Biological Process	GO:0046638	positive regulation of alpha-beta T cell differentiation	Pnp	IMP	MGI:MGI:3777968	Mouse	PMID:9122228
Biological Process	GO:0046638	positive regulation of alpha-beta T cell differentiation	Pnp	IMP	MGI:MGI:2386195	Mouse	PMID:16964310
Biological Process	GO:0045579	positive regulation of B cell differentiation	Pnp	IMP	MGI:MGI:2386195	Mouse	PMID:10859343
Biological Process	GO:0045739	positive regulation of DNA repair	Pnp	IMP	MGI:MGI:2386195	Mouse	PMID:10859343
Biological Process	GO:0032743	positive regulation of interleukin-2 production	PNP	IMP		Human	PMID:16930574
Biological Process	GO:0001916	positive regulation of T cell mediated cytotoxicity	Pnp	IMP	MGI:MGI:2386195	Mouse	PMID:10859343
Biological Process	GO:0042102	positive regulation of T cell proliferation	PNP	IDA		Human	PMID:16964310
Biological Process	GO:0042102	positive regulation of T cell proliferation	Pnp	IMP	MGI:MGI:3777967	Mouse	PMID:9122228
Biological Process	GO:0042102	positive regulation of T cell proliferation	Pnp	IMP	MGI:MGI:3777975	Mouse	PMID:9122228
Biological Process	GO:0042102	positive regulation of T cell proliferation	Pnp	IMP	MGI:MGI:3777968	Mouse	PMID:9122228
Biological Process	GO:0042102	positive regulation of T cell proliferation	Pnp	IMP	MGI:MGI:2386195	Mouse	PMID:16964310
Biological Process	GO:0042278	purine nucleoside metabolic process	Pnp	IMP	MGI:MGI:3777967	Mouse	PMID:7918681
Biological Process	GO:0042278	purine nucleoside metabolic process	Pnp	IMP	MGI:MGI:3777967	Mouse	PMID:1664183
Biological Process	GO:0042278	purine nucleoside metabolic process	Pnp	IDA		Mouse	PMID:405970
Biological Process	GO:0042278	purine nucleoside metabolic process	Pnp	IDA		Mouse	PMID:1374046
Biological Process	GO:0042278	purine nucleoside metabolic process	Pnp	IMP	MGI:MGI:3777967	Mouse	PMID:2516826
Biological Process	GO:0042278	purine nucleoside metabolic process	Pnp	IMP	MGI:MGI:3777968	Mouse	PMID:2516826
Biological Process	GO:0042278	purine nucleoside metabolic process	Pnp	IMP	MGI:MGI:3777968	Mouse	PMID:1664183
Biological Process	GO:0042278	purine nucleoside metabolic process	Pnp	IDA		Mouse	PMID:3925939
Biological Process	GO:0042278	purine nucleoside metabolic process	Pnp	IDA		Mouse	PMID:8663040
Biological Process	GO:0042278	purine nucleoside metabolic process	Pnp	IMP	MGI:MGI:3777967	Mouse	PMID:1781357
Biological Process	GO:0042278	purine nucleoside metabolic process	Pnp	IMP	MGI:MGI:3777975	Mouse	PMID:1781357
Biological Process	GO:0042278	purine nucleoside metabolic process	Pnp	IDA		Mouse	PMID:109081
Biological Process	GO:0042278	purine nucleoside metabolic process	Pnp	IMP	MGI:MGI:3777968	Mouse	PMID:7918681
Biological Process	GO:0042278	purine nucleoside metabolic process	Pnp	IMP	MGI:MGI:3777967	Mouse	PMID:9122228
Biological Process	GO:0042278	purine nucleoside metabolic process	Pnp	IMP	MGI:MGI:3777975	Mouse	PMID:9122228
Biological Process	GO:0042278	purine nucleoside metabolic process	Pnp	IMP	MGI:MGI:3777975	Mouse	PMID:1781356
Biological Process	GO:0042278	purine nucleoside metabolic process	Pnp	IMP	MGI:MGI:3777968	Mouse	PMID:1781357
Biological Process	GO:0042278	purine nucleoside metabolic process	Pnp	IMP	MGI:MGI:3777976	Mouse	PMID:1781357
Biological Process	GO:0042278	purine nucleoside metabolic process	Pnp	IDA		Mouse	PMID:6407470
Biological Process	GO:0042278	purine nucleoside metabolic process	Pnp	IDA		Mouse	PMID:7918681
Biological Process	GO:0042278	purine nucleoside metabolic process	Pnp	IMP	MGI:MGI:3777968	Mouse	PMID:9122228
Biological Process	GO:0042278	purine nucleoside metabolic process	Pnp	IMP	MGI:MGI:3777978	Mouse	PMID:1781357
Biological Process	GO:0042278	purine nucleoside metabolic process	Pnp	IDA		Rat	PMID:1834379|RGD:2291865
Biological Process	GO:0043101	purine-containing compound salvage	PNP	IDA		Human	PMID:18938130
Biological Process	GO:0010332	response to gamma radiation	Pnp	IMP	MGI:MGI:2386195	Mouse	PMID:10859343
Biological Process	GO:0009410	response to xenobiotic stimulus	PNP	IMP		Human	PMID:15047506
Biological Process	GO:0070231	T cell apoptotic process	Pnp	IMP	MGI:MGI:2386195	Mouse	PMID:10859343
Biological Process	GO:0042098	T cell proliferation	Pnp	IMP	MGI:MGI:3777975	Mouse	PMID:9122228
Biological Process	GO:0042098	T cell proliferation	Pnp	IMP	MGI:MGI:2386195	Mouse	PMID:16964310
Biological Process	GO:0042098	T cell proliferation	Pnp	IMP	MGI:MGI:3777968	Mouse	PMID:9122228
Biological Process	GO:0042098	T cell proliferation	Pnp	IMP	MGI:MGI:3777967	Mouse	PMID:9122228
Biological Process	GO:0034418	urate biosynthetic process	PNP	IDA		Human	PMID:16964310
Biological Process	GO:0034418	urate biosynthetic process	Pnp	IMP	MGI:MGI:2386195	Mouse	PMID:16964310

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern