Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PRDX4
  • Mouse genes Prdx4
  • Rat genes Prdx4
  • Zfish genes prdx4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Prdx4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	Prdx4	IPI	PR:O08807	Mouse	PMID:21835919
Molecular Function	GO:0060090	molecular adaptor activity	PRDX4	EXP		Human	PMID:21916849
Molecular Function	GO:0140313	molecular sequestering activity	PRDX4	IDA		Human	PMID:21916849
Molecular Function	GO:0005515	protein binding	PRDX4	IPI	UniProtKB:P21731	Human	PMID:17644091
Molecular Function	GO:0005515	protein binding	PRDX4	IPI	UniProtKB:P07237	Human	PMID:21057456
Molecular Function	GO:0005515	protein binding	PRDX4	IPI	UniProtKB:P30101	Human	PMID:21057456
Molecular Function	GO:0005515	protein binding	PRDX4	IPI	UniProtKB:Q15084	Human	PMID:21057456
Molecular Function	GO:0005515	protein binding	PRDX4	IPI	UniProtKB:Q8NBS9	Human	PMID:21057456
Molecular Function	GO:0005515	protein binding	PRDX4	IPI	UniProtKB:P18428	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	PRDX4	IPI	UniProtKB:P54253	Human	PMID:25959826
Molecular Function	GO:0005515	protein binding	PRDX4	IPI	UniProtKB:P54253	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Prdx4	IPI	UniProtKB:Q8NBS9-1	Mouse	MGI:MGI:5926606|PMID:24462249
Cellular Component	GO:0005737	cytoplasm	Prdx4	IDA		Mouse	PMID:11229364
Cellular Component	GO:0005829	cytosol	Prdx4	IDA		Mouse	PMID:21835919
Cellular Component	GO:0005783	endoplasmic reticulum	Prdx4	IDA		Mouse	PMID:21835919
Cellular Component	GO:0070062	extracellular exosome	PRDX4	HDA		Human	PMID:19199708
Cellular Component	GO:0005615	extracellular space	Prdx4	IDA		Rat	PMID:10025941|RGD:633622
Cellular Component	GO:0005739	mitochondrion	Prdx4	HDA		Mouse	PMID:14651853
Cellular Component	GO:0005634	nucleus	PRDX4	HDA		Human	PMID:21630459
Cellular Component	GO:0005790	smooth endoplasmic reticulum	Prdx4	IDA		Rat	PMID:22665516|RGD:8553430
Biological Process	GO:0045454	cell redox homeostasis	Prdx4	IGI	MGI:MGI:1914725	Mouse	PMID:23589496
Biological Process	GO:0045454	cell redox homeostasis	Prdx4	IGI	MGI:MGI:1354385	Mouse	PMID:23589496
Biological Process	GO:0030198	extracellular matrix organization	Prdx4	IGI	MGI:MGI:1914725	Mouse	PMID:22981861
Biological Process	GO:0030198	extracellular matrix organization	Prdx4	IGI	MGI:MGI:1354385	Mouse	PMID:22981861
Biological Process	GO:0008584	male gonad development	Prdx4	IMP	MGI:MGI:3848347	Mouse	PMID:19105792
Biological Process	GO:2000255	negative regulation of male germ cell proliferation	Prdx4	IMP	MGI:MGI:3848347	Mouse	PMID:19105792
Biological Process	GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline	Prdx4	IGI	MGI:MGI:1914725	Mouse	PMID:22981861
Biological Process	GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline	Prdx4	IGI	MGI:MGI:1354385	Mouse	PMID:22981861
Biological Process	GO:0022417	protein maturation by protein folding	Prdx4	IGI	MGI:MGI:1354385	Mouse	PMID:22981861
Biological Process	GO:0022417	protein maturation by protein folding	Prdx4	IGI	MGI:MGI:1914725	Mouse	PMID:22981861
Biological Process	GO:0072593	reactive oxygen species metabolic process	Prdx4	IDA		Mouse	PMID:11229364
Biological Process	GO:0006979	response to oxidative stress	Prdx4	IMP	MGI:MGI:3848347	Mouse	PMID:19105792
Biological Process	GO:0007283	spermatogenesis	Prdx4	IMP	MGI:MGI:3848347	Mouse	PMID:19105792

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern