Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PRDX2
  • Mouse genes Prdx2
  • Rat genes Prdx2
  • Zfish genes prdx2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Prdx2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0016209	antioxidant activity	PRDX2	IDA		Human	PMID:8144038
Molecular Function	GO:0005515	protein binding	PRDX2	IPI	UniProtKB:P10599	Human	PMID:17557078
Molecular Function	GO:0005515	protein binding	PRDX2	IPI	UniProtKB:P10599	Human	PMID:25402766
Molecular Function	GO:0005515	protein binding	PRDX2	IPI	UniProtKB:P40763	Human	PMID:25402766
Molecular Function	GO:0005515	protein binding	Prdx2	IPI	PR:Q91WA1	Mouse	PMID:17141802
Molecular Function	GO:0008379	thioredoxin peroxidase activity	PRDX2	IDA		Human	PMID:8144038
Cellular Component	GO:0005829	cytosol	Prdx2	IDA		Rat	PMID:11350800|RGD:2291832
Cellular Component	GO:0070062	extracellular exosome	PRDX2	HDA		Human	PMID:19199708
Cellular Component	GO:0070062	extracellular exosome	PRDX2	HDA		Human	PMID:20458337
Cellular Component	GO:0070062	extracellular exosome	PRDX2	HDA		Human	PMID:23533145
Cellular Component	GO:0005739	mitochondrion	Prdx2	HDA		Mouse	PMID:18614015
Cellular Component	GO:0043209	myelin sheath	Prdx2	HDA		Mouse	MGI:MGI:3834050|PMID:17634366
Biological Process	GO:0034599	cellular response to oxidative stress	PRDX2	IDA		Human	PMID:20978343
Biological Process	GO:0002357	defense response to tumor cell	PRDX2	IMP		Human	PMID:30429596
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	Prdx2	IMP	MGI:MGI:2668456	Mouse	PMID:15259009
Biological Process	GO:0042744	hydrogen peroxide catabolic process	Prdx2	IMP	MGI:MGI:2668456	Mouse	PMID:15902258
Biological Process	GO:0042743	hydrogen peroxide metabolic process	Prdx2	IMP	MGI:MGI:2668456	Mouse	PMID:17325201
Biological Process	GO:0042743	hydrogen peroxide metabolic process	Prdx2	IMP	MGI:MGI:2668456	Mouse	PMID:15259009
Biological Process	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	Prdx2	IMP	MGI:MGI:2668456	Mouse	PMID:15259009
Biological Process	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	Prdx2	IDA		Mouse	PMID:9115640
Biological Process	GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway	Prdx2	IMP	MGI:MGI:2668456	Mouse	PMID:17325201
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Prdx2	IMP		Rat	PMID:17663478|RGD:2291829
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	Prdx2	IMP	MGI:MGI:2668456	Mouse	PMID:17325201
Biological Process	GO:0045581	negative regulation of T cell differentiation	Prdx2	IMP	MGI:MGI:2668456	Mouse	PMID:16290204
Biological Process	GO:0030194	positive regulation of blood coagulation	Prdx2	IMP		Mouse	MGI:MGI:4850200|PMID:20978343
Biological Process	GO:0043410	positive regulation of MAPK cascade	Prdx2	IMP	MGI:MGI:2668456	Mouse	PMID:17325201
Biological Process	GO:0042981	regulation of apoptotic process	PRDX2	IMP		Human	PMID:12943237
Biological Process	GO:0010310	regulation of hydrogen peroxide metabolic process	Prdx2	IMP	MGI:MGI:2668456	Mouse	PMID:17325201
Biological Process	GO:0019430	removal of superoxide radicals	PRDX2	IDA		Human	PMID:20978343
Biological Process	GO:0019430	removal of superoxide radicals	Prdx2	IMP		Mouse	MGI:MGI:4850200|PMID:20978343
Biological Process	GO:0002536	respiratory burst involved in inflammatory response	Prdx2	IMP	MGI:MGI:2668456	Mouse	PMID:17325201
Biological Process	GO:0032496	response to lipopolysaccharide	Prdx2	IMP	MGI:MGI:2668456	Mouse	PMID:17325201
Biological Process	GO:0006979	response to oxidative stress	PRDX2	IMP		Human	PMID:12943237
Biological Process	GO:0006979	response to oxidative stress	Prdx2	IMP		Rat	PMID:17663478|RGD:2291829
Biological Process	GO:0043029	T cell homeostasis	Prdx2	IMP	MGI:MGI:2668456	Mouse	PMID:15259009
Biological Process	GO:0042098	T cell proliferation	Prdx2	IMP	MGI:MGI:2668456	Mouse	PMID:15259009
Biological Process	GO:0048538	thymus development	Prdx2	IMP	MGI:MGI:2668456	Mouse	PMID:15259009

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern