Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PPARGC1B
  • Mouse genes Ppargc1b
  • Rat genes Ppargc1b
  • Zfish genes ppargc1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ppargc1b

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0050682	AF-2 domain binding	PPARGC1B	IPI	UniProtKB:Q800Q2	Human	PMID:11854298
Molecular Function	GO:0030331	nuclear estrogen receptor binding	PPARGC1B	IDA		Human	PMID:11854298
Molecular Function	GO:0030374	nuclear receptor coactivator activity	PPARGC1B	IDA		Human	PMID:11854298
Molecular Function	GO:0005515	protein binding	Ppargc1b	IPI	UniProtKB:A2A935	Mouse	MGI:MGI:4365360|PMID:18483224
Molecular Function	GO:0005515	protein binding	Ppargc1b	IPI	UniProtKB:A2A935	Mouse	MGI:MGI:3770355|PMID:17618855
Molecular Function	GO:0005515	protein binding	Ppargc1b	IPI	PR:P51949	Mouse	PMID:17276355
Molecular Function	GO:0003712	transcription coregulator activity	PPARGC1B	IDA		Human	PMID:11854298
Cellular Component	GO:0005829	cytosol	PPARGC1B	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016592	mediator complex	PPARGC1B	IDA		Human	PMID:11854298
Cellular Component	GO:0005654	nucleoplasm	PPARGC1B	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	PPARGC1B	IDA		Human	PMID:11854298
Biological Process	GO:0007015	actin filament organization	Ppargc1b	IMP		Mouse	MGI:MGI:3838421|PMID:19252502
Biological Process	GO:0060346	bone trabecula formation	Ppargc1b	IMP		Mouse	MGI:MGI:3838421|PMID:19252502
Biological Process	GO:0034614	cellular response to reactive oxygen species	Ppargc1b	IDA		Mouse	MGI:MGI:3838421|PMID:19252502
Biological Process	GO:0030520	intracellular estrogen receptor signaling pathway	PPARGC1B	IDA		Human	PMID:11854298
Biological Process	GO:0006390	mitochondrial transcription	Ppargc1b	IMP		Mouse	MGI:MGI:3838421|PMID:19252502
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Ppargc1b	IMP		Mouse	MGI:MGI:3838421|PMID:19252502
Biological Process	GO:0001503	ossification	Ppargc1b	IMP		Mouse	MGI:MGI:3838421|PMID:19252502
Biological Process	GO:0010694	positive regulation of alkaline phosphatase activity	Ppargc1b	IMP		Mouse	MGI:MGI:3838421|PMID:19252502
Biological Process	GO:0045780	positive regulation of bone resorption	Ppargc1b	IMP		Mouse	MGI:MGI:3838421|PMID:19252502
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	Ppargc1b	IMP		Mouse	MGI:MGI:3693073|PMID:17090215
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Ppargc1b	IMP		Mouse	MGI:MGI:3838421|PMID:19252502
Biological Process	GO:0045672	positive regulation of osteoclast differentiation	Ppargc1b	IMP		Mouse	MGI:MGI:3838421|PMID:19252502
Biological Process	GO:0042327	positive regulation of phosphorylation	Ppargc1b	IMP		Mouse	MGI:MGI:3838421|PMID:19252502
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	PPARGC1B	IDA		Human	PMID:11854298
Biological Process	GO:0006355	regulation of DNA-templated transcription	PPARGC1B	IDA		Human	PMID:23836911
Biological Process	GO:0051591	response to cAMP	Ppargc1b	IEP		Rat	PMID:12807885|RGD:1642502
Biological Process	GO:0051384	response to glucocorticoid	Ppargc1b	IEP		Rat	PMID:12807885|RGD:1642502

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern