Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PRDX5
  • Mouse genes Prdx5
  • Rat genes Prdx5
  • Zfish genes prdx5
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Prdx5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	PRDX5	IMP		Human	PMID:18262354
Molecular Function	GO:0004601	peroxidase activity	PRDX5	IDA		Human	PMID:10521424
Molecular Function	GO:0005515	protein binding	PRDX5	IPI	UniProtKB:P50542	Human	PMID:10514471
Molecular Function	GO:0005515	protein binding	PRDX5	IPI	UniProtKB:P00441	Human	PMID:29128334
Molecular Function	GO:0005515	protein binding	PRDX5	IPI	UniProtKB:P49901	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PRDX5	IPI	UniProtKB:P55273	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PRDX5	IPI	UniProtKB:Q7Z417	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Prdx5	IPI	UniProtKB:P08228	Mouse	MGI:MGI:6189615|PMID:29128334
Molecular Function	GO:0001016	RNA polymerase III transcription regulatory region sequence-specific DNA binding	PRDX5	IDA		Human	PMID:10095767
Molecular Function	GO:0008379	thioredoxin peroxidase activity	PRDX5	EXP		Human	PMID:15280035
Molecular Function	GO:0140824	thioredoxin-dependent peroxiredoxin activity	Prdx5	IDA		Mouse	MGI:MGI:7434529|PMID:10679306
Cellular Component	GO:0005737	cytoplasm	PRDX5	IDA		Human	PMID:15785239
Cellular Component	GO:0031410	cytoplasmic vesicle	PRDX5	IDA		Human	PMID:10095767
Cellular Component	GO:0005829	cytosol	PRDX5	IDA		Human	PMID:18262354
Cellular Component	GO:0070062	extracellular exosome	PRDX5	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	PRDX5	HDA		Human	PMID:19199708
Cellular Component	GO:0070062	extracellular exosome	PRDX5	HDA		Human	PMID:23533145
Cellular Component	GO:0005615	extracellular space	PRDX5	HDA		Human	PMID:23580065
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	PRDX5	IDA		Human	PMID:15785239
Cellular Component	GO:0005739	mitochondrion	PRDX5	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	PRDX5	IDA		Human	PMID:10521424
Cellular Component	GO:0005739	mitochondrion	PRDX5	IDA		Human	PMID:10751410
Cellular Component	GO:0005739	mitochondrion	PRDX5	IDA		Human	PMID:18262354
Cellular Component	GO:0005739	mitochondrion	PRDX5	IDA		Human	PMID:31740833
Cellular Component	GO:0005739	mitochondrion	Prdx5	HDA		Mouse	PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Prdx5	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005739	mitochondrion	Prdx5	IDA		Rat	PMID:14561759|RGD:1580664
Cellular Component	GO:0005634	nucleus	PRDX5	IDA		Human	PMID:10095767
Cellular Component	GO:0005634	nucleus	PRDX5	IDA		Human	PMID:15785239
Cellular Component	GO:0048471	perinuclear region of cytoplasm	PRDX5	IDA		Human	PMID:10095767
Cellular Component	GO:0005777	peroxisome	PRDX5	IDA		Human	PMID:10521424
Cellular Component	GO:0005777	peroxisome	Prdx5	IDA		Rat	PMID:14561759|RGD:1580664
Biological Process	GO:0034614	cellular response to reactive oxygen species	PRDX5	IMP		Human	PMID:18262354
Biological Process	GO:0031101	fin regeneration	prdx5	IEP		Zfish	PMID:22278371
Biological Process	GO:0043066	negative regulation of apoptotic process	PRDX5	IMP		Human	PMID:18262354
Biological Process	GO:0016480	negative regulation of transcription by RNA polymerase III	PRDX5	IDA		Human	PMID:10095767
Biological Process	GO:0006979	response to oxidative stress	PRDX5	IDA		Human	PMID:10521424

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern