Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes POLG
  • Mouse genes Polg
  • Rat genes Polg
  • Zfish genes polg
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Polg

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008408	3'-5' exonuclease activity	POLG	IMP		Human	PMID:26554610
Molecular Function	GO:0008408	3'-5' exonuclease activity	POLG	IDA		Human	PMID:28430993
Molecular Function	GO:0003682	chromatin binding	POLG	IDA		Human	PMID:18063578
Molecular Function	GO:0003677	DNA binding	POLG	IDA		Human	PMID:10608893
Molecular Function	GO:0003887	DNA-directed DNA polymerase activity	POLG	IDA		Human	PMID:10608893
Molecular Function	GO:0003887	DNA-directed DNA polymerase activity	POLG	IDA		Human	PMID:15164064
Molecular Function	GO:0003887	DNA-directed DNA polymerase activity	POLG	IDA		Human	PMID:15177179
Molecular Function	GO:0003887	DNA-directed DNA polymerase activity	POLG	IDA		Human	PMID:19837034
Molecular Function	GO:0003887	DNA-directed DNA polymerase activity	POLG	IDA		Human	PMID:19858216
Molecular Function	GO:0003887	DNA-directed DNA polymerase activity	POLG	IDA		Human	PMID:26123486
Molecular Function	GO:0003887	DNA-directed DNA polymerase activity	POLG	IDA		Human	PMID:26446790
Molecular Function	GO:0003887	DNA-directed DNA polymerase activity	POLG	IMP		Human	PMID:26554610
Molecular Function	GO:0003887	DNA-directed DNA polymerase activity	POLG	IDA		Human	PMID:28430993
Molecular Function	GO:0003887	DNA-directed DNA polymerase activity	Polg	IDA		Rat	PMID:12565799|RGD:724601
Molecular Function	GO:0004527	exonuclease activity	Polg	IDA		Mouse	PMID:15164064
Molecular Function	GO:0002020	protease binding	POLG	IPI	UniProtKB:P36776	Human	PMID:14739292
Molecular Function	GO:0005515	protein binding	POLG	IPI	UniProtKB:Q9UHN1	Human	PMID:10608893
Molecular Function	GO:0005515	protein binding	POLG	IPI	UniProtKB:Q9UHN1	Human	PMID:16263719
Molecular Function	GO:0005515	protein binding	POLG	IPI	UniProtKB:Q92900	Human	PMID:16488880
Molecular Function	GO:0005515	protein binding	POLG	IPI	UniProtKB:Q9UHN1	Human	PMID:17762861
Molecular Function	GO:0005515	protein binding	POLG	IPI	UniProtKB:Q9UHN1	Human	PMID:19837034
Molecular Function	GO:0005515	protein binding	POLG	IPI	UniProtKB:Q9UHN1	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	POLG	IPI	UniProtKB:Q9UHN1	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	POLG	IPI	UniProtKB:P49916	Human	PMID:33855352
Molecular Function	GO:0005515	protein binding	Polg	IPI	UniProtKB:P02340|UniProtKB:P09671	Mouse	MGI:MGI:5448514|PMID:21909133
Molecular Function	GO:0005515	protein binding	Polg	IPI	PR:Q99M87	Mouse	PMID:16327803
Cellular Component	GO:0005760	gamma DNA polymerase complex	POLG	IPI		Human	PMID:19837034
Cellular Component	GO:0005760	gamma DNA polymerase complex	POLG	IDA		Human	PMID:10608893
Cellular Component	GO:0005760	gamma DNA polymerase complex	POLG	IDA		Human	PMID:19837034
Cellular Component	GO:0005760	gamma DNA polymerase complex	POLG	IDA		Human	PMID:19858216
Cellular Component	GO:0005760	gamma DNA polymerase complex	POLG	IDA		Human	PMID:26123486
Cellular Component	GO:0005760	gamma DNA polymerase complex	POLG	IDA		Human	PMID:26446790
Cellular Component	GO:0005760	gamma DNA polymerase complex	POLG	IDA		Human	PMID:26554610
Cellular Component	GO:0005760	gamma DNA polymerase complex	Polg	IDA		Rat	PMID:12565799|RGD:724601
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	POLG	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005743	mitochondrial inner membrane	Polg	HDA		Mouse	PMID:12865426
Cellular Component	GO:0005759	mitochondrial matrix	POLG	IDA		Human	PMID:19837034
Cellular Component	GO:0042645	mitochondrial nucleoid	POLG	IDA		Human	PMID:18063578
Cellular Component	GO:0005739	mitochondrion	POLG	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	Polg	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005739	mitochondrion	Polg	HDA		Mouse	PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Polg	IDA		Rat	PMID:12565799|RGD:724601
Cellular Component	GO:0032991	protein-containing complex	POLG	IDA		Human	PMID:25378300
Cellular Component	GO:0043195	terminal bouton	Polg	IDA		Rat	PMID:15979612|RGD:8694099
Biological Process	GO:0007568	aging	Polg	IEP		Rat	PMID:15979612|RGD:8694099
Biological Process	GO:0006287	base-excision repair, gap-filling	POLG	IDA		Human	PMID:15177179
Biological Process	GO:0071333	cellular response to glucose stimulus	Polg	IEP		Rat	PMID:22743328|RGD:8694093
Biological Process	GO:0008340	determination of adult lifespan	Polg	IMP	MGI:MGI:3046825	Mouse	PMID:15164064
Biological Process	GO:0006261	DNA-templated DNA replication	POLG	IDA		Human	PMID:10608893
Biological Process	GO:0006261	DNA-templated DNA replication	POLG	IDA		Human	PMID:15167897
Biological Process	GO:0006261	DNA-templated DNA replication	POLG	IDA		Human	PMID:19837034
Biological Process	GO:0006261	DNA-templated DNA replication	POLG	IDA		Human	PMID:19858216
Biological Process	GO:0006261	DNA-templated DNA replication	POLG	IDA		Human	PMID:26123486
Biological Process	GO:0006261	DNA-templated DNA replication	POLG	IDA		Human	PMID:26446790
Biological Process	GO:0006261	DNA-templated DNA replication	POLG	IDA		Human	PMID:28430993
Biological Process	GO:0006264	mitochondrial DNA replication	POLG	IDA		Human	PMID:19837034
Biological Process	GO:0006264	mitochondrial DNA replication	POLG	IMP		Human	PMID:26554610
Biological Process	GO:0006264	mitochondrial DNA replication	Polg	IMP	MGI:MGI:3584444	Mouse	PMID:15888483
Biological Process	GO:0010332	response to gamma radiation	Polg	IEP		Rat	PMID:12425958|RGD:8694104
Biological Process	GO:0055093	response to hyperoxia	Polg	IEP		Rat	PMID:8786668|RGD:8694108
Biological Process	GO:0009416	response to light stimulus	Polg	IEP		Rat	PMID:15979612|RGD:8694099

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern