Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Prkcd

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes PRKCD
- Mouse genes Prkcd
- Rat genes Prkcd
- Zfish genes prkcda,prkcdb
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Prkcd

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004699	calcium-independent protein kinase C activity	Prkcd	IDA		Rat	PMID:1915352\|RGD:1642551
Molecular Function	GO:0008047	enzyme activator activity	PRKCD	IDA		Human	PMID:16611985
Molecular Function	GO:0019899	enzyme binding	PRKCD	IPI	UniProtKB:Q02880	Human	PMID:16611985
Molecular Function	GO:0019899	enzyme binding	PRKCD	IDA		Human	PMID:18556656
Molecular Function	GO:0043560	insulin receptor substrate binding	Prkcd	IPI	UniProtKB:P35570	Mouse	MGI:MGI:3836105\|PMID:18285345
Molecular Function	GO:0005515	protein binding	PRKCD	IPI	UniProtKB:P06241	Human	PMID:10383400
Molecular Function	GO:0005515	protein binding	PRKCD	IPI	UniProtKB:Q9H4D1	Human	PMID:10948194
Molecular Function	GO:0005515	protein binding	PRKCD	IPI	UniProtKB:Q99638	Human	PMID:12628935
Molecular Function	GO:0005515	protein binding	PRKCD	IPI	UniProtKB:Q9NRY6	Human	PMID:12649167
Molecular Function	GO:0005515	protein binding	PRKCD	IPI	UniProtKB:P06241	Human	PMID:12721299
Molecular Function	GO:0005515	protein binding	PRKCD	IPI	UniProtKB:P19878	Human	PMID:15591124
Molecular Function	GO:0005515	protein binding	PRKCD	IPI	UniProtKB:P04637	Human	PMID:16377624
Molecular Function	GO:0005515	protein binding	PRKCD	IPI	UniProtKB:P11388	Human	PMID:16611985
Molecular Function	GO:0005515	protein binding	PRKCD	IPI	UniProtKB:P50552	Human	PMID:16940418
Molecular Function	GO:0005515	protein binding	PRKCD	IPI	UniProtKB:P12931	Human	PMID:19059439
Molecular Function	GO:0005515	protein binding	PRKCD	IPI	UniProtKB:P23396	Human	PMID:19059439
Molecular Function	GO:0005515	protein binding	PRKCD	IPI	UniProtKB:Q9NR28	Human	PMID:22465666
Molecular Function	GO:0005515	protein binding	PRKCD	IPI	UniProtKB:Q9BXL7	Human	PMID:22528498
Molecular Function	GO:0005515	protein binding	PRKCD	IPI	UniProtKB:P24001-2	Human	PMID:23814099
Molecular Function	GO:0005515	protein binding	PRKCD	IPI	UniProtKB:P24001-2	Human	PMID:24396867
Molecular Function	GO:0005515	protein binding	PRKCD	IPI	UniProtKB:C6GKH1	Human	PMID:24996056
Molecular Function	GO:0005515	protein binding	PRKCD	IPI	UniProtKB:P06241	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	PRKCD	IPI	UniProtKB:Q9H3D4	Human	PMID:26112605
Molecular Function	GO:0005515	protein binding	PRKCD	IPI	UniProtKB:P05067	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PRKCD	IPI	UniProtKB:Q9UBQ0-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PRKCD	IPI	UniProtKB:C0HM02	Human	PMID:34593629
Molecular Function	GO:0005515	protein binding	PRKCD	IPI	UniProtKB:P17677	Human	PMID:9139733
Molecular Function	GO:0005515	protein binding	Prkcd	IPI	UniProtKB:P23242	Mouse	MGI:MGI:5644021\|PMID:20338032
Molecular Function	GO:0005515	protein binding	Prkcd	IPI	RGD:620795\|RGD:3285	Rat	PMID:12226102\|RGD:2292213
Molecular Function	GO:0005515	protein binding	Prkcd	IPI	RGD:3853	Rat	PMID:17507557\|RGD:8694085
Molecular Function	GO:0005515	protein binding	Prkcd	IPI	RGD:1359422	Rat	PMID:19645017\|RGD:11038816
Molecular Function	GO:0005515	protein binding	Prkcd	IPI	RGD:708404	Rat	PMID:9514928\|RGD:1299423
Molecular Function	GO:0004672	protein kinase activity	PRKCD	IDA		Human	PMID:24008408
Molecular Function	GO:0004672	protein kinase activity	PRKCD	IDA		Human	PMID:34593629
Molecular Function	GO:0019901	protein kinase binding	PRKCD	IPI	UniProtKB:P00519	Human	PMID:10713049
Molecular Function	GO:0019901	protein kinase binding	PRKCD	IPI	UniProtKB:Q9BZL6	Human	PMID:28428613
Molecular Function	GO:0019901	protein kinase binding	Prkcd	IPI	RGD:620795	Rat	PMID:15337529\|RGD:2325149
Molecular Function	GO:0004697	protein kinase C activity	PRKCD	EXP		Human	PMID:12391145
Molecular Function	GO:0004697	protein kinase C activity	PRKCD	EXP		Human	PMID:18285462
Molecular Function	GO:0004697	protein kinase C activity	Prkcd	IDA		Mouse	MGI:MGI:5444805\|PMID:22885697
Molecular Function	GO:0004697	protein kinase C activity	Prkcd	EXP		Rat	PMID:12198130\|RGD:729231
Molecular Function	GO:0106310	protein serine kinase activity	PRKCD	IDA		Human	PMID:17303575
Molecular Function	GO:0004674	protein serine/threonine kinase activity	PRKCD	IDA		Human	PMID:10770950
Molecular Function	GO:0004674	protein serine/threonine kinase activity	PRKCD	IDA		Human	PMID:18285462
Molecular Function	GO:0004674	protein serine/threonine kinase activity	PRKCD	IDA		Human	PMID:19059439
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Prkcd	IDA		Mouse	MGI:MGI:5310700\|PMID:22265677
Molecular Function	GO:0070976	TIR domain binding	Prkcd	IPI	UniProtKB:P58753	Rat	PMID:17161867\|RGD:8554532
Cellular Component	GO:0005911	cell-cell junction	Prkcd	IDA		Mouse	PMID:10882525
Cellular Component	GO:0005737	cytoplasm	PRKCD	IDA		Human	PMID:15632189
Cellular Component	GO:0005737	cytoplasm	PRKCD	IDA		Human	PMID:16611985
Cellular Component	GO:0005737	cytoplasm	PRKCD	IDA		Human	PMID:18285462
Cellular Component	GO:0005737	cytoplasm	Prkcd	IDA		Mouse	PMID:10882525
Cellular Component	GO:0005737	cytoplasm	Prkcd	IDA		Rat	PMID:12663471\|RGD:1642530
Cellular Component	GO:0005829	cytosol	PRKCD	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	PRKCD	IDA		Human	PMID:10770950
Cellular Component	GO:0005829	cytosol	PRKCD	IDA		Human	PMID:15774464
Cellular Component	GO:0005829	cytosol	PRKCD	IDA		Human	PMID:17303575
Cellular Component	GO:0005829	cytosol	Prkcd	IDA		Rat	PMID:18945317\|RGD:5131884
Cellular Component	GO:0005829	cytosol	Prkcd	IDA		Rat	PMID:9705215\|RGD:5131655
Cellular Component	GO:0005829	cytosol	Prkcd	IDA		Rat	PMID:9950866\|RGD:5131658
Cellular Component	GO:0036019	endolysosome	PRKCD	IDA		Human	PMID:17303575
Cellular Component	GO:0005783	endoplasmic reticulum	PRKCD	IDA		Human	PMID:15774464
Cellular Component	GO:0005783	endoplasmic reticulum	PRKCD	IDA		Human	PMID:18556656
Cellular Component	GO:0070062	extracellular exosome	PRKCD	HDA		Human	PMID:19056867
Cellular Component	GO:0001772	immunological synapse	prkcda	IDA		Zfish	PMID:30408601
Cellular Component	GO:0016020	membrane	Prkcd	IDA		Mouse	PMID:18323529
Cellular Component	GO:0016020	membrane	Prkcd	IDA		Rat	PMID:9705215\|RGD:5131655
Cellular Component	GO:0005739	mitochondrion	Prkcd	IDA		Rat	PMID:17008461\|RGD:1642546
Cellular Component	GO:0016363	nuclear matrix	Prkcd	IDA		Mouse	PMID:10882525
Cellular Component	GO:0005634	nucleus	PRKCD	IDA		Human	PMID:15632189
Cellular Component	GO:0005634	nucleus	PRKCD	IDA		Human	PMID:15774464
Cellular Component	GO:0005634	nucleus	PRKCD	IDA		Human	PMID:16611985
Cellular Component	GO:0005634	nucleus	PRKCD	IDA		Human	PMID:18285462
Cellular Component	GO:0005634	nucleus	Prkcd	IDA		Mouse	PMID:10882525
Cellular Component	GO:0005634	nucleus	Prkcd	IDA		Rat	PMID:12663471\|RGD:1642530
Cellular Component	GO:0005886	plasma membrane	PRKCD	IDA		Human	PMID:10770950
Cellular Component	GO:0005886	plasma membrane	PRKCD	IDA		Human	PMID:15632189
Cellular Component	GO:0005886	plasma membrane	PRKCD	IDA		Human	PMID:17303575
Cellular Component	GO:0005886	plasma membrane	Prkcd	IDA		Rat	PMID:18945317\|RGD:5131884
Cellular Component	GO:0099524	postsynaptic cytosol	Prkcd	IDA		Rat	PMID:8263228\|RGD:13702395
Biological Process	GO:0032147	activation of protein kinase activity	PRKCD	IDA		Human	PMID:10713049
Biological Process	GO:0007568	aging	Prkcd	IEP		Rat	PMID:17008461\|RGD:1642546
Biological Process	GO:0006915	apoptotic process	PRKCD	IDA		Human	PMID:10770950
Biological Process	GO:0006915	apoptotic process	PRKCD	IDA		Human	PMID:12649167
Biological Process	GO:0006915	apoptotic process	Prkcd	IMP		Rat	PMID:21696630\|RGD:10047294
Biological Process	GO:0042100	B cell proliferation	Prkcd	IMP	MGI:MGI:2179710	Mouse	PMID:11976687
Biological Process	GO:0060326	cell chemotaxis	PRKCD	IMP		Human	PMID:24008408
Biological Process	GO:1904385	cellular response to angiotensin	PRKCD	IDA		Human	PMID:18285462
Biological Process	GO:0042149	cellular response to glucose starvation	Prkcd	IEP		Rat	PMID:17728702\|RGD:1642520
Biological Process	GO:0070301	cellular response to hydrogen peroxide	PRKCD	IDA		Human	PMID:10713049
Biological Process	GO:0071447	cellular response to hydroperoxide	PRKCD	IDA		Human	PMID:19059439
Biological Process	GO:0032869	cellular response to insulin stimulus	Prkcd	IEP		Rat	PMID:17046201\|RGD:1642545
Biological Process	GO:0034599	cellular response to oxidative stress	Prkcd	IDA		Rat	PMID:21696630\|RGD:10047294
Biological Process	GO:0034644	cellular response to UV	PRKCD	IDA		Human	PMID:17303575
Biological Process	GO:0090398	cellular senescence	PRKCD	IMP		Human	PMID:15282327
Biological Process	GO:0032963	collagen metabolic process	Prkcd	IMP		Rat	PMID:17728702\|RGD:1642520
Biological Process	GO:0070779	D-aspartate import across plasma membrane	Prkcd	IMP		Rat	PMID:17364745\|RGD:1642541
Biological Process	GO:0042742	defense response to bacterium	Prkcd	IMP		Mouse	MGI:MGI:5444805\|PMID:22885697
Biological Process	GO:0006974	DNA damage response	PRKCD	IMP		Human	PMID:17938203
Biological Process	GO:0016064	immunoglobulin mediated immune response	Prkcd	IMP	MGI:MGI:2179710	Mouse	PMID:11976687
Biological Process	GO:0032613	interleukin-10 production	Prkcd	IMP		Mouse	PMID:15817708
Biological Process	GO:0032615	interleukin-12 production	Prkcd	IMP		Mouse	PMID:15817708
Biological Process	GO:0035556	intracellular signal transduction	Prkcd	IDA		Rat	PMID:11562372\|RGD:628493
Biological Process	GO:0030837	negative regulation of actin filament polymerization	Prkcd	IMP		Mouse	MGI:MGI:3813784\|PMID:16940418
Biological Process	GO:0051490	negative regulation of filopodium assembly	Prkcd	IMP		Mouse	MGI:MGI:3813784\|PMID:16940418
Biological Process	GO:0034351	negative regulation of glial cell apoptotic process	PRKCD	IMP		Human	PMID:15774464
Biological Process	GO:0046627	negative regulation of insulin receptor signaling pathway	Prkcd	IMP		Mouse	MGI:MGI:3836105\|PMID:18285345
Biological Process	GO:0043407	negative regulation of MAP kinase activity	PRKCD	IMP		Human	PMID:19279008
Biological Process	GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation	Prkcd	IMP		Mouse	MGI:MGI:3843438\|PMID:14583092
Biological Process	GO:0090331	negative regulation of platelet aggregation	Prkcd	IMP		Mouse	MGI:MGI:3813784\|PMID:16940418
Biological Process	GO:0042119	neutrophil activation	PRKCD	IDA		Human	PMID:10770950
Biological Process	GO:0018105	peptidyl-serine phosphorylation	PRKCD	IDA		Human	PMID:18285462
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	PRKCD	IDA		Human	PMID:10770950
Biological Process	GO:0043065	positive regulation of apoptotic process	Prkcd	IMP		Rat	PMID:12663471\|RGD:1642530
Biological Process	GO:2001235	positive regulation of apoptotic signaling pathway	Prkcd	IDA		Mouse	PMID:15731106
Biological Process	GO:2000304	positive regulation of ceramide biosynthetic process	PRKCD	IMP		Human	PMID:19279011
Biological Process	GO:0032079	positive regulation of endodeoxyribonuclease activity	PRKCD	IMP		Human	PMID:19059439
Biological Process	GO:0046326	positive regulation of glucose import	Prkcd	IMP		Rat	PMID:17098211\|RGD:1642544
Biological Process	GO:2000753	positive regulation of glucosylceramide catabolic process	PRKCD	IMP		Human	PMID:19279011
Biological Process	GO:0043406	positive regulation of MAP kinase activity	Prkcd	IMP		Rat	PMID:16935468\|RGD:1642549
Biological Process	GO:0043410	positive regulation of MAPK cascade	Prkcd	IMP		Rat	PMID:12790799\|RGD:1642529
Biological Process	GO:1900163	positive regulation of phospholipid scramblase activity	PRKCD	IMP		Human	PMID:10770950
Biological Process	GO:0035307	positive regulation of protein dephosphorylation	PRKCD	IMP		Human	PMID:19279008
Biological Process	GO:0042307	positive regulation of protein import into nucleus	PRKCD	IMP		Human	PMID:19059439
Biological Process	GO:2000755	positive regulation of sphingomyelin catabolic process	PRKCD	IMP		Human	PMID:19279011
Biological Process	GO:0032930	positive regulation of superoxide anion generation	PRKCD	IMP		Human	PMID:19801500
Biological Process	GO:0043687	post-translational protein modification	PRKCD	IDA		Human	PMID:19059439
Biological Process	GO:0046777	protein autophosphorylation	Prkcd	IDA		Rat	PMID:10085132\|RGD:1642552
Biological Process	GO:0006468	protein phosphorylation	PRKCD	IDA		Human	PMID:10713049
Biological Process	GO:0006468	protein phosphorylation	PRKCD	IDA		Human	PMID:12649167
Biological Process	GO:0006468	protein phosphorylation	PRKCD	IDA		Human	PMID:16611985
Biological Process	GO:0006468	protein phosphorylation	PRKCD	IDA		Human	PMID:34593629
Biological Process	GO:0006468	protein phosphorylation	Prkcd	IDA		Rat	PMID:1915352\|RGD:1642551
Biological Process	GO:0032956	regulation of actin cytoskeleton organization	PRKCD	IMP		Human	PMID:22554282
Biological Process	GO:2000303	regulation of ceramide biosynthetic process	PRKCD	IDA		Human	PMID:17303575
Biological Process	GO:0042325	regulation of phosphorylation	Prkcd	IDA		Rat	PMID:21696630\|RGD:10047294
Biological Process	GO:0043200	response to amino acid	Prkcd	IEP		Rat	PMID:17210758\|RGD:1642543
Biological Process	GO:0045471	response to ethanol	Prkcd	IEP		Rat	PMID:17728104\|RGD:1642536
Biological Process	GO:0009749	response to glucose	Prkcd	IEP		Rat	PMID:12960081\|RGD:1642528
Biological Process	GO:0009408	response to heat	Prkcd	IEP		Rat	PMID:16990486\|RGD:1642547
Biological Process	GO:0042542	response to hydrogen peroxide	Prkcd	IEP		Rat	PMID:12226102\|RGD:2292213
Biological Process	GO:0042542	response to hydrogen peroxide	Prkcd	IEP		Rat	PMID:17397968\|RGD:1642300
Biological Process	GO:0001666	response to hypoxia	Prkcd	IEP		Rat	PMID:16936002\|RGD:1642548
Biological Process	GO:0009612	response to mechanical stimulus	Prkcd	IEP		Rat	PMID:17487266\|RGD:1642539
Biological Process	GO:0014070	response to organic cyclic compound	Prkcd	IEP		Rat	PMID:11478406\|RGD:1642533
Biological Process	GO:0010243	response to organonitrogen compound	Prkcd	IEP		Rat	PMID:17563398\|RGD:1642537
Biological Process	GO:0006979	response to oxidative stress	Prkcd	IMP		Rat	PMID:11576956\|RGD:1642532
Biological Process	GO:0009410	response to xenobiotic stimulus	Prkcd	IEP		Rat	PMID:17123493\|RGD:1642525
Biological Process	GO:0023021	termination of signal transduction	PRKCD	IMP		Human	PMID:19279008

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 06/12/2024 MGI 6.13

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.