Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes POLR2A
  • Mouse genes Polr2a
  • Rat genes Polr2a
  • Zfish genes polr2a
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Polr2a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001046	core promoter sequence-specific DNA binding	Polr2a	IDA		Mouse	MGI:MGI:5428344|PMID:22723415
Molecular Function	GO:0003677	DNA binding	Polr2a	IDA		Mouse	PMID:15601870
Molecular Function	GO:0019900	kinase binding	POLR2A	IPI	UniProtKB:P78362	Human	PMID:28076779
Molecular Function	GO:1990841	promoter-specific chromatin binding	POLR2A	IDA		Human	PMID:24441171
Molecular Function	GO:0005515	protein binding	POLR2A	IPI	UniProtKB:Q5TA45	Human	PMID:16239144
Molecular Function	GO:0005515	protein binding	POLR2A	IPI	UniProtKB:O00267	Human	PMID:10075709
Molecular Function	GO:0005515	protein binding	POLR2A	IPI	UniProtKB:Q9HCS7	Human	PMID:10944529
Molecular Function	GO:0005515	protein binding	POLR2A	IPI	UniProtKB:P17844	Human	PMID:12527917
Molecular Function	GO:0005515	protein binding	POLR2A	IPI	UniProtKB:O00255	Human	PMID:14992727
Molecular Function	GO:0005515	protein binding	POLR2A	IPI	UniProtKB:O60563	Human	PMID:15563843
Molecular Function	GO:0005515	protein binding	POLR2A	IPI	UniProtKB:O60583	Human	PMID:15563843
Molecular Function	GO:0005515	protein binding	POLR2A	IPI	UniProtKB:Q6P1J9	Human	PMID:15923622
Molecular Function	GO:0005515	protein binding	POLR2A	IPI	UniProtKB:Q8N7H5	Human	PMID:15923622
Molecular Function	GO:0005515	protein binding	POLR2A	IPI	UniProtKB:Q9H7N4	Human	PMID:15992770
Molecular Function	GO:0005515	protein binding	POLR2A	IPI	UniProtKB:Q6P1J9	Human	PMID:16024656
Molecular Function	GO:0005515	protein binding	POLR2A	IPI	UniProtKB:Q8N7H5	Human	PMID:16024656
Molecular Function	GO:0005515	protein binding	POLR2A	IPI	UniProtKB:Q68E01	Human	PMID:16239144
Molecular Function	GO:0005515	protein binding	POLR2A	IPI	UniProtKB:Q6P9B9	Human	PMID:16239144
Molecular Function	GO:0005515	protein binding	POLR2A	IPI	UniProtKB:Q75QN2	Human	PMID:16239144
Molecular Function	GO:0005515	protein binding	POLR2A	IPI	UniProtKB:Q96CB8	Human	PMID:16239144
Molecular Function	GO:0005515	protein binding	POLR2A	IPI	UniProtKB:Q96HW7	Human	PMID:16239144
Molecular Function	GO:0005515	protein binding	POLR2A	IPI	UniProtKB:Q9H0H0	Human	PMID:16239144
Molecular Function	GO:0005515	protein binding	POLR2A	IPI	UniProtKB:Q9NV88	Human	PMID:16239144
Molecular Function	GO:0005515	protein binding	POLR2A	IPI	UniProtKB:Q9NVH2	Human	PMID:16239144
Molecular Function	GO:0005515	protein binding	POLR2A	IPI	UniProtKB:Q9NVR2	Human	PMID:16239144
Molecular Function	GO:0005515	protein binding	POLR2A	IPI	UniProtKB:Q9UL03	Human	PMID:16239144
Molecular Function	GO:0005515	protein binding	POLR2A	IPI	UniProtKB:P17844	Human	PMID:17011493
Molecular Function	GO:0005515	protein binding	POLR2A	IPI	UniProtKB:Q62383	Human	PMID:17234882
Molecular Function	GO:0005515	protein binding	POLR2A	IPI	UniProtKB:Q7KZ85	Human	PMID:17234882
Molecular Function	GO:0005515	protein binding	POLR2A	IPI	UniProtKB:O15047	Human	PMID:17998332
Molecular Function	GO:0005515	protein binding	POLR2A	IPI	UniProtKB:Q6UXN9	Human	PMID:17998332
Molecular Function	GO:0005515	protein binding	POLR2A	IPI	UniProtKB:Q9UPS6	Human	PMID:17998332
Molecular Function	GO:0005515	protein binding	POLR2A	IPI	UniProtKB:Q9UPN6	Human	PMID:18550522
Molecular Function	GO:0005515	protein binding	POLR2A	IPI	UniProtKB:O94762-1	Human	PMID:18562274
Molecular Function	GO:0005515	protein binding	POLR2A	IPI	UniProtKB:Q96H20	Human	PMID:19819239
Molecular Function	GO:0005515	protein binding	POLR2A	IPI	UniProtKB:P23193	Human	PMID:20178742
Molecular Function	GO:0005515	protein binding	POLR2A	IPI	UniProtKB:Q8N7H5	Human	PMID:20178742
Molecular Function	GO:0005515	protein binding	POLR2A	IPI	UniProtKB:P23193	Human	PMID:20562857
Molecular Function	GO:0005515	protein binding	POLR2A	IPI	UniProtKB:P26368	Human	PMID:21536736
Molecular Function	GO:0005515	protein binding	POLR2A	IPI	UniProtKB:Q67020	Human	PMID:21994455
Molecular Function	GO:0005515	protein binding	POLR2A	IPI	UniProtKB:Q9NQG5	Human	PMID:22264791
Molecular Function	GO:0005515	protein binding	POLR2A	IPI	UniProtKB:Q9H7E2	Human	PMID:23066109
Molecular Function	GO:0005515	protein binding	POLR2A	IPI	UniProtKB:O60318	Human	PMID:23652018
Molecular Function	GO:0005515	protein binding	POLR2A	IPI	UniProtKB:O94762-1	Human	PMID:23748380
Molecular Function	GO:0005515	protein binding	POLR2A	IPI	UniProtKB:P23193	Human	PMID:23748380
Molecular Function	GO:0005515	protein binding	POLR2A	IPI	UniProtKB:L8B1Q7	Human	PMID:24418534
Molecular Function	GO:0005515	protein binding	POLR2A	IPI	UniProtKB:Q5NTY3	Human	PMID:24418534
Molecular Function	GO:0005515	protein binding	POLR2A	IPI	UniProtKB:O00267	Human	PMID:24814348
Molecular Function	GO:0005515	protein binding	POLR2A	IPI	UniProtKB:Q9UPY3-1	Human	PMID:24814348
Molecular Function	GO:0005515	protein binding	POLR2A	IPI	UniProtKB:Q96P16	Human	PMID:24981860
Molecular Function	GO:0005515	protein binding	POLR2A	IPI	UniProtKB:Q9NQG5	Human	PMID:24981860
Molecular Function	GO:0005515	protein binding	POLR2A	IPI	UniProtKB:Q96P16	Human	PMID:24997600
Molecular Function	GO:0005515	protein binding	POLR2A	IPI	UniProtKB:Q9NQG5	Human	PMID:24997600
Molecular Function	GO:0005515	protein binding	POLR2A	IPI	UniProtKB:O00267	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	POLR2A	IPI	UniProtKB:Q98140	Human	PMID:25544563
Molecular Function	GO:0005515	protein binding	POLR2A	IPI	UniProtKB:P35637	Human	PMID:26124092
Molecular Function	GO:0005515	protein binding	POLR2A	IPI	UniProtKB:O00267	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	POLR2A	IPI	UniProtKB:Q6P1J9	Human	PMID:26659056
Molecular Function	GO:0005515	protein binding	POLR2A	IPI	UniProtKB:O14744	Human	PMID:26700805
Molecular Function	GO:0005515	protein binding	POLR2A	IPI	UniProtKB:Q16637	Human	PMID:26700805
Molecular Function	GO:0005515	protein binding	POLR2A	IPI	UniProtKB:Q7Z333	Human	PMID:26700805
Molecular Function	GO:0005515	protein binding	POLR2A	IPI	UniProtKB:Q9H0D6	Human	PMID:26700805
Molecular Function	GO:0005515	protein binding	POLR2A	IPI	UniProtKB:Q9H7E2	Human	PMID:26700805
Molecular Function	GO:0005515	protein binding	POLR2A	IPI	UniProtKB:Q96C12	Human	PMID:28169274
Molecular Function	GO:0005515	protein binding	POLR2A	IPI	UniProtKB:Q9NQG5	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	POLR2A	IPI	UniProtKB:Q9NWX5	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	POLR2A	IPI	UniProtKB:O94992,UniProtKB:P50750	Human	PMID:30824372
Molecular Function	GO:0005515	protein binding	POLR2A	IPI	UniProtKB:P42285,UniProtKB:Q9Y580	Human	PMID:30824372
Molecular Function	GO:0005515	protein binding	POLR2A	IPI	UniProtKB:P50750,UniProtKB:Q9Y580	Human	PMID:30824372
Molecular Function	GO:0005515	protein binding	POLR2A	IPI	UniProtKB:Q9NWX5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	POLR2A	IPI	UniProtKB:Q8N108-16	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	POLR2A	IPI	UniProtKB:Q8WTV1	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Polr2a	IPI	UniProtKB:Q63623	Mouse	MGI:MGI:4457260|PMID:9528809
Molecular Function	GO:0005515	protein binding	Polr2a	IPI	UniProtKB:Q62383	Mouse	MGI:MGI:5508586|PMID:19141475
Molecular Function	GO:0005515	protein binding	Polr2a	IPI	UniProtKB:Q63625	Mouse	MGI:MGI:5430904|PMID:8692929
Molecular Function	GO:0005515	protein binding	Polr2a	IPI	UniProtKB:Q62093	Mouse	MGI:MGI:5918739|PMID:18641664
Molecular Function	GO:0005515	protein binding	Polr2a	IPI	UniProtKB:Q62093|UniProtKB:Q6PDM2	Mouse	MGI:MGI:5553217|PMID:23663783
Molecular Function	GO:0005515	protein binding	Polr2a	IPI	UniProtKB:O54943	Mouse	MGI:MGI:5430667|PMID:22767893
Molecular Function	GO:0005515	protein binding	Polr2a	IPI	UniProtKB:Q3TQR2	Mouse	PMID:14612417
Molecular Function	GO:0005515	protein binding	Polr2a	IPI	PR:Q9ESU6	Mouse	PMID:22509028
Molecular Function	GO:0003723	RNA binding	POLR2A	HDA		Human	PMID:22658674
Molecular Function	GO:0003723	RNA binding	POLR2A	HDA		Human	PMID:22681889
Molecular Function	GO:0031625	ubiquitin protein ligase binding	POLR2A	IPI	UniProtKB:P46934	Human	PMID:17996703
Cellular Component	GO:0000791	euchromatin	Polr2a	IDA		Mouse	MGI:MGI:5428344|PMID:22723415
Cellular Component	GO:0005634	nucleus	POLR2A	IDA		Human	PMID:14580349
Cellular Component	GO:0005634	nucleus	POLR2A	IDA		Human	PMID:16109376
Cellular Component	GO:0005634	nucleus	POLR2A	IDA		Human	PMID:9852112
Cellular Component	GO:0005634	nucleus	Polr2a	IDA		Mouse	PMID:26346254
Cellular Component	GO:0005634	nucleus	Polr2a	IDA		Rat	PMID:19095046|RGD:9681725
Cellular Component	GO:0005665	RNA polymerase II, core complex	POLR2A	IDA		Human	PMID:9852112
Biological Process	GO:0071453	cellular response to oxygen levels	Polr2a	IEP		Rat	PMID:19095046|RGD:9681725
Biological Process	GO:0006353	DNA-templated transcription termination	POLR2A	IMP		Human	PMID:26700805
Biological Process	GO:0033120	positive regulation of RNA splicing	POLR2A	IDA		Human	PMID:21536736
Biological Process	GO:0014070	response to organic cyclic compound	Polr2a	IEP		Rat	PMID:23026235|RGD:9681724
Biological Process	GO:0006366	transcription by RNA polymerase II	POLR2A	IDA		Human	PMID:9852112

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern