Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PRAME,PRAMEF1,PRAMEF10,PRAMEF11,PRAMEF12,PRAMEF13,PRAMEF15,PRAMEF17,PRAMEF18,PRAMEF19,PRAMEF20,PRAMEF22,PRAMEF25,PRAMEF26,PRAMEF27,PRAMEF33,PRAMEF4,PRAMEF5,PRAMEF6,PRAMEF7,PRAMEF8,PRAMEF9
  • Mouse genes Pramel13
  • Rat genes Pramef12
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pramel13

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042974	nuclear retinoic acid receptor binding	PRAME	IDA		Human	PMID:16179254
Molecular Function	GO:0005515	protein binding	PRAME	IPI	UniProtKB:Q15910	Human	PMID:16179254
Molecular Function	GO:1990756	ubiquitin ligase-substrate adaptor activity	PRAMEF9	IDA		Human	PMID:26138980
Molecular Function	GO:1990756	ubiquitin ligase-substrate adaptor activity	PRAME	IDA		Human	PMID:21822215
Molecular Function	GO:1990756	ubiquitin ligase-substrate adaptor activity	PRAME	IDA		Human	PMID:26138980
Molecular Function	GO:1990756	ubiquitin ligase-substrate adaptor activity	PRAMEF6	IDA		Human	PMID:26138980
Cellular Component	GO:0000785	chromatin	PRAME	IDA		Human	PMID:21822215
Cellular Component	GO:0031462	Cul2-RING ubiquitin ligase complex	PRAMEF9	IDA		Human	PMID:26138980
Cellular Component	GO:0031462	Cul2-RING ubiquitin ligase complex	PRAME	IDA		Human	PMID:21822215
Cellular Component	GO:0031462	Cul2-RING ubiquitin ligase complex	PRAME	IDA		Human	PMID:26138980
Cellular Component	GO:0031462	Cul2-RING ubiquitin ligase complex	PRAMEF6	IDA		Human	PMID:26138980
Cellular Component	GO:0005654	nucleoplasm	PRAME	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	PRAME	IDA		Human	PMID:21822215
Cellular Component	GO:0005886	plasma membrane	PRAME	IDA		Human	GO_REF:0000052
Biological Process	GO:0043066	negative regulation of apoptotic process	PRAME	IDA		Human	PMID:16179254
Biological Process	GO:0045596	negative regulation of cell differentiation	PRAME	IDA		Human	PMID:16179254
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	PRAME	IDA		Human	PMID:16179254
Biological Process	GO:0048387	negative regulation of retinoic acid receptor signaling pathway	PRAME	IDA		Human	PMID:16179254
Biological Process	GO:0008284	positive regulation of cell population proliferation	PRAME	IDA		Human	PMID:16179254
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	PRAMEF9	IDA		Human	PMID:26138980
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	PRAME	IDA		Human	PMID:26138980
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	PRAMEF6	IDA		Human	PMID:26138980
Biological Process	GO:0000209	protein polyubiquitination	PRAME	IDA		Human	PMID:21822215

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern