Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PRDX1
  • Mouse genes Prdx1
  • Rat genes Prdx1,Prdx1l1
  • Zfish genes prdx1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Prdx1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0045296	cadherin binding	PRDX1	HDA		Human	PMID:25468996
Molecular Function	GO:0020037	heme binding	Prdx1	IPI	CHEBI:30413	Rat	PMID:7577926|RGD:729570
Molecular Function	GO:0042802	identical protein binding	Prdx1	IPI	UniProtKB:P35700	Mouse	MGI:MGI:5318005|PMID:21516123
Molecular Function	GO:0042802	identical protein binding	Prdx1	IPI	RGD:620039	Rat	PMID:10535922|RGD:2291799
Molecular Function	GO:0004601	peroxidase activity	PRDX1	IDA		Human	PMID:11986303
Molecular Function	GO:0051920	peroxiredoxin activity	Prdx1	IDA		Rat	PMID:11350800|RGD:2291832
Molecular Function	GO:0051920	peroxiredoxin activity	Prdx1	IDA		Rat	PMID:7488219|RGD:2291801
Molecular Function	GO:0005515	protein binding	PRDX1	IPI	UniProtKB:P58004	Human	PMID:15105503
Molecular Function	GO:0005515	protein binding	PRDX1	IPI	UniProtKB:Q9Y6P5	Human	PMID:15105503
Molecular Function	GO:0005515	protein binding	PRDX1	IPI	UniProtKB:P10275	Human	PMID:17909037
Molecular Function	GO:0005515	protein binding	PRDX1	IPI	UniProtKB:Q9BYN0	Human	PMID:18172504
Molecular Function	GO:0005515	protein binding	PRDX1	IPI	UniProtKB:P60484	Human	PMID:19369943
Molecular Function	GO:0005515	protein binding	PRDX1	IPI	UniProtKB:P54274	Human	PMID:21044950
Molecular Function	GO:0005515	protein binding	PRDX1	IPI	UniProtKB:Q78TU8	Human	PMID:21969592
Molecular Function	GO:0005515	protein binding	PRDX1	IPI	UniProtKB:Q13043	Human	PMID:23386615
Molecular Function	GO:0005515	protein binding	PRDX1	IPI	UniProtKB:P13693	Human	PMID:27607350
Molecular Function	GO:0005515	protein binding	PRDX1	IPI	UniProtKB:P04156	Human	PMID:28671123
Molecular Function	GO:0005515	protein binding	PRDX1	IPI	UniProtKB:Q86TI2-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PRDX1	IPI	UniProtKB:Q8N7X4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Prdx1	IPI	UniProtKB:Q13043	Mouse	MGI:MGI:5318005|PMID:21516123
Molecular Function	GO:0003723	RNA binding	PRDX1	HDA		Human	PMID:22658674
Molecular Function	GO:0003723	RNA binding	PRDX1	HDA		Human	PMID:22681889
Molecular Function	GO:0008379	thioredoxin peroxidase activity	PRDX1	IDA		Human	PMID:18606987
Cellular Component	GO:0005737	cytoplasm	PRDX1	IDA		Human	PMID:17603937
Cellular Component	GO:0005737	cytoplasm	Prdx1	IDA		Rat	PMID:14623930|RGD:2291802
Cellular Component	GO:0005737	cytoplasm	Prdx1	IDA		Rat	PMID:22023808|RGD:153297778
Cellular Component	GO:0005737	cytoplasm	Prdx1	IDA		Rat	PMID:29504286|RGD:152995491
Cellular Component	GO:0005829	cytosol	Prdx1	IDA		Rat	PMID:11350800|RGD:2291832
Cellular Component	GO:0005829	cytosol	Prdx1	IDA		Rat	PMID:7488219|RGD:2291801
Cellular Component	GO:0005829	cytosol	Prdx1	IDA		Rat	PMID:7577926|RGD:729570
Cellular Component	GO:0000791	euchromatin	Prdx1	IDA		Rat	PMID:14623930|RGD:2291802
Cellular Component	GO:0070062	extracellular exosome	PRDX1	HDA		Human	PMID:19199708
Cellular Component	GO:0070062	extracellular exosome	PRDX1	HDA		Human	PMID:20458337
Cellular Component	GO:0070062	extracellular exosome	PRDX1	HDA		Human	PMID:23533145
Cellular Component	GO:0005615	extracellular space	PRDX1	HDA		Human	PMID:22664934
Cellular Component	GO:0005615	extracellular space	PRDX1	HDA		Human	PMID:23580065
Cellular Component	GO:0005759	mitochondrial matrix	Prdx1	IDA		Rat	PMID:14623930|RGD:2291802
Cellular Component	GO:0005739	mitochondrion	Prdx1	HDA		Mouse	PMID:18614015
Cellular Component	GO:0043209	myelin sheath	Prdx1	HDA		Mouse	MGI:MGI:3834050|PMID:17634366
Cellular Component	GO:0005730	nucleolus	Prdx1	IDA		Rat	PMID:14623930|RGD:2291802
Cellular Component	GO:0005634	nucleus	PRDX1	IDA		Human	PMID:17603937
Cellular Component	GO:0005634	nucleus	PRDX1	HDA		Human	PMID:21630459
Cellular Component	GO:0005782	peroxisomal matrix	Prdx1	IDA		Rat	PMID:14623930|RGD:2291802
Cellular Component	GO:0032991	protein-containing complex	prdx1	IPI	ZFIN:ZDB-GENE-040219-8	Zfish	PMID:29518406
Biological Process	GO:0034101	erythrocyte homeostasis	Prdx1	IMP	MGI:MGI:2670538	Mouse	PMID:12891360
Biological Process	GO:0048144	fibroblast proliferation	Prdx1	IMP	MGI:MGI:2670538	Mouse	PMID:12891360
Biological Process	GO:0042744	hydrogen peroxide catabolic process	PRDX1	IDA		Human	PMID:11986303
Biological Process	GO:0042744	hydrogen peroxide catabolic process	PRDX1	IDA		Human	PMID:18606987
Biological Process	GO:0045321	leukocyte activation	prdx1	IMP		Zfish	PMID:29518406
Biological Process	GO:0030101	natural killer cell activation	PRDX1	IDA		Human	PMID:8462106
Biological Process	GO:0042267	natural killer cell mediated cytotoxicity	Prdx1	IMP	MGI:MGI:2670538	Mouse	PMID:12891360
Biological Process	GO:1901222	regulation of NIK/NF-kappaB signaling	Prdx1	IMP		Mouse	PMID:15858817
Biological Process	GO:0032872	regulation of stress-activated MAPK cascade	Prdx1	IMP		Mouse	PMID:16880205
Biological Process	GO:0019430	removal of superoxide radicals	Prdx1	IMP		Mouse	PMID:16880205
Biological Process	GO:0019430	removal of superoxide radicals	Prdx1	IMP	MGI:MGI:3611932	Mouse	PMID:16170382
Biological Process	GO:0006979	response to oxidative stress	Prdx1	IDA		Mouse	PMID:8360158
Biological Process	GO:0006979	response to oxidative stress	Prdx1	IMP		Mouse	PMID:15858817
Biological Process	GO:0006979	response to oxidative stress	Prdx1	IDA		Rat	PMID:17556052|RGD:2291828
Biological Process	GO:0000302	response to reactive oxygen species	Prdx1	IMP	MGI:MGI:3611932	Mouse	PMID:16170382
Biological Process	GO:0000302	response to reactive oxygen species	Prdx1	IMP	MGI:MGI:3611932	Mouse	PMID:16297875
Biological Process	GO:0000302	response to reactive oxygen species	Prdx1	IMP	MGI:MGI:2670538	Mouse	PMID:12891360
Biological Process	GO:0001895	retina homeostasis	PRDX1	HEP		Human	PMID:23580065

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern