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Comparative GO Graph (mouse, human, rat, zebrafish)
Source
Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Pot1b

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pot1b
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:19057738-hydroxy-2'-deoxyguanosine DNA bindingPOT1IDAHumanPMID:19734539
Molecular FunctionGO:0017151DEAD/H-box RNA helicase bindingPOT1IPIUniProtKB:P54132HumanPMID:16030011
Molecular FunctionGO:0017151DEAD/H-box RNA helicase bindingPOT1IPIUniProtKB:Q14191HumanPMID:16030011
Molecular FunctionGO:1990955G-rich single-stranded DNA bindingPOT1IDAHumanPMID:19734539
Molecular FunctionGO:0098505G-rich strand telomeric DNA bindingPOT1IDAHumanPMID:17237768
Molecular FunctionGO:0098505G-rich strand telomeric DNA bindingPOT1IDAHumanPMID:21852327
Molecular FunctionGO:0098505G-rich strand telomeric DNA bindingPOT1IDAHumanPMID:22763445
Molecular FunctionGO:0005515protein bindingPOT1IPIUniProtKB:O95271HumanPMID:12768206
Molecular FunctionGO:0005515protein bindingPOT1IPIUniProtKB:P54274HumanPMID:12768206
Molecular FunctionGO:0005515protein bindingPOT1IPIUniProtKB:Q9BSI4HumanPMID:12768206
Molecular FunctionGO:0005515protein bindingPOT1IPIUniProtKB:Q96AP0HumanPMID:15181449
Molecular FunctionGO:0005515protein bindingPOT1IPIUniProtKB:Q15554HumanPMID:15383534
Molecular FunctionGO:0005515protein bindingPOT1IPIUniProtKB:Q96AP0HumanPMID:15383534
Molecular FunctionGO:0005515protein bindingPOT1IPIUniProtKB:Q15554HumanPMID:15657433
Molecular FunctionGO:0005515protein bindingPOT1IPIUniProtKB:Q96AP0HumanPMID:16189514
Molecular FunctionGO:0005515protein bindingPOT1IPIUniProtKB:Q96AP0HumanPMID:17237768
Molecular FunctionGO:0005515protein bindingPOT1IPIUniProtKB:Q15554HumanPMID:19287395
Molecular FunctionGO:0005515protein bindingPOT1IPIUniProtKB:Q15554HumanPMID:19651898
Molecular FunctionGO:0005515protein bindingPOT1IPIUniProtKB:O43704HumanPMID:21044950
Molecular FunctionGO:0005515protein bindingPOT1IPIUniProtKB:O60496HumanPMID:21044950
Molecular FunctionGO:0005515protein bindingPOT1IPIUniProtKB:O94808HumanPMID:21044950
Molecular FunctionGO:0005515protein bindingPOT1IPIUniProtKB:O95833HumanPMID:21044950
Molecular FunctionGO:0005515protein bindingPOT1IPIUniProtKB:P07355HumanPMID:21044950
Molecular FunctionGO:0005515protein bindingPOT1IPIUniProtKB:P09601HumanPMID:21044950
Molecular FunctionGO:0005515protein bindingPOT1IPIUniProtKB:P0DMV8HumanPMID:21044950
Molecular FunctionGO:0005515protein bindingPOT1IPIUniProtKB:P30838HumanPMID:21044950
Molecular FunctionGO:0005515protein bindingPOT1IPIUniProtKB:P43358HumanPMID:21044950
Molecular FunctionGO:0005515protein bindingPOT1IPIUniProtKB:P46952HumanPMID:21044950
Molecular FunctionGO:0005515protein bindingPOT1IPIUniProtKB:P50747HumanPMID:21044950
Molecular FunctionGO:0005515protein bindingPOT1IPIUniProtKB:P63313HumanPMID:21044950
Molecular FunctionGO:0005515protein bindingPOT1IPIUniProtKB:Q01064HumanPMID:21044950
Molecular FunctionGO:0005515protein bindingPOT1IPIUniProtKB:Q03426HumanPMID:21044950
Molecular FunctionGO:0005515protein bindingPOT1IPIUniProtKB:Q12851HumanPMID:21044950
Molecular FunctionGO:0005515protein bindingPOT1IPIUniProtKB:Q5SRE7HumanPMID:21044950
Molecular FunctionGO:0005515protein bindingPOT1IPIUniProtKB:Q6PJW8HumanPMID:21044950
Molecular FunctionGO:0005515protein bindingPOT1IPIUniProtKB:Q86WR7HumanPMID:21044950
Molecular FunctionGO:0005515protein bindingPOT1IPIUniProtKB:Q8IUZ5HumanPMID:21044950
Molecular FunctionGO:0005515protein bindingPOT1IPIUniProtKB:Q8WXG6HumanPMID:21044950
Molecular FunctionGO:0005515protein bindingPOT1IPIUniProtKB:Q96A49HumanPMID:21044950
Molecular FunctionGO:0005515protein bindingPOT1IPIUniProtKB:Q96A73HumanPMID:21044950
Molecular FunctionGO:0005515protein bindingPOT1IPIUniProtKB:Q96AP0HumanPMID:21044950
Molecular FunctionGO:0005515protein bindingPOT1IPIUniProtKB:Q96GU1HumanPMID:21044950
Molecular FunctionGO:0005515protein bindingPOT1IPIUniProtKB:Q99795HumanPMID:21044950
Molecular FunctionGO:0005515protein bindingPOT1IPIUniProtKB:Q9BR01HumanPMID:21044950
Molecular FunctionGO:0005515protein bindingPOT1IPIUniProtKB:Q9BRP8HumanPMID:21044950
Molecular FunctionGO:0005515protein bindingPOT1IPIUniProtKB:Q9BSI4HumanPMID:21044950
Molecular FunctionGO:0005515protein bindingPOT1IPIUniProtKB:Q9BV29HumanPMID:21044950
Molecular FunctionGO:0005515protein bindingPOT1IPIUniProtKB:Q9BWH6HumanPMID:21044950
Molecular FunctionGO:0005515protein bindingPOT1IPIUniProtKB:Q9BY11HumanPMID:21044950
Molecular FunctionGO:0005515protein bindingPOT1IPIUniProtKB:Q9NPH2HumanPMID:21044950
Molecular FunctionGO:0005515protein bindingPOT1IPIUniProtKB:Q9P0Z9HumanPMID:21044950
Molecular FunctionGO:0005515protein bindingPOT1IPIUniProtKB:Q9Y4P8HumanPMID:21044950
Molecular FunctionGO:0005515protein bindingPOT1IPIUniProtKB:Q2NKJ3HumanPMID:22763445
Molecular FunctionGO:0005515protein bindingPOT1IPIUniProtKB:Q96AP0HumanPMID:25172512
Molecular FunctionGO:0005515protein bindingPOT1IPIUniProtKB:Q549N0HumanPMID:25416956
Molecular FunctionGO:0005515protein bindingPOT1IPIUniProtKB:Q9BSI4HumanPMID:25620558
Molecular FunctionGO:0005515protein bindingPOT1IPIUniProtKB:Q15554HumanPMID:26496610
Molecular FunctionGO:0005515protein bindingPOT1IPIUniProtKB:Q96AP0HumanPMID:26496610
Molecular FunctionGO:0005515protein bindingPOT1IPIUniProtKB:Q9BSI4HumanPMID:26496610
Molecular FunctionGO:0005515protein bindingPOT1IPIUniProtKB:Q15554HumanPMID:28514442
Molecular FunctionGO:0005515protein bindingPOT1IPIUniProtKB:Q96AP0HumanPMID:28514442
Molecular FunctionGO:0005515protein bindingPOT1IPIUniProtKB:Q96AP0HumanPMID:31515488
Molecular FunctionGO:0005515protein bindingPOT1IPIUniProtKB:Q9Y281HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingPot1bIPIUniProtKB:Q5EE38-1MouseMGI:MGI:4441256|PMID:17632522
Molecular FunctionGO:0005515protein bindingPot1bIPIPR:Q91WC1MousePMID:17053789
Molecular FunctionGO:0005515protein bindingPot1bIPIPR:Q5EE38MousePMID:17053789
Molecular FunctionGO:0005515protein bindingpot1IPIZFIN:ZDB-GENE-081022-45ZfishPMID:21311760
Molecular FunctionGO:0043047single-stranded telomeric DNA bindingPOT1IMPHumanPMID:12768206
Molecular FunctionGO:0043047single-stranded telomeric DNA bindingPOT1IDAHumanPMID:15632080
Molecular FunctionGO:0043047single-stranded telomeric DNA bindingPOT1IDAHumanPMID:17237767
Molecular FunctionGO:0043047single-stranded telomeric DNA bindingPot1bIDAMousePMID:17053789
Molecular FunctionGO:0031267small GTPase bindingPot1bIDAMousePMID:23954637
Molecular FunctionGO:0010521telomerase inhibitor activityPOT1IDAHumanPMID:15632080
Molecular FunctionGO:0061821telomeric D-loop bindingPOT1IDAHumanPMID:19734539
Molecular FunctionGO:0042162telomeric DNA bindingPOT1IDAHumanPMID:23685356
Molecular FunctionGO:0042162telomeric DNA bindingPot1bIDAMouseMGI:MGI:5500098|PMID:23685356
Cellular ComponentGO:0000781chromosome, telomeric regionPOT1IDAHumanPMID:12768206
Cellular ComponentGO:0000781chromosome, telomeric regionPOT1HDAHumanPMID:19135898
Cellular ComponentGO:0000781chromosome, telomeric regionPOT1IDAHumanPMID:23685356
Cellular ComponentGO:0000781chromosome, telomeric regionPOT1IDAHumanPMID:24270157
Cellular ComponentGO:0000781chromosome, telomeric regionPot1bIDAMouseMGI:MGI:5500098|PMID:23685356
Cellular ComponentGO:0000781chromosome, telomeric regionPot1bIDAMousePMID:17053789
Cellular ComponentGO:0000783nuclear telomere cap complexPOT1IDAHumanPMID:16880378
Cellular ComponentGO:0000783nuclear telomere cap complexPot1bIDAMousePMID:17053789
Cellular ComponentGO:0005654nucleoplasmPOT1IDAHumanGO_REF:0000052
Cellular ComponentGO:0070187shelterin complexPOT1IPIHumanPMID:15383534
Cellular ComponentGO:0070187shelterin complexPOT1IDAHumanPMID:15383534
Cellular ComponentGO:0070187shelterin complexPOT1IMPHumanPMID:21852327
Cellular ComponentGO:0070187shelterin complexPOT1IDAHumanPMID:23685356
Biological ProcessGO:0090398cellular senescencePot1bIDAMousePMID:17053789
Biological ProcessGO:0090398cellular senescencePot1bIGIMGI:MGI:98834MousePMID:17053789
Biological ProcessGO:0051276chromosome organizationPot1bIMPMousePMID:17053789
Biological ProcessGO:0051276chromosome organizationPot1bIDAMousePMID:17053789
Biological ProcessGO:0051276chromosome organizationPot1bIGIMGI:MGI:98834MousePMID:17053789
Biological ProcessGO:0051276chromosome organizationPot1bIGIMGI:MGI:2141503MousePMID:17053789
Biological ProcessGO:0032508DNA duplex unwindingPOT1IDAHumanPMID:16030011
Biological ProcessGO:0070200establishment of protein localization to telomerePOT1IMPHumanPMID:25589350
Biological ProcessGO:0048239negative regulation of DNA recombination at telomerePot1bIDAMousePMID:17053789
Biological ProcessGO:0051974negative regulation of telomerase activityPOT1IDAHumanPMID:15632080
Biological ProcessGO:0032211negative regulation of telomere maintenance via telomerasePOT1IGIUniProtKB:Q96AP0HumanPMID:15181449
Biological ProcessGO:1905776positive regulation of DNA helicase activityPOT1IDAHumanPMID:19734539
Biological ProcessGO:0060383positive regulation of DNA strand elongationPOT1IDAHumanPMID:16043710
Biological ProcessGO:0051096positive regulation of helicase activityPOT1IDAHumanPMID:16030011
Biological ProcessGO:0051973positive regulation of telomerase activityPOT1IMPHumanPMID:15181449
Biological ProcessGO:0051973positive regulation of telomerase activityPOT1IDAHumanPMID:16043710
Biological ProcessGO:0051973positive regulation of telomerase activityPOT1IDAHumanPMID:17237768
Biological ProcessGO:0032212positive regulation of telomere maintenance via telomerasePOT1IMPHumanPMID:12768206
Biological ProcessGO:0032212positive regulation of telomere maintenance via telomerasePOT1IMPHumanPMID:12781132
Biological ProcessGO:0032212positive regulation of telomere maintenance via telomerasePOT1IDAHumanPMID:17237768
Biological ProcessGO:0031848protection from non-homologous end joining at telomerePot1bIDAMousePMID:17053789
Biological ProcessGO:0001558regulation of cell growthPot1bIDAMousePMID:17053789
Biological ProcessGO:1905774regulation of DNA helicase activityPOT1IDAHumanPMID:19734539
Biological ProcessGO:2001032regulation of double-strand break repair via nonhomologous end joiningPOT1IDAHumanPMID:29227966
Biological ProcessGO:0043087regulation of GTPase activityPot1bIMPMousePMID:23954637
Biological ProcessGO:0050764regulation of phagocytosisPot1bIMPMousePMID:23954637
Biological ProcessGO:0032210regulation of telomere maintenance via telomerasePOT1IGIUniProtKB:Q13315HumanPMID:26586433
Biological ProcessGO:0032202telomere assemblyPOT1IDAHumanPMID:16043710
Biological ProcessGO:0016233telomere cappingPOT1IMPHumanPMID:15657433
Biological ProcessGO:0016233telomere cappingPOT1IGIUniProtKB:Q96AP0HumanPMID:17632522
Biological ProcessGO:0016233telomere cappingPOT1IDAHumanPMID:21852327
Biological ProcessGO:0016233telomere cappingPot1bIDAMousePMID:17053789
Biological ProcessGO:0043247telomere maintenance in response to DNA damagePot1bIDAMousePMID:17053789
Biological ProcessGO:0007004telomere maintenance via telomerasePOT1IDAHumanPMID:12768206
Biological ProcessGO:0061820telomeric D-loop disassemblyPOT1IGIUniProtKB:O94761HumanPMID:22039056

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IEP Inferred from expression pattern
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  HTP Inferred from High Throughput Experiment
  HDA Inferred from High Throughput Direct Assay
  HMP Inferred from High Throughput Mutant Phenotype
  HGI Inferred from High Throughput Genetic Interaction
  HEP Inferred from High Throughput Expression Pattern

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory