Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Prkcb

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes PRKCB
- Mouse genes Prkcb
- Rat genes Prkcb
- Zfish genes prkcba,prkcbb
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Prkcb

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005246	calcium channel regulator activity	Prkcb	IDA		Mouse	PMID:11880265
Molecular Function	GO:0003682	chromatin binding	PRKCB	IDA		Human	PMID:20228790
Molecular Function	GO:0042393	histone binding	PRKCB	IDA		Human	PMID:20228790
Molecular Function	GO:0035403	histone H3T6 kinase activity	PRKCB	IDA		Human	PMID:20228790
Molecular Function	GO:0050681	nuclear androgen receptor binding	PRKCB	IDA		Human	PMID:20228790
Molecular Function	GO:0030374	nuclear receptor coactivator activity	PRKCB	IMP		Human	PMID:20228790
Molecular Function	GO:0005515	protein binding	PRKCB	IPI	UniProtKB:O60341	Human	PMID:20228790
Molecular Function	GO:0005515	protein binding	PRKCB	IPI	UniProtKB:Q9BSI4	Human	PMID:21044950
Molecular Function	GO:0005515	protein binding	PRKCB	IPI	UniProtKB:Q8NEM2	Human	PMID:25852190
Molecular Function	GO:0005515	protein binding	PRKCB	IPI	UniProtKB:Q8NEM2	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	Prkcb	IPI	UniProtKB:P48736	Mouse	MGI:MGI:5514086\|PMID:23824069
Molecular Function	GO:0005515	protein binding	Prkcb	IPI	UniProtKB:Q13873	Mouse	MGI:MGI:3696512\|PMID:15188402
Molecular Function	GO:0005515	protein binding	Prkcb	IPI	UniProtKB:P56537	Mouse	MGI:MGI:5014451\|PMID:21665150
Molecular Function	GO:0005515	protein binding	Prkcb	IPI	PR:Q5NCC3	Mouse	PMID:17893151
Molecular Function	GO:0005515	protein binding	Prkcb	IPI	UniProtKB:Q8WV44-2	Rat	PMID:17893151\|RGD:8553520
Molecular Function	GO:0005515	protein binding	Prkcb	IPI	UniProtKB:P18052	Rat	PMID:7537734\|RGD:8554305
Molecular Function	GO:0005515	protein binding	Prkcb	IPI	UniProtKB:Q62920	Rat	PMID:8940095\|RGD:632670
Molecular Function	GO:0004697	protein kinase C activity	PRKCB	EXP		Human	PMID:12391145
Molecular Function	GO:0004697	protein kinase C activity	PRKCB	IDA		Human	PMID:25982116
Molecular Function	GO:0004697	protein kinase C activity	Prkcb	IDA		Mouse	PMID:27226533
Molecular Function	GO:0004697	protein kinase C activity	Prkcb	IDA		Mouse	PMID:15545601
Molecular Function	GO:0004697	protein kinase C activity	Prkcb	IDA		Mouse	PMID:12618484
Molecular Function	GO:0004697	protein kinase C activity	Prkcb	IDA		Rat	PMID:11507002\|RGD:631236
Molecular Function	GO:0005080	protein kinase C binding	PRKCB	IPI	UniProtKB:Q16512	Human	PMID:20228790
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Prkcb	IDA		Mouse	PMID:23775122
Cellular Component	GO:0031526	brush border membrane	Prkcb	IDA		Rat	PMID:17272350\|RGD:2308883
Cellular Component	GO:0044305	calyx of Held	Prkcb	IDA		Mouse	PMID:21658591
Cellular Component	GO:0044305	calyx of Held	Prkcb	IMP		Mouse	PMID:21658591
Cellular Component	GO:0005813	centrosome	Prkcb	IDA		Rat	PMID:14594954\|RGD:1625528
Cellular Component	GO:0005737	cytoplasm	PRKCB	IDA		Human	PMID:15632189
Cellular Component	GO:0005737	cytoplasm	Prkcb	IDA		Mouse	PMID:12826667
Cellular Component	GO:0005737	cytoplasm	Prkcb	IDA		Mouse	PMID:14613966
Cellular Component	GO:0005829	cytosol	PRKCB	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	Prkcb	IDA		Rat	PMID:18945317\|RGD:5131884
Cellular Component	GO:0005829	cytosol	Prkcb	IDA		Rat	PMID:9705215\|RGD:5131655
Cellular Component	GO:0070062	extracellular exosome	PRKCB	HDA		Human	PMID:20458337
Cellular Component	GO:0005654	nucleoplasm	PRKCB	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	PRKCB	IDA		Human	PMID:20228790
Cellular Component	GO:0005634	nucleus	Prkcb	IDA		Mouse	PMID:14613966
Cellular Component	GO:0005886	plasma membrane	PRKCB	IDA		Human	PMID:15632189
Cellular Component	GO:0005886	plasma membrane	Prkcb	IDA		Mouse	PMID:27226533
Cellular Component	GO:0005886	plasma membrane	Prkcb	IDA		Rat	PMID:18945317\|RGD:5131884
Cellular Component	GO:0098793	presynapse	Prkcb	IMP		Mouse	MGI:MGI:5141567\|PMID:21658591
Cellular Component	GO:0099523	presynaptic cytosol	Prkcb	IDA		Mouse	PMID:21658591
Cellular Component	GO:0008091	spectrin	Prkcb	IDA		Mouse	MGI:MGI:1346761\|PMID:10534118
Biological Process	GO:0042113	B cell activation	Prkcb	IMP		Mouse	MGI:MGI:3626015\|PMID:12118249
Biological Process	GO:0050853	B cell receptor signaling pathway	Prkcb	IMP		Mouse	MGI:MGI:3626015\|PMID:12118249
Biological Process	GO:0007596	blood coagulation	prkcbb	IMP	ZFIN:ZDB-MRPHLNO-150609-4	Zfish	PMID:21951302
Biological Process	GO:0006816	calcium ion transport	Prkcb	IDA		Mouse	PMID:11880265
Biological Process	GO:0071322	cellular response to carbohydrate stimulus	Prkcb	IDA		Mouse	PMID:16585392
Biological Process	GO:0018894	dibenzo-p-dioxin metabolic process	Prkcb	IEP		Rat	PMID:16797713\|RGD:5131886
Biological Process	GO:0035162	embryonic hemopoiesis	prkcbb	IMP	ZFIN:ZDB-MRPHLNO-090504-3	Zfish	PMID:16089502
Biological Process	GO:0006874	intracellular calcium ion homeostasis	Prkcb	IDA		Mouse	PMID:11880265
Biological Process	GO:0010829	negative regulation of glucose transmembrane transport	Prkcb	IMP		Mouse	MGI:MGI:3624907\|PMID:10499500
Biological Process	GO:0046627	negative regulation of insulin receptor signaling pathway	Prkcb	IDA		Rat	PMID:11714718\|RGD:8553365
Biological Process	GO:0007207	phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway	Prkcb	IDA		Mouse	PMID:27226533
Biological Process	GO:0045766	positive regulation of angiogenesis	Prkcb	IMP		Mouse	MGI:MGI:2157264\|PMID:11805327
Biological Process	GO:0050861	positive regulation of B cell receptor signaling pathway	Prkcb	IMP		Mouse	MGI:MGI:3700457\|PMID:16301747
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	Prkcb	IMP		Mouse	MGI:MGI:3626015\|PMID:12118249
Biological Process	GO:0032024	positive regulation of insulin secretion	Prkcb	IDA		Mouse	PMID:27226533
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	Prkcb	IMP		Mouse	MGI:MGI:3700457\|PMID:16301747
Biological Process	GO:0042488	positive regulation of odontogenesis of dentin-containing tooth	Prkcb	IEP		Rat	PMID:15763930\|RGD:1625521
Biological Process	GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway	Prkcb	IMP		Mouse	MGI:MGI:2157264\|PMID:11805327
Biological Process	GO:0043687	post-translational protein modification	PRKCB	IDA		Human	PMID:20228790
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	Prkcb	IDA		Mouse	PMID:21658591
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	Prkcb	IMP		Mouse	PMID:21658591
Biological Process	GO:0006468	protein phosphorylation	Prkcb	IDA		Mouse	PMID:12618484
Biological Process	GO:0006468	protein phosphorylation	Prkcb	IDA		Mouse	PMID:15545601
Biological Process	GO:0014059	regulation of dopamine secretion	Prkcb	IMP		Rat	PMID:15647254\|RGD:1625522
Biological Process	GO:0010827	regulation of glucose transmembrane transport	PRKCB	IDA		Human	PMID:25982116
Biological Process	GO:0040008	regulation of growth	Prkcb	IMP		Rat	PMID:3345563\|RGD:1299012
Biological Process	GO:2000300	regulation of synaptic vesicle exocytosis	Prkcb	IMP		Mouse	PMID:21658591
Biological Process	GO:2000300	regulation of synaptic vesicle exocytosis	Prkcb	IDA		Mouse	PMID:21658591
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	PRKCB	IMP		Human	PMID:20228790
Biological Process	GO:0045471	response to ethanol	Prkcb	IEP		Rat	PMID:16997974\|RGD:1625518
Biological Process	GO:0009749	response to glucose	Prkcb	IEP		Rat	PMID:15030177\|RGD:1625526
Biological Process	GO:0033280	response to vitamin D	Prkcb	IEP		Rat	PMID:10206343\|RGD:1625620
Biological Process	GO:0009410	response to xenobiotic stimulus	Prkcb	IMP		Rat	PMID:15647254\|RGD:1625522

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.