Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PRF1
  • Mouse genes Prf1
  • Rat genes Prf1
  • Zfish genes prf1.1,prf1.2,prf1.3,prf1.5,prf1.6,prf1.7,prf1.8,prf1.9
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Prf1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005509	calcium ion binding	Prf1	IDA		Mouse	MGI:MGI:7327230|PMID:35148176
Molecular Function	GO:0005509	calcium ion binding	Prf1	IDA		Mouse	PMID:21037563
Molecular Function	GO:0005509	calcium ion binding	Prf1	IDA		Mouse	PMID:26306037
Molecular Function	GO:0042802	identical protein binding	PRF1	IPI	UniProtKB:P14222	Human	PMID:21037563
Molecular Function	GO:0042802	identical protein binding	PRF1	IPI	UniProtKB:P14222	Human	PMID:21685908
Molecular Function	GO:0005515	protein binding	PRF1	IPI	UniProtKB:P10144	Human	PMID:11911826
Molecular Function	GO:0005515	protein binding	PRF1	IPI	UniProtKB:Q15323	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PRF1	IPI	UniProtKB:A8MQ03	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PRF1	IPI	UniProtKB:P0DPK4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PRF1	IPI	UniProtKB:Q15323	Human	PMID:32296183
Molecular Function	GO:0022829	wide pore channel activity	PRF1	IDA		Human	PMID:20038786
Molecular Function	GO:0022829	wide pore channel activity	PRF1	IDA		Human	PMID:20889983
Molecular Function	GO:0022829	wide pore channel activity	Prf1	IDA		Mouse	MGI:MGI:7327230|PMID:35148176
Molecular Function	GO:0022829	wide pore channel activity	Prf1	IDA		Mouse	PMID:35705808
Molecular Function	GO:0022829	wide pore channel activity	Prf1	IDA		Mouse	PMID:26306037
Molecular Function	GO:0022829	wide pore channel activity	Prf1	IDA		Mouse	PMID:21037563
Cellular Component	GO:0044194	cytolytic granule	PRF1	IDA		Human	PMID:24088571
Cellular Component	GO:0044194	cytolytic granule	PRF1	IDA		Human	PMID:9756476
Cellular Component	GO:0044194	cytolytic granule	Prf1	IDA		Mouse	MGI:MGI:66009|PMID:8164737
Cellular Component	GO:0044194	cytolytic granule	Prf1	IDA		Mouse	PMID:19915045
Cellular Component	GO:0031410	cytoplasmic vesicle	Prf1	IDA		Mouse	PMID:11856751
Cellular Component	GO:0031410	cytoplasmic vesicle	Prf1	IDA		Rat	PMID:17622272|RGD:6482824
Cellular Component	GO:0005829	cytosol	PRF1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005615	extracellular space	Prf1	IDA		Rat	PMID:17622272|RGD:6482824
Cellular Component	GO:0001772	immunological synapse	Prf1	IDA		Mouse	PMID:8164737
Cellular Component	GO:0016020	membrane	PRF1	HDA		Human	PMID:19946888
Cellular Component	GO:0016020	membrane	PRF1	IDA		Human	PMID:20889983
Cellular Component	GO:0016020	membrane	Prf1	IDA		Mouse	MGI:MGI:7327230|PMID:35148176
Cellular Component	GO:0016020	membrane	Prf1	IDA		Mouse	PMID:21037563
Cellular Component	GO:0005886	plasma membrane	PRF1	IDA		Human	PMID:20038786
Cellular Component	GO:0005886	plasma membrane	PRF1	IDA		Human	PMID:21037563
Cellular Component	GO:0005886	plasma membrane	Prf1	IDA		Mouse	PMID:35705808
Biological Process	GO:0006915	apoptotic process	Prf1	IDA		Rat	PMID:15843543|RGD:6482825
Biological Process	GO:0007623	circadian rhythm	Prf1	IMP		Rat	PMID:16309885|RGD:1599931
Biological Process	GO:0002357	defense response to tumor cell	Prf1	IMP		Mouse	MGI:MGI:66009|PMID:8164737
Biological Process	GO:0051607	defense response to virus	Prf1	IMP		Mouse	MGI:MGI:66009|PMID:8164737
Biological Process	GO:0140507	granzyme-mediated programmed cell death signaling pathway	Prf1	IDA		Mouse	PMID:35705808
Biological Process	GO:0002418	immune response to tumor cell	Prf1	IMP		Mouse	MGI:MGI:66009|PMID:8164737
Biological Process	GO:0001771	immunological synapse formation	PRF1	IDA		Human	PMID:21438968
Biological Process	GO:0051712	positive regulation of killing of cells of another organism	PRF1	IDA		Human	PMID:9756476
Biological Process	GO:0051260	protein homooligomerization	PRF1	IDA		Human	PMID:20889983
Biological Process	GO:0051260	protein homooligomerization	Prf1	IDA		Mouse	MGI:MGI:5285144|PMID:21037563
Biological Process	GO:0051260	protein homooligomerization	Prf1	IDA		Mouse	MGI:MGI:7327230|PMID:35148176
Biological Process	GO:0017038	protein import	PRF1	IDA		Human	PMID:20038786
Biological Process	GO:0017038	protein import	Prf1	IDA		Mouse	PMID:21037563
Biological Process	GO:0009306	protein secretion	Prf1	IDA		Mouse	PMID:35705808
Biological Process	GO:0071806	protein transmembrane transport	PRF1	IDA		Human	PMID:20038786
Biological Process	GO:0071806	protein transmembrane transport	Prf1	IDA		Mouse	PMID:21037563
Biological Process	GO:0045471	response to ethanol	Prf1	IEP		Rat	PMID:14978081|RGD:1599933
Biological Process	GO:0001913	T cell mediated cytotoxicity	Prf1	IDA		Mouse	PMID:21037563
Biological Process	GO:0001913	T cell mediated cytotoxicity	Prf1	IDA		Mouse	PMID:26306037
Biological Process	GO:0001913	T cell mediated cytotoxicity	Prf1	IDA		Mouse	PMID:15454490

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern