Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes POLB
  • Mouse genes Polb
  • Rat genes Polb
  • Zfish genes polb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Polb

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003684	damaged DNA binding	Polb	IDA		Rat	PMID:12388548|RGD:633643
Molecular Function	GO:0003677	DNA binding	Polb	IDA		Rat	PMID:11330999|RGD:8554455
Molecular Function	GO:0003887	DNA-directed DNA polymerase activity	POLB	IDA		Human	PMID:16600869
Molecular Function	GO:0003887	DNA-directed DNA polymerase activity	POLB	IDA		Human	PMID:9207062
Molecular Function	GO:0003887	DNA-directed DNA polymerase activity	Polb	IDA		Rat	PMID:17412650|RGD:2302580
Molecular Function	GO:0003887	DNA-directed DNA polymerase activity	polb	IDA		Zfish	PMID:22018137
Molecular Function	GO:0019899	enzyme binding	POLB	IPI	UniProtKB:Q96LA8	Human	PMID:16600869
Molecular Function	GO:0019899	enzyme binding	POLB	IPI	UniProtKB:Q7Z6Z7	Human	PMID:19713937
Molecular Function	GO:0019899	enzyme binding	POLB	IPI	UniProtKB:Q96K76	Human	PMID:21362556
Molecular Function	GO:0016829	lyase activity	POLB	IDA		Human	PMID:16600869
Molecular Function	GO:0046872	metal ion binding	Polb	IDA		Rat	PMID:11330999|RGD:8554455
Molecular Function	GO:0008017	microtubule binding	POLB	IDA		Human	PMID:15725623
Molecular Function	GO:0005515	protein binding	POLB	IPI	UniProtKB:P18887	Human	PMID:15520167
Molecular Function	GO:0005515	protein binding	POLB	IPI	UniProtKB:Q9H5J8	Human	PMID:15520167
Molecular Function	GO:0005515	protein binding	POLB	IPI	UniProtKB:Q92567	Human	PMID:25260657
Molecular Function	GO:0005515	protein binding	POLB	IPI	UniProtKB:P29144	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	POLB	IPI	UniProtKB:P29144	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	POLB	IPI	UniProtKB:P18887	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	POLB	IPI	UniProtKB:P18887	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	POLB	IPI	UniProtKB:P29144	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	POLB	IPI	UniProtKB:O76024	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	POLB	IPI	UniProtKB:P27695	Human	PMID:9207062
Molecular Function	GO:0005515	protein binding	Polb	IPI	RGD:620108	Rat	PMID:11734998|RGD:5688251
Molecular Function	GO:0005515	protein binding	Polb	IPI	RGD:619823	Rat	PMID:17412650|RGD:2302580
Molecular Function	GO:0005515	protein binding	Polb	IPI	UniProtKB:P18887	Rat	PMID:20351257|RGD:13432237
Molecular Function	GO:0005515	protein binding	Polb	IPI	UniProtKB:P18887	Rat	PMID:25456813|RGD:13432291
Cellular Component	GO:0005737	cytoplasm	POLB	IDA		Human	PMID:15725623
Cellular Component	GO:0005737	cytoplasm	POLB	IDA		Human	PMID:19713937
Cellular Component	GO:0005737	cytoplasm	POLB	IDA		Human	PMID:21362556
Cellular Component	GO:0005874	microtubule	POLB	IDA		Human	PMID:15725623
Cellular Component	GO:0005634	nucleus	POLB	IDA		Human	PMID:19713937
Cellular Component	GO:0005634	nucleus	POLB	IDA		Human	PMID:21362556
Cellular Component	GO:0005634	nucleus	Polb	IDA		Rat	PMID:17412650|RGD:2302580
Cellular Component	GO:0005634	nucleus	Polb	IDA		Rat	PMID:967678|RGD:2316779
Cellular Component	GO:0032991	protein-containing complex	POLB	IDA		Human	PMID:25378300
Cellular Component	GO:0005876	spindle microtubule	POLB	IDA		Human	PMID:15725623
Biological Process	GO:0007568	aging	Polb	IEP		Rat	PMID:15979612|RGD:8694099
Biological Process	GO:0006915	apoptotic process	Polb	IMP	MGI:MGI:5427084	Mouse	PMID:24388753
Biological Process	GO:0006284	base-excision repair	POLB	IDA		Human	PMID:16600869
Biological Process	GO:0006284	base-excision repair	POLB	IMP		Human	PMID:21362556
Biological Process	GO:0006287	base-excision repair, gap-filling	Polb	IMP		Mouse	PMID:15177179
Biological Process	GO:0006287	base-excision repair, gap-filling	Polb	IDA		Rat	PMID:17412650|RGD:2302580
Biological Process	GO:0071897	DNA biosynthetic process	polb	IDA		Zfish	PMID:22018137|ZFIN:ZDB-PUB-111111-3
Biological Process	GO:0006974	DNA damage response	POLB	IMP		Human	PMID:21362556
Biological Process	GO:0048872	homeostasis of number of cells	Polb	IMP	MGI:MGI:5427084	Mouse	PMID:24388753
Biological Process	GO:0071707	immunoglobulin heavy chain V-D-J recombination	Polb	IMP	MGI:MGI:5427084	Mouse	PMID:24388753
Biological Process	GO:0001701	in utero embryonic development	Polb	IMP	MGI:MGI:4950969	Mouse	PMID:27996060
Biological Process	GO:0006954	inflammatory response	Polb	IMP	MGI:MGI:5427084	Mouse	PMID:24388753
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	Polb	IMP		Mouse	PMID:10197627
Biological Process	GO:0048535	lymph node development	Polb	IMP	MGI:MGI:5427084	Mouse	PMID:24388753
Biological Process	GO:0051402	neuron apoptotic process	Polb	IGI	MGI:MGI:98834	Mouse	PMID:15485914
Biological Process	GO:0006290	pyrimidine dimer repair	Polb	IDA		Rat	PMID:12388548|RGD:633643
Biological Process	GO:0045471	response to ethanol	Polb	IEP		Rat	PMID:18259862|RGD:2316775
Biological Process	GO:0010332	response to gamma radiation	Polb	IEP		Rat	PMID:12425958|RGD:8694104
Biological Process	GO:0055093	response to hyperoxia	Polb	IEP		Rat	PMID:8786668|RGD:8694108
Biological Process	GO:0007435	salivary gland morphogenesis	Polb	IMP	MGI:MGI:5427084	Mouse	PMID:24388753
Biological Process	GO:0016445	somatic diversification of immunoglobulins	Polb	IMP	MGI:MGI:5427084	Mouse	PMID:24388753
Biological Process	GO:0016446	somatic hypermutation of immunoglobulin genes	Polb	IMP	MGI:MGI:5427084	Mouse	PMID:24388753
Biological Process	GO:0048536	spleen development	Polb	IMP	MGI:MGI:5427084	Mouse	PMID:24388753

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern