Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PRKD1
  • Mouse genes Prkd1
  • Rat genes Prkd1
  • Zfish genes prkd1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Prkd1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	PRKD1	IPI	UniProtKB:Q15139	Human	PMID:10831594
Molecular Function	GO:0016301	kinase activity	PRKD1	IDA		Human	PMID:24623306
Molecular Function	GO:0005515	protein binding	PRKD1	IPI	UniProtKB:Q07021	Human	PMID:10831594
Molecular Function	GO:0005515	protein binding	PRKD1	IPI	UniProtKB:O75689	Human	PMID:12893243
Molecular Function	GO:0005515	protein binding	PRKD1	IPI	UniProtKB:P02795	Human	PMID:14550308
Molecular Function	GO:0005515	protein binding	PRKD1	IPI	UniProtKB:P12830	Human	PMID:15695390
Molecular Function	GO:0005515	protein binding	PRKD1	IPI	UniProtKB:Q8C2B3-1	Human	PMID:18509061
Molecular Function	GO:0005515	protein binding	PRKD1	IPI	UniProtKB:O15264	Human	PMID:19135240
Molecular Function	GO:0005515	protein binding	PRKD1	IPI	UniProtKB:Q8NEB9	Human	PMID:22095288
Molecular Function	GO:0005515	protein binding	PRKD1	IPI	UniProtKB:P08238	Human	PMID:22939624
Molecular Function	GO:0005515	protein binding	PRKD1	IPI	UniProtKB:P53367	Human	PMID:22981988
Molecular Function	GO:0005515	protein binding	PRKD1	IPI	UniProtKB:Q96RU2	Human	PMID:24623306
Molecular Function	GO:0005515	protein binding	Prkd1	IPI	UniProtKB:P05106	Mouse	MGI:MGI:5553245|PMID:17485491
Molecular Function	GO:0004697	protein kinase C activity	PRKD1	IDA		Human	PMID:12637538
Molecular Function	GO:0004674	protein serine/threonine kinase activity	PRKD1	IDA		Human	PMID:18440775
Molecular Function	GO:0004674	protein serine/threonine kinase activity	PRKD1	IDA		Human	PMID:22095288
Molecular Function	GO:0004674	protein serine/threonine kinase activity	PRKD1	IMP		Human	PMID:28428613
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Prkd1	IDA		Mouse	MGI:MGI:5913002|PMID:28716882
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Prkd1	IDA		Rat	PMID:12057008|RGD:724658
Cellular Component	GO:0000421	autophagosome membrane	PRKD1	IDA		Human	PMID:22095288
Cellular Component	GO:0005938	cell cortex	Prkd1	IDA		Mouse	PMID:10882525
Cellular Component	GO:0005911	cell-cell junction	Prkd1	IDA		Mouse	PMID:10882525
Cellular Component	GO:0005737	cytoplasm	Prkd1	IDA		Mouse	PMID:10882525
Cellular Component	GO:0005829	cytosol	PRKD1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	Prkd1	IDA		Mouse	MGI:MGI:5306327|PMID:11239398
Cellular Component	GO:0005794	Golgi apparatus	PRKD1	IDA		Human	PMID:11239398
Cellular Component	GO:0005634	nucleus	Prkd1	IDA		Mouse	PMID:10882525
Cellular Component	GO:0005886	plasma membrane	PRKD1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	Prkd1	IDA		Mouse	MGI:MGI:5306327|PMID:11239398
Cellular Component	GO:0005886	plasma membrane	Prkd1	IDA		Mouse	PMID:10882525
Cellular Component	GO:0005802	trans-Golgi network	PRKD1	IDA		Human	PMID:19211839
Cellular Component	GO:0005802	trans-Golgi network	Prkd1	IDA		Mouse	MGI:MGI:5306327|PMID:11239398
Biological Process	GO:0034198	cellular response to amino acid starvation	PRKD1	IMP		Human	PMID:22095288
Biological Process	GO:0071447	cellular response to hydroperoxide	PRKD1	IMP		Human	PMID:22095288
Biological Process	GO:0034599	cellular response to oxidative stress	PRKD1	IDA		Human	PMID:12505989
Biological Process	GO:0035924	cellular response to vascular endothelial growth factor stimulus	PRKD1	IMP		Human	PMID:18059339
Biological Process	GO:0035924	cellular response to vascular endothelial growth factor stimulus	PRKD1	IMP		Human	PMID:18332134
Biological Process	GO:0035924	cellular response to vascular endothelial growth factor stimulus	PRKD1	IMP		Human	PMID:18440775
Biological Process	GO:0035924	cellular response to vascular endothelial growth factor stimulus	PRKD1	IGI	UniProtKB:Q9BZL6	Human	PMID:20497126
Biological Process	GO:0050829	defense response to Gram-negative bacterium	Prkd1	IMP		Mouse	MGI:MGI:5787845|PMID:27184844
Biological Process	GO:0007030	Golgi organization	PRKD1	IMP		Human	PMID:19211839
Biological Process	GO:0048193	Golgi vesicle transport	Prkd1	IMP		Mouse	MGI:MGI:5306327|PMID:11239398
Biological Process	GO:0035556	intracellular signal transduction	PRKD1	IMP		Human	PMID:18059339
Biological Process	GO:0035556	intracellular signal transduction	PRKD1	IMP		Human	PMID:18440775
Biological Process	GO:0035556	intracellular signal transduction	Prkd1	IDA		Rat	PMID:12057008|RGD:724658
Biological Process	GO:0060548	negative regulation of cell death	PRKD1	IMP		Human	PMID:12505989
Biological Process	GO:0018105	peptidyl-serine phosphorylation	PRKD1	IDA		Human	PMID:18440775
Biological Process	GO:0018105	peptidyl-serine phosphorylation	PRKD1	IMP		Human	PMID:28428613
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	PRKD1	IDA		Human	PMID:22095288
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	PRKD1	IMP		Human	PMID:28428613
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	Prkd1	IMP		Mouse	MGI:MGI:6221361|PMID:27782176
Biological Process	GO:0045766	positive regulation of angiogenesis	PRKD1	IMP		Human	PMID:18332134
Biological Process	GO:0045766	positive regulation of angiogenesis	PRKD1	IMP		Human	PMID:18440775
Biological Process	GO:0045766	positive regulation of angiogenesis	PRKD1	IGI	UniProtKB:Q9BZL6	Human	PMID:20497126
Biological Process	GO:0010508	positive regulation of autophagy	PRKD1	IMP		Human	PMID:22095288
Biological Process	GO:0043536	positive regulation of blood vessel endothelial cell migration	PRKD1	IMP		Human	PMID:18440775
Biological Process	GO:0043536	positive regulation of blood vessel endothelial cell migration	PRKD1	IGI	UniProtKB:Q9BZL6	Human	PMID:20497126
Biological Process	GO:0032793	positive regulation of CREB transcription factor activity	PRKD1	IGI	UniProtKB:Q9BZL6	Human	PMID:20497126
Biological Process	GO:2001028	positive regulation of endothelial cell chemotaxis	PRKD1	IMP		Human	PMID:18440775
Biological Process	GO:0038033	positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway	PRKD1	IMP		Human	PMID:18440775
Biological Process	GO:0038033	positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway	PRKD1	IGI	UniProtKB:Q9BZL6	Human	PMID:20497126
Biological Process	GO:0010595	positive regulation of endothelial cell migration	PRKD1	IMP		Human	PMID:18332134
Biological Process	GO:0001938	positive regulation of endothelial cell proliferation	PRKD1	IGI	UniProtKB:Q9BZL6	Human	PMID:20497126
Biological Process	GO:1901727	positive regulation of histone deacetylase activity	PRKD1	IGI	UniProtKB:Q9BZL6	Human	PMID:20497126
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	PRKD1	IMP		Human	PMID:12505989
Biological Process	GO:0010976	positive regulation of neuron projection development	PRKD1	IMP		Human	PMID:19211839
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PRKD1	IMP		Human	PMID:12505989
Biological Process	GO:1900227	positive regulation of NLRP3 inflammasome complex assembly	Prkd1	IDA		Mouse	MGI:MGI:5913002|PMID:28716882
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	Prkd1	IMP		Mouse	MGI:MGI:5306577|PMID:19029091
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	PRKD1	IGI	UniProtKB:Q9BZL6	Human	PMID:20497126
Biological Process	GO:0042307	positive regulation of protein import into nucleus	Prkd1	IMP		Mouse	MGI:MGI:5787845|PMID:27184844
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	PRKD1	IMP		Human	PMID:18059339
Biological Process	GO:0046777	protein autophosphorylation	PRKD1	IDA		Human	PMID:24623306
Biological Process	GO:0089700	protein kinase D signaling	PRKD1	IGI	UniProtKB:Q9BZL6	Human	PMID:20497126
Biological Process	GO:0045765	regulation of angiogenesis	prkd1	IMP	ZFIN:ZDB-MRPHLNO-131001-5	Zfish	PMID:23874489
Biological Process	GO:0010837	regulation of keratinocyte proliferation	Prkd1	IMP		Mouse	MGI:MGI:4838519|PMID:20463010
Biological Process	GO:1901490	regulation of lymphangiogenesis	prkd1	IMP	ZFIN:ZDB-MRPHLNO-131001-5	Zfish	PMID:23874489
Biological Process	GO:0051279	regulation of release of sequestered calcium ion into cytosol	Prkd1	IDA		Mouse	PMID:23479225
Biological Process	GO:0048010	vascular endothelial growth factor receptor signaling pathway	PRKD1	IMP		Human	PMID:18059339

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern