Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PRKACB
  • Mouse genes Prkacb
  • Rat genes Prkacb
  • Zfish genes prkacba,prkacbb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Prkacb

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	PRKACB	IDA		Human	PMID:12420224
Molecular Function	GO:0005524	ATP binding	Prkacb	IDA		Mouse	MGI:MGI:1099550|PMID:9368018
Molecular Function	GO:0004691	cAMP-dependent protein kinase activity	PRKACB	IDA		Human	PMID:12420224
Molecular Function	GO:0004691	cAMP-dependent protein kinase activity	Prkacb	IDA		Mouse	MGI:MGI:1099550|PMID:9368018
Molecular Function	GO:0004691	cAMP-dependent protein kinase activity	Prkacb	IDA		Rat	PMID:11907174|RGD:2312572
Molecular Function	GO:0004691	cAMP-dependent protein kinase activity	Prkacb	IDA		Rat	PMID:16816331|RGD:2312556
Molecular Function	GO:0000287	magnesium ion binding	PRKACB	IDA		Human	PMID:12420224
Molecular Function	GO:0000287	magnesium ion binding	Prkacb	IDA		Mouse	MGI:MGI:1099550|PMID:9368018
Molecular Function	GO:0005515	protein binding	PRKACB	IPI	UniProtKB:P08238	Human	PMID:22939624
Molecular Function	GO:0005515	protein binding	PRKACB	IPI	UniProtKB:P08238	Human	PMID:23455922
Molecular Function	GO:0005515	protein binding	PRKACB	IPI	UniProtKB:Q92624	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PRKACB	IPI	UniProtKB:P61925	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PRKACB	IPI	UniProtKB:Q5T686	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PRKACB	IPI	UniProtKB:P05067	Human	PMID:32814053
Molecular Function	GO:0031625	ubiquitin protein ligase binding	PRKACB	IDA		Human	PMID:21423175
Cellular Component	GO:0005952	cAMP-dependent protein kinase complex	Prkacb	IDA		Rat	PMID:11907174|RGD:2312572
Cellular Component	GO:0005952	cAMP-dependent protein kinase complex	Prkacb	IDA		Rat	PMID:16816331|RGD:2312556
Cellular Component	GO:0005813	centrosome	PRKACB	IDA		Human	PMID:21399614
Cellular Component	GO:0097546	ciliary base	Prkacb	IDA		Mouse	PMID:22007132
Cellular Component	GO:0005737	cytoplasm	Prkacb	IDA		Rat	PMID:18550536|RGD:2312619
Cellular Component	GO:0005829	cytosol	Prkacb	IDA		Rat	PMID:12150772|RGD:7327190
Cellular Component	GO:0070062	extracellular exosome	PRKACB	HDA		Human	PMID:23533145
Cellular Component	GO:0005634	nucleus	Prkacb	IDA		Rat	PMID:12150772|RGD:7327190
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Prkacb	IDA		Rat	PMID:18550536|RGD:2312619
Biological Process	GO:0051447	negative regulation of meiotic cell cycle	Prkacb	IDA		Rat	PMID:16816331|RGD:2312556
Biological Process	GO:1901621	negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning	Prkacb	IGI	MGI:MGI:97592	Mouse	PMID:22007132
Biological Process	GO:0001843	neural tube closure	Prkacb	IGI	MGI:MGI:97592	Mouse	PMID:22007132
Biological Process	GO:0006468	protein phosphorylation	PRKACB	IDA		Human	PMID:12420224
Biological Process	GO:0006468	protein phosphorylation	PRKACB	IDA		Human	PMID:21880142
Biological Process	GO:0006468	protein phosphorylation	Prkacb	IDA		Mouse	MGI:MGI:1099550|PMID:9368018
Biological Process	GO:0006468	protein phosphorylation	Prkacb	IDA		Rat	PMID:11907174|RGD:2312572
Biological Process	GO:0006468	protein phosphorylation	Prkacb	IDA		Rat	PMID:16816331|RGD:2312556
Biological Process	GO:0070613	regulation of protein processing	Prkacb	IGI	MGI:MGI:97592	Mouse	PMID:22007132
Biological Process	GO:0097338	response to clozapine	Prkacb	IEP		Rat	PMID:11907174|RGD:2312572

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern