Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PRKD2
  • Mouse genes Prkd2
  • Rat genes Prkd2
  • Zfish genes prkd2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Prkd2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	PRKD2	IPI	UniProtKB:Q04917	Human	PMID:17962809
Molecular Function	GO:0005515	protein binding	PRKD2	IPI	UniProtKB:Q8WUI4	Human	PMID:17962809
Molecular Function	GO:0005515	protein binding	PRKD2	IPI	UniProtKB:P06239	Human	PMID:19192391
Molecular Function	GO:0005515	protein binding	PRKD2	IPI	UniProtKB:Q04917	Human	PMID:28514442
Molecular Function	GO:0004672	protein kinase activity	PRKD2	IDA		Human	PMID:17077180
Molecular Function	GO:0005080	protein kinase C binding	PRKD2	IPI	UniProtKB:Q05655	Human	PMID:28428613
Molecular Function	GO:0004674	protein serine/threonine kinase activity	PRKD2	IDA		Human	PMID:18440775
Molecular Function	GO:0004674	protein serine/threonine kinase activity	PRKD2	IMP		Human	PMID:28428613
Cellular Component	GO:0005737	cytoplasm	PRKD2	IDA		Human	PMID:17077180
Cellular Component	GO:0005829	cytosol	PRKD2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	PRKD2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	PRKD2	IDA		Human	PMID:17077180
Biological Process	GO:0035924	cellular response to vascular endothelial growth factor stimulus	PRKD2	IMP		Human	PMID:18059339
Biological Process	GO:0035924	cellular response to vascular endothelial growth factor stimulus	PRKD2	IMP		Human	PMID:18440775
Biological Process	GO:0035924	cellular response to vascular endothelial growth factor stimulus	PRKD2	IGI	UniProtKB:Q15139	Human	PMID:20497126
Biological Process	GO:0003272	endocardial cushion formation	prkd2	IMP	ZFIN:ZDB-MRPHLNO-140312-1	Zfish	PMID:21730303
Biological Process	GO:0003272	endocardial cushion formation	prkd2	IMP	ZFIN:ZDB-GENO-140327-10	Zfish	PMID:21730303
Biological Process	GO:0035556	intracellular signal transduction	PRKD2	IMP		Human	PMID:18059339
Biological Process	GO:0035556	intracellular signal transduction	PRKD2	IMP		Human	PMID:18440775
Biological Process	GO:0018105	peptidyl-serine phosphorylation	PRKD2	IDA		Human	PMID:18440775
Biological Process	GO:0018105	peptidyl-serine phosphorylation	PRKD2	IMP		Human	PMID:28428613
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	PRKD2	IMP		Human	PMID:28428613
Biological Process	GO:0045766	positive regulation of angiogenesis	PRKD2	IMP		Human	PMID:18440775
Biological Process	GO:0045766	positive regulation of angiogenesis	PRKD2	IMP		Human	PMID:19001381
Biological Process	GO:0045766	positive regulation of angiogenesis	PRKD2	IGI	UniProtKB:Q15139	Human	PMID:20497126
Biological Process	GO:0043536	positive regulation of blood vessel endothelial cell migration	PRKD2	IMP		Human	PMID:18440775
Biological Process	GO:0043536	positive regulation of blood vessel endothelial cell migration	PRKD2	IGI	UniProtKB:Q15139	Human	PMID:20497126
Biological Process	GO:0045785	positive regulation of cell adhesion	PRKD2	IMP		Human	PMID:17951978
Biological Process	GO:0032793	positive regulation of CREB transcription factor activity	PRKD2	IGI	UniProtKB:Q15139	Human	PMID:20497126
Biological Process	GO:2000573	positive regulation of DNA biosynthetic process	Prkd2	IDA		Mouse	MGI:MGI:5306299|PMID:17226786
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	PRKD2	IMP		Human	PMID:19192391
Biological Process	GO:2001028	positive regulation of endothelial cell chemotaxis	PRKD2	IMP		Human	PMID:18440775
Biological Process	GO:0038033	positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway	PRKD2	IMP		Human	PMID:18440775
Biological Process	GO:0038033	positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway	PRKD2	IGI	UniProtKB:Q15139	Human	PMID:20497126
Biological Process	GO:0010595	positive regulation of endothelial cell migration	PRKD2	IMP		Human	PMID:19001381
Biological Process	GO:0001938	positive regulation of endothelial cell proliferation	PRKD2	IMP		Human	PMID:19001381
Biological Process	GO:0001938	positive regulation of endothelial cell proliferation	PRKD2	IGI	UniProtKB:Q15139	Human	PMID:20497126
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Prkd2	IDA		Mouse	MGI:MGI:5306299|PMID:17226786
Biological Process	GO:0045743	positive regulation of fibroblast growth factor receptor signaling pathway	PRKD2	IMP		Human	PMID:19001381
Biological Process	GO:1901727	positive regulation of histone deacetylase activity	PRKD2	IGI	UniProtKB:Q15139	Human	PMID:20497126
Biological Process	GO:0032743	positive regulation of interleukin-2 production	Prkd2	IMP		Mouse	MGI:MGI:4849903|PMID:20819079
Biological Process	GO:0032757	positive regulation of interleukin-8 production	PRKD2	IMP		Human	PMID:16928771
Biological Process	GO:1902533	positive regulation of intracellular signal transduction	PRKD2	IMP		Human	PMID:18440775
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PRKD2	IMP		Human	PMID:15604256
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PRKD2	IMP		Human	PMID:16928771
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PRKD2	IMP		Human	PMID:28428613
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	PRKD2	IGI	UniProtKB:Q15139	Human	PMID:20497126
Biological Process	GO:0050862	positive regulation of T cell receptor signaling pathway	Prkd2	IMP		Mouse	MGI:MGI:4849903|PMID:20819079
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	PRKD2	IDA		Human	PMID:17077180
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	PRKD2	IMP		Human	PMID:18059339
Biological Process	GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway	PRKD2	IMP		Human	PMID:19001381
Biological Process	GO:0046777	protein autophosphorylation	PRKD2	IDA		Human	PMID:17077180
Biological Process	GO:0089700	protein kinase D signaling	PRKD2	IGI	UniProtKB:Q15139	Human	PMID:20497126
Biological Process	GO:0006468	protein phosphorylation	PRKD2	IDA		Human	PMID:22228765
Biological Process	GO:0070232	regulation of T cell apoptotic process	PRKD2	IMP		Human	PMID:17077180
Biological Process	GO:0050852	T cell receptor signaling pathway	PRKD2	IDA		Human	PMID:17077180
Biological Process	GO:0048010	vascular endothelial growth factor receptor signaling pathway	PRKD2	IMP		Human	PMID:18059339

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern