Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PRKCZ
  • Mouse genes Prkcz
  • Rat genes Prkcz
  • Zfish genes prkcz
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Prkcz

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0071889	14-3-3 protein binding	Prkcz	IPI	RGD:3979	Rat	PMID:17308302|RGD:1642660
Molecular Function	GO:0043274	phospholipase binding	Prkcz	IPI	RGD:3350	Rat	PMID:16113073|RGD:1642674
Molecular Function	GO:0015459	potassium channel regulator activity	Prkcz	IMP		Rat	PMID:15062979|RGD:1642685
Molecular Function	GO:0005515	protein binding	PRKCZ	IPI	UniProtKB:Q07021	Human	PMID:10831594
Molecular Function	GO:0005515	protein binding	PRKCZ	IPI	UniProtKB:P41743	Human	PMID:11260256
Molecular Function	GO:0005515	protein binding	PRKCZ	IPI	UniProtKB:Q9BYG5	Human	PMID:11260256
Molecular Function	GO:0005515	protein binding	PRKCZ	IPI	UniProtKB:Q9NPB6	Human	PMID:11260256
Molecular Function	GO:0005515	protein binding	PRKCZ	IPI	UniProtKB:P37198	Human	PMID:11755531
Molecular Function	GO:0005515	protein binding	PRKCZ	IPI	UniProtKB:O75689	Human	PMID:12893243
Molecular Function	GO:0005515	protein binding	PRKCZ	IPI	UniProtKB:Q9BYG4	Human	PMID:14676191
Molecular Function	GO:0005515	protein binding	PRKCZ	IPI	UniProtKB:Q9BYG5	Human	PMID:14676191
Molecular Function	GO:0005515	protein binding	PRKCZ	IPI	UniProtKB:Q9NPB6	Human	PMID:14676191
Molecular Function	GO:0005515	protein binding	PRKCZ	IPI	UniProtKB:P14314	Human	PMID:15707389
Molecular Function	GO:0005515	protein binding	PRKCZ	IPI	UniProtKB:Q9NPB6	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	PRKCZ	IPI	UniProtKB:Q96P53	Human	PMID:16792529
Molecular Function	GO:0005515	protein binding	PRKCZ	IPI	UniProtKB:Q9BYG4	Human	PMID:17057644
Molecular Function	GO:0005515	protein binding	PRKCZ	IPI	UniProtKB:Q9NPB6	Human	PMID:17057644
Molecular Function	GO:0005515	protein binding	PRKCZ	IPI	UniProtKB:P16554	Human	PMID:17203073
Molecular Function	GO:0005515	protein binding	PRKCZ	IPI	UniProtKB:P49757-1	Human	PMID:17203073
Molecular Function	GO:0005515	protein binding	PRKCZ	IPI	UniProtKB:P63027	Human	PMID:17313651
Molecular Function	GO:0005515	protein binding	PRKCZ	IPI	UniProtKB:P40337	Human	PMID:17350623
Molecular Function	GO:0005515	protein binding	PRKCZ	IPI	UniProtKB:Q9NPB6	Human	PMID:17350623
Molecular Function	GO:0005515	protein binding	PRKCZ	IPI	UniProtKB:Q04759	Human	PMID:17588663
Molecular Function	GO:0005515	protein binding	PRKCZ	IPI	UniProtKB:Q8IX03	Human	PMID:18190796
Molecular Function	GO:0005515	protein binding	PRKCZ	IPI	UniProtKB:P31749	Human	PMID:18650932
Molecular Function	GO:0005515	protein binding	PRKCZ	IPI	UniProtKB:Q15109	Human	PMID:21829704
Molecular Function	GO:0005515	protein binding	PRKCZ	IPI	UniProtKB:P08238	Human	PMID:22939624
Molecular Function	GO:0005515	protein binding	PRKCZ	IPI	UniProtKB:P41743	Human	PMID:24375676
Molecular Function	GO:0005515	protein binding	PRKCZ	IPI	UniProtKB:O95999	Human	PMID:25011391
Molecular Function	GO:0005515	protein binding	PRKCZ	IPI	UniProtKB:P41743	Human	PMID:25852190
Molecular Function	GO:0005515	protein binding	PRKCZ	IPI	UniProtKB:Q07021	Human	PMID:25852190
Molecular Function	GO:0005515	protein binding	PRKCZ	IPI	UniProtKB:Q9BYG4	Human	PMID:25852190
Molecular Function	GO:0005515	protein binding	PRKCZ	IPI	UniProtKB:Q9BYG5	Human	PMID:25852190
Molecular Function	GO:0005515	protein binding	PRKCZ	IPI	UniProtKB:Q9NPB6	Human	PMID:25852190
Molecular Function	GO:0005515	protein binding	PRKCZ	IPI	UniProtKB:Q9UKG1	Human	PMID:26583432
Molecular Function	GO:0005515	protein binding	PRKCZ	IPI	UniProtKB:P14598	Human	PMID:27040869
Molecular Function	GO:0005515	protein binding	PRKCZ	IPI	UniProtKB:Q9BYG5	Human	PMID:27107012
Molecular Function	GO:0005515	protein binding	PRKCZ	IPI	UniProtKB:P41743	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	PRKCZ	IPI	UniProtKB:Q9BYG4	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	PRKCZ	IPI	UniProtKB:Q9BYG5	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	PRKCZ	IPI	UniProtKB:P41743	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	PRKCZ	IPI	UniProtKB:Q07021	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	PRKCZ	IPI	UniProtKB:Q9BYG4	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	PRKCZ	IPI	UniProtKB:Q9BYG5	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	PRKCZ	IPI	UniProtKB:Q9BYG5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PRKCZ	IPI	UniProtKB:P41743	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	PRKCZ	IPI	UniProtKB:Q9BYG4	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	PRKCZ	IPI	UniProtKB:Q9BYG5	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	Prkcz	IPI	UniProtKB:Q04207	Mouse	MGI:MGI:4946475|PMID:21131967
Molecular Function	GO:0005515	protein binding	Prkcz	IPI	UniProtKB:Q62151	Mouse	MGI:MGI:6189240|PMID:21829704
Molecular Function	GO:0005515	protein binding	Prkcz	IPI	UniProtKB:P63044	Mouse	MGI:MGI:5693229|PMID:17313651
Molecular Function	GO:0005515	protein binding	Prkcz	IPI	UniProtKB:Q8BUB4	Mouse	MGI:MGI:5693231|PMID:16792529
Molecular Function	GO:0005515	protein binding	Prkcz	IPI	PR:P97477	Mouse	PMID:19668197
Molecular Function	GO:0005515	protein binding	Prkcz	IPI	UniProtKB:Q6IBS0	Rat	PMID:10406962|RGD:8554241
Molecular Function	GO:0005515	protein binding	Prkcz	IPI	RGD:69287	Rat	PMID:12431995|RGD:634214
Molecular Function	GO:0005515	protein binding	Prkcz	IPI	RGD:736484	Rat	PMID:12813044|RGD:1642708
Molecular Function	GO:0005515	protein binding	Prkcz	IPI	RGD:69065	Rat	PMID:17219052|RGD:9835345
Molecular Function	GO:0005515	protein binding	Prkcz	IPI	RGD:70982	Rat	PMID:17728459|RGD:2302549
Molecular Function	GO:0005515	protein binding	Prkcz	IPI	RGD:632286	Rat	PMID:19028678|RGD:2317440
Molecular Function	GO:0005515	protein binding	Prkcz	IPI	RGD:708404	Rat	PMID:9514928|RGD:1299423
Molecular Function	GO:0005515	protein binding	Prkcz	IPI	RGD:619708	Rat	PMID:9971736|RGD:728650
Molecular Function	GO:0004672	protein kinase activity	PRKCZ	IDA		Human	PMID:10770950
Molecular Function	GO:0004672	protein kinase activity	Prkcz	IDA		Mouse	PMID:14730360
Molecular Function	GO:0019901	protein kinase binding	Prkcz	IPI	RGD:69480	Rat	PMID:9768361|RGD:1642663
Molecular Function	GO:0004697	protein kinase C activity	PRKCZ	EXP		Human	PMID:12391145
Molecular Function	GO:0004697	protein kinase C activity	Prkcz	IDA		Rat	PMID:20570724|RGD:5131661
Molecular Function	GO:0004674	protein serine/threonine kinase activity	PRKCZ	IDA		Human	PMID:15069075
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Prkcz	IDA		Mouse	MGI:MGI:4946475|PMID:21131967
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Prkcz	IDA		Rat	PMID:12130632|RGD:729628
Molecular Function	GO:0044877	protein-containing complex binding	Prkcz	IPI	RGD:69287|RGD:61828	Rat	PMID:10477520|RGD:1642693
Molecular Function	GO:0044877	protein-containing complex binding	Prkcz	IPI	RGD:1309628|RGD:619968	Rat	PMID:15707389|RGD:1642697
Cellular Component	GO:0045179	apical cortex	Prkcz	IDA		Mouse	PMID:15950600
Cellular Component	GO:0016324	apical plasma membrane	Prkcz	IDA		Mouse	PMID:20551175
Cellular Component	GO:0043203	axon hillock	Prkcz	IDA		Mouse	PMID:19668197
Cellular Component	GO:0005923	bicellular tight junction	Prkcz	IDA		Mouse	PMID:15950600
Cellular Component	GO:0005923	bicellular tight junction	Prkcz	IDA		Mouse	PMID:15775979
Cellular Component	GO:0005938	cell cortex	Prkcz	IDA		Mouse	PMID:15950600
Cellular Component	GO:0031252	cell leading edge	Prkcz	IDA		Rat	PMID:19885391|RGD:5131959
Cellular Component	GO:0005911	cell-cell junction	PRKCZ	IDA		Human	PMID:20332120
Cellular Component	GO:0005737	cytoplasm	Prkcz	IDA		Mouse	PMID:12871585
Cellular Component	GO:0005737	cytoplasm	Prkcz	IDA		Mouse	PMID:10882525
Cellular Component	GO:0005737	cytoplasm	Prkcz	IDA		Mouse	PMID:14730360
Cellular Component	GO:0005737	cytoplasm	Prkcz	IDA		Rat	PMID:20570724|RGD:5131661
Cellular Component	GO:0005829	cytosol	PRKCZ	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	Prkcz	IDA		Rat	PMID:17308302|RGD:1642660
Cellular Component	GO:0005829	cytosol	Prkcz	IDA		Rat	PMID:9705215|RGD:5131655
Cellular Component	GO:0070062	extracellular exosome	PRKCZ	HDA		Human	PMID:19056867
Cellular Component	GO:0098978	glutamatergic synapse	Prkcz	IDA		Rat	PMID:18667614|RGD:13702194
Cellular Component	GO:0098978	glutamatergic synapse	Prkcz	IMP		Rat	PMID:18667614|RGD:13702194
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Prkcz	IDA		Rat	PMID:16525020|RGD:1642671
Cellular Component	GO:0045121	membrane raft	Prkcz	IDA		Rat	PMID:17308302|RGD:1642660
Cellular Component	GO:0005815	microtubule organizing center	Prkcz	IGI	MGI:MGI:894678	Mouse	PMID:19668197
Cellular Component	GO:0005815	microtubule organizing center	Prkcz	IGI	MGI:MGI:1932915	Mouse	PMID:19668197
Cellular Component	GO:0035748	myelin sheath abaxonal region	Prkcz	IDA		Mouse	MGI:MGI:4441217|PMID:20237282
Cellular Component	GO:0005635	nuclear envelope	Prkcz	IDA		Mouse	PMID:10882525
Cellular Component	GO:0016363	nuclear matrix	Prkcz	IDA		Mouse	PMID:10882525
Cellular Component	GO:0005634	nucleus	Prkcz	IDA		Mouse	PMID:10882525
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Prkcz	IDA		Rat	PMID:16525020|RGD:1642671
Cellular Component	GO:0005886	plasma membrane	PRKCZ	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	Prkcz	IDA		Mouse	PMID:10882525
Cellular Component	GO:0005886	plasma membrane	Prkcz	IDA		Rat	PMID:11525734|RGD:8554364
Cellular Component	GO:0005886	plasma membrane	Prkcz	IDA		Rat	PMID:16525020|RGD:1642671
Cellular Component	GO:0014069	postsynaptic density	Prkcz	IDA		Rat	PMID:24298142|RGD:13702306
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Prkcz	IDA		Rat	PMID:18667614|RGD:13702194
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Prkcz	IMP		Rat	PMID:18667614|RGD:13702194
Cellular Component	GO:0001725	stress fiber	Prkcz	IDA		Rat	PMID:16525020|RGD:1642671
Cellular Component	GO:0031982	vesicle	PRKCZ	IDA		Human	PMID:17313651
Cellular Component	GO:0031982	vesicle	Prkcz	IDA		Mouse	MGI:MGI:5693229|PMID:17313651
Biological Process	GO:0031584	activation of phospholipase D activity	Prkcz	IMP		Rat	PMID:16113073|RGD:1642674
Biological Process	GO:0032148	activation of protein kinase B activity	Prkcz	IMP		Rat	PMID:15007074|RGD:1642700
Biological Process	GO:0016477	cell migration	Prkcz	IMP		Rat	PMID:19885391|RGD:5131959
Biological Process	GO:0007166	cell surface receptor signaling pathway	Prkcz	IMP		Rat	PMID:15007074|RGD:1642700
Biological Process	GO:0032869	cellular response to insulin stimulus	Prkcz	IMP		Rat	PMID:16525020|RGD:1642671
Biological Process	GO:0061972	dermal bone morphogenesis	prkcz	IMP	ZFIN:ZDB-GENO-180503-14	Zfish	PMID:28835471
Biological Process	GO:0030010	establishment of cell polarity	Prkcz	IMP		Rat	PMID:11525734|RGD:8554364
Biological Process	GO:0048699	generation of neurons	prkcz	IGI	ZFIN:ZDB-MRPHLNO-060118-3,ZFIN:ZDB-MRPHLNO-070511-1	Zfish	PMID:17881520
Biological Process	GO:0035556	intracellular signal transduction	Prkcz	IDA		Rat	PMID:12130632|RGD:729628
Biological Process	GO:0007616	long-term memory	Prkcz	IMP		Rat	PMID:17702943|RGD:1642657
Biological Process	GO:0060291	long-term synaptic potentiation	Prkcz	IMP		Rat	PMID:11914719|RGD:8554098
Biological Process	GO:0051899	membrane depolarization	Prkcz	IMP		Rat	PMID:15381257|RGD:1642699
Biological Process	GO:0060081	membrane hyperpolarization	Prkcz	IMP		Rat	PMID:15062979|RGD:1642685
Biological Process	GO:0000226	microtubule cytoskeleton organization	Prkcz	IGI	MGI:MGI:894678	Mouse	PMID:19668197
Biological Process	GO:0000226	microtubule cytoskeleton organization	Prkcz	IMP		Mouse	PMID:15882626
Biological Process	GO:0000226	microtubule cytoskeleton organization	Prkcz	IGI	MGI:MGI:1932915	Mouse	PMID:19668197
Biological Process	GO:0043066	negative regulation of apoptotic process	Prkcz	IDA		Rat	PMID:17346242|RGD:1642658
Biological Process	GO:0051346	negative regulation of hydrolase activity	Prkcz	IDA		Rat	PMID:17346242|RGD:1642658
Biological Process	GO:0046627	negative regulation of insulin receptor signaling pathway	PRKCZ	IMP		Human	PMID:15069075
Biological Process	GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation	PRKCZ	IMP		Human	PMID:15069075
Biological Process	GO:0031333	negative regulation of protein-containing complex assembly	PRKCZ	IMP		Human	PMID:15069075
Biological Process	GO:1990138	neuron projection extension	Prkcz	IGI	MGI:MGI:1932915	Mouse	PMID:19668197
Biological Process	GO:1990138	neuron projection extension	Prkcz	IGI	MGI:MGI:1919369	Mouse	PMID:19668197
Biological Process	GO:1990138	neuron projection extension	Prkcz	IGI	MGI:MGI:894678	Mouse	PMID:19668197
Biological Process	GO:0007097	nuclear migration	prkcz	IGI	ZFIN:ZDB-MRPHLNO-060118-3,ZFIN:ZDB-MRPHLNO-070511-1	Zfish	PMID:17881520
Biological Process	GO:0018105	peptidyl-serine phosphorylation	PRKCZ	IDA		Human	PMID:15069075
Biological Process	GO:0018105	peptidyl-serine phosphorylation	Prkcz	IDA		Rat	PMID:12061804|RGD:631973
Biological Process	GO:0035845	photoreceptor cell outer segment organization	prkcz	IGI	ZFIN:ZDB-MRPHLNO-060118-3,ZFIN:ZDB-MRPHLNO-070511-1	Zfish	PMID:25144710
Biological Process	GO:0008284	positive regulation of cell population proliferation	Prkcz	IMP		Rat	PMID:16679391|RGD:1642668
Biological Process	GO:0001954	positive regulation of cell-matrix adhesion	Prkcz	IMP		Rat	PMID:16113073|RGD:1642674
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PRKCZ	IMP		Human	PMID:11035106
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Prkcz	IMP		Rat	PMID:8557035|RGD:8554313
Biological Process	GO:2000463	positive regulation of excitatory postsynaptic potential	Prkcz	IDA		Rat	PMID:11914719|RGD:8554098
Biological Process	GO:0046628	positive regulation of insulin receptor signaling pathway	Prkcz	IMP		Rat	PMID:9374484|RGD:8553908
Biological Process	GO:0032733	positive regulation of interleukin-10 production	Prkcz	IMP		Mouse	MGI:MGI:3584076|PMID:15987782
Biological Process	GO:0032736	positive regulation of interleukin-13 production	Prkcz	IMP		Mouse	MGI:MGI:3584076|PMID:15987782
Biological Process	GO:0032753	positive regulation of interleukin-4 production	Prkcz	IMP		Mouse	MGI:MGI:3584076|PMID:15987782
Biological Process	GO:0032754	positive regulation of interleukin-5 production	Prkcz	IMP		Mouse	MGI:MGI:3584076|PMID:15987782
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	Prkcz	IMP		Rat	PMID:8557035|RGD:8554313
Biological Process	GO:0051222	positive regulation of protein transport	Prkcz	IMP		Rat	PMID:15007074|RGD:1642700
Biological Process	GO:0050806	positive regulation of synaptic transmission	Prkcz	IMP		Rat	PMID:15728837|RGD:1642696
Biological Process	GO:2000553	positive regulation of T-helper 2 cell cytokine production	Prkcz	IMP		Mouse	MGI:MGI:3584076|PMID:15987782
Biological Process	GO:0045630	positive regulation of T-helper 2 cell differentiation	Prkcz	IMP		Mouse	MGI:MGI:3584076|PMID:15987782
Biological Process	GO:0035778	pronephric nephron tubule epithelial cell differentiation	prkcz	IGI	ZFIN:ZDB-MRPHLNO-060118-3,ZFIN:ZDB-MRPHLNO-070511-1	Zfish	PMID:25446529
Biological Process	GO:0070528	protein kinase C signaling	Prkcz	IMP		Rat	PMID:20570724|RGD:5131661
Biological Process	GO:0008104	protein localization	Prkcz	IMP		Rat	PMID:19885391|RGD:5131959
Biological Process	GO:0072659	protein localization to plasma membrane	Prkcz	IMP		Mouse	PMID:16455755
Biological Process	GO:0006468	protein phosphorylation	PRKCZ	IDA		Human	PMID:10770950
Biological Process	GO:0006468	protein phosphorylation	PRKCZ	IDA		Human	PMID:17313651
Biological Process	GO:0006468	protein phosphorylation	Prkcz	IDA		Mouse	PMID:14730360
Biological Process	GO:0006468	protein phosphorylation	Prkcz	IDA		Rat	PMID:10477520|RGD:1642693
Biological Process	GO:0006468	protein phosphorylation	Prkcz	IDA		Rat	PMID:20570724|RGD:5131661
Biological Process	GO:0090049	regulation of cell migration involved in sprouting angiogenesis	prkcz	IMP	ZFIN:ZDB-MRPHLNO-070511-1	Zfish	PMID:22936663
Biological Process	GO:0098696	regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	Prkcz	IDA		Rat	PMID:18667614|RGD:13702194
Biological Process	GO:0098696	regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	Prkcz	IMP		Rat	PMID:18667614|RGD:13702194
Biological Process	GO:0060042	retina morphogenesis in camera-type eye	prkcz	IGI	ZFIN:ZDB-GENO-070514-3,ZFIN:ZDB-MRPHLNO-070511-1	Zfish	PMID:17223574
Biological Process	GO:0060042	retina morphogenesis in camera-type eye	prkcz	IGI	ZFIN:ZDB-MRPHLNO-060118-3,ZFIN:ZDB-MRPHLNO-070511-1	Zfish	PMID:17223574
Biological Process	GO:0007165	signal transduction	Prkcz	IDA		Rat	PMID:11779137|RGD:70640
Biological Process	GO:0047496	vesicle transport along microtubule	Prkcz	IMP		Rat	PMID:16734659|RGD:1642664

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern