Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PRLR
  • Mouse genes Prlr
  • Rat genes Prlr
  • Zfish genes prlra,prlrb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Prlr

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008289	lipid binding	PRLR	EXP		Human	PMID:25846210
Molecular Function	GO:0017046	peptide hormone binding	PRLR	IPI	UniProtKB:P01241	Human	PMID:7984244
Molecular Function	GO:0004925	prolactin receptor activity	PRLR	IDA		Human	PMID:10585417
Molecular Function	GO:0004925	prolactin receptor activity	Prlr	IMP	MGI:MGI:1888377	Mouse	PMID:11706048
Molecular Function	GO:0004925	prolactin receptor activity	Prlr	IDA		Mouse	PMID:6303755
Molecular Function	GO:0004925	prolactin receptor activity	Prlr	IMP		Rat	PMID:11835322|RGD:729660
Molecular Function	GO:0005515	protein binding	PRLR	IPI	UniProtKB:P63104	Human	PMID:12819209
Molecular Function	GO:0005515	protein binding	PRLR	IPI	UniProtKB:Q8IY26	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PRLR	IPI	UniProtKB:Q9Y5U4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Prlr	IPI	PR:Q3UHD9	Mouse	PMID:20075866
Molecular Function	GO:0005515	protein binding	Prlr	IPI	PR:P42230	Mouse	PMID:20075866
Molecular Function	GO:0019901	protein kinase binding	Prlr	IPI	RGD:2641	Rat	PMID:7935483|RGD:2324928
Cellular Component	GO:0009986	cell surface	PRLR	IDA		Human	PMID:10585417
Biological Process	GO:0042976	activation of Janus kinase activity	PRLR	IDA		Human	PMID:10585417
Biological Process	GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity	PRLR	IDA		Human	PMID:10585417
Biological Process	GO:0097011	cellular response to granulocyte macrophage colony-stimulating factor stimulus	Prlr	IMP		Rat	PMID:8650199|RGD:151665811
Biological Process	GO:0097011	cellular response to granulocyte macrophage colony-stimulating factor stimulus	Prlr	IMP		Rat	PMID:9447986|RGD:151667430
Biological Process	GO:0007595	lactation	Prlr	IGI	MGI:MGI:1354910	Mouse	PMID:11445538
Biological Process	GO:0007595	lactation	Prlr	IMP	MGI:MGI:1888377	Mouse	PMID:11706048
Biological Process	GO:0007595	lactation	Prlr	IMP	MGI:MGI:1888377	Mouse	PMID:16469767
Biological Process	GO:0051179	localization	PRLR	EXP		Human	PMID:25846210
Biological Process	GO:0060749	mammary gland alveolus development	Prlr	IGI	MGI:MGI:1201787	Mouse	PMID:16469767
Biological Process	GO:0060749	mammary gland alveolus development	Prlr	IGI	MGI:MGI:1354910	Mouse	PMID:11445538
Biological Process	GO:0060749	mammary gland alveolus development	Prlr	IMP	MGI:MGI:1888377	Mouse	PMID:16469767
Biological Process	GO:0060644	mammary gland epithelial cell differentiation	Prlr	IGI	MGI:MGI:1335079	Mouse	PMID:16469767
Biological Process	GO:0061180	mammary gland epithelium development	Prlr	IMP		Mouse	PMID:12040017
Biological Process	GO:0043066	negative regulation of apoptotic process	PRLR	IDA		Human	PMID:10585417
Biological Process	GO:0030890	positive regulation of B cell proliferation	Prlr	IMP		Rat	PMID:8650199|RGD:151665811
Biological Process	GO:0030890	positive regulation of B cell proliferation	Prlr	IMP		Rat	PMID:9447986|RGD:151667430
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	Prlr	IMP		Mouse	MGI:MGI:3775328|PMID:18253483
Biological Process	GO:0031954	positive regulation of protein autophosphorylation	Prlr	IMP		Rat	PMID:8650199|RGD:151665811
Biological Process	GO:0031954	positive regulation of protein autophosphorylation	Prlr	IMP		Rat	PMID:9447986|RGD:151667430
Biological Process	GO:0060736	prostate gland growth	Prlr	IMP	MGI:MGI:1888377	Mouse	PMID:12810576
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	Prlr	IMP	MGI:MGI:1888377	Mouse	PMID:16469767
Biological Process	GO:0030155	regulation of cell adhesion	Prlr	IMP	MGI:MGI:1888377	Mouse	PMID:11706048
Biological Process	GO:0030856	regulation of epithelial cell differentiation	Prlr	IMP	MGI:MGI:1888377	Mouse	PMID:11706048
Biological Process	GO:0009617	response to bacterium	Prlr	IEP		Mouse	PMID:23012479

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern