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Comparative GO Graph (mouse, human, rat, zebrafish)
Source
Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Ppp3ca

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ppp3ca
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:0051117ATPase bindingPPP3CAIPIUniProtKB:P23634HumanPMID:15955804
Molecular FunctionGO:0004723calcium-dependent protein serine/threonine phosphatase activityPpp3caIDARatPMID:12135494|RGD:729536
Molecular FunctionGO:0005516calmodulin bindingPPP3CAIDAHumanPMID:11005320
Molecular FunctionGO:0005516calmodulin bindingPPP3CAIDAHumanPMID:18384083
Molecular FunctionGO:0005516calmodulin bindingPPP3CAIDAHumanPMID:19404396
Molecular FunctionGO:0005516calmodulin bindingPpp3caIDAMouseMGI:MGI:6119999|PMID:26794871
Molecular FunctionGO:0005516calmodulin bindingPpp3caIDARatPMID:12135494|RGD:729536
Molecular FunctionGO:0033192calmodulin-dependent protein phosphatase activityPPP3CAIDAHumanPMID:18815128
Molecular FunctionGO:0033192calmodulin-dependent protein phosphatase activityPPP3CAIDAHumanPMID:19154138
Molecular FunctionGO:0033192calmodulin-dependent protein phosphatase activityPPP3CAIDAHumanPMID:23468591
Molecular FunctionGO:0033192calmodulin-dependent protein phosphatase activityPPP3CAIMPHumanPMID:30254215
Molecular FunctionGO:0033192calmodulin-dependent protein phosphatase activityPpp3caIDAMouseMGI:MGI:6119999|PMID:26794871
Molecular FunctionGO:0033192calmodulin-dependent protein phosphatase activityPpp3caIDARatPMID:24018048|RGD:13507300
Molecular FunctionGO:0016018cyclosporin A bindingPPP3CAIDAHumanPMID:12218175
Molecular FunctionGO:0016018cyclosporin A bindingPPP3CAIDAHumanPMID:12357034
Molecular FunctionGO:0019899enzyme bindingPPP3CAIDAHumanPMID:11005320
Molecular FunctionGO:0140677molecular function activator activityPPP3CAEXPHumanPMID:24018048
Molecular FunctionGO:0140677molecular function activator activityPPP3CAIDAHumanPMID:24018048
Molecular FunctionGO:0140677molecular function activator activityPPP3CAEXPHumanPMID:24191726
Molecular FunctionGO:0140677molecular function activator activityPPP3CAEXPHumanPMID:27187005
Molecular FunctionGO:0004721phosphoprotein phosphatase activityPpp3caIDAMousePMID:16024798
Molecular FunctionGO:0004721phosphoprotein phosphatase activityPpp3caIDARatPMID:1322410|RGD:727532
Molecular FunctionGO:0005515protein bindingPPP3CAIPIUniProtKB:Q9NP98HumanPMID:11114196
Molecular FunctionGO:0005515protein bindingPPP3CAIPIUniProtKB:Q9NPC6HumanPMID:11114196
Molecular FunctionGO:0005515protein bindingPPP3CAIPIUniProtKB:Q8TDC0HumanPMID:11842093
Molecular FunctionGO:0005515protein bindingPPP3CAIPIUniProtKB:P62937,UniProtKB:P63098HumanPMID:12218175
Molecular FunctionGO:0005515protein bindingPPP3CAIPIUniProtKB:P62937,UniProtKB:P63098HumanPMID:12357034
Molecular FunctionGO:0005515protein bindingPPP3CAIPIUniProtKB:P62993HumanPMID:12577067
Molecular FunctionGO:0005515protein bindingPPP3CAIPIUniProtKB:P53805HumanPMID:12809556
Molecular FunctionGO:0005515protein bindingPPP3CAIPIUniProtKB:Q96GX8HumanPMID:16189514
Molecular FunctionGO:0005515protein bindingPPP3CAIPIUniProtKB:P62993HumanPMID:17474147
Molecular FunctionGO:0005515protein bindingPPP3CAIPIUniProtKB:Q13469HumanPMID:18218901
Molecular FunctionGO:0005515protein bindingPPP3CAIPIUniProtKB:O00429HumanPMID:18838687
Molecular FunctionGO:0005515protein bindingPPP3CAIPIUniProtKB:P54578HumanPMID:19896943
Molecular FunctionGO:0005515protein bindingPPP3CAIPIUniProtKB:P63098HumanPMID:19896943
Molecular FunctionGO:0005515protein bindingPPP3CAIPIUniProtKB:P62993HumanPMID:21900206
Molecular FunctionGO:0005515protein bindingPPP3CAIPIUniProtKB:P19634HumanPMID:22688515
Molecular FunctionGO:0005515protein bindingPPP3CAIPIUniProtKB:Q8VHW5HumanPMID:24418105
Molecular FunctionGO:0005515protein bindingPPP3CAIPIUniProtKB:P63098HumanPMID:25416956
Molecular FunctionGO:0005515protein bindingPPP3CAIPIUniProtKB:Q96GX8HumanPMID:25416956
Molecular FunctionGO:0005515protein bindingPPP3CAIPIUniProtKB:Q13469HumanPMID:26248042
Molecular FunctionGO:0005515protein bindingPPP3CAIPIUniProtKB:Q9UKA8HumanPMID:26248042
Molecular FunctionGO:0005515protein bindingPPP3CAIPIUniProtKB:P63098HumanPMID:27974827
Molecular FunctionGO:0005515protein bindingPPP3CAIPIUniProtKB:Q96GX8HumanPMID:28881575
Molecular FunctionGO:0005515protein bindingPPP3CAIPIUniProtKB:Q3U182HumanPMID:30611118
Molecular FunctionGO:0005515protein bindingPPP3CAIPIUniProtKB:Q68ED7HumanPMID:30611118
Molecular FunctionGO:0005515protein bindingPPP3CAIPIUniProtKB:P63098HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingPPP3CAIPIUniProtKB:Q96N06HumanPMID:34446558
Molecular FunctionGO:0005515protein bindingPPP3CAIPIUniProtKB:P63098HumanPMID:8524402
Molecular FunctionGO:0005515protein bindingPpp3caIPIUniProtKB:Q9Z2R6MouseMGI:MGI:6383261|PMID:31696965
Molecular FunctionGO:0005515protein bindingPpp3caIPIUniProtKB:Q60803|UniProtKB:Q9WUL6MouseMGI:MGI:6216148|PMID:26029823
Molecular FunctionGO:0005515protein bindingPpp3caIPIUniProtKB:Q63810MouseMGI:MGI:6119999|PMID:26794871
Molecular FunctionGO:0005515protein bindingPpp3caIPIUniProtKB:Q3U182MouseMGI:MGI:5319409|PMID:22495310
Molecular FunctionGO:0005515protein bindingPpp3caIPIUniProtKB:Q63810-2MouseMGI:MGI:4821678|PMID:20639889
Molecular FunctionGO:0005515protein bindingPpp3caIPIUniProtKB:Q9JHG6MouseMGI:MGI:6148615|PMID:12809556
Molecular FunctionGO:0005515protein bindingPpp3caIPIUniProtKB:E9QLJ0MousePMID:21427212
Molecular FunctionGO:0005515protein bindingPpp3caIPIPR:P10417MousePMID:12617961
Molecular FunctionGO:0005515protein bindingPpp3caIPIPR:P22723MousePMID:12574411
Molecular FunctionGO:0005515protein bindingPpp3caIPIPR:P10417MousePMID:16717086
Molecular FunctionGO:0005515protein bindingPpp3caIPIPR:P10637MousePMID:18639592
Molecular FunctionGO:0005515protein bindingPpp3caIPIPR:Q3UVC0MousePMID:19560418
Molecular FunctionGO:0005515protein bindingPpp3caIPIPR:P11881MousePMID:12617961
Molecular FunctionGO:0005515protein bindingPpp3caIPIPR:P50462MousePMID:15665106
Molecular FunctionGO:0005515protein bindingPpp3caIPIPR:P63137MousePMID:12574411
Molecular FunctionGO:0005515protein bindingPpp3caIPIPR:P62812MousePMID:12574411
Molecular FunctionGO:0005515protein bindingPpp3caIPIUniProtKB:Q99653RatPMID:10593895|RGD:8554338
Molecular FunctionGO:0005515protein bindingPpp3caIPIRGD:620103RatPMID:15120593|RGD:1579942
Molecular FunctionGO:0005515protein bindingPpp3caIPIUniProtKB:P22002RatPMID:19478199|RGD:8553443
Molecular FunctionGO:0005515protein bindingPpp3caIPIRGD:628808RatPMID:24418105|RGD:8553314
Molecular FunctionGO:0005515protein bindingPpp3caIPIUniProtKB:Q8VHW5RatPMID:24418105|RGD:8553314
Molecular FunctionGO:0046983protein dimerization activityPPP3CAIPIUniProtKB:P16298HumanPMID:11005320
Molecular FunctionGO:0046983protein dimerization activityPPP3CAIPIUniProtKB:Q08209HumanPMID:11005320
Molecular FunctionGO:0004722protein serine/threonine phosphatase activityPPP3CAIMPHumanPMID:30611118
Molecular FunctionGO:0004722protein serine/threonine phosphatase activityPpp3caIDARatPMID:12135494|RGD:729536
Molecular FunctionGO:0044877protein-containing complex bindingPpp3caIDARatPMID:12135494|RGD:729536
Cellular ComponentGO:0005955calcineurin complexPPP3CAIDAHumanPMID:12218175
Cellular ComponentGO:0005955calcineurin complexPPP3CAIDAHumanPMID:12357034
Cellular ComponentGO:0005955calcineurin complexPPP3CAIDAHumanPMID:22343722
Cellular ComponentGO:0005955calcineurin complexPPP3CAIDAHumanPMID:22688515
Cellular ComponentGO:0005955calcineurin complexPPP3CAIDAHumanPMID:23468591
Cellular ComponentGO:0005955calcineurin complexPPP3CAIDAHumanPMID:27974827
Cellular ComponentGO:0005955calcineurin complexPpp3caIDAMouseMGI:MGI:6119999|PMID:26794871
Cellular ComponentGO:0005955calcineurin complexPpp3caIDAMousePMID:12617961
Cellular ComponentGO:0005955calcineurin complexPpp3caIDARatPMID:12135494|RGD:729536
Cellular ComponentGO:0005737cytoplasmPPP3CAIDAHumanPMID:15955804
Cellular ComponentGO:0005737cytoplasmPPP3CAIDAHumanPMID:19154138
Cellular ComponentGO:0005737cytoplasmPPP3CAIDAHumanPMID:22343722
Cellular ComponentGO:0005737cytoplasmPpp3caIDAMouseMGI:MGI:6869989|PMID:16968888
Cellular ComponentGO:0005737cytoplasmPpp3caIDAMouseMGI:MGI:3610779|PMID:16286645
Cellular ComponentGO:0009898cytoplasmic side of plasma membranePPP3CAIDAHumanPMID:22343722
Cellular ComponentGO:0005829cytosolPPP3CAIDAHumanGO_REF:0000052
Cellular ComponentGO:0005829cytosolPpp3caIDAMousePMID:12617961
Cellular ComponentGO:0005829cytosolPpp3caIDARatPMID:16150427|RGD:1580673
Cellular ComponentGO:0043197dendritic spinePPP3CAIDAHumanPMID:22343722
Cellular ComponentGO:0098978glutamatergic synapsePpp3caIMPMousePMID:11257222
Cellular ComponentGO:0098978glutamatergic synapsePpp3caIDAMousePMID:11257222
Cellular ComponentGO:0005739mitochondrionPpp3caIDAMousePMID:12617961
Cellular ComponentGO:0005654nucleoplasmPPP3CAIDAHumanGO_REF:0000052
Cellular ComponentGO:0005634nucleusPpp3caIDAMousePMID:12617961
Cellular ComponentGO:0005886plasma membranePPP3CAIDAHumanPMID:15955804
Cellular ComponentGO:0005886plasma membranePPP3CAIDAHumanPMID:28881575
Cellular ComponentGO:0098794postsynapsePpp3caIMPMouseMGI:MGI:3772038|PMID:11257222
Cellular ComponentGO:0098685Schaffer collateral - CA1 synapsePpp3caIMPMousePMID:11257222
Cellular ComponentGO:0098685Schaffer collateral - CA1 synapsePpp3caIDAMousePMID:11257222
Cellular ComponentGO:0036057slit diaphragmPpp3caIDARatPMID:27009276|RGD:11537650
Cellular ComponentGO:0045202synapsePpp3caIDARatPMID:1313851|RGD:13702322
Cellular ComponentGO:0045202synapsePpp3caIDARatPMID:16150427|RGD:1580673
Cellular ComponentGO:0030018Z discPpp3caIDAMousePMID:15665106
Biological ProcessGO:0007568agingPpp3caIEPRatPMID:16150427|RGD:1580673
Biological ProcessGO:0007420brain developmentPpp3caIEPRatPMID:16367768|RGD:1580674
Biological ProcessGO:0097720calcineurin-mediated signalingPPP3CAIMPHumanPMID:11005320
Biological ProcessGO:0033173calcineurin-NFAT signaling cascadePPP3CAIMPHumanPMID:15955804
Biological ProcessGO:0033173calcineurin-NFAT signaling cascadePPP3CAIDAHumanPMID:19154138
Biological ProcessGO:0033173calcineurin-NFAT signaling cascadePPP3CAIMPHumanPMID:22343722
Biological ProcessGO:0033173calcineurin-NFAT signaling cascadePPP3CAIDAHumanPMID:22688515
Biological ProcessGO:0033173calcineurin-NFAT signaling cascadePPP3CAIMPHumanPMID:23468591
Biological ProcessGO:0033173calcineurin-NFAT signaling cascadePPP3CAIMPHumanPMID:26248042
Biological ProcessGO:0033173calcineurin-NFAT signaling cascadePpp3caIDAMousePMID:9017603
Biological ProcessGO:0033173calcineurin-NFAT signaling cascadePpp3caIGIMGI:MGI:102463MousePMID:18676376
Biological ProcessGO:0033173calcineurin-NFAT signaling cascadePpp3caIDAMousePMID:21427212
Biological ProcessGO:0033173calcineurin-NFAT signaling cascadePpp3caIMPMousePMID:9515963
Biological ProcessGO:0033173calcineurin-NFAT signaling cascadePpp3caIGIMGI:MGI:103296MousePMID:18676376
Biological ProcessGO:0033173calcineurin-NFAT signaling cascadePpp3caIMPMousePMID:9515964
Biological ProcessGO:0033173calcineurin-NFAT signaling cascadePpp3caIDAMousePMID:19188439
Biological ProcessGO:0006816calcium ion transportPpp3caIMPMousePMID:12660151
Biological ProcessGO:0019722calcium-mediated signalingPpp3caIGIMGI:MGI:3610315MousePMID:19560418
Biological ProcessGO:0014898cardiac muscle hypertrophy in response to stressPpp3caIGIMGI:MGI:103296MousePMID:12370307
Biological ProcessGO:0071333cellular response to glucose stimulusPpp3caIMPRatPMID:19965390|RGD:2316628
Biological ProcessGO:0048813dendrite morphogenesisPpp3caIMPMousePMID:23407945
Biological ProcessGO:0016311dephosphorylationPpp3caIDAMousePMID:16024798
Biological ProcessGO:0016311dephosphorylationPpp3caIDAMousePMID:12574411
Biological ProcessGO:0008544epidermis developmentPpp3caIMPMouseMGI:MGI:4443285|PMID:19626032
Biological ProcessGO:0060079excitatory postsynaptic potentialPpp3caIGIMGI:MGI:95815MousePMID:17428973
Biological ProcessGO:0000082G1/S transition of mitotic cell cyclePpp3caIMPMousePMID:12660151
Biological ProcessGO:0030216keratinocyte differentiationPpp3caIMPMouseMGI:MGI:4443285|PMID:19626032
Biological ProcessGO:0050804modulation of chemical synaptic transmissionPpp3caIMPMouseMGI:MGI:1336514|PMID:10200317
Biological ProcessGO:0050804modulation of chemical synaptic transmissionPpp3caIMPMousePMID:15590926
Biological ProcessGO:0033555multicellular organismal response to stressPpp3caIDAMousePMID:11782539
Biological ProcessGO:0035562negative regulation of chromatin bindingPpp3caIMPMousePMID:23407945
Biological ProcessGO:0050774negative regulation of dendrite morphogenesisPpp3caIMPMousePMID:23407945
Biological ProcessGO:0010629negative regulation of gene expressionPpp3caIDAMouseMGI:MGI:5562625|PMID:24161931
Biological ProcessGO:0046676negative regulation of insulin secretionPpp3caIMPRatPMID:19965390|RGD:2316628
Biological ProcessGO:0023057negative regulation of signalingPpp3caIMPMouseMGI:MGI:6216148|PMID:26029823
Biological ProcessGO:0070262peptidyl-serine dephosphorylationPPP3CAIMPHumanPMID:30611118
Biological ProcessGO:0042104positive regulation of activated T cell proliferationPpp3caIMPMouseMGI:MGI:2150686|PMID:8627154
Biological ProcessGO:0010613positive regulation of cardiac muscle hypertrophyPpp3caIGIUniProtKB:P61296MouseMGI:MGI:5562625|PMID:24161931
Biological ProcessGO:0010613positive regulation of cardiac muscle hypertrophyPpp3caIGIRNAcentral:URS0000021B51_10090MouseMGI:MGI:5784969|PMID:24657879
Biological ProcessGO:1903244positive regulation of cardiac muscle hypertrophy in response to stressPpp3caIDAMouseMGI:MGI:3848765|PMID:19287093
Biological ProcessGO:0045785positive regulation of cell adhesionPPP3CAIMPHumanPMID:21785830
Biological ProcessGO:0030335positive regulation of cell migrationPPP3CAIMPHumanPMID:20422345
Biological ProcessGO:0030335positive regulation of cell migrationPPP3CAIMPHumanPMID:21785830
Biological ProcessGO:1905205positive regulation of connective tissue replacementPpp3caIGIRNAcentral:URS0000021B51_10090MouseMGI:MGI:5784969|PMID:24657879
Biological ProcessGO:0051091positive regulation of DNA-binding transcription factor activityPpp3caIDAMousePMID:23261540
Biological ProcessGO:0045807positive regulation of endocytosisPpp3caIMPMouseMGI:MGI:5905268|PMID:20032460
Biological ProcessGO:0010628positive regulation of gene expressionPpp3caIDAMouseMGI:MGI:5562625|PMID:24161931
Biological ProcessGO:0090193positive regulation of glomerulus developmentPpp3caIMPMouseMGI:MGI:3487305|PMID:15509543
Biological ProcessGO:0045669positive regulation of osteoblast differentiationPpp3caIMPMouseMGI:MGI:3610779|PMID:16286645
Biological ProcessGO:0045672positive regulation of osteoclast differentiationPpp3caIMPMouseMGI:MGI:6869989|PMID:16968888
Biological ProcessGO:0046878positive regulation of saliva secretionPpp3caIMPMouseMGI:MGI:4943357|PMID:21435446
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IIPPP3CAIDAHumanPMID:22688515
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IIPpp3caIGIUniProtKB:Q60591MouseMGI:MGI:5562625|PMID:24161931
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IIPpp3caIDAMousePMID:12808150
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IIPpp3caIGIMGI:MGI:103296MousePMID:17229811
Biological ProcessGO:0099170postsynaptic modulation of chemical synaptic transmissionPpp3caIDAMousePMID:11257222
Biological ProcessGO:0099170postsynaptic modulation of chemical synaptic transmissionPpp3caIMPMousePMID:11257222
Biological ProcessGO:0006470protein dephosphorylationPPP3CAIDAHumanPMID:18815128
Biological ProcessGO:0006470protein dephosphorylationPPP3CAIDAHumanPMID:19154138
Biological ProcessGO:0006470protein dephosphorylationPpp3caIDAMouseMGI:MGI:6119999|PMID:26794871
Biological ProcessGO:0006470protein dephosphorylationPpp3caIMPMousePMID:19560418
Biological ProcessGO:0006470protein dephosphorylationPpp3caIMPMousePMID:31637311
Biological ProcessGO:0006470protein dephosphorylationPpp3caIDARatPMID:12135494|RGD:729536
Biological ProcessGO:0006470protein dephosphorylationPpp3caIDARatPMID:1322410|RGD:727532
Biological ProcessGO:0006470protein dephosphorylationPpp3caIDARatPMID:24018048|RGD:13507300
Biological ProcessGO:0006606protein import into nucleusPpp3caIMPMousePMID:31637311
Biological ProcessGO:0006606protein import into nucleusPpp3caIDAMousePMID:11782539
Biological ProcessGO:0061006regulation of cell proliferation involved in kidney morphogenesisPpp3caIMPMouseMGI:MGI:3487305|PMID:15509543
Biological ProcessGO:0097205renal filtrationPpp3caIMPMouseMGI:MGI:3640049|PMID:16735444
Biological ProcessGO:0001975response to amphetaminePpp3caIEPRatPMID:11954050|RGD:727362
Biological ProcessGO:0051592response to calcium ionPPP3CAIDAHumanPMID:18815128
Biological ProcessGO:0048741skeletal muscle fiber developmentPpp3caIMPMouseMGI:MGI:3641363|PMID:12773574
Biological ProcessGO:0048741skeletal muscle fiber developmentPpp3caIMPMousePMID:16024798
Biological ProcessGO:0014883transition between fast and slow fiberPpp3caIDAMousePMID:21427212

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IEP Inferred from expression pattern
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  HTP Inferred from High Throughput Experiment
  HDA Inferred from High Throughput Direct Assay
  HMP Inferred from High Throughput Mutant Phenotype
  HGI Inferred from High Throughput Genetic Interaction
  HEP Inferred from High Throughput Expression Pattern

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory