Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PPIA
  • Mouse genes Ppia
  • Rat genes LOC100911252,Ppia,Ppial4d,Ppial4g
  • Zfish genes ppiaa,ppiab,ppifa
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ppia

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0016018	cyclosporin A binding	PPIA	IDA		Human	PMID:12218175
Molecular Function	GO:0016018	cyclosporin A binding	PPIA	IDA		Human	PMID:12357034
Molecular Function	GO:0016018	cyclosporin A binding	PPIA	IMP		Human	PMID:2001362
Molecular Function	GO:0016018	cyclosporin A binding	PPIA	IDA		Human	PMID:20676357
Molecular Function	GO:0016018	cyclosporin A binding	Ppia	IDA		Rat	PMID:19832699|RGD:7247324
Molecular Function	GO:1904399	heparan sulfate binding	PPIA	IDA		Human	PMID:11943775
Molecular Function	GO:0005178	integrin binding	Ppia	IDA		Mouse	MGI:MGI:6450355|PMID:24429998
Molecular Function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	PPIA	IDA		Human	PMID:14993672
Molecular Function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	PPIA	IMP		Human	PMID:2001362
Molecular Function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	PPIA	IDA		Human	PMID:20676357
Molecular Function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	PPIA	IMP		Human	PMID:21245143
Molecular Function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	PPIA	IMP		Human	PMID:21593166
Molecular Function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	PPIA	IMP		Human	PMID:25678563
Molecular Function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	Ppia	IMP		Mouse	MGI:MGI:6450355|PMID:24429998
Molecular Function	GO:0005515	protein binding	PPIA	IPI	UniProtKB:P35613	Human	PMID:11353871
Molecular Function	GO:0005515	protein binding	PPIA	IPI	UniProtKB:P35613-2	Human	PMID:11353871
Molecular Function	GO:0005515	protein binding	PPIA	IPI	UniProtKB:P35613-2	Human	PMID:11943775
Molecular Function	GO:0005515	protein binding	PPIA	IPI	UniProtKB:P63098,UniProtKB:Q08209	Human	PMID:12218175
Molecular Function	GO:0005515	protein binding	PPIA	IPI	UniProtKB:P63098,UniProtKB:Q08209	Human	PMID:12357034
Molecular Function	GO:0005515	protein binding	PPIA	IPI	UniProtKB:Q72497	Human	PMID:12730686
Molecular Function	GO:0005515	protein binding	PPIA	IPI	UniProtKB:P59595	Human	PMID:15358143
Molecular Function	GO:0005515	protein binding	PPIA	IPI	UniProtKB:P35613	Human	PMID:15688292
Molecular Function	GO:0005515	protein binding	PPIA	IPI	UniProtKB:P35613-2	Human	PMID:15688292
Molecular Function	GO:0005515	protein binding	PPIA	IPI	UniProtKB:P59595	Human	PMID:15688292
Molecular Function	GO:0005515	protein binding	PPIA	IPI	UniProtKB:P05067	Human	PMID:16049941
Molecular Function	GO:0005515	protein binding	PPIA	IPI	UniProtKB:O00267	Human	PMID:16169070
Molecular Function	GO:0005515	protein binding	PPIA	IPI	UniProtKB:Q16849	Human	PMID:16273344
Molecular Function	GO:0005515	protein binding	PPIA	IPI	UniProtKB:Q9WMB5	Human	PMID:20147391
Molecular Function	GO:0005515	protein binding	PPIA	IPI	UniProtKB:P35613-2	Human	PMID:21245143
Molecular Function	GO:0005515	protein binding	PPIA	IPI	UniProtKB:Q99IB8	Human	PMID:21593166
Molecular Function	GO:0005515	protein binding	PPIA	IPI	UniProtKB:P0C6X7:PRO_0000037309	Human	PMID:22046132
Molecular Function	GO:0005515	protein binding	PPIA	IPI	UniProtKB:Q72497	Human	PMID:22174692
Molecular Function	GO:0005515	protein binding	PPIA	IPI	UniProtKB:Q99IB8:PRO_0000045602	Human	PMID:23152499
Molecular Function	GO:0005515	protein binding	PPIA	IPI	UniProtKB:Q99IB8:PRO_0000045602	Human	PMID:23935497
Molecular Function	GO:0005515	protein binding	PPIA	IPI	UniProtKB:Q8TBB1	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PPIA	IPI	UniProtKB:P0DOE7	Human	PMID:25556234
Molecular Function	GO:0005515	protein binding	PPIA	IPI	UniProtKB:P07910	Human	PMID:25678563
Molecular Function	GO:0005515	protein binding	PPIA	IPI	UniProtKB:P09651	Human	PMID:25678563
Molecular Function	GO:0005515	protein binding	PPIA	IPI	UniProtKB:P22626	Human	PMID:25678563
Molecular Function	GO:0005515	protein binding	PPIA	IPI	UniProtKB:P38159	Human	PMID:25678563
Molecular Function	GO:0005515	protein binding	PPIA	IPI	UniProtKB:P52272	Human	PMID:25678563
Molecular Function	GO:0005515	protein binding	PPIA	IPI	UniProtKB:P61978	Human	PMID:25678563
Molecular Function	GO:0005515	protein binding	PPIA	IPI	UniProtKB:Q13148	Human	PMID:25678563
Molecular Function	GO:0005515	protein binding	PPIA	IPI	UniProtKB:Q99683	Human	PMID:26095851
Molecular Function	GO:0005515	protein binding	PPIA	IPI	UniProtKB:P46108-1	Human	PMID:26656091
Molecular Function	GO:0005515	protein binding	PPIA	IPI	UniProtKB:Q12778	Human	PMID:31063815
Molecular Function	GO:0005515	protein binding	PPIA	IPI	UniProtKB:O43614	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PPIA	IPI	UniProtKB:O75376	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PPIA	IPI	UniProtKB:P05067	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PPIA	IPI	UniProtKB:P62841	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PPIA	IPI	UniProtKB:Q00535	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PPIA	IPI	UniProtKB:P0DTC9	Human	PMID:34161778
Molecular Function	GO:0005515	protein binding	PPIA	IPI	UniProtKB:P0DTC9	Human	PMID:34462738
Molecular Function	GO:0005515	protein binding	PPIA	IPI	UniProtKB:P0DTC9	Human	PMID:34901782
Molecular Function	GO:0005515	protein binding	Ppia	IPI	UniProtKB:Q921F2	Mouse	MGI:MGI:6450400|PMID:25678563
Molecular Function	GO:0005515	protein binding	Ppia	IPI	PR:Q99KP6	Mouse	PMID:16352598
Molecular Function	GO:0003723	RNA binding	PPIA	HDA		Human	PMID:22658674
Molecular Function	GO:0003723	RNA binding	PPIA	HDA		Human	PMID:22681889
Cellular Component	GO:0005737	cytoplasm	PPIA	IDA		Human	PMID:26095851
Cellular Component	GO:0005829	cytosol	PPIA	HDA		Human	PMID:16780588
Cellular Component	GO:0070062	extracellular exosome	PPIA	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	PPIA	HDA		Human	PMID:19199708
Cellular Component	GO:0070062	extracellular exosome	PPIA	HDA		Human	PMID:20458337
Cellular Component	GO:0070062	extracellular exosome	PPIA	HDA		Human	PMID:23533145
Cellular Component	GO:0005576	extracellular region	PPIA	IDA		Human	PMID:16527992
Cellular Component	GO:0005615	extracellular space	PPIA	HDA		Human	PMID:16502470
Cellular Component	GO:0005615	extracellular space	Ppia	HDA		Mouse	MGI:MGI:5640941|PMID:24006456
Cellular Component	GO:0005615	extracellular space	Ppia	IDA		Mouse	PMID:29921611
Cellular Component	GO:0005925	focal adhesion	PPIA	HDA		Human	PMID:21423176
Cellular Component	GO:0016020	membrane	PPIA	HDA		Human	PMID:19946888
Cellular Component	GO:0043209	myelin sheath	Ppia	HDA		Mouse	MGI:MGI:3834050|PMID:17634366
Cellular Component	GO:0005634	nucleus	PPIA	HDA		Human	PMID:16780588
Cellular Component	GO:0005634	nucleus	PPIA	IDA		Human	PMID:25678563
Cellular Component	GO:0032991	protein-containing complex	PPIA	IDA		Human	PMID:12218175
Cellular Component	GO:0031982	vesicle	PPIA	HDA		Human	PMID:19190083
Biological Process	GO:0032148	activation of protein kinase B activity	PPIA	IDA		Human	PMID:23180369
Biological Process	GO:0006915	apoptotic process	PPIA	IDA		Human	PMID:15130913
Biological Process	GO:0006915	apoptotic process	PPIA	IMP		Human	PMID:31063815
Biological Process	GO:0060352	cell adhesion molecule production	PPIA	IDA		Human	PMID:15130913
Biological Process	GO:0034599	cellular response to oxidative stress	PPIA	IDA		Human	PMID:16527992
Biological Process	GO:0042118	endothelial cell activation	PPIA	IDA		Human	PMID:15130913
Biological Process	GO:0030595	leukocyte chemotaxis	PPIA	IMP		Human	PMID:21245143
Biological Process	GO:0034389	lipid droplet organization	PPIA	IMP		Human	PMID:21711559
Biological Process	GO:1902176	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	PPIA	IMP		Human	PMID:26095851
Biological Process	GO:0032515	negative regulation of phosphoprotein phosphatase activity	Ppia	IDA		Rat	PMID:19832699|RGD:7247324
Biological Process	GO:0061944	negative regulation of protein K48-linked ubiquitination	PPIA	IMP		Human	PMID:30328013
Biological Process	GO:0006469	negative regulation of protein kinase activity	PPIA	IDA		Human	PMID:26095851
Biological Process	GO:0001933	negative regulation of protein phosphorylation	PPIA	IDA		Human	PMID:26095851
Biological Process	GO:0032873	negative regulation of stress-activated MAPK cascade	PPIA	IMP		Human	PMID:26095851
Biological Process	GO:1903901	negative regulation of viral life cycle	PPIA	IMP		Human	PMID:19207730
Biological Process	GO:1903901	negative regulation of viral life cycle	PPIA	IMP		Human	PMID:22347431
Biological Process	GO:0030182	neuron differentiation	Ppia	IMP		Mouse	PMID:16352598
Biological Process	GO:0030593	neutrophil chemotaxis	PPIA	IDA		Human	PMID:11943775
Biological Process	GO:0030168	platelet activation	Ppia	IMP		Mouse	MGI:MGI:6450355|PMID:24429998
Biological Process	GO:0070527	platelet aggregation	Ppia	IMP		Mouse	MGI:MGI:6450355|PMID:24429998
Biological Process	GO:0043410	positive regulation of MAPK cascade	PPIA	IDA		Human	PMID:15130913
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PPIA	IDA		Human	PMID:15130913
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PPIA	IDA		Human	PMID:23180369
Biological Process	GO:0035307	positive regulation of protein dephosphorylation	PPIA	IMP		Human	PMID:31063815
Biological Process	GO:0001934	positive regulation of protein phosphorylation	PPIA	IDA		Human	PMID:11943775
Biological Process	GO:0050714	positive regulation of protein secretion	PPIA	IMP		Human	PMID:21711559
Biological Process	GO:0045070	positive regulation of viral genome replication	PPIA	IMP		Human	PMID:19932913
Biological Process	GO:0000413	protein peptidyl-prolyl isomerization	PPIA	IDA		Human	PMID:14993672
Biological Process	GO:0000413	protein peptidyl-prolyl isomerization	PPIA	IDA		Human	PMID:20676357
Biological Process	GO:2001233	regulation of apoptotic signaling pathway	PPIA	IMP		Human	PMID:23180369
Biological Process	GO:0045069	regulation of viral genome replication	PPIA	IMP		Human	PMID:11250896
Biological Process	GO:0001666	response to hypoxia	ppiab	IDA		Zfish	PMID:16709914

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern