Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PPARA
  • Mouse genes Ppara
  • Rat genes Ppara
  • Zfish genes pparaa,pparab
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ppara

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001216	DNA-binding transcription activator activity	PPARA	IDA		Human	PMID:26983400
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PPARA	IDA		Human	PMID:9748239
Molecular Function	GO:0003700	DNA-binding transcription factor activity	PPARA	IDA		Human	PMID:19955185
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Ppara	IMP		Mouse	MGI:MGI:3689805|PMID:16271724
Molecular Function	GO:0140297	DNA-binding transcription factor binding	PPARA	IPI	UniProtKB:P42224	Human	PMID:26504087
Molecular Function	GO:0140297	DNA-binding transcription factor binding	Ppara	IPI	RGD:2327	Rat	PMID:15661831|RGD:152995267
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	PPARA	IDA		Human	PMID:9748239
Molecular Function	GO:0008289	lipid binding	PPARA	IDA		Human	PMID:12955147
Molecular Function	GO:0008289	lipid binding	Ppara	IDA		Mouse	MGI:MGI:2674175|PMID:12955147
Molecular Function	GO:0097371	MDM2/MDM4 family protein binding	Ppara	IPI	RGD:1305332	Rat	PMID:19103650|RGD:2317368
Molecular Function	GO:0031435	mitogen-activated protein kinase kinase kinase binding	Ppara	IPI	RGD:1309438	Rat	PMID:28821620|RGD:155804266
Molecular Function	GO:0051525	NFAT protein binding	Ppara	IPI	RGD:1310749	Rat	PMID:22198280|RGD:5687133
Molecular Function	GO:0004879	nuclear receptor activity	PPARA	IDA		Human	PMID:12955147
Molecular Function	GO:0004879	nuclear receptor activity	PPARA	IDA		Human	PMID:19955185
Molecular Function	GO:0004879	nuclear receptor activity	Ppara	IMP		Rat	PMID:12189208|RGD:729665
Molecular Function	GO:0004879	nuclear receptor activity	Ppara	IMP		Rat	PMID:12966092|RGD:1580224
Molecular Function	GO:0003707	nuclear steroid receptor activity	PPARA	IDA		Human	PMID:19955185
Molecular Function	GO:0019902	phosphatase binding	Ppara	IPI	RGD:620849	Rat	PMID:8910358|RGD:728628
Molecular Function	GO:0005515	protein binding	PPARA	IPI	UniProtKB:P19793	Human	PMID:11915042
Molecular Function	GO:0005515	protein binding	PPARA	IPI	UniProtKB:Q3L8U1-3	Human	PMID:16554032
Molecular Function	GO:0005515	protein binding	PPARA	IPI	UniProtKB:O75376	Human	PMID:19955185
Molecular Function	GO:0005515	protein binding	PPARA	IPI	UniProtKB:O75376	Human	PMID:21775429
Molecular Function	GO:0005515	protein binding	PPARA	IPI	UniProtKB:Q96EB6	Human	PMID:24043310
Molecular Function	GO:0005515	protein binding	PPARA	IPI	UniProtKB:Q13133	Human	PMID:24713062
Molecular Function	GO:0005515	protein binding	PPARA	IPI	UniProtKB:P62993	Human	PMID:25814554
Molecular Function	GO:0005515	protein binding	PPARA	IPI	UniProtKB:D3DTS7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PPARA	IPI	UniProtKB:G5E9A7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PPARA	IPI	UniProtKB:P02768-3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PPARA	IPI	UniProtKB:P06307	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PPARA	IPI	UniProtKB:P06396	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PPARA	IPI	UniProtKB:P13473-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PPARA	IPI	UniProtKB:P22607	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PPARA	IPI	UniProtKB:P37173	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PPARA	IPI	UniProtKB:P42858	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PPARA	IPI	UniProtKB:P45973	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PPARA	IPI	UniProtKB:P54725	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PPARA	IPI	UniProtKB:P55072	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PPARA	IPI	UniProtKB:P55212	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PPARA	IPI	UniProtKB:P62826	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PPARA	IPI	UniProtKB:Q14957	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PPARA	IPI	UniProtKB:Q7Z699	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PPARA	IPI	UniProtKB:Q8WXH2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PPARA	IPI	UniProtKB:Q15648	Human	PMID:9653119
Molecular Function	GO:0005515	protein binding	Ppara	IPI	UniProtKB:O54943	Mouse	MGI:MGI:4429726|PMID:20159955
Molecular Function	GO:0005515	protein binding	Ppara	IPI	UniProtKB:Q91ZP3-1	Mouse	MGI:MGI:3770090|PMID:16950137
Molecular Function	GO:0005515	protein binding	Ppara	IPI	UniProtKB:P97784|UniProtKB:Q9R194	Mouse	MGI:MGI:6107163|PMID:28683290
Molecular Function	GO:0005515	protein binding	Ppara	IPI	UniProtKB:Q925J9	Mouse	MGI:MGI:1097733|PMID:9325263
Molecular Function	GO:0005515	protein binding	Ppara	IPI	UniProtKB:O88559	Mouse	MGI:MGI:5295314|PMID:22001208
Molecular Function	GO:0005515	protein binding	Ppara	IPI	UniProtKB:A2A935	Mouse	MGI:MGI:3806432|PMID:18719582
Molecular Function	GO:0005515	protein binding	Ppara	IPI	UniProtKB:Q99J47	Mouse	PMID:28930673
Molecular Function	GO:0005515	protein binding	Ppara	IPI	PR:P97742	Mouse	PMID:16271724
Molecular Function	GO:0005515	protein binding	Ppara	IPI	PR:P28700	Mouse	PMID:16271724
Molecular Function	GO:0005515	protein binding	Ppara	IPI	PR:O70343	Mouse	PMID:20385772
Molecular Function	GO:0005515	protein binding	Ppara	IPI	PR:Q91ZP3	Mouse	PMID:20385772
Molecular Function	GO:0005515	protein binding	Ppara	IPI	UniProtKB:Q99967	Rat	PMID:15051727|RGD:8554269
Molecular Function	GO:0005515	protein binding	Ppara	IPI	RGD:3612	Rat	PMID:15870285|RGD:5688307
Molecular Function	GO:0005515	protein binding	Ppara	IPI	RGD:1308681	Rat	PMID:16280383|RGD:11035228
Molecular Function	GO:0005515	protein binding	Ppara	IPI	RGD:620109	Rat	PMID:20132223|RGD:5688153
Molecular Function	GO:0019904	protein domain specific binding	Ppara	IDA		Rat	PMID:12189208|RGD:729665
Molecular Function	GO:0044877	protein-containing complex binding	Ppara	IPI	RGD:1566399|CHEBI:15647	Rat	PMID:12189208|RGD:729665
Molecular Function	GO:0044877	protein-containing complex binding	Ppara	IMP		Rat	PMID:20132223|RGD:5688153
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	PPARA	IDA		Human	PMID:9748239
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Ppara	IDA		Mouse	PMID:15232616
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Ppara	IDA		Mouse	PMID:12015306
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	PPARA	IPI	UniProtKB:O75376	Human	PMID:19955185
Molecular Function	GO:0043565	sequence-specific DNA binding	Ppara	IDA		Mouse	MGI:MGI:3689805|PMID:16271724
Molecular Function	GO:0043565	sequence-specific DNA binding	Ppara	IDA		Rat	PMID:16280383|RGD:11035228
Molecular Function	GO:0038023	signaling receptor activity	Ppara	IDA		Mouse	PMID:12802337
Molecular Function	GO:0001223	transcription coactivator binding	Ppara	IPI	RGD:620925	Rat	PMID:22464285|RGD:10059644
Molecular Function	GO:0008134	transcription factor binding	Ppara	IDA		Mouse	PMID:15232616
Molecular Function	GO:0031624	ubiquitin conjugating enzyme binding	PPARA	IPI	UniProtKB:P63279	Human	PMID:19955185
Cellular Component	GO:0005654	nucleoplasm	PPARA	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	PPARA	IDA		Human	PMID:24639097
Cellular Component	GO:0005634	nucleus	Ppara	IDA		Rat	PMID:12189208|RGD:729665
Cellular Component	GO:0005634	nucleus	Ppara	IDA		Rat	PMID:22198280|RGD:5687133
Biological Process	GO:0035095	behavioral response to nicotine	Ppara	IDA		Rat	PMID:20801430|RGD:5687142
Biological Process	GO:0070417	cellular response to cold	pparab	IDA		Zfish	PMID:16990399
Biological Process	GO:0009267	cellular response to starvation	Ppara	IMP		Mouse	MGI:MGI:5474727|PMID:23209793
Biological Process	GO:0032922	circadian regulation of gene expression	Ppara	IDA		Mouse	MGI:MGI:4429726|PMID:20159955
Biological Process	GO:0070166	enamel mineralization	Ppara	IMP	MGI:MGI:1857774	Mouse	PMID:19320717
Biological Process	GO:0008544	epidermis development	Ppara	IMP	MGI:MGI:1857774	Mouse	PMID:12485431
Biological Process	GO:0006631	fatty acid metabolic process	Ppara	IMP		Mouse	PMID:9488698
Biological Process	GO:0006631	fatty acid metabolic process	Ppara	IMP	MGI:MGI:1857774	Mouse	PMID:15007068
Biological Process	GO:0006631	fatty acid metabolic process	Ppara	IMP		Rat	PMID:12600885|RGD:633661
Biological Process	GO:0006631	fatty acid metabolic process	Ppara	IMP		Rat	PMID:12853447|RGD:1580225
Biological Process	GO:0006631	fatty acid metabolic process	Ppara	IMP		Rat	PMID:16183630|RGD:1580683
Biological Process	GO:0006094	gluconeogenesis	Ppara	IMP	MGI:MGI:1857774	Mouse	PMID:15232616
Biological Process	GO:0007507	heart development	Ppara	IEP		Rat	PMID:15754086|RGD:1625767
Biological Process	GO:0010876	lipid localization	Ppara	IEP		Rat	PMID:27939985|RGD:15036816
Biological Process	GO:0042157	lipoprotein metabolic process	Ppara	IMP		Rat	PMID:15537571|RGD:1580223
Biological Process	GO:0032099	negative regulation of appetite	Ppara	IMP		Mouse	MGI:MGI:2674175|PMID:12955147
Biological Process	GO:0045776	negative regulation of blood pressure	Ppara	IMP		Rat	PMID:15967866|RGD:1580222
Biological Process	GO:0061052	negative regulation of cell growth involved in cardiac muscle cell development	Ppara	IMP		Rat	PMID:22198280|RGD:5687133
Biological Process	GO:0010887	negative regulation of cholesterol storage	PPARA	IDA		Human	PMID:19114110
Biological Process	GO:1900016	negative regulation of cytokine production involved in inflammatory response	PPARA	IMP		Human	PMID:31574452
Biological Process	GO:0045820	negative regulation of glycolytic process	PPARA	IDA		Human	PMID:19955185
Biological Process	GO:1903944	negative regulation of hepatocyte apoptotic process	PPARA	IMP		Human	PMID:31574452
Biological Process	GO:0050728	negative regulation of inflammatory response	PPARA	IDA		Human	PMID:21636785
Biological Process	GO:1903038	negative regulation of leukocyte cell-cell adhesion	PPARA	IDA		Human	PMID:21636785
Biological Process	GO:0010745	negative regulation of macrophage derived foam cell differentiation	PPARA	IDA		Human	PMID:19114110
Biological Process	GO:1902894	negative regulation of miRNA transcription	PPARA	IDA		Human	PMID:21636785
Biological Process	GO:1901215	negative regulation of neuron death	Ppara	IMP		Rat	PMID:20221904|RGD:5687143
Biological Process	GO:1901215	negative regulation of neuron death	Ppara	IDA		Rat	PMID:21375604|RGD:8693656
Biological Process	GO:0032091	negative regulation of protein binding	Ppara	IMP		Rat	PMID:22198280|RGD:5687133
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	PPARA	IMP		Human	PMID:31574452
Biological Process	GO:1903427	negative regulation of reactive oxygen species biosynthetic process	PPARA	IMP		Human	PMID:31574452
Biological Process	GO:0010891	negative regulation of sequestering of triglyceride	PPARA	IDA		Human	PMID:12700342
Biological Process	GO:2000272	negative regulation of signaling receptor activity	PPARA	IDA		Human	PMID:12700342
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	PPARA	IDA		Human	PMID:12700342
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	PPARA	IDA		Human	PMID:9748239
Biological Process	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	PPARA	IDA		Human	PMID:31611175
Biological Process	GO:2001171	positive regulation of ATP biosynthetic process	PPARA	IMP		Human	PMID:31574452
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	PPARA	IDA		Human	PMID:12955147
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Ppara	IMP		Mouse	MGI:MGI:2674175|PMID:12955147
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Ppara	IMP	MGI:MGI:1857774	Mouse	PMID:15007068
Biological Process	GO:0046321	positive regulation of fatty acid oxidation	Ppara	IMP		Mouse	MGI:MGI:3526480|PMID:15639194
Biological Process	GO:0045722	positive regulation of gluconeogenesis	Ppara	IMP	MGI:MGI:1857774	Mouse	PMID:15232616
Biological Process	GO:0046889	positive regulation of lipid biosynthetic process	PPARA	IMP		Human	PMID:25592151
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	PPARA	IDA		Human	PMID:19955185
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	PPARA	IDA		Human	PMID:20837115
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	PPARA	IDA		Human	PMID:9748239
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Ppara	IMP		Mouse	MGI:MGI:5474727|PMID:23209793
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Ppara	IMP	MGI:MGI:1857774	Mouse	PMID:16571721
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Ppara	IDA		Mouse	PMID:16571721
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Ppara	IDA		Mouse	PMID:8041794
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Ppara	IGI	MGI:MGI:1891340	Mouse	PMID:20385772
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Ppara	IDA		Mouse	PMID:20385772
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Ppara	IGI	MGI:MGI:1342774	Mouse	PMID:20385772
Biological Process	GO:0045070	positive regulation of viral genome replication	PPARA	IMP		Human	PMID:22479552
Biological Process	GO:0010565	regulation of cellular ketone metabolic process	PPARA	IDA		Human	PMID:19955185
Biological Process	GO:0042752	regulation of circadian rhythm	Ppara	IDA		Mouse	MGI:MGI:4429726|PMID:20159955
Biological Process	GO:0006355	regulation of DNA-templated transcription	Ppara	IDA		Rat	PMID:12189208|RGD:729665
Biological Process	GO:0019217	regulation of fatty acid metabolic process	PPARA	IDA		Human	PMID:19955185
Biological Process	GO:0010468	regulation of gene expression	Ppara	IMP		Mouse	PMID:15313227
Biological Process	GO:0010883	regulation of lipid storage	Ppara	IEP		Rat	PMID:27939985|RGD:15036816
Biological Process	GO:0014823	response to activity	pparab	IDA		Zfish	PMID:16990399
Biological Process	GO:0045471	response to ethanol	Ppara	IEP		Rat	PMID:27939985|RGD:15036816
Biological Process	GO:0001666	response to hypoxia	Ppara	IDA		Rat	PMID:15292030|RGD:2315862
Biological Process	GO:0032868	response to insulin	Ppara	IMP		Rat	PMID:16183630|RGD:1580683
Biological Process	GO:0014070	response to organic cyclic compound	Ppara	IEP		Rat	PMID:27939985|RGD:15036816
Biological Process	GO:0042060	wound healing	Ppara	IMP	MGI:MGI:1857774	Mouse	PMID:11514592

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern