Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes POMC
  • Mouse genes Pomc
  • Rat genes Pomc
  • Zfish genes pomca,pomcb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pomc

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001664	G protein-coupled receptor binding	POMC	IDA		Human	PMID:19452503
Molecular Function	GO:0005179	hormone activity	POMC	IMP		Human	PMID:9620771
Molecular Function	GO:0005179	hormone activity	Pomc	IDA		Mouse	PMID:15467755
Molecular Function	GO:0005184	neuropeptide hormone activity	pomca	IDA		Zfish	PMID:14709799
Molecular Function	GO:0005515	protein binding	POMC	IPI	UniProtKB:O75031	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	POMC	IPI	UniProtKB:P51687	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	POMC	IPI	UniProtKB:P62508-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	POMC	IPI	UniProtKB:Q13064	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	POMC	IPI	UniProtKB:Q68D86	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	POMC	IPI	UniProtKB:Q7RTU4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	POMC	IPI	UniProtKB:Q7Z4H3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	POMC	IPI	UniProtKB:Q8IVS8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	POMC	IPI	UniProtKB:Q8N8Y2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	POMC	IPI	UniProtKB:Q8NI38	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	POMC	IPI	UniProtKB:Q96HA8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	POMC	IPI	UniProtKB:Q99757	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	POMC	IPI	UniProtKB:Q9NX04	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	POMC	IPI	UniProtKB:Q9NYB9-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	POMC	IPI	UniProtKB:Q9P2K6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	POMC	IPI	UniProtKB:Q9UMX2-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Pomc	IPI	PR:Q00493	Mouse	PMID:16219686
Molecular Function	GO:0005515	protein binding	Pomc	IPI	PR:P47867	Mouse	PMID:16219686
Molecular Function	GO:0005515	protein binding	Pomc	IPI	PR:P26339	Mouse	PMID:16219686
Molecular Function	GO:0005102	signaling receptor binding	POMC	IMP		Human	PMID:9620771
Molecular Function	GO:0070996	type 1 melanocortin receptor binding	POMC	IDA		Human	PMID:18292087
Molecular Function	GO:0070996	type 1 melanocortin receptor binding	POMC	IPI	UniProtKB:Q01726	Human	PMID:19743876
Molecular Function	GO:0031781	type 3 melanocortin receptor binding	POMC	IPI	UniProtKB:P41968	Human	PMID:19743876
Molecular Function	GO:0031782	type 4 melanocortin receptor binding	POMC	IPI	UniProtKB:P32245	Human	PMID:19743876
Cellular Component	GO:0005737	cytoplasm	Pomc	IDA		Mouse	PMID:18388149
Cellular Component	GO:0005576	extracellular region	Pomc	IDA		Rat	PMID:15316242|RGD:1601431
Cellular Component	GO:0005615	extracellular space	POMC	IDA		Human	PMID:9620771
Cellular Component	GO:0005615	extracellular space	Pomc	IDA		Mouse	PMID:16219686
Cellular Component	GO:0030141	secretory granule	Pomc	IDA		Mouse	PMID:1329576
Cellular Component	GO:0030141	secretory granule	Pomc	IDA		Mouse	PMID:16219686
Biological Process	GO:0019722	calcium-mediated signaling	Pomc	IMP		Mouse	MGI:MGI:6716959|PMID:25096581
Biological Process	GO:0007267	cell-cell signaling	POMC	IMP		Human	PMID:9620771
Biological Process	GO:0033059	cellular pigmentation	POMC	IMP		Human	PMID:9620771
Biological Process	GO:0006091	generation of precursor metabolites and energy	POMC	IMP		Human	PMID:9620771
Biological Process	GO:0042593	glucose homeostasis	Pomc	IMP	MGI:MGI:2687084	Mouse	PMID:21184805
Biological Process	GO:0032400	melanosome localization	pomca	IMP	ZFIN:ZDB-MRPHLNO-110112-3	Zfish	PMID:21209207
Biological Process	GO:0033555	multicellular organismal response to stress	pomca	IEP		Zfish	PMID:25748166
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	POMC	IDA		Human	PMID:10233018
Biological Process	GO:0007218	neuropeptide signaling pathway	pomca	IDA		Zfish	PMID:14709799
Biological Process	GO:0043950	positive regulation of cAMP-mediated signaling	Pomc	IDA		Mouse	MGI:MGI:6716959|PMID:25096581
Biological Process	GO:0140668	positive regulation of oxytocin production	Pomc	IDA		Mouse	MGI:MGI:6716959|PMID:25096581
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	POMC	IDA		Human	PMID:18292087
Biological Process	GO:0032098	regulation of appetite	POMC	IMP		Human	PMID:9620771
Biological Process	GO:0008217	regulation of blood pressure	Pomc	IGI	MGI:MGI:88106	Mouse	PMID:16243970
Biological Process	GO:0008217	regulation of blood pressure	Pomc	IGI	MGI:MGI:88105	Mouse	PMID:16243970
Biological Process	GO:2000852	regulation of corticosterone secretion	Pomc	IMP	MGI:MGI:2687084	Mouse	PMID:21184805
Biological Process	GO:0070873	regulation of glycogen metabolic process	Pomc	IMP	MGI:MGI:2687084	Mouse	PMID:21184805
Biological Process	GO:1902036	regulation of hematopoietic stem cell differentiation	pomca	IGI	ZFIN:ZDB-GENE-041014-294	Zfish	PMID:27424782
Biological Process	GO:1902036	regulation of hematopoietic stem cell differentiation	pomcb	IGI	ZFIN:ZDB-GENE-030513-2	Zfish	PMID:27424782
Biological Process	GO:1990680	response to melanocyte-stimulating hormone	Pomc	IDA		Mouse	MGI:MGI:6716959|PMID:25096581
Biological Process	GO:0007165	signal transduction	POMC	IMP		Human	PMID:9620771

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern