Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Prkce

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes PRKCE
- Mouse genes Prkce
- Rat genes Prkce
- Zfish genes prkcea,prkceb
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Prkce

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0071889	14-3-3 protein binding	Prkce	IPI	UniProtKB:Q9CQV8	Mouse	MGI:MGI:5306290\|PMID:18604201
Molecular Function	GO:0003785	actin monomer binding	Prkce	IDA		Mouse	MGI:MGI:5306325\|PMID:11746497
Molecular Function	GO:0004699	calcium-independent protein kinase C activity	Prkce	IDA		Mouse	PMID:10879655
Molecular Function	GO:0008047	enzyme activator activity	PRKCE	IMP		Human	PMID:18556656
Molecular Function	GO:0019899	enzyme binding	PRKCE	IPI	UniProtKB:P52824	Human	PMID:15632189
Molecular Function	GO:0019899	enzyme binding	PRKCE	IDA		Human	PMID:18556656
Molecular Function	GO:0035276	ethanol binding	Prkce	IDA		Mouse	PMID:19432558
Molecular Function	GO:0005515	protein binding	PRKCE	IPI	UniProtKB:P15056	Human	PMID:16810323
Molecular Function	GO:0005515	protein binding	PRKCE	IPI	UniProtKB:P17252	Human	PMID:16810323
Molecular Function	GO:0005515	protein binding	PRKCE	IPI	UniProtKB:Q15349	Human	PMID:16810323
Molecular Function	GO:0005515	protein binding	PRKCE	IPI	UniProtKB:P59047	Human	PMID:19542546
Molecular Function	GO:0005515	protein binding	PRKCE	IPI	UniProtKB:P63104	Human	PMID:19662078
Molecular Function	GO:0005515	protein binding	PRKCE	IPI	UniProtKB:P08238	Human	PMID:20353823
Molecular Function	GO:0005515	protein binding	PRKCE	IPI	UniProtKB:P15056	Human	PMID:21625473
Molecular Function	GO:0005515	protein binding	PRKCE	IPI	UniProtKB:P08238	Human	PMID:22939624
Molecular Function	GO:0005515	protein binding	PRKCE	IPI	UniProtKB:C6GKH1	Human	PMID:24996056
Molecular Function	GO:0005515	protein binding	PRKCE	IPI	UniProtKB:Q9BPZ7	Human	PMID:28934384
Molecular Function	GO:0005515	protein binding	PRKCE	IPI	UniProtKB:P08238	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	PRKCE	IPI	UniProtKB:P17252	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	PRKCE	IPI	UniProtKB:P63104	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	PRKCE	IPI	UniProtKB:P05067	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PRKCE	IPI	UniProtKB:P37840	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PRKCE	IPI	UniProtKB:C0HM02	Human	PMID:34593629
Molecular Function	GO:0005515	protein binding	Prkce	IPI	UniProtKB:Q9CQV8	Mouse	MGI:MGI:5508583\|PMID:19429675
Molecular Function	GO:0005515	protein binding	Prkce	IPI	UniProtKB:P23242	Mouse	MGI:MGI:5644021\|PMID:20338032
Molecular Function	GO:0005515	protein binding	Prkce	IPI	UniProtKB:Q9CQV8	Mouse	MGI:MGI:5306290\|PMID:18604201
Molecular Function	GO:0005515	protein binding	Prkce	IPI	UniProtKB:Q9CQV8	Mouse	MGI:MGI:5512837\|PMID:18237277
Molecular Function	GO:0005515	protein binding	Prkce	IPI	UniProtKB:P23242	Mouse	MGI:MGI:5644028\|PMID:11139474
Molecular Function	GO:0005515	protein binding	Prkce	IPI	RGD:628746	Rat	PMID:9360998\|RGD:727623
Molecular Function	GO:0005515	protein binding	Prkce	IPI	RGD:708404	Rat	PMID:9514928\|RGD:1299423
Molecular Function	GO:0005515	protein binding	Prkce	IPI	RGD:619708	Rat	PMID:9971736\|RGD:728650
Molecular Function	GO:0004672	protein kinase activity	PRKCE	IDA		Human	PMID:19542546
Molecular Function	GO:0004672	protein kinase activity	PRKCE	IDA		Human	PMID:34593629
Molecular Function	GO:0019901	protein kinase binding	Prkce	IPI	RGD:62004	Rat	PMID:17084383\|RGD:2326120
Molecular Function	GO:0019901	protein kinase binding	Prkce	IPI	RGD:620795	Rat	PMID:19952103\|RGD:2325147
Molecular Function	GO:0004697	protein kinase C activity	PRKCE	IDA		Human	PMID:18556656
Molecular Function	GO:0004697	protein kinase C activity	Prkce	IMP		Rat	PMID:22619279\|RGD:10047170
Molecular Function	GO:0004674	protein serine/threonine kinase activity	PRKCE	IDA		Human	PMID:15695813
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Prkce	IDA		Mouse	PMID:17875639
Molecular Function	GO:0017124	SH3 domain binding	Prkce	IPI	RGD:62004	Rat	PMID:17084383\|RGD:2326120
Molecular Function	GO:0030546	signaling receptor activator activity	Prkce	IDA		Mouse	PMID:17875639
Molecular Function	GO:0005102	signaling receptor binding	Prkce	IPI	RGD:2277	Rat	PMID:20383739\|RGD:7206836
Cellular Component	GO:0071944	cell periphery	Prkce	IDA		Mouse	MGI:MGI:5306296\|PMID:17611075
Cellular Component	GO:0005737	cytoplasm	PRKCE	IDA		Human	PMID:15632189
Cellular Component	GO:0005737	cytoplasm	PRKCE	IDA		Human	PMID:19542546
Cellular Component	GO:0005737	cytoplasm	Prkce	IDA		Mouse	PMID:14613966
Cellular Component	GO:0005829	cytosol	PRKCE	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	PRKCE	IDA		Human	PMID:17603037
Cellular Component	GO:0005829	cytosol	Prkce	IDA		Mouse	PMID:11884367
Cellular Component	GO:0005829	cytosol	Prkce	IDA		Rat	PMID:18945317\|RGD:5131884
Cellular Component	GO:0005829	cytosol	Prkce	IDA		Rat	PMID:9705215\|RGD:5131655
Cellular Component	GO:0005829	cytosol	Prkce	IDA		Rat	PMID:9950866\|RGD:5131658
Cellular Component	GO:0005783	endoplasmic reticulum	PRKCE	IDA		Human	PMID:18556656
Cellular Component	GO:0098978	glutamatergic synapse	Prkce	IDA		Rat	PMID:8481800\|RGD:13702341
Cellular Component	GO:0005794	Golgi apparatus	Prkce	IDA		Mouse	MGI:MGI:5306296\|PMID:17611075
Cellular Component	GO:0000139	Golgi membrane	Prkce	IDA		Rat	PMID:9360998\|RGD:727623
Cellular Component	GO:0045111	intermediate filament cytoskeleton	PRKCE	IDA		Human	GO_REF:0000052
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	PRKCE	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016020	membrane	Prkce	IDA		Mouse	MGI:MGI:5306309\|PMID:16270034
Cellular Component	GO:0016020	membrane	Prkce	IDA		Mouse	PMID:18323529
Cellular Component	GO:0016020	membrane	Prkce	IDA		Rat	PMID:17084383\|RGD:2326120
Cellular Component	GO:0005739	mitochondrion	Prkce	IDA		Mouse	PMID:11884367
Cellular Component	GO:0031594	neuromuscular junction	Prkce	EXP		Rat	PMID:26625935\|RGD:11353024
Cellular Component	GO:0031594	neuromuscular junction	Prkce	IDA		Rat	PMID:26625935\|RGD:11353024
Cellular Component	GO:0005634	nucleus	Prkce	IDA		Mouse	PMID:14613966
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Prkce	IDA		Mouse	MGI:MGI:5306296\|PMID:17611075
Cellular Component	GO:0005886	plasma membrane	PRKCE	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	PRKCE	IDA		Human	PMID:15632189
Cellular Component	GO:0005886	plasma membrane	PRKCE	IDA		Human	PMID:17603037
Cellular Component	GO:0005886	plasma membrane	Prkce	IDA		Rat	PMID:18945317\|RGD:5131884
Cellular Component	GO:0099523	presynaptic cytosol	Prkce	IDA		Rat	PMID:8481800\|RGD:13702341
Cellular Component	GO:0030315	T-tubule	Prkce	IDA		Rat	PMID:19525381\|RGD:2317914
Biological Process	GO:0031589	cell-substrate adhesion	Prkce	IMP	MGI:MGI:3524969	Mouse	PMID:15949469
Biological Process	GO:0031589	cell-substrate adhesion	Prkce	IGI	MGI:MGI:87963	Mouse	PMID:15949469
Biological Process	GO:0071361	cellular response to ethanol	Prkce	IGI	MGI:MGI:95623	Mouse	PMID:17875639
Biological Process	GO:0071456	cellular response to hypoxia	Prkce	IDA		Mouse	PMID:18070622
Biological Process	GO:0036120	cellular response to platelet-derived growth factor stimulus	Prkce	IMP		Rat	PMID:22619279\|RGD:10047170
Biological Process	GO:0071380	cellular response to prostaglandin E stimulus	Prkce	IDA		Mouse	PMID:23479225
Biological Process	GO:0051649	establishment of localization in cell	Prkce	IMP	MGI:MGI:2152043	Mouse	PMID:17728398
Biological Process	GO:0051649	establishment of localization in cell	Prkce	IMP		Mouse	PMID:12837755
Biological Process	GO:0003094	glomerular filtration	prkceb	IMP	ZFIN:ZDB-MRPHLNO-170404-1	Zfish	PMID:25962121
Biological Process	GO:0030073	insulin secretion	Prkce	IMP		Mouse	PMID:12837755
Biological Process	GO:0035556	intracellular signal transduction	Prkce	IDA		Rat	PMID:11562372\|RGD:628493
Biological Process	GO:0031663	lipopolysaccharide-mediated signaling pathway	Prkce	IMP		Mouse	MGI:MGI:3652658\|PMID:16757566
Biological Process	GO:0031663	lipopolysaccharide-mediated signaling pathway	Prkce	IMP	MGI:MGI:3609215	Mouse	PMID:11696589
Biological Process	GO:0035641	locomotory exploration behavior	Prkce	IGI	MGI:MGI:88496	Mouse	PMID:17908177
Biological Process	GO:0002281	macrophage activation involved in immune response	Prkce	IMP	MGI:MGI:3609215	Mouse	PMID:11696589
Biological Process	GO:0000165	MAPK cascade	Prkce	IDA		Mouse	PMID:11884367
Biological Process	GO:0070254	mucus secretion	Prkce	IMP	MGI:MGI:2152043	Mouse	PMID:17728398
Biological Process	GO:0043066	negative regulation of apoptotic process	Prkce	IMP		Rat	PMID:20383739\|RGD:7206836
Biological Process	GO:0051562	negative regulation of mitochondrial calcium ion concentration	Prkce	IMP		Rat	PMID:20383739\|RGD:7206836
Biological Process	GO:0010917	negative regulation of mitochondrial membrane potential	Prkce	IMP		Rat	PMID:20383739\|RGD:7206836
Biological Process	GO:0031397	negative regulation of protein ubiquitination	Prkce	IMP		Mouse	MGI:MGI:5689082\|PMID:25470454
Biological Process	GO:0051280	negative regulation of release of sequestered calcium ion into cytosol	Prkce	IMP		Rat	PMID:20383739\|RGD:7206836
Biological Process	GO:0018105	peptidyl-serine phosphorylation	PRKCE	IDA		Human	PMID:15695813
Biological Process	GO:0018105	peptidyl-serine phosphorylation	Prkce	IMP		Rat	PMID:22619279\|RGD:10047170
Biological Process	GO:0072015	podocyte development	prkceb	IMP	ZFIN:ZDB-MRPHLNO-170404-1	Zfish	PMID:25962121
Biological Process	GO:0030838	positive regulation of actin filament polymerization	Prkce	IDA		Mouse	MGI:MGI:5306325\|PMID:11746497
Biological Process	GO:0010811	positive regulation of cell-substrate adhesion	Prkce	IMP	MGI:MGI:3524969	Mouse	PMID:15949469
Biological Process	GO:0010811	positive regulation of cell-substrate adhesion	Prkce	IGI	MGI:MGI:87963	Mouse	PMID:15949469
Biological Process	GO:2001031	positive regulation of cellular glucuronidation	PRKCE	IMP		Human	PMID:18556656
Biological Process	GO:0032467	positive regulation of cytokinesis	PRKCE	IMP		Human	PMID:18604201
Biological Process	GO:0010634	positive regulation of epithelial cell migration	PRKCE	IMP		Human	PMID:17603037
Biological Process	GO:0010763	positive regulation of fibroblast migration	Prkce	IMP		Mouse	MGI:MGI:5306309\|PMID:16270034
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	Prkce	IMP	MGI:MGI:3609215	Mouse	PMID:11696589
Biological Process	GO:0032024	positive regulation of insulin secretion	Prkce	IMP		Mouse	PMID:12837755
Biological Process	GO:0050996	positive regulation of lipid catabolic process	Prkce	IMP	MGI:MGI:2680163	Mouse	PMID:19401415
Biological Process	GO:0043410	positive regulation of MAPK cascade	Prkce	IMP	MGI:MGI:3609215	Mouse	PMID:11696589
Biological Process	GO:0043410	positive regulation of MAPK cascade	Prkce	IDA		Mouse	PMID:11884367
Biological Process	GO:0070257	positive regulation of mucus secretion	Prkce	IMP	MGI:MGI:2152043	Mouse	PMID:17728398
Biological Process	GO:0032230	positive regulation of synaptic transmission, GABAergic	Prkce	IMP	MGI:MGI:2152043	Mouse	PMID:17875639
Biological Process	GO:0090303	positive regulation of wound healing	PRKCE	IMP		Human	PMID:17603037
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	Prkce	EXP		Rat	PMID:26625935\|RGD:11353024
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	Prkce	IDA		Rat	PMID:26625935\|RGD:11353024
Biological Process	GO:0006468	protein phosphorylation	PRKCE	IDA		Human	PMID:18556656
Biological Process	GO:0006468	protein phosphorylation	PRKCE	IDA		Human	PMID:34593629
Biological Process	GO:0006468	protein phosphorylation	Prkce	IDA		Mouse	PMID:12551921
Biological Process	GO:0061178	regulation of insulin secretion involved in cellular response to glucose stimulus	Prkce	IMP	MGI:MGI:2680163	Mouse	PMID:19401415
Biological Process	GO:0019216	regulation of lipid metabolic process	Prkce	IMP	MGI:MGI:2680163	Mouse	PMID:19401415
Biological Process	GO:0050730	regulation of peptidyl-tyrosine phosphorylation	Prkce	IMP		Mouse	PMID:11940581
Biological Process	GO:0051279	regulation of release of sequestered calcium ion into cytosol	Prkce	IDA		Mouse	PMID:23479225
Biological Process	GO:0051279	regulation of release of sequestered calcium ion into cytosol	Prkce	IMP	MGI:MGI:2152043	Mouse	PMID:15905535
Biological Process	GO:0043278	response to morphine	Prkce	IMP	MGI:MGI:2152043	Mouse	PMID:16899053
Biological Process	GO:0051932	synaptic transmission, GABAergic	Prkce	IMP	MGI:MGI:2152043	Mouse	PMID:17875639
Biological Process	GO:0035669	TRAM-dependent toll-like receptor 4 signaling pathway	Prkce	IMP		Mouse	MGI:MGI:3652658\|PMID:16757566

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.