Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PON1
  • Mouse genes Pon1
  • Rat genes Pon1
  • Zfish genes pon1,pon2,pon3.1,pon3.2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pon1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004063	aryldialkylphosphatase activity	PON1	IDA		Human	PMID:15098021
Molecular Function	GO:0004063	aryldialkylphosphatase activity	PON1	IDA		Human	PMID:7638166
Molecular Function	GO:0004063	aryldialkylphosphatase activity	Pon1	IDA		Rat	PMID:11015468|RGD:731237
Molecular Function	GO:0004063	aryldialkylphosphatase activity	Pon1	IDA		Rat	PMID:16214326|RGD:1580194
Molecular Function	GO:0004064	arylesterase activity	PON1	IDA		Human	PMID:15098021
Molecular Function	GO:0004064	arylesterase activity	PON1	IDA		Human	PMID:7638166
Molecular Function	GO:0004064	arylesterase activity	Pon1	IMP	MGI:MGI:2148702	Mouse	PMID:9685159
Molecular Function	GO:0005509	calcium ion binding	PON1	IDA		Human	PMID:15098021
Molecular Function	GO:0005543	phospholipid binding	PON1	IDA		Human	PMID:10479665
Molecular Function	GO:0042803	protein homodimerization activity	PON1	IDA		Human	PMID:15772423
Cellular Component	GO:0072562	blood microparticle	PON1	HDA		Human	PMID:22516433
Cellular Component	GO:0070062	extracellular exosome	PON1	HDA		Human	PMID:23533145
Cellular Component	GO:0005615	extracellular space	PON1	IDA		Human	PMID:7638166
Cellular Component	GO:0005615	extracellular space	Pon1	IDA		Rat	PMID:16214326|RGD:1580194
Cellular Component	GO:0034364	high-density lipoprotein particle	PON1	IDA		Human	PMID:15721011
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Pon1	IDA		Rat	PMID:16052486|RGD:1580195
Cellular Component	GO:0034366	spherical high-density lipoprotein particle	PON1	IDA		Human	PMID:16682745
Biological Process	GO:0019439	aromatic compound catabolic process	PON1	IDA		Human	PMID:15772423
Biological Process	GO:0046395	carboxylic acid catabolic process	PON1	IDA		Human	PMID:7638166
Biological Process	GO:0008203	cholesterol metabolic process	Pon1	IMP	MGI:MGI:2148702	Mouse	PMID:9685159
Biological Process	GO:0006629	lipid metabolic process	Pon1	IEP		Rat	PMID:11015468|RGD:731237
Biological Process	GO:0046434	organophosphate catabolic process	PON1	IDA		Human	PMID:7638166
Biological Process	GO:0046470	phosphatidylcholine metabolic process	PON1	IDA		Human	PMID:15721011
Biological Process	GO:0051099	positive regulation of binding	PON1	IDA		Human	PMID:15721011
Biological Process	GO:0010875	positive regulation of cholesterol efflux	PON1	IDA		Human	PMID:15721011
Biological Process	GO:0032411	positive regulation of transporter activity	PON1	IDA		Human	PMID:15721011
Biological Process	GO:0070542	response to fatty acid	Pon1	IEP		Rat	PMID:23383120|RGD:8547690
Biological Process	GO:1902617	response to fluoride	Pon1	IDA		Rat	PMID:24384758|RGD:8547691
Biological Process	GO:0032496	response to lipopolysaccharide	Pon1	IEP		Rat	PMID:29174038|RGD:153350090
Biological Process	GO:0031667	response to nutrient levels	Pon1	IEP		Rat	PMID:21562236|RGD:8547657
Biological Process	GO:0009636	response to toxic substance	Pon1	IMP	MGI:MGI:2148702	Mouse	PMID:9685159

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern