Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes POLA1
  • Mouse genes Pola1
  • Rat genes Pola1
  • Zfish genes pola1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pola1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	POLA1	IDA		Human	PMID:16762037
Molecular Function	GO:0003677	DNA binding	POLA1	IDA		Human	PMID:16762037
Molecular Function	GO:0003887	DNA-directed DNA polymerase activity	POLA1	IDA		Human	PMID:26975377
Molecular Function	GO:0003887	DNA-directed DNA polymerase activity	POLA1	IDA		Human	PMID:3359994
Molecular Function	GO:0003887	DNA-directed DNA polymerase activity	POLA1	IMP		Human	PMID:4084590
Molecular Function	GO:0003887	DNA-directed DNA polymerase activity	POLA1	IDA		Human	PMID:8026492
Molecular Function	GO:0003887	DNA-directed DNA polymerase activity	POLA1	IDA		Human	PMID:893425
Molecular Function	GO:0003887	DNA-directed DNA polymerase activity	Pola1	IDA		Mouse	PMID:8106564
Molecular Function	GO:0003887	DNA-directed DNA polymerase activity	Pola1	IDA		Mouse	PMID:9584195
Molecular Function	GO:0003887	DNA-directed DNA polymerase activity	Pola1	IDA		Rat	PMID:7354082|RGD:724599
Molecular Function	GO:0003887	DNA-directed DNA polymerase activity	Pola1	IMP		Rat	PMID:7503737|RGD:2307013
Molecular Function	GO:0003887	DNA-directed DNA polymerase activity	Pola1	IMP		Rat	PMID:8576284|RGD:1580606
Molecular Function	GO:0003690	double-stranded DNA binding	Pola1	IDA		Rat	PMID:7670930|RGD:1580605
Molecular Function	GO:0000166	nucleotide binding	POLA1	IDA		Human	PMID:3139084
Molecular Function	GO:0005515	protein binding	POLA1	IPI	UniProtKB:O75419	Human	PMID:10518787
Molecular Function	GO:0005515	protein binding	POLA1	IPI	UniProtKB:P33993	Human	PMID:10518787
Molecular Function	GO:0005515	protein binding	POLA1	IPI	UniProtKB:P29558-1	Human	PMID:10869558
Molecular Function	GO:0005515	protein binding	POLA1	IPI	UniProtKB:P27694	Human	PMID:1311258
Molecular Function	GO:0005515	protein binding	POLA1	IPI	UniProtKB:Q14683	Human	PMID:16438930
Molecular Function	GO:0005515	protein binding	POLA1	IPI	UniProtKB:P03070	Human	PMID:17666013
Molecular Function	GO:0005515	protein binding	POLA1	IPI	UniProtKB:P27694	Human	PMID:17666013
Molecular Function	GO:0005515	protein binding	POLA1	IPI	UniProtKB:P06750	Human	PMID:2243771
Molecular Function	GO:0005515	protein binding	POLA1	IPI	UniProtKB:P81460	Human	PMID:2243771
Molecular Function	GO:0005515	protein binding	POLA1	IPI	UniProtKB:P10193	Human	PMID:7644508
Molecular Function	GO:0005515	protein binding	POLA1	IPI	UniProtKB:P03070	Human	PMID:8380896
Molecular Function	GO:0005515	protein binding	POLA1	IPI	UniProtKB:P06400	Human	PMID:9395244
Molecular Function	GO:0005515	protein binding	POLA1	IPI	UniProtKB:P09874	Human	PMID:9518481
Molecular Function	GO:0005515	protein binding	Pola1	IPI	UniProtKB:P20664	Mouse	MGI:MGI:3687659|PMID:10523676
Molecular Function	GO:0005515	protein binding	Pola1	IPI	UniProtKB:P33611	Mouse	MGI:MGI:3687659|PMID:10523676
Molecular Function	GO:0005515	protein binding	Pola1	IPI	PR:P33611	Mouse	PMID:9584195
Molecular Function	GO:0019901	protein kinase binding	POLA1	IPI	UniProtKB:O14519	Human	PMID:9506968
Molecular Function	GO:0017076	purine nucleotide binding	Pola1	IMP		Rat	PMID:7670930|RGD:1580605
Molecular Function	GO:0019103	pyrimidine nucleotide binding	Pola1	IMP		Rat	PMID:7670930|RGD:1580605
Molecular Function	GO:0008270	zinc ion binding	POLA1	IDA		Human	PMID:26975377
Cellular Component	GO:0005658	alpha DNA polymerase:primase complex	POLA1	IPI		Human	PMID:26975377
Cellular Component	GO:0005658	alpha DNA polymerase:primase complex	POLA1	IDA		Human	PMID:2175912
Cellular Component	GO:0005658	alpha DNA polymerase:primase complex	POLA1	IDA		Human	PMID:22465957
Cellular Component	GO:0005658	alpha DNA polymerase:primase complex	POLA1	IDA		Human	PMID:26975377
Cellular Component	GO:0005658	alpha DNA polymerase:primase complex	POLA1	IDA		Human	PMID:8026492
Cellular Component	GO:0005658	alpha DNA polymerase:primase complex	Pola1	IPI		Mouse	MGI:MGI:3687659|PMID:10523676
Cellular Component	GO:0005658	alpha DNA polymerase:primase complex	Pola1	IDA		Mouse	MGI:MGI:6478526|PMID:8026492
Cellular Component	GO:0005658	alpha DNA polymerase:primase complex	Pola1	IDA		Mouse	PMID:9584195
Cellular Component	GO:0005658	alpha DNA polymerase:primase complex	Pola1	IDA		Rat	PMID:7670930|RGD:1580605
Cellular Component	GO:0000785	chromatin	POLA1	IDA		Human	PMID:9815285
Cellular Component	GO:0005829	cytosol	POLA1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	POLA1	IDA		Human	PMID:27019227
Cellular Component	GO:0005635	nuclear envelope	POLA1	IDA		Human	PMID:9518481
Cellular Component	GO:0016363	nuclear matrix	POLA1	IDA		Human	PMID:1903085
Cellular Component	GO:0005730	nucleolus	POLA1	IDA		Human	PMID:9518481
Cellular Component	GO:0005654	nucleoplasm	POLA1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	POLA1	IDA		Human	PMID:7045121
Cellular Component	GO:0005634	nucleus	POLA1	IDA		Human	PMID:16762037
Cellular Component	GO:0005634	nucleus	POLA1	IDA		Human	PMID:4084590
Cellular Component	GO:0005634	nucleus	Pola1	IDA		Mouse	PMID:9584195
Biological Process	GO:0071897	DNA biosynthetic process	Pola1	IMP		Rat	PMID:9099618|RGD:7247275
Biological Process	GO:0006281	DNA repair	POLA1	IMP		Human	PMID:11470886
Biological Process	GO:0006260	DNA replication	POLA1	IMP		Human	PMID:16762037
Biological Process	GO:0006260	DNA replication	POLA1	IMP		Human	PMID:31006512
Biological Process	GO:0006260	DNA replication	POLA1	IMP		Human	PMID:3917431
Biological Process	GO:0006260	DNA replication	POLA1	IMP		Human	PMID:4084590
Biological Process	GO:0006260	DNA replication	Pola1	IDA		Mouse	PMID:8106564
Biological Process	GO:0006260	DNA replication	Pola1	IMP		Mouse	PMID:8125989
Biological Process	GO:0006260	DNA replication	Pola1	IDA		Mouse	PMID:9584195
Biological Process	GO:0006260	DNA replication	Pola1	IMP		Rat	PMID:7503737|RGD:2307013
Biological Process	GO:0006260	DNA replication	Pola1	IMP		Rat	PMID:8576284|RGD:1580606
Biological Process	GO:0006270	DNA replication initiation	POLA1	IDA		Human	PMID:2175912
Biological Process	GO:0006270	DNA replication initiation	POLA1	IDA		Human	PMID:26975377
Biological Process	GO:0006270	DNA replication initiation	Pola1	IDA		Mouse	MGI:MGI:3687659|PMID:10523676
Biological Process	GO:0006269	DNA replication, synthesis of RNA primer	POLA1	IDA		Human	PMID:2175912
Biological Process	GO:0006269	DNA replication, synthesis of RNA primer	POLA1	IDA		Human	PMID:27019227
Biological Process	GO:0006269	DNA replication, synthesis of RNA primer	POLA1	IDA		Human	PMID:8026492
Biological Process	GO:0006269	DNA replication, synthesis of RNA primer	Pola1	IDA		Mouse	MGI:MGI:6478526|PMID:8026492
Biological Process	GO:0006271	DNA strand elongation involved in DNA replication	POLA1	IMP		Human	PMID:4084590
Biological Process	GO:0000731	DNA synthesis involved in DNA repair	POLA1	IMP		Human	PMID:11470886
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	POLA1	IMP		Human	PMID:11470886
Biological Process	GO:0006273	lagging strand elongation	POLA1	IDA		Human	PMID:2175912
Biological Process	GO:0006273	lagging strand elongation	POLA1	IDA		Human	PMID:7910375
Biological Process	GO:0006272	leading strand elongation	POLA1	IDA		Human	PMID:2175912
Biological Process	GO:0006272	leading strand elongation	POLA1	IDA		Human	PMID:7910375
Biological Process	GO:0032479	regulation of type I interferon production	POLA1	IMP		Human	PMID:27019227

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern