Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes POLG2
  • Mouse genes Polg2
  • Rat genes Polg2
  • Zfish genes polg2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Polg2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0070182	DNA polymerase binding	POLG2	IPI	UniProtKB:P54098	Human	PMID:10608893
Molecular Function	GO:0030337	DNA polymerase processivity factor activity	POLG2	IDA		Human	PMID:10608893
Molecular Function	GO:0030337	DNA polymerase processivity factor activity	POLG2	IDA		Human	PMID:19837034
Molecular Function	GO:0030337	DNA polymerase processivity factor activity	POLG2	IDA		Human	PMID:19858216
Molecular Function	GO:0030337	DNA polymerase processivity factor activity	POLG2	IDA		Human	PMID:26123486
Molecular Function	GO:0003887	DNA-directed DNA polymerase activity	Polg2	IDA		Mouse	PMID:10666468
Molecular Function	GO:0003690	double-stranded DNA binding	POLG2	IDA		Human	PMID:10608893
Molecular Function	GO:0003690	double-stranded DNA binding	POLG2	IDA		Human	PMID:26123486
Molecular Function	GO:0042802	identical protein binding	Polg2	IPI	UniProtKB:Q9QZM2	Mouse	MGI:MGI:1930386|PMID:11172710
Molecular Function	GO:0005515	protein binding	POLG2	IPI	UniProtKB:P54098	Human	PMID:16263719
Molecular Function	GO:0005515	protein binding	POLG2	IPI	UniProtKB:P54098	Human	PMID:17762861
Molecular Function	GO:0005515	protein binding	POLG2	IPI	UniProtKB:P54098	Human	PMID:19837034
Molecular Function	GO:0005515	protein binding	POLG2	IPI	UniProtKB:P54098	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	POLG2	IPI	UniProtKB:P54098	Human	PMID:28514442
Cellular Component	GO:0005760	gamma DNA polymerase complex	POLG2	IPI		Human	PMID:19837034
Cellular Component	GO:0005760	gamma DNA polymerase complex	POLG2	IDA		Human	PMID:10608893
Cellular Component	GO:0005760	gamma DNA polymerase complex	POLG2	IDA		Human	PMID:19837034
Cellular Component	GO:0005760	gamma DNA polymerase complex	POLG2	IDA		Human	PMID:19858216
Cellular Component	GO:0005760	gamma DNA polymerase complex	POLG2	IDA		Human	PMID:26123486
Cellular Component	GO:0005760	gamma DNA polymerase complex	POLG2	IDA		Human	PMID:26446790
Cellular Component	GO:0005760	gamma DNA polymerase complex	POLG2	IDA		Human	PMID:26554610
Cellular Component	GO:0005759	mitochondrial matrix	POLG2	IDA		Human	PMID:19837034
Cellular Component	GO:0042645	mitochondrial nucleoid	POLG2	IDA		Human	PMID:18063578
Cellular Component	GO:0042645	mitochondrial nucleoid	POLG2	IDA		Human	PMID:26123486
Cellular Component	GO:0005739	mitochondrion	POLG2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	Polg2	HDA		Mouse	PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Polg2	HDA		Mouse	PMID:18614015
Biological Process	GO:0006261	DNA-templated DNA replication	POLG2	IDA		Human	PMID:10608893
Biological Process	GO:0006261	DNA-templated DNA replication	POLG2	IDA		Human	PMID:15167897
Biological Process	GO:0006261	DNA-templated DNA replication	POLG2	IDA		Human	PMID:19837034
Biological Process	GO:0006261	DNA-templated DNA replication	POLG2	IDA		Human	PMID:19858216
Biological Process	GO:0006261	DNA-templated DNA replication	POLG2	IDA		Human	PMID:26123486
Biological Process	GO:0006261	DNA-templated DNA replication	POLG2	IDA		Human	PMID:26446790
Biological Process	GO:0006261	DNA-templated DNA replication	POLG2	IDA		Human	PMID:28430993
Biological Process	GO:0001701	in utero embryonic development	Polg2	IMP	MGI:MGI:5470227	Mouse	PMID:23197651
Biological Process	GO:0032042	mitochondrial DNA metabolic process	Polg2	IMP	MGI:MGI:5470227	Mouse	PMID:23197651
Biological Process	GO:0006264	mitochondrial DNA replication	POLG2	IDA		Human	PMID:19837034
Biological Process	GO:0070584	mitochondrion morphogenesis	Polg2	IMP	MGI:MGI:5470227	Mouse	PMID:23197651
Biological Process	GO:1900264	positive regulation of DNA-directed DNA polymerase activity	POLG2	IDA		Human	PMID:10608893
Biological Process	GO:1900264	positive regulation of DNA-directed DNA polymerase activity	POLG2	IDA		Human	PMID:19837034
Biological Process	GO:1900264	positive regulation of DNA-directed DNA polymerase activity	POLG2	IDA		Human	PMID:19858216
Biological Process	GO:1900264	positive regulation of DNA-directed DNA polymerase activity	POLG2	IDA		Human	PMID:26123486
Biological Process	GO:0022904	respiratory electron transport chain	Polg2	IMP	MGI:MGI:5470227	Mouse	PMID:23197651

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern