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Comparative GO Graph (mouse, human, rat, zebrafish)
Source
Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Prkci

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Prkci
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:0005543phospholipid bindingPRKCIIDAHumanPMID:8226978
Molecular FunctionGO:0005515protein bindingPRKCIIPIUniProtKB:Q9NPB6HumanPMID:11257119
Molecular FunctionGO:0005515protein bindingPRKCIIPIUniProtKB:P60953HumanPMID:11260256
Molecular FunctionGO:0005515protein bindingPRKCIIPIUniProtKB:P63000HumanPMID:11260256
Molecular FunctionGO:0005515protein bindingPRKCIIPIUniProtKB:Q05513HumanPMID:11260256
Molecular FunctionGO:0005515protein bindingPRKCIIPIUniProtKB:Q9BYG4HumanPMID:11260256
Molecular FunctionGO:0005515protein bindingPRKCIIPIUniProtKB:Q9BYG5HumanPMID:11260256
Molecular FunctionGO:0005515protein bindingPRKCIIPIUniProtKB:Q9NPB6HumanPMID:11260256
Molecular FunctionGO:0005515protein bindingPRKCIIPIUniProtKB:P04406HumanPMID:11724794
Molecular FunctionGO:0005515protein bindingPRKCIIPIUniProtKB:Q6P1M3HumanPMID:12725730
Molecular FunctionGO:0005515protein bindingPRKCIIPIUniProtKB:O75689HumanPMID:12893243
Molecular FunctionGO:0005515protein bindingPRKCIIPIUniProtKB:P60953HumanPMID:14676191
Molecular FunctionGO:0005515protein bindingPRKCIIPIUniProtKB:Q04917HumanPMID:14676191
Molecular FunctionGO:0005515protein bindingPRKCIIPIUniProtKB:Q13501HumanPMID:14676191
Molecular FunctionGO:0005515protein bindingPRKCIIPIUniProtKB:Q8ND90HumanPMID:14676191
Molecular FunctionGO:0005515protein bindingPRKCIIPIUniProtKB:Q8TEW0HumanPMID:14676191
Molecular FunctionGO:0005515protein bindingPRKCIIPIUniProtKB:Q96L34HumanPMID:14676191
Molecular FunctionGO:0005515protein bindingPRKCIIPIUniProtKB:Q9BYG4HumanPMID:14676191
Molecular FunctionGO:0005515protein bindingPRKCIIPIUniProtKB:Q9BYG5HumanPMID:14676191
Molecular FunctionGO:0005515protein bindingPRKCIIPIUniProtKB:Q9NPB6HumanPMID:14676191
Molecular FunctionGO:0005515protein bindingPRKCIIPIUniProtKB:Q9NPB6HumanPMID:15590654
Molecular FunctionGO:0005515protein bindingPRKCIIPIUniProtKB:Q9NPB6HumanPMID:16189514
Molecular FunctionGO:0005515protein bindingPRKCIIPIUniProtKB:Q96P53HumanPMID:16792529
Molecular FunctionGO:0005515protein bindingPRKCIIPIUniProtKB:Q9NPB6HumanPMID:17057644
Molecular FunctionGO:0005515protein bindingPRKCIIPIUniProtKB:P63027HumanPMID:17313651
Molecular FunctionGO:0005515protein bindingPRKCIIPIUniProtKB:Q04917HumanPMID:17979178
Molecular FunctionGO:0005515protein bindingPRKCIIPIUniProtKB:Q9H8V3HumanPMID:19617897
Molecular FunctionGO:0005515protein bindingPRKCIIPIUniProtKB:Q9NPB6HumanPMID:19617897
Molecular FunctionGO:0005515protein bindingPRKCIIPIUniProtKB:Q13501HumanPMID:20562859
Molecular FunctionGO:0005515protein bindingPRKCIIPIUniProtKB:Q13501HumanPMID:20808283
Molecular FunctionGO:0005515protein bindingPRKCIIPIUniProtKB:Q9NPB6HumanPMID:21516116
Molecular FunctionGO:0005515protein bindingPRKCIIPIUniProtKB:P08151-1HumanPMID:23446420
Molecular FunctionGO:0005515protein bindingPRKCIIPIUniProtKB:Q05513HumanPMID:24375676
Molecular FunctionGO:0005515protein bindingPRKCIIPIUniProtKB:P48431HumanPMID:24525231
Molecular FunctionGO:0005515protein bindingPRKCIIPIUniProtKB:Q6AWC2HumanPMID:24682284
Molecular FunctionGO:0005515protein bindingPRKCIIPIUniProtKB:Q8IX03HumanPMID:24682284
Molecular FunctionGO:0005515protein bindingPRKCIIPIUniProtKB:Q9ULE0HumanPMID:24682284
Molecular FunctionGO:0005515protein bindingPRKCIIPIUniProtKB:Q9BYG5HumanPMID:25416956
Molecular FunctionGO:0005515protein bindingPRKCIIPIUniProtKB:Q9NPB6HumanPMID:25416956
Molecular FunctionGO:0005515protein bindingPRKCIIPIUniProtKB:Q05513HumanPMID:25852190
Molecular FunctionGO:0005515protein bindingPRKCIIPIUniProtKB:Q9BYG5HumanPMID:26496610
Molecular FunctionGO:0005515protein bindingPRKCIIPIUniProtKB:Q9NPB6HumanPMID:26496610
Molecular FunctionGO:0005515protein bindingPRKCIIPIUniProtKB:P78545HumanPMID:26977885
Molecular FunctionGO:0005515protein bindingPRKCIIPIUniProtKB:Q05513HumanPMID:28514442
Molecular FunctionGO:0005515protein bindingPRKCIIPIUniProtKB:Q9BYG5HumanPMID:28514442
Molecular FunctionGO:0005515protein bindingPRKCIIPIUniProtKB:Q05513HumanPMID:31980649
Molecular FunctionGO:0005515protein bindingPRKCIIPIUniProtKB:Q13501HumanPMID:31980649
Molecular FunctionGO:0005515protein bindingPRKCIIPIUniProtKB:Q8TEW0HumanPMID:31980649
Molecular FunctionGO:0005515protein bindingPRKCIIPIUniProtKB:Q9BYG4HumanPMID:31980649
Molecular FunctionGO:0005515protein bindingPRKCIIPIUniProtKB:Q9BYG5HumanPMID:31980649
Molecular FunctionGO:0005515protein bindingPRKCIIPIUniProtKB:Q13501HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingPRKCIIPIUniProtKB:Q6FHY5HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingPRKCIIPIUniProtKB:Q96RE7HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingPRKCIIPIUniProtKB:Q9BYG5HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingPRKCIIPIUniProtKB:Q9NPB6-2HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingPRKCIIPIUniProtKB:Q05513HumanPMID:32707033
Molecular FunctionGO:0005515protein bindingPrkciIPIUniProtKB:Q8TEW0MouseMGI:MGI:5925772|PMID:22579248
Molecular FunctionGO:0005515protein bindingPrkciIPIUniProtKB:Q8R1S4MouseMGI:MGI:5474897|PMID:23446420
Molecular FunctionGO:0005515protein bindingPrkciIPIUniProtKB:Q8BUB4MouseMGI:MGI:5693231|PMID:16792529
Molecular FunctionGO:0005515protein bindingPrkciIPIUniProtKB:P63044MouseMGI:MGI:5693229|PMID:17313651
Molecular FunctionGO:0005515protein bindingPrkciIPIUniProtKB:Q62824RatPMID:19885391|RGD:5131959
Molecular FunctionGO:0004672protein kinase activityPRKCIIDAHumanPMID:11724794
Molecular FunctionGO:0004697protein kinase C activityPrkciIDAMouseMGI:MGI:3843448|PMID:9819385
Molecular FunctionGO:0004674protein serine/threonine kinase activityPRKCIIDAHumanPMID:21983565
Molecular FunctionGO:0004674protein serine/threonine kinase activityPRKCIIDAHumanPMID:8226978
Cellular ComponentGO:0045177apical part of cellPrkciIDAMousePMID:14758363
Cellular ComponentGO:0016324apical plasma membranePrkciIDAMousePMID:16892058
Cellular ComponentGO:0005923bicellular tight junctionPrkciIDARatPMID:9763423|RGD:633671
Cellular ComponentGO:0005903brush borderPrkciIDAMousePMID:33129760
Cellular ComponentGO:0031252cell leading edgePrkciIDARatPMID:19885391|RGD:5131959
Cellular ComponentGO:0005737cytoplasmPrkciIDAMousePMID:14685273
Cellular ComponentGO:0005737cytoplasmPrkciIDAMousePMID:10882525
Cellular ComponentGO:0005829cytosolPRKCIIDAHumanGO_REF:0000052
Cellular ComponentGO:0005829cytosolPRKCIIDAHumanPMID:11257119
Cellular ComponentGO:0005829cytosolPRKCIIDAHumanPMID:21419810
Cellular ComponentGO:0005829cytosolPrkciIDARatPMID:18945317|RGD:5131884
Cellular ComponentGO:0005829cytosolPrkciIDARatPMID:9950866|RGD:5131658
Cellular ComponentGO:0070062extracellular exosomePRKCIHDAHumanPMID:19056867
Cellular ComponentGO:0098978glutamatergic synapsePrkciEXPRatPMID:23511975|RGD:13702261
Cellular ComponentGO:0098978glutamatergic synapsePrkciIDARatPMID:23511975|RGD:13702261
Cellular ComponentGO:0098978glutamatergic synapsePrkciIMPRatPMID:23511975|RGD:13702261
Cellular ComponentGO:0045171intercellular bridgePRKCIIDAHumanGO_REF:0000052
Cellular ComponentGO:0015630microtubule cytoskeletonPRKCIIDAHumanGO_REF:0000052
Cellular ComponentGO:0005634nucleusPRKCIIDAHumanPMID:11260256
Cellular ComponentGO:0005634nucleusPRKCIIDAHumanPMID:21419810
Cellular ComponentGO:0005634nucleusPrkciIDAMousePMID:10882525
Cellular ComponentGO:0120157PAR polarity complexPRKCIIPIHumanPMID:11257119
Cellular ComponentGO:0005886plasma membranePrkciIDARatPMID:18945317|RGD:5131884
Cellular ComponentGO:0005886plasma membraneprkciIDAZfishPMID:18058913
Cellular ComponentGO:0098685Schaffer collateral - CA1 synapsePrkciEXPRatPMID:23511975|RGD:13702261
Cellular ComponentGO:0098685Schaffer collateral - CA1 synapsePrkciIDARatPMID:23511975|RGD:13702261
Cellular ComponentGO:0098685Schaffer collateral - CA1 synapsePrkciIMPRatPMID:23511975|RGD:13702261
Cellular ComponentGO:0043220Schmidt-Lanterman incisurePrkciIDAMouseMGI:MGI:4441217|PMID:20237282
Cellular ComponentGO:0005915zonula adherensprkciIDAZfishPMID:11591316
Biological ProcessGO:0007015actin filament organizationPrkciIMPMGI:MGI:3054940MousePMID:15322187
Biological ProcessGO:0034334adherens junction maintenanceprkciIMPZFIN:ZDB-GENO-980202-388ZfishPMID:11591316
Biological ProcessGO:0034334adherens junction maintenanceprkciIMPZFIN:ZDB-GENO-980202-197ZfishPMID:11591316
Biological ProcessGO:0034332adherens junction organizationprkciIMPZFIN:ZDB-GENO-980202-197ZfishPMID:11591316
Biological ProcessGO:0034332adherens junction organizationprkciIMPZFIN:ZDB-GENO-980202-388ZfishPMID:11591316
Biological ProcessGO:0045176apical protein localizationprkciIMPZFIN:ZDB-GENO-070130-5ZfishPMID:27249668
Biological ProcessGO:0007420brain developmentprkciIMPZFIN:ZDB-GENO-070130-5ZfishPMID:19051268
Biological ProcessGO:0016477cell migrationPrkciIMPRatPMID:19885391|RGD:5131959
Biological ProcessGO:0030031cell projection assemblyprkciIGIZFIN:ZDB-GENE-011105-1ZfishPMID:27249668
Biological ProcessGO:0030031cell projection assemblyprkciIMPZFIN:ZDB-GENO-980202-996ZfishPMID:27249668
Biological ProcessGO:0030031cell projection assemblyprkciIMPZFIN:ZDB-MRPHLNO-100419-12ZfishPMID:27249668
Biological ProcessGO:0030031cell projection assemblyprkciIGIZFIN:ZDB-GENE-060825-69ZfishPMID:27249668
Biological ProcessGO:0030031cell projection assemblyprkciIMPZFIN:ZDB-GENO-070130-5ZfishPMID:27249668
Biological ProcessGO:0030031cell projection assemblyprkciIGIZFIN:ZDB-GENE-030131-9877ZfishPMID:27249668
Biological ProcessGO:0045217cell-cell junction maintenanceprkciIMPZFIN:ZDB-MRPHLNO-060118-3ZfishPMID:21262462
Biological ProcessGO:0045216cell-cell junction organizationPRKCIIMPHumanPMID:11257119
Biological ProcessGO:0032869cellular response to insulin stimulusPrkciIMPMouseMGI:MGI:3843448|PMID:9819385
Biological ProcessGO:0032869cellular response to insulin stimulusPrkciIMPRatPMID:12975478|RGD:2314946
Biological ProcessGO:0007502digestive tract mesoderm developmentprkciIMPZFIN:ZDB-GENO-980202-388ZfishPMID:14576439
Biological ProcessGO:0048546digestive tract morphogenesisprkciIMPZFIN:ZDB-GENO-980202-388ZfishPMID:11591316
Biological ProcessGO:0048546digestive tract morphogenesisprkciIMPZFIN:ZDB-GENO-980202-197ZfishPMID:11591316
Biological ProcessGO:0021744dorsal motor nucleus of vagus nerve developmentprkciIMPZFIN:ZDB-MRPHLNO-060118-3ZfishPMID:21262462
Biological ProcessGO:0035050embryonic heart tube developmentprkciIMPZFIN:ZDB-GENO-980202-197ZfishPMID:10491254
Biological ProcessGO:0035050embryonic heart tube developmentprkciIMPZFIN:ZDB-GENO-980202-388ZfishPMID:16319113
Biological ProcessGO:0035089establishment of apical/basal cell polarityPrkciIMPMGI:MGI:3526850,MGI:MGI:3608904MousePMID:16267237
Biological ProcessGO:0000132establishment of mitotic spindle orientationprkciIMPZFIN:ZDB-GENO-980202-388ZfishPMID:11591316
Biological ProcessGO:0000132establishment of mitotic spindle orientationprkciIMPZFIN:ZDB-GENO-980202-197ZfishPMID:11591316
Biological ProcessGO:0045197establishment or maintenance of epithelial cell apical/basal polarityPRKCIIDAHumanPMID:11257119
Biological ProcessGO:0016332establishment or maintenance of polarity of embryonic epitheliumprkciIMPZFIN:ZDB-MRPHLNO-060118-3ZfishPMID:16319113
Biological ProcessGO:0042462eye photoreceptor cell developmentPrkciIMPMGI:MGI:3526850,MGI:MGI:3608904MousePMID:16267237
Biological ProcessGO:0048699generation of neuronsprkciIMPZFIN:ZDB-GENO-071217-12ZfishPMID:17881520
Biological ProcessGO:0048699generation of neuronsprkciIGIZFIN:ZDB-MRPHLNO-060118-3,ZFIN:ZDB-MRPHLNO-070511-1ZfishPMID:17881520
Biological ProcessGO:0048194Golgi vesicle buddingPrkciIDARatPMID:12871960|RGD:724652
Biological ProcessGO:0007507heart developmentprkciIMPZFIN:ZDB-GENO-040824-5ZfishPMID:19652097
Biological ProcessGO:0045199maintenance of epithelial cell apical/basal polarityprkciIMPZFIN:ZDB-MRPHLNO-060118-3ZfishPMID:21262462
Biological ProcessGO:0008078mesodermal cell migrationprkciIMPZFIN:ZDB-GENO-980202-388ZfishPMID:14576439
Biological ProcessGO:0001738morphogenesis of a polarized epitheliumprkciIMPZFIN:ZDB-GENO-980202-197ZfishPMID:11591316
Biological ProcessGO:0001738morphogenesis of a polarized epitheliumprkciIMPZFIN:ZDB-GENO-980202-388ZfishPMID:11591316
Biological ProcessGO:0034351negative regulation of glial cell apoptotic processPRKCIIMPHumanPMID:21419810
Biological ProcessGO:0043524negative regulation of neuron apoptotic processPRKCIIDAHumanPMID:10467349
Biological ProcessGO:0001841neural tube formationprkciIGIZFIN:ZDB-GENO-090819-1ZfishPMID:18817769
Biological ProcessGO:0007405neuroblast proliferationprkciIMPZFIN:ZDB-MRPHLNO-060118-3ZfishPMID:20453852
Biological ProcessGO:0007097nuclear migrationprkciIMPZFIN:ZDB-GENO-071217-12ZfishPMID:17881520
Biological ProcessGO:0007097nuclear migrationprkciIGIZFIN:ZDB-MRPHLNO-060118-3,ZFIN:ZDB-MRPHLNO-070511-1ZfishPMID:17881520
Biological ProcessGO:0042476odontogenesisprkciIMPZFIN:ZDB-GENO-120207-2ZfishPMID:22253766
Biological ProcessGO:0018105peptidyl-serine phosphorylationPRKCIIDAHumanPMID:21983565
Biological ProcessGO:0035845photoreceptor cell outer segment organizationprkciIGIZFIN:ZDB-MRPHLNO-060118-3,ZFIN:ZDB-MRPHLNO-070511-1ZfishPMID:25144710
Biological ProcessGO:0035845photoreceptor cell outer segment organizationprkciIMPZFIN:ZDB-MRPHLNO-060118-3ZfishPMID:25144710
Biological ProcessGO:2000353positive regulation of endothelial cell apoptotic processPRKCIIMPHumanPMID:19327373
Biological ProcessGO:0060252positive regulation of glial cell proliferationPRKCIIMPHumanPMID:21419810
Biological ProcessGO:0046326positive regulation of glucose importPrkciIMPMouseMGI:MGI:3843448|PMID:9819385
Biological ProcessGO:0010976positive regulation of neuron projection developmentPRKCIIMPHumanPMID:10467349
Biological ProcessGO:0051092positive regulation of NF-kappaB transcription factor activityPRKCIIDAHumanPMID:10467349
Biological ProcessGO:1903078positive regulation of protein localization to plasma membranePrkciIMPMouseMGI:MGI:3843448|PMID:9819385
Biological ProcessGO:0035778pronephric nephron tubule epithelial cell differentiationprkciIGIZFIN:ZDB-MRPHLNO-060118-3,ZFIN:ZDB-MRPHLNO-070511-1ZfishPMID:25446529
Biological ProcessGO:0008104protein localizationPrkciIMPRatPMID:19885391|RGD:5131959
Biological ProcessGO:0006468protein phosphorylationPRKCIIDAHumanPMID:8226978
Biological ProcessGO:0006468protein phosphorylationPrkciIDAMouseMGI:MGI:3843448|PMID:9819385
Biological ProcessGO:0099072regulation of postsynaptic membrane neurotransmitter receptor levelsPrkciEXPRatPMID:23511975|RGD:13702261
Biological ProcessGO:0099072regulation of postsynaptic membrane neurotransmitter receptor levelsPrkciIDARatPMID:23511975|RGD:13702261
Biological ProcessGO:0099072regulation of postsynaptic membrane neurotransmitter receptor levelsPrkciIEPRatPMID:23511975|RGD:13702261
Biological ProcessGO:0099072regulation of postsynaptic membrane neurotransmitter receptor levelsPrkciIMPRatPMID:23511975|RGD:13702261
Biological ProcessGO:0070555response to interleukin-1PrkciIMPRatPMID:19782155|RGD:2314941
Biological ProcessGO:0043434response to peptide hormonePrkciIDARatPMID:15649420|RGD:2314942
Biological ProcessGO:0060041retina development in camera-type eyeprkciIMPZFIN:ZDB-GENO-980202-197ZfishPMID:11591316
Biological ProcessGO:0060041retina development in camera-type eyeprkciIMPZFIN:ZDB-GENO-980202-388ZfishPMID:11591316
Biological ProcessGO:0060041retina development in camera-type eyeprkciIMPZFIN:ZDB-GENO-040824-5ZfishPMID:15716491
Biological ProcessGO:0060042retina morphogenesis in camera-type eyeprkciIMPZFIN:ZDB-MRPHLNO-060118-3ZfishPMID:17223574
Biological ProcessGO:0060042retina morphogenesis in camera-type eyeprkciIGIZFIN:ZDB-GENO-070514-3,ZFIN:ZDB-MRPHLNO-070511-1ZfishPMID:17223574
Biological ProcessGO:0060042retina morphogenesis in camera-type eyeprkciIMPZFIN:ZDB-GENO-070514-2ZfishPMID:17223574
Biological ProcessGO:0060042retina morphogenesis in camera-type eyeprkciIMPZFIN:ZDB-GENO-070514-3ZfishPMID:17223574
Biological ProcessGO:0060042retina morphogenesis in camera-type eyeprkciIGIZFIN:ZDB-MRPHLNO-060118-3,ZFIN:ZDB-MRPHLNO-070511-1ZfishPMID:17223574
Biological ProcessGO:0021591ventricular system developmentprkciIMPZFIN:ZDB-GENO-980202-197ZfishPMID:9007238

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IEP Inferred from expression pattern
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  HTP Inferred from High Throughput Experiment
  HDA Inferred from High Throughput Direct Assay
  HMP Inferred from High Throughput Mutant Phenotype
  HGI Inferred from High Throughput Genetic Interaction
  HEP Inferred from High Throughput Expression Pattern

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory