Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PRKDC
  • Mouse genes Prkdc
  • Rat genes Prkdc
  • Zfish genes prkdc
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Prkdc

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004677	DNA-dependent protein kinase activity	PRKDC	IDA		Human	PMID:15194694
Molecular Function	GO:0004677	DNA-dependent protein kinase activity	Prkdc	IDA		Mouse	PMID:23836881
Molecular Function	GO:0003690	double-stranded DNA binding	PRKDC	IDA		Human	PMID:22504299
Molecular Function	GO:0003690	double-stranded DNA binding	Prkdc	IDA		Mouse	PMID:20150414
Molecular Function	GO:0019899	enzyme binding	Prkdc	IPI	UniProtKB:P04797	Mouse	MGI:MGI:4887284|PMID:20972425
Molecular Function	GO:0140678	molecular function inhibitor activity	PRKDC	IDA		Human	PMID:33273464
Molecular Function	GO:0005515	protein binding	PRKDC	IPI	UniProtKB:P09629	Human	PMID:17308091
Molecular Function	GO:0005515	protein binding	PRKDC	IPI	UniProtKB:P12956	Human	PMID:17308091
Molecular Function	GO:0005515	protein binding	PRKDC	IPI	UniProtKB:P13010	Human	PMID:17308091
Molecular Function	GO:0005515	protein binding	PRKDC	IPI	UniProtKB:P25490	Human	PMID:18026119
Molecular Function	GO:0005515	protein binding	PRKDC	IPI	UniProtKB:P12956	Human	PMID:19303849
Molecular Function	GO:0005515	protein binding	PRKDC	IPI	UniProtKB:P13010	Human	PMID:19303849
Molecular Function	GO:0005515	protein binding	PRKDC	IPI	UniProtKB:Q96RI1-2	Human	PMID:19833092
Molecular Function	GO:0005515	protein binding	PRKDC	IPI	UniProtKB:P13010	Human	PMID:20023628
Molecular Function	GO:0005515	protein binding	PRKDC	IPI	UniProtKB:O43918	Human	PMID:20085707
Molecular Function	GO:0005515	protein binding	PRKDC	IPI	UniProtKB:P13010	Human	PMID:20085707
Molecular Function	GO:0005515	protein binding	PRKDC	IPI	UniProtKB:P12956	Human	PMID:20711232
Molecular Function	GO:0005515	protein binding	PRKDC	IPI	UniProtKB:P13010	Human	PMID:20711232
Molecular Function	GO:0005515	protein binding	PRKDC	IPI	UniProtKB:P12956	Human	PMID:21575865
Molecular Function	GO:0005515	protein binding	PRKDC	IPI	UniProtKB:P14921	Human	PMID:21575865
Molecular Function	GO:0005515	protein binding	PRKDC	IPI	UniProtKB:P17947	Human	PMID:21575865
Molecular Function	GO:0005515	protein binding	PRKDC	IPI	UniProtKB:P50549	Human	PMID:21575865
Molecular Function	GO:0005515	protein binding	PRKDC	IPI	UniProtKB:P09874,UniProtKB:P12956,UniProtKB:P13010	Human	PMID:22504299
Molecular Function	GO:0005515	protein binding	PRKDC	IPI	UniProtKB:P09874,UniProtKB:P23381	Human	PMID:22504299
Molecular Function	GO:0005515	protein binding	PRKDC	IPI	UniProtKB:Q96SD1	Human	PMID:22529269
Molecular Function	GO:0005515	protein binding	PRKDC	IPI	UniProtKB:Q6PJG6	Human	PMID:22977523
Molecular Function	GO:0005515	protein binding	PRKDC	IPI	UniProtKB:Q9BPZ7	Human	PMID:24365180
Molecular Function	GO:0005515	protein binding	PRKDC	IPI	UniProtKB:P10276	Human	PMID:25303530
Molecular Function	GO:0005515	protein binding	PRKDC	IPI	UniProtKB:P09874	Human	PMID:25749521
Molecular Function	GO:0005515	protein binding	PRKDC	IPI	UniProtKB:P12956	Human	PMID:25749521
Molecular Function	GO:0005515	protein binding	PRKDC	IPI	UniProtKB:Q9C0C2	Human	PMID:25749521
Molecular Function	GO:0005515	protein binding	PRKDC	IPI	UniProtKB:Q92570	Human	PMID:25852083
Molecular Function	GO:0005515	protein binding	PRKDC	IPI	UniProtKB:Q96SD1	Human	PMID:25941166
Molecular Function	GO:0005515	protein binding	PRKDC	IPI	UniProtKB:P10275	Human	PMID:26175416
Molecular Function	GO:0005515	protein binding	PRKDC	IPI	UniProtKB:P12956	Human	PMID:26175416
Molecular Function	GO:0005515	protein binding	PRKDC	IPI	UniProtKB:P07954-2	Human	PMID:26237645
Molecular Function	GO:0005515	protein binding	PRKDC	IPI	UniProtKB:P12956	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	PRKDC	IPI	UniProtKB:P13010	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	PRKDC	IPI	UniProtKB:Q92993	Human	PMID:32832608
Molecular Function	GO:0005515	protein binding	PRKDC	IPI	UniProtKB:Q12905	Human	PMID:9442054
Molecular Function	GO:0005515	protein binding	PRKDC	IPI	UniProtKB:Q12906	Human	PMID:9442054
Molecular Function	GO:0005515	protein binding	Prkdc	IPI	UniProtKB:P97784|UniProtKB:Q9R194	Mouse	MGI:MGI:5554971|PMID:24158435
Molecular Function	GO:0005515	protein binding	Prkdc	IPI	UniProtKB:P00533	Mouse	MGI:MGI:5582160|PMID:21266349
Molecular Function	GO:0019904	protein domain specific binding	PRKDC	IPI	UniProtKB:P23381	Human	PMID:22504299
Molecular Function	GO:0004672	protein kinase activity	PRKDC	IMP		Human	PMID:22504299
Molecular Function	GO:0004672	protein kinase activity	PRKDC	IDA		Human	PMID:7671312
Molecular Function	GO:0004674	protein serine/threonine kinase activity	PRKDC	IDA		Human	PMID:19303849
Molecular Function	GO:0004674	protein serine/threonine kinase activity	PRKDC	IDA		Human	PMID:24485452
Molecular Function	GO:0004674	protein serine/threonine kinase activity	PRKDC	IDA		Human	PMID:26237645
Molecular Function	GO:0004674	protein serine/threonine kinase activity	PRKDC	IDA		Human	PMID:29478807
Molecular Function	GO:0004674	protein serine/threonine kinase activity	PRKDC	IDA		Human	PMID:32103174
Molecular Function	GO:0004674	protein serine/threonine kinase activity	PRKDC	IDA		Human	PMID:33273464
Molecular Function	GO:0004674	protein serine/threonine kinase activity	PRKDC	IDA		Human	PMID:35460603
Molecular Function	GO:0003723	RNA binding	PRKDC	HDA		Human	PMID:22658674
Molecular Function	GO:0003723	RNA binding	PRKDC	HDA		Human	PMID:22681889
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	PRKDC	IPI	UniProtKB:P22415	Human	PMID:19303849
Molecular Function	GO:0034511	U3 snoRNA binding	PRKDC	IDA		Human	PMID:32103174
Cellular Component	GO:0000785	chromatin	PRKDC	IDA		Human	PMID:29478807
Cellular Component	GO:0000781	chromosome, telomeric region	PRKDC	HDA		Human	PMID:19135898
Cellular Component	GO:0070418	DNA-dependent protein kinase complex	PRKDC	IPI		Human	PMID:28840859
Cellular Component	GO:0005958	DNA-dependent protein kinase-DNA ligase 4 complex	PRKDC	IDA		Human	PMID:15194694
Cellular Component	GO:0016020	membrane	PRKDC	HDA		Human	PMID:19946888
Cellular Component	GO:0070419	nonhomologous end joining complex	PRKDC	IDA		Human	PMID:20383123
Cellular Component	GO:0070419	nonhomologous end joining complex	PRKDC	IDA		Human	PMID:25941166
Cellular Component	GO:0005730	nucleolus	PRKDC	IDA		Human	PMID:27829214
Cellular Component	GO:0005730	nucleolus	PRKDC	IDA		Human	PMID:32103174
Cellular Component	GO:0005654	nucleoplasm	PRKDC	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	PRKDC	IDA		Human	PMID:22504299
Cellular Component	GO:0005634	nucleus	PRKDC	IDA		Human	PMID:32103174
Cellular Component	GO:0005634	nucleus	Prkdc	IDA		Mouse	PMID:12604618
Cellular Component	GO:0032991	protein-containing complex	PRKDC	IMP		Human	PMID:22504299
Cellular Component	GO:0032993	protein-DNA complex	PRKDC	IDA		Human	PMID:22504299
Cellular Component	GO:0032040	small-subunit processome	PRKDC	IDA		Human	PMID:32103174
Cellular Component	GO:0005667	transcription regulator complex	PRKDC	IDA		Human	PMID:19303849
Biological Process	GO:0002218	activation of innate immune response	PRKDC	IDA		Human	PMID:28712728
Biological Process	GO:0030183	B cell differentiation	prkdc	IMP	ZFIN:ZDB-GENO-171005-1	Zfish	PMID:27566103
Biological Process	GO:0030183	B cell differentiation	prkdc	IMP	ZFIN:ZDB-GENO-170927-4	Zfish	PMID:27810924
Biological Process	GO:0002326	B cell lineage commitment	Prkdc	IMP	MGI:MGI:1857113	Mouse	PMID:8788039
Biological Process	GO:0007420	brain development	Prkdc	IGI	MGI:MGI:107202	Mouse	PMID:16687486
Biological Process	GO:0032869	cellular response to insulin stimulus	PRKDC	IMP		Human	PMID:19303849
Biological Process	GO:0006974	DNA damage response	PRKDC	IDA		Human	PMID:26237645
Biological Process	GO:0006974	DNA damage response	PRKDC	IDA		Human	PMID:29478807
Biological Process	GO:0006974	DNA damage response	PRKDC	IDA		Human	PMID:35460603
Biological Process	GO:0006302	double-strand break repair	PRKDC	IMP		Human	PMID:18710952
Biological Process	GO:0006302	double-strand break repair	Prkdc	IMP	MGI:MGI:2667593	Mouse	PMID:11751629
Biological Process	GO:0006302	double-strand break repair	Prkdc	IMP	MGI:MGI:1857113	Mouse	PMID:12604618
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	Prkdc	IMP		Mouse	PMID:23836881
Biological Process	GO:0035234	ectopic germ cell programmed cell death	Prkdc	IMP	MGI:MGI:2667593	Mouse	PMID:17145779
Biological Process	GO:0007507	heart development	Prkdc	IGI	MGI:MGI:107202	Mouse	PMID:16687486
Biological Process	GO:0002327	immature B cell differentiation	Prkdc	IMP	MGI:MGI:2383951	Mouse	PMID:9768755
Biological Process	GO:0071707	immunoglobulin heavy chain V-D-J recombination	prkdc	IMP	ZFIN:ZDB-GENO-171005-1	Zfish	PMID:27566103
Biological Process	GO:0033152	immunoglobulin V(D)J recombination	Prkdc	IMP	MGI:MGI:2383951	Mouse	PMID:9768755
Biological Process	GO:0033152	immunoglobulin V(D)J recombination	prkdc	IMP	ZFIN:ZDB-GENO-170927-4	Zfish	PMID:27810924
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	Prkdc	IMP	MGI:MGI:1857113	Mouse	PMID:12604618
Biological Process	GO:0030098	lymphocyte differentiation	Prkdc	IMP	MGI:MGI:1857113	Mouse	PMID:8133891
Biological Process	GO:0000460	maturation of 5.8S rRNA	PRKDC	IDA		Human	PMID:32103174
Biological Process	GO:0031571	mitotic G1 DNA damage checkpoint signaling	PRKDC	IMP		Human	PMID:21731742
Biological Process	GO:0043066	negative regulation of apoptotic process	PRKDC	IMP		Human	PMID:24485452
Biological Process	GO:2000773	negative regulation of cellular senescence	Prkdc	IMP		Rat	PMID:22981234|RGD:8696027
Biological Process	GO:0002638	negative regulation of immunoglobulin production	Prkdc	IMP		Rat	PMID:22981234|RGD:8696027
Biological Process	GO:0045824	negative regulation of innate immune response	PRKDC	IDA		Human	PMID:33273464
Biological Process	GO:0001933	negative regulation of protein phosphorylation	Prkdc	IMP		Mouse	MGI:MGI:5554971|PMID:24158435
Biological Process	GO:2001229	negative regulation of response to gamma radiation	Prkdc	IMP		Rat	PMID:22981234|RGD:8696027
Biological Process	GO:0018105	peptidyl-serine phosphorylation	PRKDC	IDA		Human	PMID:15194694
Biological Process	GO:0018105	peptidyl-serine phosphorylation	PRKDC	IDA		Human	PMID:19303849
Biological Process	GO:0018105	peptidyl-serine phosphorylation	PRKDC	IDA		Human	PMID:32103174
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	PRKDC	IDA		Human	PMID:32103174
Biological Process	GO:0043065	positive regulation of apoptotic process	Prkdc	IMP	MGI:MGI:2667593	Mouse	PMID:17145779
Biological Process	GO:0048639	positive regulation of developmental growth	Prkdc	IMP		Rat	PMID:22981234|RGD:8696027
Biological Process	GO:2001034	positive regulation of double-strand break repair via nonhomologous end joining	PRKDC	IDA		Human	PMID:26237645
Biological Process	GO:0045648	positive regulation of erythrocyte differentiation	Prkdc	IMP		Mouse	MGI:MGI:6414739|PMID:32103174
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	Prkdc	IMP		Rat	PMID:22981234|RGD:8696027
Biological Process	GO:0002684	positive regulation of immune system process	Prkdc	IMP		Rat	PMID:22981234|RGD:8696027
Biological Process	GO:0045621	positive regulation of lymphocyte differentiation	Prkdc	IMP		Mouse	MGI:MGI:6414739|PMID:32103174
Biological Process	GO:1905221	positive regulation of platelet formation	Prkdc	IMP		Mouse	MGI:MGI:6414739|PMID:32103174
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	PRKDC	IMP		Human	PMID:19303849
Biological Process	GO:0045727	positive regulation of translation	Prkdc	IMP		Mouse	MGI:MGI:6414739|PMID:32103174
Biological Process	GO:0002328	pro-B cell differentiation	Prkdc	IMP	MGI:MGI:2383951	Mouse	PMID:9768755
Biological Process	GO:0031648	protein destabilization	Prkdc	IDA		Mouse	PMID:15194694
Biological Process	GO:0006468	protein phosphorylation	PRKDC	IMP		Human	PMID:22504299
Biological Process	GO:0006468	protein phosphorylation	PRKDC	IDA		Human	PMID:26237645
Biological Process	GO:0042752	regulation of circadian rhythm	Prkdc	IMP		Mouse	MGI:MGI:5554971|PMID:24158435
Biological Process	GO:0050678	regulation of epithelial cell proliferation	PRKDC	IMP		Human	PMID:18710952
Biological Process	GO:1902036	regulation of hematopoietic stem cell differentiation	Prkdc	IMP		Mouse	MGI:MGI:6414739|PMID:32103174
Biological Process	GO:0048660	regulation of smooth muscle cell proliferation	PRKDC	IMP		Human	PMID:25852083
Biological Process	GO:0014823	response to activity	Prkdc	IEP		Rat	PMID:21622964|RGD:8696029
Biological Process	GO:0010332	response to gamma radiation	Prkdc	IMP	MGI:MGI:2383951	Mouse	PMID:9768755
Biological Process	GO:0010212	response to ionizing radiation	Prkdc	IMP	MGI:MGI:1857934	Mouse	PMID:20150414
Biological Process	GO:0034462	small-subunit processome assembly	PRKDC	IDA		Human	PMID:32103174
Biological Process	GO:0001756	somitogenesis	Prkdc	IGI	MGI:MGI:107202	Mouse	PMID:16687486
Biological Process	GO:0048536	spleen development	Prkdc	IMP		Rat	PMID:22981234|RGD:8696027
Biological Process	GO:0030217	T cell differentiation	prkdc	IMP	ZFIN:ZDB-GENO-170927-4	Zfish	PMID:27810924
Biological Process	GO:0030217	T cell differentiation	prkdc	IMP	ZFIN:ZDB-GENO-171005-1	Zfish	PMID:27566103
Biological Process	GO:0033077	T cell differentiation in thymus	Prkdc	IMP	MGI:MGI:2383951	Mouse	PMID:9768755
Biological Process	GO:0002360	T cell lineage commitment	Prkdc	IMP	MGI:MGI:1857113	Mouse	PMID:8788039
Biological Process	GO:0033153	T cell receptor V(D)J recombination	Prkdc	IMP	MGI:MGI:2383951	Mouse	PMID:9768755
Biological Process	GO:0033153	T cell receptor V(D)J recombination	prkdc	IMP	ZFIN:ZDB-GENO-170927-4	Zfish	PMID:27810924
Biological Process	GO:0033153	T cell receptor V(D)J recombination	prkdc	IMP	ZFIN:ZDB-GENO-171005-1	Zfish	PMID:27566103
Biological Process	GO:0016233	telomere capping	PRKDC	IMP		Human	PMID:18710952
Biological Process	GO:0000723	telomere maintenance	Prkdc	IMP	MGI:MGI:1857113	Mouse	PMID:15010310
Biological Process	GO:0048538	thymus development	Prkdc	IMP		Rat	PMID:22981234|RGD:8696027
Biological Process	GO:0033151	V(D)J recombination	Prkdc	IGI	MGI:MGI:107202	Mouse	PMID:23836881

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern