Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes POLQ
  • Mouse genes Polq
  • Rat genes Polq
  • Zfish genes polq
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Polq

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0051575	5'-deoxyribose-5-phosphate lyase activity	POLQ	IDA		Human	PMID:19188258
Molecular Function	GO:0003682	chromatin binding	POLQ	IDA		Human	PMID:25642963
Molecular Function	GO:0003887	DNA-directed DNA polymerase activity	POLQ	IDA		Human	PMID:14576298
Molecular Function	GO:0003887	DNA-directed DNA polymerase activity	POLQ	IMP		Human	PMID:22135286
Molecular Function	GO:0003887	DNA-directed DNA polymerase activity	POLQ	IDA		Human	PMID:25643323
Molecular Function	GO:0003887	DNA-directed DNA polymerase activity	Polq	IMP		Mouse	MGI:MGI:5621198|PMID:25642960
Molecular Function	GO:0005515	protein binding	POLQ	IPI	UniProtKB:Q06609	Human	PMID:25642963
Molecular Function	GO:0017116	single-stranded DNA helicase activity	POLQ	IDA		Human	PMID:14576298
Cellular Component	GO:0005829	cytosol	POLQ	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005794	Golgi apparatus	POLQ	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	POLQ	IDA		Human	GO_REF:0000052
Biological Process	GO:0006284	base-excision repair	POLQ	IDA		Human	PMID:19188258
Biological Process	GO:0006974	DNA damage response	POLQ	IDA		Human	PMID:25642963
Biological Process	GO:0006974	DNA damage response	POLQ	IDA		Human	PMID:25643323
Biological Process	GO:0006281	DNA repair	Polq	IGI	MGI:MGI:107202	Mouse	PMID:15542845
Biological Process	GO:0006281	DNA repair	Polq	IMP	MGI:MGI:2656007	Mouse	PMID:15542845
Biological Process	GO:0006281	DNA repair	Polq	IMP	MGI:MGI:2656007	Mouse	PMID:12663541
Biological Process	GO:0006302	double-strand break repair	POLQ	IDA		Human	PMID:22135286
Biological Process	GO:0097681	double-strand break repair via alternative nonhomologous end joining	POLQ	IDA		Human	PMID:25643323
Biological Process	GO:0097681	double-strand break repair via alternative nonhomologous end joining	Polq	IDA		Mouse	MGI:MGI:5621198|PMID:25642960
Biological Process	GO:2000042	negative regulation of double-strand break repair via homologous recombination	POLQ	IDA		Human	PMID:25642963
Biological Process	GO:2000042	negative regulation of double-strand break repair via homologous recombination	Polq	IDA		Mouse	MGI:MGI:5621198|PMID:25642960
Biological Process	GO:0051260	protein homooligomerization	POLQ	IDA		Human	PMID:25643323
Biological Process	GO:0016446	somatic hypermutation of immunoglobulin genes	Polq	IMP		Mouse	MGI:MGI:3609287|PMID:16222339
Biological Process	GO:0016446	somatic hypermutation of immunoglobulin genes	Polq	IMP		Mouse	MGI:MGI:3692678|PMID:16890500
Biological Process	GO:0016446	somatic hypermutation of immunoglobulin genes	Polq	IMP		Mouse	MGI:MGI:3603978|PMID:16172387

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern