Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PRKAR1A
  • Mouse genes Prkar1a
  • Rat genes Prkar1a
  • Zfish genes prkar1aa,prkar1ab
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Prkar1a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0030552	cAMP binding	Prkar1a	IDA		Rat	PMID:11907174|RGD:2312572
Molecular Function	GO:0004862	cAMP-dependent protein kinase inhibitor activity	PRKAR1A	IDA		Human	PMID:21812984
Molecular Function	GO:0004862	cAMP-dependent protein kinase inhibitor activity	Prkar1a	IMP		Mouse	PMID:27803029
Molecular Function	GO:0004862	cAMP-dependent protein kinase inhibitor activity	Prkar1a	IMP		Mouse	PMID:32735622
Molecular Function	GO:0004862	cAMP-dependent protein kinase inhibitor activity	Prkar1a	IMP		Mouse	PMID:32212257
Molecular Function	GO:0008603	cAMP-dependent protein kinase regulator activity	PRKAR1A	IDA		Human	PMID:21812984
Molecular Function	GO:0008603	cAMP-dependent protein kinase regulator activity	Prkar1a	IDA		Mouse	PMID:21502359
Molecular Function	GO:0008603	cAMP-dependent protein kinase regulator activity	Prkar1a	IMP	MGI:MGI:2182091,MGI:MGI:3512112	Mouse	PMID:18316483
Molecular Function	GO:0008603	cAMP-dependent protein kinase regulator activity	Prkar1a	IDA		Mouse	PMID:7775586
Molecular Function	GO:0008603	cAMP-dependent protein kinase regulator activity	Prkar1a	IGI	MGI:MGI:97592	Mouse	PMID:12004056
Molecular Function	GO:0008603	cAMP-dependent protein kinase regulator activity	Prkar1a	IMP	MGI:MGI:2183602	Mouse	PMID:12004056
Molecular Function	GO:0008603	cAMP-dependent protein kinase regulator activity	Prkar1a	IDA		Rat	PMID:11907174|RGD:2312572
Molecular Function	GO:0008603	cAMP-dependent protein kinase regulator activity	Prkar1a	IDA		Rat	PMID:16816331|RGD:2312556
Molecular Function	GO:0005515	protein binding	PRKAR1A	IPI	UniProtKB:P03259-2	Human	PMID:11414803
Molecular Function	GO:0005515	protein binding	PRKAR1A	IPI	UniProtKB:P17612	Human	PMID:15655353
Molecular Function	GO:0005515	protein binding	PRKAR1A	IPI	UniProtKB:P35250	Human	PMID:15655353
Molecular Function	GO:0005515	protein binding	PRKAR1A	IPI	UniProtKB:Q9BSF0	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	PRKAR1A	IPI	UniProtKB:Q9H8W4	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	PRKAR1A	IPI	UniProtKB:Q9GZX7	Human	PMID:16387847
Molecular Function	GO:0005515	protein binding	PRKAR1A	IPI	UniProtKB:P51817	Human	PMID:16491121
Molecular Function	GO:0005515	protein binding	PRKAR1A	IPI	UniProtKB:P15311	Human	PMID:17911601
Molecular Function	GO:0005515	protein binding	PRKAR1A	IPI	UniProtKB:Q9H3P7	Human	PMID:17911601
Molecular Function	GO:0005515	protein binding	PRKAR1A	IPI	UniProtKB:Q9H8W4	Human	PMID:19060904
Molecular Function	GO:0005515	protein binding	PRKAR1A	IPI	UniProtKB:Q01105	Human	PMID:20195357
Molecular Function	GO:0005515	protein binding	PRKAR1A	IPI	UniProtKB:Q9H0R8	Human	PMID:20562859
Molecular Function	GO:0005515	protein binding	PRKAR1A	IPI	UniProtKB:P17612	Human	PMID:23455922
Molecular Function	GO:0005515	protein binding	PRKAR1A	IPI	UniProtKB:P17612	Human	PMID:24605759
Molecular Function	GO:0005515	protein binding	PRKAR1A	IPI	UniProtKB:P17612	Human	PMID:24700472
Molecular Function	GO:0005515	protein binding	PRKAR1A	IPI	UniProtKB:P17612	Human	PMID:24855271
Molecular Function	GO:0005515	protein binding	PRKAR1A	IPI	UniProtKB:P17612	Human	PMID:25477193
Molecular Function	GO:0005515	protein binding	PRKAR1A	IPI	UniProtKB:P31321	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	PRKAR1A	IPI	UniProtKB:Q9BSF0	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	PRKAR1A	IPI	UniProtKB:P17612	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	PRKAR1A	IPI	UniProtKB:P31321	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	PRKAR1A	IPI	UniProtKB:O43687-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PRKAR1A	IPI	UniProtKB:P0C7A2-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PRKAR1A	IPI	UniProtKB:P17612	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PRKAR1A	IPI	UniProtKB:P24588	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PRKAR1A	IPI	UniProtKB:P31321	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PRKAR1A	IPI	UniProtKB:Q86UC2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PRKAR1A	IPI	UniProtKB:Q86Y01	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PRKAR1A	IPI	UniProtKB:Q8N0X7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PRKAR1A	IPI	UniProtKB:Q9BSF0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PRKAR1A	IPI	UniProtKB:Q9H6J7-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PRKAR1A	IPI	UniProtKB:P17612	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	PRKAR1A	IPI	UniProtKB:P17612	Human	PMID:33058759
Molecular Function	GO:0005515	protein binding	Prkar1a	IPI	UniProtKB:O54918-1	Mouse	MGI:MGI:5508733|PMID:21151042
Molecular Function	GO:0005515	protein binding	Prkar1a	IPI	UniProtKB:Q60662	Mouse	MGI:MGI:1328474|PMID:9852104
Molecular Function	GO:0005515	protein binding	Prkar1a	IPI	UniProtKB:O70585	Mouse	MGI:MGI:3722528|PMID:17610895
Molecular Function	GO:0005515	protein binding	Prkar1a	IPI	MGI:2684060	Mouse	PMID:21502359
Molecular Function	GO:0005515	protein binding	Prkar1a	IPI	PR:Q9D9W0	Mouse	PMID:30026308
Molecular Function	GO:0005515	protein binding	Prkar1a	IPI	PR:Q7TN79	Mouse	PMID:12804576
Molecular Function	GO:0005515	protein binding	Prkar1a	IPI	UniProtKB:P84060|UniProtKB:Q2PQA9	Rat	PMID:17610895|RGD:126781731
Molecular Function	GO:0005515	protein binding	Prkar1a	IPI	UniProtKB:Q5VU43-11	Rat	PMID:21569246|RGD:10047194
Molecular Function	GO:0019904	protein domain specific binding	PRKAR1A	IPI	UniProtKB:O43572	Human	PMID:25097019
Molecular Function	GO:0019904	protein domain specific binding	PRKAR1A	IPI	UniProtKB:P15311	Human	PMID:25097019
Molecular Function	GO:0019904	protein domain specific binding	PRKAR1A	IPI	UniProtKB:Q9P0M2	Human	PMID:25097019
Molecular Function	GO:0034236	protein kinase A catalytic subunit binding	PRKAR1A	IPI	UniProtKB:P17612	Human	PMID:17911601
Molecular Function	GO:0034236	protein kinase A catalytic subunit binding	PRKAR1A	IPI	UniProtKB:P17612-1	Human	PMID:21812984
Molecular Function	GO:0034236	protein kinase A catalytic subunit binding	PRKAR1A	IPI	UniProtKB:P17612-2	Human	PMID:21812984
Molecular Function	GO:0034236	protein kinase A catalytic subunit binding	Prkar1a	IPI	PR:P05132	Mouse	PMID:30026308
Molecular Function	GO:0031625	ubiquitin protein ligase binding	PRKAR1A	IDA		Human	PMID:21423175
Cellular Component	GO:0005930	axoneme	PRKAR1A	IDA		Human	PMID:12475942
Cellular Component	GO:0005952	cAMP-dependent protein kinase complex	Prkar1a	IDA		Mouse	PMID:21502359
Cellular Component	GO:0005952	cAMP-dependent protein kinase complex	Prkar1a	IDA		Rat	PMID:11907174|RGD:2312572
Cellular Component	GO:0005952	cAMP-dependent protein kinase complex	Prkar1a	IDA		Rat	PMID:16816331|RGD:2312556
Cellular Component	GO:0005813	centrosome	Prkar1a	IDA		Mouse	PMID:30026308
Cellular Component	GO:0005737	cytoplasm	PRKAR1A	IDA		Human	PMID:17911601
Cellular Component	GO:0005737	cytoplasm	Prkar1a	IDA		Mouse	PMID:21502359
Cellular Component	GO:0005737	cytoplasm	Prkar1a	IDA		Mouse	PMID:30026308
Cellular Component	GO:0005737	cytoplasm	Prkar1a	IDA		Rat	PMID:12210127|RGD:2312593
Cellular Component	GO:0005829	cytosol	Prkar1a	IDA		Mouse	PMID:33185461
Cellular Component	GO:0098978	glutamatergic synapse	Prkar1a	EXP		Mouse	PMID:24413018
Cellular Component	GO:0098978	glutamatergic synapse	Prkar1a	IDA		Mouse	PMID:24413018
Cellular Component	GO:0001772	immunological synapse	PRKAR1A	IDA		Human	PMID:17911601
Cellular Component	GO:0016020	membrane	PRKAR1A	HDA		Human	PMID:19946888
Cellular Component	GO:0005771	multivesicular body	Prkar1a	IDA		Mouse	PMID:21502359
Cellular Component	GO:0031594	neuromuscular junction	Prkar1a	IDA		Mouse	PMID:8794865
Cellular Component	GO:0031588	nucleotide-activated protein kinase complex	PRKAR1A	IDA		Human	PMID:21812984
Cellular Component	GO:0044853	plasma membrane raft	PRKAR1A	IDA		Human	PMID:17911601
Cellular Component	GO:0032991	protein-containing complex	PRKAR1A	IDA		Human	GO_REF:0000054
Cellular Component	GO:0032991	protein-containing complex	PRKAR1A	IDA		Human	PMID:25097019
Cellular Component	GO:0097224	sperm connecting piece	Prkar1a	IDA		Mouse	PMID:30026308
Cellular Component	GO:0045202	synapse	Prkar1a	IDA		Mouse	PMID:24413018
Cellular Component	GO:0045202	synapse	Prkar1a	EXP		Mouse	PMID:24413018
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	Prkar1a	IMP		Mouse	PMID:9075801
Biological Process	GO:0060038	cardiac muscle cell proliferation	Prkar1a	IMP	MGI:MGI:2182091,MGI:MGI:3512112	Mouse	PMID:18316483
Biological Process	GO:0071377	cellular response to glucagon stimulus	Prkar1a	IMP		Mouse	PMID:32735622
Biological Process	GO:0007143	female meiotic nuclear division	Prkar1a	IEP		Rat	PMID:12088872|RGD:633705
Biological Process	GO:0007507	heart development	Prkar1a	IMP	MGI:MGI:2182091,MGI:MGI:3512112	Mouse	PMID:18316483
Biological Process	GO:0001707	mesoderm formation	Prkar1a	IMP	MGI:MGI:2183602	Mouse	PMID:12004056
Biological Process	GO:0046007	negative regulation of activated T cell proliferation	PRKAR1A	IMP		Human	PMID:17911601
Biological Process	GO:2000480	negative regulation of cAMP-dependent protein kinase activity	PRKAR1A	IDA		Human	PMID:21812984
Biological Process	GO:0010629	negative regulation of gene expression	PRKAR1A	IMP		Human	PMID:28159925
Biological Process	GO:0045835	negative regulation of meiotic nuclear division	Prkar1a	IEP		Rat	PMID:12088872|RGD:633705
Biological Process	GO:0006469	negative regulation of protein kinase activity	Prkar1a	IMP	MGI:MGI:2182091,MGI:MGI:3512112	Mouse	PMID:18316483
Biological Process	GO:0032024	positive regulation of insulin secretion	Prkar1a	IMP		Mouse	PMID:9075801
Biological Process	GO:0045859	regulation of protein kinase activity	Prkar1a	IDA		Rat	PMID:11907174|RGD:2312572
Biological Process	GO:0045859	regulation of protein kinase activity	Prkar1a	IDA		Rat	PMID:16816331|RGD:2312556
Biological Process	GO:0045214	sarcomere organization	Prkar1a	IMP	MGI:MGI:2182091,MGI:MGI:3512112	Mouse	PMID:18316483

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern