Comparative GO Graph (mouse, human, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PRKG1
  • Mouse genes Prkg1
  • Rat genes
  • Zfish genes prkg1a,prkg1b,prkg1l
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Prkg1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005246	calcium channel regulator activity	PRKG1	IDA		Human	PMID:21402151
Molecular Function	GO:0030553	cGMP binding	Prkg1	IDA		Mouse	MGI:MGI:1890119|PMID:10671526
Molecular Function	GO:0004692	cGMP-dependent protein kinase activity	PRKG1	IDA		Human	PMID:21402151
Molecular Function	GO:0004692	cGMP-dependent protein kinase activity	Prkg1	IDA		Mouse	MGI:MGI:1890119|PMID:10671526
Molecular Function	GO:0005515	protein binding	PRKG1	IPI	UniProtKB:Q9Y6F6	Human	PMID:16990611
Molecular Function	GO:0005515	protein binding	PRKG1	IPI	UniProtKB:O76074	Human	PMID:18757735
Molecular Function	GO:0005515	protein binding	PRKG1	IPI	UniProtKB:Q13873	Human	PMID:19424179
Molecular Function	GO:0005515	protein binding	PRKG1	IPI	UniProtKB:Q9HCX4	Human	PMID:21402151
Molecular Function	GO:0005515	protein binding	PRKG1	IPI	UniProtKB:O15015	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PRKG1	IPI	UniProtKB:P25791	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PRKG1	IPI	UniProtKB:Q86V42	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PRKG1	IPI	UniProtKB:O15015	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	PRKG1	IPI	UniProtKB:P25791	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	PRKG1	IPI	UniProtKB:Q86V42	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	Prkg1	IPI	UniProtKB:Q9DBR7	Mouse	MGI:MGI:3789432|PMID:18448676
Molecular Function	GO:0005515	protein binding	Prkg1	IPI	UniProtKB:O35607	Mouse	MGI:MGI:5508584|PMID:19424179
Molecular Function	GO:0005515	protein binding	Prkg1	IPI	UniProtKB:Q9CUD8	Mouse	PMID:10671526
Molecular Function	GO:0005515	protein binding	Prkg1	IPI	PR:Q9WUX5	Mouse	PMID:15483626
Molecular Function	GO:0004672	protein kinase activity	PRKG1	IMP		Human	PMID:25447536
Molecular Function	GO:0004672	protein kinase activity	Prkg1	IDA		Mouse	MGI:MGI:1890119|PMID:10671526
Molecular Function	GO:0004672	protein kinase activity	Prkg1	IDA		Mouse	PMID:15465019
Cellular Component	GO:0005737	cytoplasm	PRKG1	IDA		Human	PMID:21402151
Cellular Component	GO:0005794	Golgi apparatus	Prkg1	IDA		Mouse	MGI:MGI:1890119|PMID:10671526
Cellular Component	GO:0005886	plasma membrane	PRKG1	IDA		Human	PMID:21402151
Cellular Component	GO:0005886	plasma membrane	Prkg1	IMP		Mouse	MGI:MGI:3836877|PMID:19127022
Cellular Component	GO:0005886	plasma membrane	Prkg1	IDA		Mouse	MGI:MGI:5306301|PMID:16990611
Biological Process	GO:0019934	cGMP-mediated signaling	Prkg1	IMP	MGI:MGI:2181586	Mouse	PMID:15483626
Biological Process	GO:0048668	collateral sprouting	Prkg1	IMP	MGI:MGI:2668650	Mouse	PMID:17954614
Biological Process	GO:0016358	dendrite development	Prkg1	IMP	MGI:MGI:2181586	Mouse	PMID:16154207
Biological Process	GO:0030900	forebrain development	Prkg1	IMP	MGI:MGI:2181586	Mouse	PMID:16154207
Biological Process	GO:0090331	negative regulation of platelet aggregation	PRKG1	IMP		Human	PMID:16990611
Biological Process	GO:0045986	negative regulation of smooth muscle contraction	Prkg1	IMP	MGI:MGI:2181586	Mouse	PMID:15483626
Biological Process	GO:1904753	negative regulation of vascular associated smooth muscle cell migration	PRKG1	IDA		Human	PMID:25447536
Biological Process	GO:1904706	negative regulation of vascular associated smooth muscle cell proliferation	PRKG1	IDA		Human	PMID:25447536
Biological Process	GO:0001764	neuron migration	Prkg1	IMP	MGI:MGI:2181586	Mouse	PMID:16154207
Biological Process	GO:0006468	protein phosphorylation	Prkg1	IDA		Mouse	MGI:MGI:1890119|PMID:10671526
Biological Process	GO:0043087	regulation of GTPase activity	PRKG1	IMP		Human	PMID:14608379
Biological Process	GO:0060087	relaxation of vascular associated smooth muscle	Prkg1	IMP	MGI:MGI:2181586	Mouse	PMID:15483626
Biological Process	GO:0007165	signal transduction	Prkg1	IDA		Mouse	MGI:MGI:1890119|PMID:10671526

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern