Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PPM1A
  • Mouse genes Ppm1a
  • Rat genes Ppm1a
  • Zfish genes ppm1aa,ppm1ab
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ppm1a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0033192	calmodulin-dependent protein phosphatase activity	PPM1A	IDA		Human	PMID:11559703
Molecular Function	GO:0004721	phosphoprotein phosphatase activity	Ppm1a	IDA		Mouse	PMID:23088624
Molecular Function	GO:0004721	phosphoprotein phosphatase activity	Ppm1a	IDA		Mouse	PMID:25100727
Molecular Function	GO:0004721	phosphoprotein phosphatase activity	Ppm1a	IDA		Mouse	PMID:14654243
Molecular Function	GO:0004721	phosphoprotein phosphatase activity	Ppm1a	IDA		Rat	PMID:16844074|RGD:7241141
Molecular Function	GO:0005515	protein binding	PPM1A	IPI	UniProtKB:O14640	Human	PMID:10644691
Molecular Function	GO:0005515	protein binding	PPM1A	IPI	UniProtKB:O14641	Human	PMID:10644691
Molecular Function	GO:0005515	protein binding	PPM1A	IPI	UniProtKB:O15169	Human	PMID:10644691
Molecular Function	GO:0005515	protein binding	PPM1A	IPI	UniProtKB:Q92997	Human	PMID:10644691
Molecular Function	GO:0005515	protein binding	PPM1A	IPI	UniProtKB:P84022	Human	PMID:16751101
Molecular Function	GO:0005515	protein binding	PPM1A	IPI	UniProtKB:Q15796	Human	PMID:16751101
Molecular Function	GO:0005515	protein binding	PPM1A	IPI	UniProtKB:P32121	Human	PMID:17620599
Molecular Function	GO:0005515	protein binding	PPM1A	IPI	UniProtKB:P49407	Human	PMID:17620599
Molecular Function	GO:0005515	protein binding	PPM1A	IPI	UniProtKB:O14920	Human	PMID:18930133
Molecular Function	GO:0005515	protein binding	PPM1A	IPI	UniProtKB:Q9H6Z4	Human	PMID:21960005
Molecular Function	GO:0005515	protein binding	PPM1A	IPI	UniProtKB:P28482	Human	PMID:23560844
Molecular Function	GO:0005515	protein binding	PPM1A	IPI	UniProtKB:Q16539	Human	PMID:23560844
Molecular Function	GO:0005515	protein binding	PPM1A	IPI	UniProtKB:P00533	Human	PMID:28065597
Molecular Function	GO:0005515	protein binding	PPM1A	IPI	UniProtKB:P08069	Human	PMID:28065597
Molecular Function	GO:0005515	protein binding	Ppm1a	IPI	UniProtKB:P27884	Rat	PMID:15728831|RGD:8554004
Molecular Function	GO:0005515	protein binding	Ppm1a	IPI	UniProtKB:Q00975	Rat	PMID:15728831|RGD:8554004
Molecular Function	GO:0004722	protein serine/threonine phosphatase activity	PPM1A	IDA		Human	PMID:10644691
Molecular Function	GO:0004722	protein serine/threonine phosphatase activity	PPM1A	IDA		Human	PMID:11559703
Molecular Function	GO:0004722	protein serine/threonine phosphatase activity	PPM1A	IDA		Human	PMID:20801214
Molecular Function	GO:0070412	R-SMAD binding	PPM1A	IPI	UniProtKB:Q15796	Human	PMID:16751101
Molecular Function	GO:0044325	transmembrane transporter binding	Ppm1a	IDA		Rat	PMID:15728831|RGD:8554004
Cellular Component	GO:0005829	cytosol	PPM1A	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	Ppm1a	IDA		Mouse	MGI:MGI:5470043|PMID:23088624
Cellular Component	GO:0016020	membrane	Ppm1a	IDA		Mouse	MGI:MGI:5470043|PMID:23088624
Cellular Component	GO:0043005	neuron projection	Ppm1a	IDA		Rat	PMID:15728831|RGD:8554004
Cellular Component	GO:0005634	nucleus	PPM1A	IDA		Human	PMID:16751101
Cellular Component	GO:0005634	nucleus	Ppm1a	IDA		Mouse	PMID:21829547
Cellular Component	GO:0005886	plasma membrane	PPM1A	IDA		Human	GO_REF:0000052
Biological Process	GO:0051216	cartilage development	ppm1aa	IGI	ZFIN:ZDB-GENO-230118-9,ZFIN:ZDB-MRPHLNO-221205-4	Zfish	PMID:35712083
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	Ppm1a	IDA		Mouse	PMID:21829547
Biological Process	GO:0016311	dephosphorylation	PPM1A	IDA		Human	PMID:10644691
Biological Process	GO:0006499	N-terminal protein myristoylation	Ppm1a	IDA		Mouse	MGI:MGI:5470043|PMID:23088624
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	Ppm1a	IMP		Mouse	PMID:25100727
Biological Process	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	PPM1A	IMP		Human	PMID:18930133
Biological Process	GO:1901223	negative regulation of NIK/NF-kappaB signaling	PPM1A	IMP		Human	PMID:18930133
Biological Process	GO:0010991	negative regulation of SMAD protein complex assembly	PPM1A	IDA		Human	PMID:16751101
Biological Process	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	PPM1A	IDA		Human	PMID:16751101
Biological Process	GO:0035970	peptidyl-threonine dephosphorylation	PPM1A	IDA		Human	PMID:11559703
Biological Process	GO:0035970	peptidyl-threonine dephosphorylation	PPM1A	IDA		Human	PMID:20801214
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	PPM1A	IDA		Human	PMID:10644691
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	PPM1A	IDA		Human	PMID:10644691
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	PPM1A	HMP		Human	PMID:12761501
Biological Process	GO:0046827	positive regulation of protein export from nucleus	Ppm1a	IMP		Mouse	PMID:25100727
Biological Process	GO:0006470	protein dephosphorylation	PPM1A	IMP		Human	PMID:18930133
Biological Process	GO:0006470	protein dephosphorylation	Ppm1a	IMP		Mouse	MGI:MGI:5470043|PMID:23088624
Biological Process	GO:0006470	protein dephosphorylation	Ppm1a	IMP		Mouse	PMID:25100727
Biological Process	GO:0006470	protein dephosphorylation	Ppm1a	IDA		Mouse	PMID:14664809
Biological Process	GO:0006611	protein export from nucleus	Ppm1a	IMP		Mouse	PMID:25100727

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern