Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PPP3CB
  • Mouse genes Ppp3cb
  • Rat genes Ppp3cb
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ppp3cb

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005509	calcium ion binding	PPP3CB	IDA		Human	PMID:8524402
Molecular Function	GO:0004723	calcium-dependent protein serine/threonine phosphatase activity	Ppp3cb	IDA		Rat	PMID:12135494|RGD:729536
Molecular Function	GO:0005516	calmodulin binding	PPP3CB	IDA		Human	PMID:11005320
Molecular Function	GO:0005516	calmodulin binding	PPP3CB	IDA		Human	PMID:2556704
Molecular Function	GO:0005516	calmodulin binding	PPP3CB	IDA		Human	PMID:26794871
Molecular Function	GO:0005516	calmodulin binding	Ppp3cb	IDA		Rat	PMID:12135494|RGD:729536
Molecular Function	GO:0033192	calmodulin-dependent protein phosphatase activity	PPP3CB	IDA		Human	PMID:19154138
Molecular Function	GO:0033192	calmodulin-dependent protein phosphatase activity	PPP3CB	IDA		Human	PMID:25720963
Molecular Function	GO:0033192	calmodulin-dependent protein phosphatase activity	PPP3CB	IDA		Human	PMID:26794871
Molecular Function	GO:0033192	calmodulin-dependent protein phosphatase activity	PPP3CB	IDA		Human	PMID:32753672
Molecular Function	GO:0033192	calmodulin-dependent protein phosphatase activity	Ppp3cb	IMP		Mouse	MGI:MGI:5306323|PMID:11978799
Molecular Function	GO:0019899	enzyme binding	PPP3CB	IDA		Human	PMID:11005320
Molecular Function	GO:0005515	protein binding	PPP3CB	IPI	UniProtKB:P14316	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	PPP3CB	IPI	UniProtKB:Q99J34	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	PPP3CB	IPI	UniProtKB:P19634	Human	PMID:22688515
Molecular Function	GO:0005515	protein binding	PPP3CB	IPI	UniProtKB:P63098	Human	PMID:26794871
Molecular Function	GO:0005515	protein binding	PPP3CB	IPI	UniProtKB:Q96N06	Human	PMID:34446558
Molecular Function	GO:0005515	protein binding	Ppp3cb	IPI	UniProtKB:Q9WVC7	Mouse	MGI:MGI:5508576|PMID:19883655
Molecular Function	GO:0005515	protein binding	Ppp3cb	IPI	UniProtKB:D3YVF0	Mouse	MGI:MGI:5447853|PMID:22940692
Molecular Function	GO:0005515	protein binding	Ppp3cb	IPI	UniProtKB:Q60803|UniProtKB:Q9WUL6	Mouse	MGI:MGI:6216148|PMID:26029823
Molecular Function	GO:0005515	protein binding	Ppp3cb	IPI	UniProtKB:Q9Z2R6	Mouse	MGI:MGI:6383261|PMID:31696965
Molecular Function	GO:0005515	protein binding	Ppp3cb	IPI	RGD:620103	Rat	PMID:15120593|RGD:1579942
Molecular Function	GO:0005515	protein binding	Ppp3cb	IPI	UniProtKB:Q9WVC7	Rat	PMID:19883655|RGD:6902942
Molecular Function	GO:0005515	protein binding	Ppp3cb	IPI	RGD:628808	Rat	PMID:24418105|RGD:8553314
Molecular Function	GO:0046983	protein dimerization activity	PPP3CB	IPI	UniProtKB:Q08209	Human	PMID:11005320
Molecular Function	GO:0030346	protein phosphatase 2B binding	PPP3CB	IDA		Human	PMID:2556704
Molecular Function	GO:0004722	protein serine/threonine phosphatase activity	Ppp3cb	IDA		Mouse	PMID:12091710
Molecular Function	GO:0004722	protein serine/threonine phosphatase activity	Ppp3cb	IDA		Mouse	PMID:11904392
Molecular Function	GO:0044877	protein-containing complex binding	Ppp3cb	IDA		Rat	PMID:12135494|RGD:729536
Cellular Component	GO:0005955	calcineurin complex	PPP3CB	IDA		Human	PMID:22688515
Cellular Component	GO:0005955	calcineurin complex	PPP3CB	IDA		Human	PMID:26794871
Cellular Component	GO:0005955	calcineurin complex	PPP3CB	IDA		Human	PMID:8524402
Cellular Component	GO:0005737	cytoplasm	PPP3CB	IDA		Human	PMID:19154138
Cellular Component	GO:0098978	glutamatergic synapse	Ppp3cb	IDA		Mouse	PMID:20810903
Cellular Component	GO:0098978	glutamatergic synapse	Ppp3cb	IMP		Mouse	PMID:20810903
Cellular Component	GO:0005886	plasma membrane	Ppp3cb	IDA		Mouse	MGI:MGI:5306323|PMID:11978799
Cellular Component	GO:0005886	plasma membrane	Ppp3cb	IDA		Rat	PMID:11978799|RGD:8553382
Cellular Component	GO:0032991	protein-containing complex	Ppp3cb	IDA		Rat	PMID:16306226|RGD:2312613
Cellular Component	GO:0045202	synapse	Ppp3cb	IDA		Rat	PMID:1313851|RGD:13702322
Cellular Component	GO:0030315	T-tubule	Ppp3cb	IDA		Mouse	MGI:MGI:3848765|PMID:19287093
Cellular Component	GO:0030018	Z disc	Ppp3cb	IDA		Mouse	MGI:MGI:3848765|PMID:19287093
Biological Process	GO:0007420	brain development	Ppp3cb	IEP		Rat	PMID:16367768|RGD:1580674
Biological Process	GO:0097720	calcineurin-mediated signaling	PPP3CB	IMP		Human	PMID:11005320
Biological Process	GO:0033173	calcineurin-NFAT signaling cascade	PPP3CB	IDA		Human	PMID:19154138
Biological Process	GO:0033173	calcineurin-NFAT signaling cascade	PPP3CB	IDA		Human	PMID:22688515
Biological Process	GO:0017156	calcium-ion regulated exocytosis	Ppp3cb	IDA		Mouse	MGI:MGI:5306323|PMID:11978799
Biological Process	GO:0007507	heart development	Ppp3cb	IMP	MGI:MGI:2181294	Mouse	PMID:11904392
Biological Process	GO:0031987	locomotion involved in locomotory behavior	Ppp3cb	IMP	MGI:MGI:107163	Mouse	PMID:16648267
Biological Process	GO:0001946	lymphangiogenesis	Ppp3cb	IGI	MGI:MGI:103178	Mouse	PMID:19233846
Biological Process	GO:0001946	lymphangiogenesis	Ppp3cb	IGI	MGI:MGI:102469	Mouse	PMID:19233846
Biological Process	GO:0046716	muscle cell cellular homeostasis	Ppp3cb	IEP		Rat	PMID:11997253|RGD:628398
Biological Process	GO:0023057	negative regulation of signaling	Ppp3cb	IMP		Mouse	MGI:MGI:6216148|PMID:26029823
Biological Process	GO:0001915	negative regulation of T cell mediated cytotoxicity	Ppp3cb	IMP	MGI:MGI:2181294	Mouse	PMID:18097009
Biological Process	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	Ppp3cb	IMP		Mouse	MGI:MGI:5306323|PMID:11978799
Biological Process	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	Ppp3cb	IMP		Rat	PMID:11978799|RGD:8553382
Biological Process	GO:1905673	positive regulation of lysosome organization	PPP3CB	IDA		Human	PMID:25720963
Biological Process	GO:1905673	positive regulation of lysosome organization	PPP3CB	IDA		Human	PMID:32753672
Biological Process	GO:1900182	positive regulation of protein localization to nucleus	PPP3CB	IDA		Human	PMID:25720963
Biological Process	GO:1900182	positive regulation of protein localization to nucleus	PPP3CB	IDA		Human	PMID:32753672
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	PPP3CB	IDA		Human	PMID:22688515
Biological Process	GO:0006470	protein dephosphorylation	PPP3CB	IDA		Human	PMID:19154138
Biological Process	GO:0006470	protein dephosphorylation	PPP3CB	IDA		Human	PMID:26794871
Biological Process	GO:0006470	protein dephosphorylation	Ppp3cb	IMP		Mouse	MGI:MGI:5306323|PMID:11978799
Biological Process	GO:0006470	protein dephosphorylation	Ppp3cb	IMP	MGI:MGI:2181294	Mouse	PMID:12091710
Biological Process	GO:0006470	protein dephosphorylation	Ppp3cb	IDA		Rat	PMID:12135494|RGD:729536
Biological Process	GO:0006468	protein phosphorylation	Ppp3cb	IMP		Mouse	MGI:MGI:5306323|PMID:11978799
Biological Process	GO:0010468	regulation of gene expression	Ppp3cb	IMP	MGI:MGI:2181294	Mouse	PMID:18097009
Biological Process	GO:0050796	regulation of insulin secretion	Ppp3cb	IDA		Rat	PMID:11978799|RGD:8553382
Biological Process	GO:1900242	regulation of synaptic vesicle endocytosis	Ppp3cb	IDA		Mouse	PMID:20810903
Biological Process	GO:1900242	regulation of synaptic vesicle endocytosis	Ppp3cb	IMP		Mouse	PMID:20810903
Biological Process	GO:0001975	response to amphetamine	Ppp3cb	IEP		Rat	PMID:11954050|RGD:727362
Biological Process	GO:0034097	response to cytokine	Ppp3cb	IMP	MGI:MGI:2181294	Mouse	PMID:18097009
Biological Process	GO:0006950	response to stress	Ppp3cb	IMP	MGI:MGI:107163	Mouse	PMID:16648267
Biological Process	GO:0048741	skeletal muscle fiber development	Ppp3cb	IMP		Mouse	MGI:MGI:3641363|PMID:12773574
Biological Process	GO:0030217	T cell differentiation	Ppp3cb	IMP	MGI:MGI:2181294	Mouse	PMID:12091710
Biological Process	GO:0043029	T cell homeostasis	Ppp3cb	IMP	MGI:MGI:2181294	Mouse	PMID:18097009
Biological Process	GO:0001913	T cell mediated cytotoxicity	Ppp3cb	IMP	MGI:MGI:2181294	Mouse	PMID:18097009

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern