Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes POT1
  • Mouse genes Pot1a
  • Rat genes Pot1
  • Zfish genes pot1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pot1a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:1905773	8-hydroxy-2'-deoxyguanosine DNA binding	POT1	IDA		Human	PMID:19734539
Molecular Function	GO:0017151	DEAD/H-box RNA helicase binding	POT1	IPI	UniProtKB:P54132	Human	PMID:16030011
Molecular Function	GO:0017151	DEAD/H-box RNA helicase binding	POT1	IPI	UniProtKB:Q14191	Human	PMID:16030011
Molecular Function	GO:1990955	G-rich single-stranded DNA binding	POT1	IDA		Human	PMID:19734539
Molecular Function	GO:0098505	G-rich strand telomeric DNA binding	POT1	IDA		Human	PMID:17237768
Molecular Function	GO:0098505	G-rich strand telomeric DNA binding	POT1	IDA		Human	PMID:21852327
Molecular Function	GO:0098505	G-rich strand telomeric DNA binding	POT1	IDA		Human	PMID:22763445
Molecular Function	GO:0005515	protein binding	POT1	IPI	UniProtKB:O95271	Human	PMID:12768206
Molecular Function	GO:0005515	protein binding	POT1	IPI	UniProtKB:P54274	Human	PMID:12768206
Molecular Function	GO:0005515	protein binding	POT1	IPI	UniProtKB:Q9BSI4	Human	PMID:12768206
Molecular Function	GO:0005515	protein binding	POT1	IPI	UniProtKB:Q96AP0	Human	PMID:15181449
Molecular Function	GO:0005515	protein binding	POT1	IPI	UniProtKB:Q15554	Human	PMID:15383534
Molecular Function	GO:0005515	protein binding	POT1	IPI	UniProtKB:Q96AP0	Human	PMID:15383534
Molecular Function	GO:0005515	protein binding	POT1	IPI	UniProtKB:Q15554	Human	PMID:15657433
Molecular Function	GO:0005515	protein binding	POT1	IPI	UniProtKB:Q96AP0	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	POT1	IPI	UniProtKB:Q96AP0	Human	PMID:17237768
Molecular Function	GO:0005515	protein binding	POT1	IPI	UniProtKB:Q15554	Human	PMID:19287395
Molecular Function	GO:0005515	protein binding	POT1	IPI	UniProtKB:Q15554	Human	PMID:19651898
Molecular Function	GO:0005515	protein binding	POT1	IPI	UniProtKB:O43704	Human	PMID:21044950
Molecular Function	GO:0005515	protein binding	POT1	IPI	UniProtKB:O60496	Human	PMID:21044950
Molecular Function	GO:0005515	protein binding	POT1	IPI	UniProtKB:O94808	Human	PMID:21044950
Molecular Function	GO:0005515	protein binding	POT1	IPI	UniProtKB:O95833	Human	PMID:21044950
Molecular Function	GO:0005515	protein binding	POT1	IPI	UniProtKB:P07355	Human	PMID:21044950
Molecular Function	GO:0005515	protein binding	POT1	IPI	UniProtKB:P09601	Human	PMID:21044950
Molecular Function	GO:0005515	protein binding	POT1	IPI	UniProtKB:P0DMV8	Human	PMID:21044950
Molecular Function	GO:0005515	protein binding	POT1	IPI	UniProtKB:P30838	Human	PMID:21044950
Molecular Function	GO:0005515	protein binding	POT1	IPI	UniProtKB:P43358	Human	PMID:21044950
Molecular Function	GO:0005515	protein binding	POT1	IPI	UniProtKB:P46952	Human	PMID:21044950
Molecular Function	GO:0005515	protein binding	POT1	IPI	UniProtKB:P50747	Human	PMID:21044950
Molecular Function	GO:0005515	protein binding	POT1	IPI	UniProtKB:P63313	Human	PMID:21044950
Molecular Function	GO:0005515	protein binding	POT1	IPI	UniProtKB:Q01064	Human	PMID:21044950
Molecular Function	GO:0005515	protein binding	POT1	IPI	UniProtKB:Q03426	Human	PMID:21044950
Molecular Function	GO:0005515	protein binding	POT1	IPI	UniProtKB:Q12851	Human	PMID:21044950
Molecular Function	GO:0005515	protein binding	POT1	IPI	UniProtKB:Q5SRE7	Human	PMID:21044950
Molecular Function	GO:0005515	protein binding	POT1	IPI	UniProtKB:Q6PJW8	Human	PMID:21044950
Molecular Function	GO:0005515	protein binding	POT1	IPI	UniProtKB:Q86WR7	Human	PMID:21044950
Molecular Function	GO:0005515	protein binding	POT1	IPI	UniProtKB:Q8IUZ5	Human	PMID:21044950
Molecular Function	GO:0005515	protein binding	POT1	IPI	UniProtKB:Q8WXG6	Human	PMID:21044950
Molecular Function	GO:0005515	protein binding	POT1	IPI	UniProtKB:Q96A49	Human	PMID:21044950
Molecular Function	GO:0005515	protein binding	POT1	IPI	UniProtKB:Q96A73	Human	PMID:21044950
Molecular Function	GO:0005515	protein binding	POT1	IPI	UniProtKB:Q96AP0	Human	PMID:21044950
Molecular Function	GO:0005515	protein binding	POT1	IPI	UniProtKB:Q96GU1	Human	PMID:21044950
Molecular Function	GO:0005515	protein binding	POT1	IPI	UniProtKB:Q99795	Human	PMID:21044950
Molecular Function	GO:0005515	protein binding	POT1	IPI	UniProtKB:Q9BR01	Human	PMID:21044950
Molecular Function	GO:0005515	protein binding	POT1	IPI	UniProtKB:Q9BRP8	Human	PMID:21044950
Molecular Function	GO:0005515	protein binding	POT1	IPI	UniProtKB:Q9BSI4	Human	PMID:21044950
Molecular Function	GO:0005515	protein binding	POT1	IPI	UniProtKB:Q9BV29	Human	PMID:21044950
Molecular Function	GO:0005515	protein binding	POT1	IPI	UniProtKB:Q9BWH6	Human	PMID:21044950
Molecular Function	GO:0005515	protein binding	POT1	IPI	UniProtKB:Q9BY11	Human	PMID:21044950
Molecular Function	GO:0005515	protein binding	POT1	IPI	UniProtKB:Q9NPH2	Human	PMID:21044950
Molecular Function	GO:0005515	protein binding	POT1	IPI	UniProtKB:Q9P0Z9	Human	PMID:21044950
Molecular Function	GO:0005515	protein binding	POT1	IPI	UniProtKB:Q9Y4P8	Human	PMID:21044950
Molecular Function	GO:0005515	protein binding	POT1	IPI	UniProtKB:Q2NKJ3	Human	PMID:22763445
Molecular Function	GO:0005515	protein binding	POT1	IPI	UniProtKB:Q96AP0	Human	PMID:25172512
Molecular Function	GO:0005515	protein binding	POT1	IPI	UniProtKB:Q549N0	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	POT1	IPI	UniProtKB:Q9BSI4	Human	PMID:25620558
Molecular Function	GO:0005515	protein binding	POT1	IPI	UniProtKB:Q15554	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	POT1	IPI	UniProtKB:Q96AP0	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	POT1	IPI	UniProtKB:Q9BSI4	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	POT1	IPI	UniProtKB:Q15554	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	POT1	IPI	UniProtKB:Q96AP0	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	POT1	IPI	UniProtKB:Q96AP0	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	POT1	IPI	UniProtKB:Q9Y281	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Pot1a	IPI	UniProtKB:Q96AP0	Mouse	MGI:MGI:5919331|PMID:22101936
Molecular Function	GO:0005515	protein binding	Pot1a	IPI	UniProtKB:Q5EE38-1|UniProtKB:Q96AP0	Mouse	MGI:MGI:4441256|PMID:17632522
Molecular Function	GO:0005515	protein binding	Pot1a	IPI	PR:Q5EE38	Mouse	PMID:17053789
Molecular Function	GO:0005515	protein binding	Pot1a	IPI	PR:Q30D77	Mouse	PMID:17053789
Molecular Function	GO:0005515	protein binding	pot1	IPI	ZFIN:ZDB-GENE-081022-45	Zfish	PMID:21311760
Molecular Function	GO:0043047	single-stranded telomeric DNA binding	POT1	IMP		Human	PMID:12768206
Molecular Function	GO:0043047	single-stranded telomeric DNA binding	POT1	IDA		Human	PMID:15632080
Molecular Function	GO:0043047	single-stranded telomeric DNA binding	POT1	IDA		Human	PMID:17237767
Molecular Function	GO:0043047	single-stranded telomeric DNA binding	Pot1a	IDA		Mouse	PMID:17053789
Molecular Function	GO:0010521	telomerase inhibitor activity	POT1	IDA		Human	PMID:15632080
Molecular Function	GO:0061821	telomeric D-loop binding	POT1	IDA		Human	PMID:19734539
Molecular Function	GO:0042162	telomeric DNA binding	POT1	IDA		Human	PMID:23685356
Molecular Function	GO:0042162	telomeric DNA binding	Pot1a	IDA		Mouse	MGI:MGI:4441108|PMID:19854130
Molecular Function	GO:0042162	telomeric DNA binding	Pot1a	IDA		Mouse	MGI:MGI:5500098|PMID:23685356
Cellular Component	GO:0000781	chromosome, telomeric region	POT1	IDA		Human	PMID:12768206
Cellular Component	GO:0000781	chromosome, telomeric region	POT1	HDA		Human	PMID:19135898
Cellular Component	GO:0000781	chromosome, telomeric region	POT1	IDA		Human	PMID:23685356
Cellular Component	GO:0000781	chromosome, telomeric region	POT1	IDA		Human	PMID:24270157
Cellular Component	GO:0000781	chromosome, telomeric region	Pot1a	IDA		Mouse	MGI:MGI:5500098|PMID:23685356
Cellular Component	GO:0000783	nuclear telomere cap complex	POT1	IDA		Human	PMID:16880378
Cellular Component	GO:0000783	nuclear telomere cap complex	Pot1a	IDA		Mouse	PMID:17053789
Cellular Component	GO:0005654	nucleoplasm	POT1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0070187	shelterin complex	POT1	IPI		Human	PMID:15383534
Cellular Component	GO:0070187	shelterin complex	POT1	IDA		Human	PMID:15383534
Cellular Component	GO:0070187	shelterin complex	POT1	IMP		Human	PMID:21852327
Cellular Component	GO:0070187	shelterin complex	POT1	IDA		Human	PMID:23685356
Biological Process	GO:0051276	chromosome organization	Pot1a	IGI	MGI:MGI:98834	Mouse	PMID:17053789
Biological Process	GO:0051276	chromosome organization	Pot1a	IGI	MGI:MGI:1920086	Mouse	PMID:17053789
Biological Process	GO:0032508	DNA duplex unwinding	POT1	IDA		Human	PMID:16030011
Biological Process	GO:0070200	establishment of protein localization to telomere	POT1	IMP		Human	PMID:25589350
Biological Process	GO:0051974	negative regulation of telomerase activity	POT1	IDA		Human	PMID:15632080
Biological Process	GO:0032211	negative regulation of telomere maintenance via telomerase	POT1	IGI	UniProtKB:Q96AP0	Human	PMID:15181449
Biological Process	GO:1905776	positive regulation of DNA helicase activity	POT1	IDA		Human	PMID:19734539
Biological Process	GO:0060383	positive regulation of DNA strand elongation	POT1	IDA		Human	PMID:16043710
Biological Process	GO:0051096	positive regulation of helicase activity	POT1	IDA		Human	PMID:16030011
Biological Process	GO:0051973	positive regulation of telomerase activity	POT1	IMP		Human	PMID:15181449
Biological Process	GO:0051973	positive regulation of telomerase activity	POT1	IDA		Human	PMID:16043710
Biological Process	GO:0051973	positive regulation of telomerase activity	POT1	IDA		Human	PMID:17237768
Biological Process	GO:0032212	positive regulation of telomere maintenance via telomerase	POT1	IMP		Human	PMID:12768206
Biological Process	GO:0032212	positive regulation of telomere maintenance via telomerase	POT1	IMP		Human	PMID:12781132
Biological Process	GO:0032212	positive regulation of telomere maintenance via telomerase	POT1	IDA		Human	PMID:17237768
Biological Process	GO:1905774	regulation of DNA helicase activity	POT1	IDA		Human	PMID:19734539
Biological Process	GO:2001032	regulation of double-strand break repair via nonhomologous end joining	POT1	IDA		Human	PMID:29227966
Biological Process	GO:0032210	regulation of telomere maintenance via telomerase	POT1	IGI	UniProtKB:Q13315	Human	PMID:26586433
Biological Process	GO:0032202	telomere assembly	POT1	IDA		Human	PMID:16043710
Biological Process	GO:0016233	telomere capping	POT1	IMP		Human	PMID:15657433
Biological Process	GO:0016233	telomere capping	POT1	IGI	UniProtKB:Q96AP0	Human	PMID:17632522
Biological Process	GO:0016233	telomere capping	POT1	IDA		Human	PMID:21852327
Biological Process	GO:0007004	telomere maintenance via telomerase	POT1	IDA		Human	PMID:12768206
Biological Process	GO:0061820	telomeric D-loop disassembly	POT1	IGI	UniProtKB:O94761	Human	PMID:22039056

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern