Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PRL
  • Mouse genes Prl
  • Rat genes Prl
  • Zfish genes prl,prl2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Prl

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	PRL	IPI	UniProtKB:P16471-1	Human	PMID:22325776
Molecular Function	GO:0005515	protein binding	PRL	IPI	UniProtKB:P16471-7	Human	PMID:23048206
Molecular Function	GO:0005515	protein binding	PRL	IPI	UniProtKB:Q6FHY5	Human	PMID:32296183
Cellular Component	GO:0005576	extracellular region	Prl	IDA		Rat	PMID:12193569|RGD:625674
Cellular Component	GO:0005615	extracellular space	Prl	IDA		Rat	PMID:24882100|RGD:151667420
Cellular Component	GO:0030141	secretory granule	Prl	IDA		Mouse	PMID:9247267
Cellular Component	GO:0030141	secretory granule	Prl	IDA		Mouse	PMID:16219686
Cellular Component	GO:0030141	secretory granule	Prl	IDA		Rat	PMID:17341846|RGD:1642573
Biological Process	GO:0008283	cell population proliferation	Prl	IGI	MGI:MGI:94924	Mouse	PMID:9247268
Biological Process	GO:0032870	cellular response to hormone stimulus	Prl	IEP		Rat	PMID:17873321|RGD:1642561
Biological Process	GO:0007623	circadian rhythm	Prl	IEP		Rat	PMID:17726143|RGD:1642564
Biological Process	GO:0050673	epithelial cell proliferation	Prl	IGI	MGI:MGI:94924	Mouse	PMID:9247268
Biological Process	GO:0030879	mammary gland development	Prl	IGI	MGI:MGI:105088	Mouse	PMID:18425773
Biological Process	GO:0042711	maternal behavior	Prl	IGI	MGI:MGI:1924378	Mouse	PMID:23071095
Biological Process	GO:0042711	maternal behavior	Prl	IGI	MGI:MGI:95824	Mouse	PMID:23071095
Biological Process	GO:0050801	monoatomic ion homeostasis	prl	IMP	ZFIN:ZDB-GENO-180405-4	Zfish	PMID:26726070
Biological Process	GO:0050801	monoatomic ion homeostasis	prl	IMP	ZFIN:ZDB-GENO-180405-5	Zfish	PMID:26726070
Biological Process	GO:0033555	multicellular organismal response to stress	Prl	IEP		Rat	PMID:17573075|RGD:1642569
Biological Process	GO:0033555	multicellular organismal response to stress	prl	IEP		Zfish	PMID:25748166
Biological Process	GO:0043066	negative regulation of apoptotic process	prl	IMP	ZFIN:ZDB-MRPHLNO-070424-1	Zfish	PMID:19032987
Biological Process	GO:0001937	negative regulation of endothelial cell proliferation	PRL	IDA		Human	PMID:23619365
Biological Process	GO:0042698	ovulation cycle	Prl	IEP		Rat	PMID:17499646|RGD:1642571
Biological Process	GO:0007567	parturition	Prl	IEP		Rat	PMID:17641097|RGD:1642566
Biological Process	GO:0008284	positive regulation of cell population proliferation	Prl	IGI	MGI:MGI:94924	Mouse	PMID:9247268
Biological Process	GO:0008284	positive regulation of cell population proliferation	Prl	IMP		Rat	PMID:17640386|RGD:1642567
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	Prl	IGI	MGI:MGI:94924	Mouse	PMID:9247268
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	Prl	IDA		Rat	PMID:11751614|RGD:70433
Biological Process	GO:1902895	positive regulation of miRNA transcription	PRL	IDA		Human	PMID:23619365
Biological Process	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	PRL	IDA		Human	PMID:12552091
Biological Process	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	Prl	IGI	MGI:MGI:102709	Mouse	PMID:12388746
Biological Process	GO:0030278	regulation of ossification	Prl	IMP		Rat	PMID:17218965|RGD:1642577
Biological Process	GO:0046425	regulation of receptor signaling pathway via JAK-STAT	Prl	IDA		Mouse	PMID:12147240
Biological Process	GO:0032355	response to estradiol	Prl	IEP		Rat	PMID:17122082|RGD:1642579
Biological Process	GO:0045471	response to ethanol	Prl	IEP		Rat	PMID:17526938|RGD:1642570
Biological Process	GO:0032496	response to lipopolysaccharide	Prl	IEP		Rat	PMID:17706967|RGD:1642565
Biological Process	GO:0036005	response to macrophage colony-stimulating factor	Prl	IEP		Rat	PMID:24882100|RGD:151667420
Biological Process	GO:0007584	response to nutrient	Prl	IEP		Rat	PMID:17447162|RGD:1642572
Biological Process	GO:0014070	response to organic cyclic compound	Prl	IEP		Rat	PMID:17190974|RGD:1642578
Biological Process	GO:0009410	response to xenobiotic stimulus	Prl	IEP		Rat	PMID:17581744|RGD:1642568

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern