Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PPARD
  • Mouse genes Ppard
  • Rat genes Ppard
  • Zfish genes pparda,ppardb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ppard

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	Ppard	IDA		Mouse	PMID:8041794
Molecular Function	GO:0003700	DNA-binding transcription factor activity	PPARD	IDA		Human	PMID:12955147
Molecular Function	GO:0003700	DNA-binding transcription factor activity	PPARD	IDA		Human	PMID:15001550
Molecular Function	GO:0003700	DNA-binding transcription factor activity	PPARD	IDA		Human	PMID:35675826
Molecular Function	GO:0140297	DNA-binding transcription factor binding	PPARD	IPI	UniProtKB:P42224	Human	PMID:26504087
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Ppard	IDA		Mouse	MGI:MGI:5705218|PMID:20445066
Molecular Function	GO:0005504	fatty acid binding	Ppard	IDA		Rat	PMID:12600885|RGD:633661
Molecular Function	GO:0070539	linoleic acid binding	PPARD	IDA		Human	PMID:10198642
Molecular Function	GO:0008289	lipid binding	PPARD	IDA		Human	PMID:12955147
Molecular Function	GO:0051059	NF-kappaB binding	Ppard	IPI	RGD:727889	Rat	PMID:15728586|RGD:1580656
Molecular Function	GO:0004879	nuclear receptor activity	PPARD	IDA		Human	PMID:12955147
Molecular Function	GO:0005515	protein binding	PPARD	IPI	UniProtKB:P55055-1	Human	PMID:15722453
Molecular Function	GO:0005515	protein binding	PPARD	IPI	UniProtKB:Q13133	Human	PMID:15722453
Molecular Function	GO:0005515	protein binding	PPARD	IPI	UniProtKB:O60341	Human	PMID:23455924
Molecular Function	GO:0005515	protein binding	Ppard	IPI	UniProtKB:P97784|UniProtKB:Q9R194	Mouse	MGI:MGI:5913754|PMID:28751364
Molecular Function	GO:0005515	protein binding	Ppard	IPI	UniProtKB:P97784|UniProtKB:Q9R194	Mouse	MGI:MGI:6107163|PMID:28683290
Molecular Function	GO:0005515	protein binding	Ppard	IPI	PR:Q925J9	Mouse	PMID:15001550
Molecular Function	GO:0005515	protein binding	Ppard	IPI	PR:Q9WU42	Mouse	PMID:15001550
Molecular Function	GO:0005515	protein binding	Ppard	IPI	PR:P70365	Mouse	PMID:15001550
Molecular Function	GO:0005515	protein binding	Ppard	IPI	PR:P28700	Mouse	PMID:10385625
Molecular Function	GO:0005515	protein binding	Ppard	IPI	PR:Q60974	Mouse	PMID:15001550
Molecular Function	GO:0005515	protein binding	Ppard	IPI	PR:O09000	Mouse	PMID:15001550
Molecular Function	GO:0005515	protein binding	Ppard	IPI	PR:Q8CBD1	Mouse	PMID:15001550
Molecular Function	GO:0005515	protein binding	Ppard	IPI	PR:Q61026	Mouse	PMID:15001550
Molecular Function	GO:0043565	sequence-specific DNA binding	pparda	IDA		Zfish	PMID:27979767
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	PPARD	IDA		Human	PMID:28473536
Molecular Function	GO:0001223	transcription coactivator binding	PPARD	IPI	UniProtKB:Q61026	Human	PMID:15001550
Cellular Component	GO:0000785	chromatin	Ppard	IDA		Mouse	MGI:MGI:5705218|PMID:20445066
Cellular Component	GO:0000785	chromatin	pparda	IDA		Zfish	PMID:27979767
Cellular Component	GO:0005634	nucleus	PPARD	IDA		Human	PMID:35675826
Cellular Component	GO:0005634	nucleus	Ppard	IDA		Mouse	PMID:10385625
Cellular Component	GO:0005634	nucleus	Ppard	IDA		Rat	PMID:19965574|RGD:2324877
Biological Process	GO:0060612	adipose tissue development	Ppard	IMP	MGI:MGI:2386684	Mouse	PMID:11756685
Biological Process	GO:0042640	anagen	Ppard	IMP	MGI:MGI:3575004	Mouse	PMID:15713628
Biological Process	GO:0006915	apoptotic process	PPARD	IMP		Human	PMID:12909723
Biological Process	GO:0097190	apoptotic signaling pathway	PPARD	IMP		Human	PMID:11551955
Biological Process	GO:0008366	axon ensheathment	Ppard	IMP	MGI:MGI:1889516	Mouse	PMID:10866668
Biological Process	GO:0030154	cell differentiation	Ppard	IDA		Mouse	PMID:16581799
Biological Process	GO:0030154	cell differentiation	Ppard	IMP		Mouse	PMID:16581799
Biological Process	GO:0008283	cell population proliferation	Ppard	IMP	MGI:MGI:2386684	Mouse	PMID:11756685
Biological Process	GO:0031589	cell-substrate adhesion	Ppard	IMP	MGI:MGI:3575004	Mouse	PMID:11514592
Biological Process	GO:0071456	cellular response to hypoxia	Ppard	IGI	MGI:MGI:106918	Mouse	PMID:24011070
Biological Process	GO:0071456	cellular response to hypoxia	Ppard	IGI	MGI:MGI:2676890	Mouse	PMID:24011070
Biological Process	GO:0071456	cellular response to hypoxia	Ppard	IGI	MGI:MGI:3618742	Mouse	PMID:24011070
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Ppard	IDA		Rat	PMID:15728586|RGD:1580656
Biological Process	GO:0031669	cellular response to nutrient levels	PPARD	IDA		Human	PMID:35675826
Biological Process	GO:0046697	decidualization	Ppard	IEP		Rat	PMID:12773104|RGD:2324898
Biological Process	GO:0007566	embryo implantation	Ppard	IDA		Mouse	PMID:10385625
Biological Process	GO:0007566	embryo implantation	Ppard	IEP		Rat	PMID:12773104|RGD:2324898
Biological Process	GO:0097009	energy homeostasis	PPARD	IDA		Human	PMID:35675826
Biological Process	GO:0097009	energy homeostasis	Ppard	IMP		Mouse	MGI:MGI:3843109|PMID:19345188
Biological Process	GO:0050673	epithelial cell proliferation	Ppard	IGI	MGI:MGI:88039	Mouse	PMID:11756685
Biological Process	GO:0050673	epithelial cell proliferation	Ppard	IGI	MGI:MGI:88039	Mouse	PMID:14758356
Biological Process	GO:0070341	fat cell proliferation	Ppard	IMP	MGI:MGI:2386684	Mouse	PMID:11756685
Biological Process	GO:0006635	fatty acid beta-oxidation	Ppard	IEP		Mouse	MGI:MGI:3688371|PMID:14676330
Biological Process	GO:0019395	fatty acid oxidation	Ppard	IDA		Rat	PMID:12600885|RGD:633661
Biological Process	GO:0015908	fatty acid transport	Ppard	IEP		Mouse	MGI:MGI:3688371|PMID:14676330
Biological Process	GO:0007507	heart development	Ppard	IEP		Rat	PMID:15754086|RGD:1625767
Biological Process	GO:0051546	keratinocyte migration	Ppard	IMP	MGI:MGI:3575004	Mouse	PMID:11514592
Biological Process	GO:0043616	keratinocyte proliferation	Ppard	IMP	MGI:MGI:3575004	Mouse	PMID:11511099
Biological Process	GO:0006629	lipid metabolic process	Ppard	IMP	MGI:MGI:1889516	Mouse	PMID:10866668
Biological Process	GO:0006629	lipid metabolic process	Ppard	IMP	MGI:MGI:3623147	Mouse	PMID:16581799
Biological Process	GO:0006629	lipid metabolic process	Ppard	IDA		Rat	PMID:20338185|RGD:2324873
Biological Process	GO:0043066	negative regulation of apoptotic process	Ppard	IDA		Rat	PMID:16337160|RGD:2324894
Biological Process	GO:0030308	negative regulation of cell growth	Ppard	IDA		Rat	PMID:18293166|RGD:2324884
Biological Process	GO:0032966	negative regulation of collagen biosynthetic process	Ppard	IMP		Rat	PMID:17346664|RGD:2324888
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	Ppard	IGI	MGI:MGI:88039	Mouse	PMID:14758356
Biological Process	GO:0050728	negative regulation of inflammatory response	Ppard	IDA		Rat	PMID:17461989|RGD:2324886
Biological Process	GO:1902894	negative regulation of miRNA transcription	Ppard	IDA		Mouse	MGI:MGI:5705218|PMID:20445066
Biological Process	GO:0045662	negative regulation of myoblast differentiation	Ppard	IMP		Mouse	MGI:MGI:5319147|PMID:22040534
Biological Process	GO:0014912	negative regulation of smooth muscle cell migration	Ppard	IDA		Rat	PMID:18585719|RGD:2324882
Biological Process	GO:0048662	negative regulation of smooth muscle cell proliferation	Ppard	IDA		Rat	PMID:18585719|RGD:2324882
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Ppard	IDA		Mouse	PMID:8041794
Biological Process	GO:0014032	neural crest cell development	pparda	IGI	ZFIN:ZDB-GENE-040718-410	Zfish	PMID:27979767
Biological Process	GO:0014065	phosphatidylinositol 3-kinase signaling	Ppard	IDA		Mouse	PMID:16581799
Biological Process	GO:0008654	phospholipid biosynthetic process	Ppard	IDA		Rat	PMID:17148578|RGD:2324892
Biological Process	GO:0001890	placenta development	Ppard	IMP	MGI:MGI:2386684	Mouse	PMID:11756685
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	PPARD	IDA		Human	PMID:12955147
Biological Process	GO:0045684	positive regulation of epidermis development	Ppard	IDA		Rat	PMID:19675577|RGD:2324879
Biological Process	GO:0070346	positive regulation of fat cell proliferation	Ppard	IMP	MGI:MGI:2386684	Mouse	PMID:11756685
Biological Process	GO:0046321	positive regulation of fatty acid oxidation	Ppard	IMP		Rat	PMID:19965574|RGD:2324877
Biological Process	GO:0010628	positive regulation of gene expression	Ppard	IMP		Mouse	MGI:MGI:5319147|PMID:22040534
Biological Process	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	Ppard	IDA		Rat	PMID:19965574|RGD:2324877
Biological Process	GO:2000288	positive regulation of myoblast proliferation	Ppard	IMP		Mouse	MGI:MGI:5319147|PMID:22040534
Biological Process	GO:2000277	positive regulation of oxidative phosphorylation uncoupler activity	Ppard	IMP		Mouse	MGI:MGI:3843109|PMID:19345188
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	Ppard	IDA		Mouse	PMID:16581799
Biological Process	GO:0043415	positive regulation of skeletal muscle tissue regeneration	Ppard	IMP		Mouse	MGI:MGI:5319147|PMID:22040534
Biological Process	GO:0006029	proteoglycan metabolic process	Ppard	IDA		Rat	PMID:17140817|RGD:2324893
Biological Process	GO:0042127	regulation of cell population proliferation	Ppard	IGI	MGI:MGI:88039	Mouse	PMID:15380519
Biological Process	GO:0050678	regulation of epithelial cell proliferation	Ppard	IMP	MGI:MGI:1889516	Mouse	PMID:10866668
Biological Process	GO:0045598	regulation of fat cell differentiation	Ppard	IMP	MGI:MGI:2386684	Mouse	PMID:11756685
Biological Process	GO:0014842	regulation of skeletal muscle satellite cell proliferation	Ppard	IMP		Mouse	MGI:MGI:5319147|PMID:22040534
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	PPARD	IDA		Human	PMID:35675826
Biological Process	GO:0014823	response to activity	Ppard	IEP		Rat	PMID:20233940|RGD:2324874
Biological Process	GO:0014823	response to activity	pparda	IDA		Zfish	PMID:16990399
Biological Process	GO:0009749	response to glucose	Ppard	IEP		Rat	PMID:18573863|RGD:2313781
Biological Process	GO:0010033	response to organic substance	Ppard	IEP		Rat	PMID:18338635|RGD:2324883
Biological Process	GO:0010033	response to organic substance	Ppard	IEP		Rat	PMID:18843091|RGD:2324881
Biological Process	GO:0033189	response to vitamin A	Ppard	IEP		Rat	PMID:19342198|RGD:2324880
Biological Process	GO:0042311	vasodilation	Ppard	IDA		Rat	PMID:19906781|RGD:2324878
Biological Process	GO:0006776	vitamin A metabolic process	Ppard	IMP		Rat	PMID:12576510|RGD:1625187
Biological Process	GO:0042060	wound healing	Ppard	IMP	MGI:MGI:3575004	Mouse	PMID:11514592

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern