Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Prdm16

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes PRDM16
- Mouse genes Prdm16
- Rat genes Prdm16
- Zfish genes prdm16
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Prdm16

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Prdm16	IDA		Mouse	PMID:28930673
Molecular Function	GO:0140297	DNA-binding transcription factor binding	PRDM16	IPI	UniProtKB:Q7TSH3	Human	PMID:25578880
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	PRDM16	IDA		Human	PMID:12816872
Molecular Function	GO:0046974	histone H3K9 methyltransferase activity	Prdm16	IDA		Mouse	MGI:MGI:6274969\|PMID:22939622
Molecular Function	GO:0005515	protein binding	PRDM16	IPI	UniProtKB:P12755	Human	PMID:19049980
Molecular Function	GO:0005515	protein binding	PRDM16	IPI	UniProtKB:P84022	Human	PMID:19049980
Molecular Function	GO:0005515	protein binding	PRDM16	IPI	UniProtKB:Q13547	Human	PMID:19049980
Molecular Function	GO:0005515	protein binding	PRDM16	IPI	UniProtKB:Q15796	Human	PMID:19049980
Molecular Function	GO:0005515	protein binding	PRDM16	IPI	UniProtKB:Q09028	Human	PMID:30462309
Molecular Function	GO:0005515	protein binding	Prdm16	IPI	UniProtKB:Q5DW34-1	Mouse	MGI:MGI:5559375\|PMID:24196706
Molecular Function	GO:0005515	protein binding	Prdm16	IPI	UniProtKB:Q8VHJ7	Mouse	MGI:MGI:4365360\|PMID:18483224
Molecular Function	GO:0005515	protein binding	Prdm16	IPI	UniProtKB:P28033\|UniProtKB:P53566\|UniProtKB:Q00322	Mouse	MGI:MGI:4355762\|PMID:19641492
Molecular Function	GO:0005515	protein binding	Prdm16	IPI	UniProtKB:O70343	Mouse	MGI:MGI:4365360\|PMID:18483224
Molecular Function	GO:0005515	protein binding	Prdm16	IPI	UniProtKB:Q8VHJ7	Mouse	MGI:MGI:3770355\|PMID:17618855
Molecular Function	GO:0005515	protein binding	Prdm16	IPI	UniProtKB:Q8BUN5	Mouse	MGI:MGI:3715554\|PMID:17467076
Molecular Function	GO:0005515	protein binding	Prdm16	IPI	UniProtKB:P23204\|UniProtKB:P37238	Mouse	MGI:MGI:3806432\|PMID:18719582
Molecular Function	GO:0005515	protein binding	Prdm16	IPI	UniProtKB:O70343	Mouse	MGI:MGI:3770355\|PMID:17618855
Molecular Function	GO:0005515	protein binding	Prdm16	IPI	UniProtKB:Q99J47	Mouse	PMID:28930673
Molecular Function	GO:0043565	sequence-specific DNA binding	PRDM16	IDA		Human	PMID:12816872
Molecular Function	GO:0043565	sequence-specific DNA binding	Prdm16	IDA		Mouse	MGI:MGI:3770355\|PMID:17618855
Molecular Function	GO:0046332	SMAD binding	Prdm16	IPI	PR:Q8BUN5	Mouse	PMID:17467076
Molecular Function	GO:0000976	transcription cis-regulatory region binding	PRDM16	IDA		Human	PMID:12816872
Molecular Function	GO:0003713	transcription coactivator activity	Prdm16	IDA		Mouse	MGI:MGI:3770355\|PMID:17618855
Molecular Function	GO:0003713	transcription coactivator activity	Prdm16	IDA		Mouse	MGI:MGI:3806432\|PMID:18719582
Cellular Component	GO:0016235	aggresome	PRDM16	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	PRDM16	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	PRDM16	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	PRDM16	IDA		Human	PMID:19049980
Cellular Component	GO:0005634	nucleus	Prdm16	IDA		Mouse	MGI:MGI:4365360\|PMID:18483224
Cellular Component	GO:0017053	transcription repressor complex	Prdm16	IDA		Mouse	MGI:MGI:4365360\|PMID:18483224
Biological Process	GO:0050873	brown fat cell differentiation	Prdm16	IDA		Mouse	MGI:MGI:4365360\|PMID:18483224
Biological Process	GO:0050873	brown fat cell differentiation	Prdm16	IDA		Mouse	MGI:MGI:4355762\|PMID:19641492
Biological Process	GO:0050873	brown fat cell differentiation	Prdm16	IDA		Mouse	MGI:MGI:3806432\|PMID:18719582
Biological Process	GO:0050873	brown fat cell differentiation	Prdm16	IMP		Mouse	MGI:MGI:3770355\|PMID:17618855
Biological Process	GO:0050873	brown fat cell differentiation	Prdm16	IMP	MGI:MGI:2135565,MGI:MGI:5564782	Mouse	PMID:24703692
Biological Process	GO:0050873	brown fat cell differentiation	Prdm16	IMP	MGI:MGI:2669525,MGI:MGI:5564782	Mouse	PMID:24703692
Biological Process	GO:0061337	cardiac conduction	prdm16	IGI	ZFIN:ZDB-MRPHLNO-130823-4,ZFIN:ZDB-MRPHLNO-130823-5	Zfish	PMID:23768516
Biological Process	GO:0060038	cardiac muscle cell proliferation	prdm16	IMP	ZFIN:ZDB-MRPHLNO-130823-4	Zfish	PMID:23768516
Biological Process	GO:0048701	embryonic cranial skeleton morphogenesis	prdm16	IMP	ZFIN:ZDB-MRPHLNO-130225-4	Zfish	PMID:23109401
Biological Process	GO:0048702	embryonic neurocranium morphogenesis	prdm16	IGI	ZFIN:ZDB-MRPHLNO-050221-1,ZFIN:ZDB-MRPHLNO-130225-4	Zfish	PMID:23109401
Biological Process	GO:0048702	embryonic neurocranium morphogenesis	prdm16	IGI	ZFIN:ZDB-MRPHLNO-130225-2,ZFIN:ZDB-MRPHLNO-130225-4	Zfish	PMID:23109401
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	prdm16	IGI	ZFIN:ZDB-MRPHLNO-050221-1,ZFIN:ZDB-MRPHLNO-130225-4	Zfish	PMID:23109401
Biological Process	GO:0060047	heart contraction	prdm16	IMP	ZFIN:ZDB-MRPHLNO-130823-4	Zfish	PMID:23768516
Biological Process	GO:0002244	hematopoietic progenitor cell differentiation	prdm16	IMP		Zfish	PMID:24240475
Biological Process	GO:0060218	hematopoietic stem cell differentiation	prdm16	IMP	ZFIN:ZDB-MRPHLNO-130225-4	Zfish	PMID:27797851
Biological Process	GO:0070828	heterochromatin organization	Prdm16	IMP		Mouse	MGI:MGI:6274969\|PMID:22939622
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	PRDM16	IDA		Human	PMID:12816872
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Prdm16	IDA		Mouse	MGI:MGI:4365360\|PMID:18483224
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	PRDM16	IDA		Human	PMID:19049980
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Prdm16	IMP	MGI:MGI:2135565,MGI:MGI:5564782	Mouse	PMID:24703692
Biological Process	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	PRDM16	IMP		Human	PMID:19049980
Biological Process	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	Prdm16	IMP	MGI:MGI:3576024	Mouse	PMID:20007998
Biological Process	GO:0022008	neurogenesis	Prdm16	IDA		Mouse	PMID:19050759
Biological Process	GO:0090336	positive regulation of brown fat cell differentiation	Prdm16	IMP	MGI:MGI:2135565,MGI:MGI:5564782	Mouse	PMID:24703692
Biological Process	GO:0090336	positive regulation of brown fat cell differentiation	Prdm16	IMP	MGI:MGI:2669525,MGI:MGI:5564782	Mouse	PMID:24703692
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	Prdm16	IMP		Mouse	MGI:MGI:5582980\|PMID:24703692
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	Prdm16	IMP		Mouse	MGI:MGI:5564780\|PMID:24439384
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	PRDM16	IDA		Human	PMID:25578880
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Prdm16	IDA		Mouse	MGI:MGI:4355762\|PMID:19641492
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Prdm16	IDA		Mouse	MGI:MGI:4365360\|PMID:18483224
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Prdm16	IDA		Mouse	PMID:28930673
Biological Process	GO:0043457	regulation of cellular respiration	Prdm16	IDA		Mouse	MGI:MGI:4365360\|PMID:18483224
Biological Process	GO:0043457	regulation of cellular respiration	Prdm16	IDA		Mouse	MGI:MGI:3770355\|PMID:17618855
Biological Process	GO:0060021	roof of mouth development	Prdm16	IMP	MGI:MGI:3576024	Mouse	PMID:20007998
Biological Process	GO:0035019	somatic stem cell population maintenance	Prdm16	IDA		Mouse	PMID:19379700
Biological Process	GO:0019827	stem cell population maintenance	Prdm16	IMP	MGI:MGI:2135565,MGI:MGI:5564782	Mouse	PMID:24703692
Biological Process	GO:0019827	stem cell population maintenance	Prdm16	IGI	MGI:MGI:95457	Mouse	PMID:24703692
Biological Process	GO:0043586	tongue development	Prdm16	IMP	MGI:MGI:3576024	Mouse	PMID:20007998
Biological Process	GO:0050872	white fat cell differentiation	Prdm16	IDA		Mouse	MGI:MGI:4365360\|PMID:18483224

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 08/21/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.