Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PRDM7,PRDM9
  • Mouse genes Prdm9
  • Rat genes Prdm9
  • Zfish genes prdm9
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Prdm9

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0046975	histone H3K36 methyltransferase activity	PRDM9	IMP		Human	PMID:24634223
Molecular Function	GO:0046975	histone H3K36 methyltransferase activity	Prdm9	IMP		Mouse	MGI:MGI:5784565|PMID:27362481
Molecular Function	GO:0042800	histone H3K4 methyltransferase activity	PRDM9	IDA		Human	PMID:24095733
Molecular Function	GO:0042800	histone H3K4 methyltransferase activity	PRDM9	IMP		Human	PMID:24634223
Molecular Function	GO:0042800	histone H3K4 methyltransferase activity	PRDM9	IDA		Human	PMID:26833727
Molecular Function	GO:0042800	histone H3K4 methyltransferase activity	PRDM7	IDA		Human	PMID:27129774
Molecular Function	GO:0042800	histone H3K4 methyltransferase activity	Prdm9	IMP		Mouse	MGI:MGI:6442007|PMID:32374261
Molecular Function	GO:0042800	histone H3K4 methyltransferase activity	Prdm9	EXP		Mouse	MGI:MGI:3608186|PMID:16292313
Molecular Function	GO:0042800	histone H3K4 methyltransferase activity	Prdm9	IMP		Mouse	MGI:MGI:5784565|PMID:27362481
Molecular Function	GO:0042800	histone H3K4 methyltransferase activity	Prdm9	IDA		Mouse	MGI:MGI:6355794|PMID:24095733
Molecular Function	GO:0042800	histone H3K4 methyltransferase activity	Prdm9	IMP		Mouse	PMID:22028627
Molecular Function	GO:0042800	histone H3K4 methyltransferase activity	Prdm9	IDA		Mouse	PMID:16292313
Molecular Function	GO:0042800	histone H3K4 methyltransferase activity	Prdm9	IMP		Mouse	PMID:16292313
Molecular Function	GO:0005515	protein binding	PRDM7	IPI	UniProtKB:Q13077	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	Prdm9	IPI	UniProtKB:P70281,UniProtKB:Q61545,UniProtKB:Q62209|UniProtKB:P70281,UniProtKB:Q61545,UniProtKB:Q62209,UniProtKB:Q8C5S7|UniProtKB:P70281,UniProtKB:Q62209,UniProtKB:Q8C5S7|UniProtKB:Q61545|UniProtKB:Q9CWW7|UniProtKB:Q9WTK2,UniProtKB:Q9Z148	Mouse	MGI:MGI:6355525|PMID:27932493
Molecular Function	GO:0005515	protein binding	Prdm9	IPI	UniProtKB:Q61545|UniProtKB:Q9CWW7	Mouse	MGI:MGI:6258144|PMID:30365547
Molecular Function	GO:0042803	protein homodimerization activity	Prdm9	IDA		Mouse	MGI:MGI:6355794|PMID:24095733
Molecular Function	GO:0010844	recombination hotspot binding	PRDM9	IMP		Human	PMID:20044539
Molecular Function	GO:0010844	recombination hotspot binding	PRDM9	IDA		Human	PMID:26833727
Molecular Function	GO:0010844	recombination hotspot binding	PRDM9	IDA		Human	PMID:29072575
Molecular Function	GO:0010844	recombination hotspot binding	Prdm9	IDA		Mouse	PMID:22028627
Molecular Function	GO:0010844	recombination hotspot binding	Prdm9	IMP	MGI:MGI:5311020	Mouse	PMID:24151354
Molecular Function	GO:0043565	sequence-specific DNA binding	Prdm9	IDA		Mouse	PMID:22028627
Molecular Function	GO:0000976	transcription cis-regulatory region binding	PRDM9	IMP		Human	PMID:29072575
Cellular Component	GO:0000785	chromatin	Prdm9	IDA		Mouse	MGI:MGI:6114980|PMID:29478809
Cellular Component	GO:0005634	nucleus	Prdm9	IDA		Mouse	MGI:MGI:6102131|PMID:25894966
Cellular Component	GO:0005634	nucleus	Prdm9	IDA		Mouse	MGI:MGI:6355525|PMID:27932493
Cellular Component	GO:0005634	nucleus	Prdm9	IDA		Mouse	MGI:MGI:6114980|PMID:29478809
Biological Process	GO:1990918	double-strand break repair involved in meiotic recombination	Prdm9	IMP		Mouse	MGI:MGI:6102131|PMID:25894966
Biological Process	GO:1990918	double-strand break repair involved in meiotic recombination	Prdm9	IMP		Mouse	MGI:MGI:6114980|PMID:29478809
Biological Process	GO:0007292	female gamete generation	Prdm9	IMP		Mouse	MGI:MGI:6114980|PMID:29478809
Biological Process	GO:0080182	histone H3-K4 trimethylation	PRDM7	IDA		Human	PMID:27129774
Biological Process	GO:0007129	homologous chromosome pairing at meiosis	Prdm9	IMP		Mouse	MGI:MGI:6114980|PMID:29478809
Biological Process	GO:0007129	homologous chromosome pairing at meiosis	Prdm9	IMP		Mouse	MGI:MGI:6102131|PMID:25894966
Biological Process	GO:0048232	male gamete generation	Prdm9	IMP		Mouse	MGI:MGI:6114980|PMID:29478809
Biological Process	GO:0007127	meiosis I	Prdm9	IMP		Mouse	PMID:16292313
Biological Process	GO:0006311	meiotic gene conversion	PRDM9	IDA		Human	PMID:21750151
Biological Process	GO:0043066	negative regulation of apoptotic process	Prdm9	IMP		Mouse	MGI:MGI:6355525|PMID:27932493
Biological Process	GO:1905516	positive regulation of fertilization	Prdm9	IMP		Mouse	MGI:MGI:6102131|PMID:25894966
Biological Process	GO:0060903	positive regulation of meiosis I	Prdm9	IMP		Mouse	PMID:16292313
Biological Process	GO:0010845	positive regulation of reciprocal meiotic recombination	PRDM9	IMP		Human	PMID:21750151
Biological Process	GO:0010845	positive regulation of reciprocal meiotic recombination	Prdm9	IMP		Mouse	PMID:20044538
Biological Process	GO:0010845	positive regulation of reciprocal meiotic recombination	Prdm9	IMP		Mouse	PMID:22028627
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Prdm9	IDA		Mouse	PMID:16292313
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Prdm9	IMP		Mouse	PMID:16292313
Biological Process	GO:0007283	spermatogenesis	Prdm9	IMP	MGI:MGI:3623909	Mouse	PMID:19074312

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern