Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PRDX3
  • Mouse genes Prdx3
  • Rat genes Prdx3
  • Zfish genes prdx3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Prdx3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	PRDX3	IMP		Human	PMID:18262354
Molecular Function	GO:0042802	identical protein binding	PRDX3	IPI	UniProtKB:P30048	Human	PMID:21988832
Molecular Function	GO:0042802	identical protein binding	PRDX3	IPI	UniProtKB:P30048	Human	PMID:25914057
Molecular Function	GO:0042802	identical protein binding	Prdx3	IPI	PR:P20108	Mouse	PMID:11591653
Molecular Function	GO:0005515	protein binding	PRDX3	IPI	UniProtKB:O43283	Human	PMID:12492477
Molecular Function	GO:0005515	protein binding	PRDX3	IPI	UniProtKB:Q96S38	Human	PMID:15750338
Molecular Function	GO:0005515	protein binding	PRDX3	IPI	UniProtKB:O15287	Human	PMID:17060495
Molecular Function	GO:0005515	protein binding	PRDX3	IPI	UniProtKB:Q59H18	Human	PMID:18205602
Molecular Function	GO:0005515	protein binding	PRDX3	IPI	UniProtKB:Q9HC98	Human	PMID:20873783
Molecular Function	GO:0005515	protein binding	PRDX3	IPI	UniProtKB:Q5S007	Human	PMID:21850687
Molecular Function	GO:0005515	protein binding	PRDX3	IPI	UniProtKB:Q5S007	Human	PMID:24459295
Molecular Function	GO:0005515	protein binding	PRDX3	IPI	UniProtKB:Q9H8Y8	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PRDX3	IPI	UniProtKB:Q9H8Y8	Human	PMID:29892012
Molecular Function	GO:0005515	protein binding	PRDX3	IPI	UniProtKB:Q5S007	Human	PMID:31046837
Molecular Function	GO:0005515	protein binding	PRDX3	IPI	UniProtKB:Q9H8Y8	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	PRDX3	IPI	UniProtKB:Q15935	Human	PMID:32296183
Molecular Function	GO:0019901	protein kinase binding	PRDX3	IPI	UniProtKB:Q5S007	Human	PMID:21850687
Molecular Function	GO:0008379	thioredoxin peroxidase activity	PRDX3	IDA		Human	PMID:21850687
Cellular Component	GO:0005737	cytoplasm	PRDX3	IDA		Human	PMID:18205602
Cellular Component	GO:0005829	cytosol	PRDX3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	PRDX3	IDA		Human	PMID:21850687
Cellular Component	GO:0005769	early endosome	PRDX3	IDA		Human	PMID:15750338
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	PRDX3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	PRDX3	IDA		Human	PMID:17893648
Cellular Component	GO:0005739	mitochondrion	PRDX3	IDA		Human	PMID:18262354
Cellular Component	GO:0005739	mitochondrion	PRDX3	IDA		Human	PMID:21850687
Cellular Component	GO:0005739	mitochondrion	Prdx3	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005739	mitochondrion	Prdx3	HDA		Mouse	PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Prdx3	IDA		Rat	PMID:12887684|RGD:2290400
Cellular Component	GO:0043209	myelin sheath	Prdx3	HDA		Mouse	MGI:MGI:3834050|PMID:17634366
Cellular Component	GO:0005654	nucleoplasm	PRDX3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	PRDX3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0032991	protein-containing complex	PRDX3	IDA		Human	PMID:20873783
Biological Process	GO:0034599	cellular response to oxidative stress	PRDX3	IDA		Human	PMID:21850687
Biological Process	GO:0034614	cellular response to reactive oxygen species	PRDX3	IMP		Human	PMID:18262354
Biological Process	GO:0042744	hydrogen peroxide catabolic process	PRDX3	IDA		Human	PMID:7733872
Biological Process	GO:0042744	hydrogen peroxide catabolic process	PRDX3	IMP		Human	PMID:18195003
Biological Process	GO:0001893	maternal placenta development	Prdx3	IMP	MGI:MGI:3700138	Mouse	PMID:18544346
Biological Process	GO:0007005	mitochondrion organization	PRDX3	IMP		Human	PMID:12011429
Biological Process	GO:0030099	myeloid cell differentiation	Prdx3	IMP		Mouse	PMID:2210385
Biological Process	GO:0043066	negative regulation of apoptotic process	PRDX3	IMP		Human	PMID:18262354
Biological Process	GO:0043066	negative regulation of apoptotic process	PRDX3	IDA		Human	PMID:21850687
Biological Process	GO:0033673	negative regulation of kinase activity	PRDX3	IDA		Human	PMID:18205602
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Prdx3	IMP		Rat	PMID:12887684|RGD:2290400
Biological Process	GO:0018171	peptidyl-cysteine oxidation	PRDX3	IDA		Human	PMID:21850687
Biological Process	GO:0008284	positive regulation of cell population proliferation	PRDX3	IDA		Human	PMID:12011429
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PRDX3	IDA		Human	PMID:12492477
Biological Process	GO:0051881	regulation of mitochondrial membrane potential	PRDX3	IMP		Human	PMID:12011429
Biological Process	GO:0042542	response to hydrogen peroxide	PRDX3	IDA		Human	PMID:17893648
Biological Process	GO:0032496	response to lipopolysaccharide	Prdx3	IMP	MGI:MGI:3700138	Mouse	PMID:17316558
Biological Process	GO:0006979	response to oxidative stress	PRDX3	IMP		Human	PMID:18195003
Biological Process	GO:0006979	response to oxidative stress	Prdx3	IMP	MGI:MGI:3700138	Mouse	PMID:17316558
Biological Process	GO:0006979	response to oxidative stress	Prdx3	IMP	MGI:MGI:3700138	Mouse	PMID:18544346

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern