Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PNPLA3
  • Mouse genes Pnpla3
  • Rat genes Pnpla3
  • Zfish genes pnpla3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pnpla3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity	PNPLA3	IDA		Human	PMID:22560221
Molecular Function	GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity	Pnpla3	IDA		Mouse	MGI:MGI:5426312|PMID:22560221
Molecular Function	GO:0051265	diolein transacylation activity	PNPLA3	IDA		Human	PMID:15364929
Molecular Function	GO:0036042	long-chain fatty acyl-CoA binding	PNPLA3	IDA		Human	PMID:22560221
Molecular Function	GO:0036042	long-chain fatty acyl-CoA binding	Pnpla3	IDA		Mouse	MGI:MGI:5426312|PMID:22560221
Molecular Function	GO:0042171	lysophosphatidic acid acyltransferase activity	PNPLA3	IDA		Human	PMID:22560221
Molecular Function	GO:0042171	lysophosphatidic acid acyltransferase activity	Pnpla3	IDA		Mouse	MGI:MGI:5426312|PMID:22560221
Molecular Function	GO:0035727	lysophosphatidic acid binding	PNPLA3	IDA		Human	PMID:22560221
Molecular Function	GO:0035727	lysophosphatidic acid binding	Pnpla3	IDA		Mouse	MGI:MGI:5426312|PMID:22560221
Molecular Function	GO:0051264	mono-olein transacylation activity	PNPLA3	IDA		Human	PMID:15364929
Molecular Function	GO:0004623	phospholipase A2 activity	PNPLA3	IDA		Human	PMID:15364929
Molecular Function	GO:0004806	triglyceride lipase activity	PNPLA3	IDA		Human	PMID:15364929
Molecular Function	GO:0004806	triglyceride lipase activity	PNPLA3	IDA		Human	PMID:20034933
Molecular Function	GO:0004806	triglyceride lipase activity	PNPLA3	IDA		Human	PMID:22560221
Molecular Function	GO:0004806	triglyceride lipase activity	Pnpla3	IDA		Mouse	MGI:MGI:5426312|PMID:22560221
Cellular Component	GO:0005811	lipid droplet	PNPLA3	IDA		Human	PMID:20034933
Cellular Component	GO:0005811	lipid droplet	PNPLA3	IDA		Human	PMID:22560221
Cellular Component	GO:0005811	lipid droplet	PNPLA3	IDA		Human	PMID:23398201
Cellular Component	GO:0005811	lipid droplet	Pnpla3	IDA		Mouse	MGI:MGI:5426312|PMID:22560221
Cellular Component	GO:0016020	membrane	PNPLA3	IDA		Human	PMID:22560221
Cellular Component	GO:0016020	membrane	Pnpla3	IDA		Mouse	MGI:MGI:5426312|PMID:22560221
Cellular Component	GO:0016020	membrane	Pnpla3	IDA		Mouse	PMID:11431482
Biological Process	GO:1905243	cellular response to 3,3',5-triiodo-L-thyronine	Pnpla3	IEP		Rat	PMID:19619606|RGD:14985223
Biological Process	GO:0032869	cellular response to insulin stimulus	Pnpla3	IEP		Rat	PMID:19619606|RGD:14985223
Biological Process	GO:0006650	glycerophospholipid metabolic process	PNPLA3	IDA		Human	PMID:22560221
Biological Process	GO:0006650	glycerophospholipid metabolic process	Pnpla3	IDA		Mouse	MGI:MGI:5426312|PMID:22560221
Biological Process	GO:0034389	lipid droplet organization	PNPLA3	IMP		Human	PMID:23398201
Biological Process	GO:0001889	liver development	pnpla3	IMP	ZFIN:ZDB-MRPHLNO-131120-1	Zfish	PMID:23813869
Biological Process	GO:0001676	long-chain fatty acid metabolic process	PNPLA3	IDA		Human	PMID:22560221
Biological Process	GO:0001676	long-chain fatty acid metabolic process	Pnpla3	IDA		Mouse	MGI:MGI:5426312|PMID:22560221
Biological Process	GO:0006654	phosphatidic acid biosynthetic process	PNPLA3	IDA		Human	PMID:22560221
Biological Process	GO:0006654	phosphatidic acid biosynthetic process	Pnpla3	IDA		Mouse	MGI:MGI:5426312|PMID:22560221
Biological Process	GO:0002021	response to dietary excess	Pnpla3	IMP		Mouse	MGI:MGI:5426312|PMID:22560221
Biological Process	GO:0009744	response to sucrose	Pnpla3	IEP		Rat	PMID:12565853|RGD:14985226
Biological Process	GO:0036153	triglyceride acyl-chain remodeling	PNPLA3	IDA		Human	PMID:24511104
Biological Process	GO:0019432	triglyceride biosynthetic process	PNPLA3	IDA		Human	PMID:15364929
Biological Process	GO:0019432	triglyceride biosynthetic process	PNPLA3	IDA		Human	PMID:22560221
Biological Process	GO:0019432	triglyceride biosynthetic process	Pnpla3	IDA		Mouse	MGI:MGI:5426312|PMID:22560221
Biological Process	GO:0019433	triglyceride catabolic process	PNPLA3	IDA		Human	PMID:15364929
Biological Process	GO:0019433	triglyceride catabolic process	PNPLA3	IDA		Human	PMID:22560221
Biological Process	GO:0019433	triglyceride catabolic process	Pnpla3	IDA		Mouse	MGI:MGI:5426312|PMID:22560221
Biological Process	GO:0050872	white fat cell differentiation	Pnpla3	IEP		Rat	PMID:19619606|RGD:14985223

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern