Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Prmt5

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes PRMT5
- Mouse genes Prmt5
- Rat genes Prmt5
- Zfish genes prmt5
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Prmt5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	Prmt5	IMP		Mouse	PMID:18347060
Molecular Function	GO:0070888	E-box binding	Prmt5	IDA		Mouse	MGI:MGI:5464222\|PMID:23133559
Molecular Function	GO:0070612	histone H2AR3 methyltransferase activity	Prmt5	IDA		Mouse	PMID:16699504
Molecular Function	GO:0044020	histone H4R3 methyltransferase activity	PRMT5	IDA		Human	PMID:22143770
Molecular Function	GO:0044020	histone H4R3 methyltransferase activity	PRMT5	IMP		Human	PMID:25284789
Molecular Function	GO:0044020	histone H4R3 methyltransferase activity	Prmt5	IMP		Mouse	MGI:MGI:5464222\|PMID:23133559
Molecular Function	GO:0044020	histone H4R3 methyltransferase activity	Prmt5	IDA		Mouse	PMID:16699504
Molecular Function	GO:0044020	histone H4R3 methyltransferase activity	prmt5	IMP	ZFIN:ZDB-GENO-200922-4	Zfish	PMID:31533925
Molecular Function	GO:0042054	histone methyltransferase activity	prmt5	IMP	ZFIN:ZDB-GENO-200922-4	Zfish	PMID:31533925
Molecular Function	GO:0042802	identical protein binding	PRMT5	IPI	UniProtKB:O14744	Human	PMID:11756452
Molecular Function	GO:0042802	identical protein binding	PRMT5	IPI	UniProtKB:O14744	Human	PMID:22365833
Molecular Function	GO:0042802	identical protein binding	PRMT5	IPI	UniProtKB:O14744	Human	PMID:23071334
Molecular Function	GO:0008327	methyl-CpG binding	PRMT5	IDA		Human	PMID:25284789
Molecular Function	GO:0008168	methyltransferase activity	PRMT5	IDA		Human	PMID:15369763
Molecular Function	GO:0008168	methyltransferase activity	PRMT5	IDA		Human	PMID:19011621
Molecular Function	GO:0002039	p53 binding	PRMT5	IPI	UniProtKB:P04637	Human	PMID:19011621
Molecular Function	GO:0005515	protein binding	PRMT5	IPI	UniProtKB:P54105	Human	PMID:11756452
Molecular Function	GO:0005515	protein binding	PRMT5	IPI	UniProtKB:Q9BQA1	Human	PMID:11756452
Molecular Function	GO:0005515	protein binding	PRMT5	IPI	UniProtKB:P62993	Human	PMID:12577067
Molecular Function	GO:0005515	protein binding	PRMT5	IPI	UniProtKB:Q8BUV6	Human	PMID:16087681
Molecular Function	GO:0005515	protein binding	PRMT5	IPI	UniProtKB:Q9NQ92	Human	PMID:18404153
Molecular Function	GO:0005515	protein binding	PRMT5	IPI	UniProtKB:P54105	Human	PMID:18984161
Molecular Function	GO:0005515	protein binding	PRMT5	IPI	UniProtKB:Q99LG4	Human	PMID:19011621
Molecular Function	GO:0005515	protein binding	PRMT5	IPI	UniProtKB:Q86UQ8-1	Human	PMID:19234465
Molecular Function	GO:0005515	protein binding	PRMT5	IPI	UniProtKB:Q9Y6K1	Human	PMID:19234465
Molecular Function	GO:0005515	protein binding	PRMT5	IPI	UniProtKB:Q91XC0	Human	PMID:20133701
Molecular Function	GO:0005515	protein binding	PRMT5	IPI	UniProtKB:P46783	Human	PMID:20159986
Molecular Function	GO:0005515	protein binding	PRMT5	IPI	UniProtKB:Q08379	Human	PMID:20421892
Molecular Function	GO:0005515	protein binding	PRMT5	IPI	UniProtKB:O75044	Human	PMID:20810653
Molecular Function	GO:0005515	protein binding	PRMT5	IPI	UniProtKB:P62805	Human	PMID:20951943
Molecular Function	GO:0005515	protein binding	PRMT5	IPI	UniProtKB:Q9BQA1	Human	PMID:20951943
Molecular Function	GO:0005515	protein binding	PRMT5	IPI	UniProtKB:Q9BRS2	Human	PMID:21081503
Molecular Function	GO:0005515	protein binding	PRMT5	IPI	UniProtKB:P31269	Human	PMID:22269951
Molecular Function	GO:0005515	protein binding	PRMT5	IPI	UniProtKB:Q01094	Human	PMID:22327218
Molecular Function	GO:0005515	protein binding	PRMT5	IPI	UniProtKB:P54105	Human	PMID:22365833
Molecular Function	GO:0005515	protein binding	PRMT5	IPI	UniProtKB:Q86U06	Human	PMID:22365833
Molecular Function	GO:0005515	protein binding	PRMT5	IPI	UniProtKB:Q9BQA1	Human	PMID:22365833
Molecular Function	GO:0005515	protein binding	PRMT5	IPI	UniProtKB:P62805	Human	PMID:23071334
Molecular Function	GO:0005515	protein binding	PRMT5	IPI	UniProtKB:Q9BQA1	Human	PMID:23071334
Molecular Function	GO:0005515	protein binding	PRMT5	IPI	UniProtKB:Q16526	Human	PMID:23133559
Molecular Function	GO:0005515	protein binding	PRMT5	IPI	UniProtKB:P63104	Human	PMID:23455924
Molecular Function	GO:0005515	protein binding	PRMT5	IPI	UniProtKB:Q86U06	Human	PMID:23455924
Molecular Function	GO:0005515	protein binding	PRMT5	IPI	UniProtKB:Q8N8U2	Human	PMID:23455924
Molecular Function	GO:0005515	protein binding	PRMT5	IPI	UniProtKB:Q8TE85	Human	PMID:23455924
Molecular Function	GO:0005515	protein binding	PRMT5	IPI	UniProtKB:Q8WVJ2	Human	PMID:23455924
Molecular Function	GO:0005515	protein binding	PRMT5	IPI	UniProtKB:Q96RU7	Human	PMID:23455924
Molecular Function	GO:0005515	protein binding	PRMT5	IPI	UniProtKB:Q9BX10	Human	PMID:23455924
Molecular Function	GO:0005515	protein binding	PRMT5	IPI	UniProtKB:P03418	Human	PMID:23892143
Molecular Function	GO:0005515	protein binding	PRMT5	IPI	UniProtKB:Q9BQA1	Human	PMID:23892143
Molecular Function	GO:0005515	protein binding	PRMT5	IPI	UniProtKB:Q9NX58	Human	PMID:25092918
Molecular Function	GO:0005515	protein binding	PRMT5	IPI	UniProtKB:Q9Y3Y2	Human	PMID:25284789
Molecular Function	GO:0005515	protein binding	PRMT5	IPI	UniProtKB:Q9BRS2	Human	PMID:25852190
Molecular Function	GO:0005515	protein binding	PRMT5	IPI	UniProtKB:P24928	Human	PMID:26700805
Molecular Function	GO:0005515	protein binding	PRMT5	IPI	UniProtKB:Q16637	Human	PMID:26700805
Molecular Function	GO:0005515	protein binding	PRMT5	IPI	UniProtKB:Q9BQA1	Human	PMID:26763441
Molecular Function	GO:0005515	protein binding	PRMT5	IPI	UniProtKB:P62805	Human	PMID:26912361
Molecular Function	GO:0005515	protein binding	PRMT5	IPI	UniProtKB:Q9BQA1	Human	PMID:26912361
Molecular Function	GO:0005515	protein binding	PRMT5	IPI	UniProtKB:O15197-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PRMT5	IPI	UniProtKB:O95995	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PRMT5	IPI	UniProtKB:P38919	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PRMT5	IPI	UniProtKB:Q08289	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PRMT5	IPI	UniProtKB:Q08426	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PRMT5	IPI	UniProtKB:Q14241	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PRMT5	IPI	UniProtKB:Q16543	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PRMT5	IPI	UniProtKB:Q63ZY3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PRMT5	IPI	UniProtKB:Q8TBB1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PRMT5	IPI	UniProtKB:Q96E35	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PRMT5	IPI	UniProtKB:Q96HA8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PRMT5	IPI	UniProtKB:Q9NX04	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PRMT5	IPI	UniProtKB:Q9BRS2	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	PRMT5	IPI	UniProtKB:P01019	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PRMT5	IPI	UniProtKB:P01100	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PRMT5	IPI	UniProtKB:P03952	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PRMT5	IPI	UniProtKB:P06858	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PRMT5	IPI	UniProtKB:P21964-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PRMT5	IPI	UniProtKB:P31930	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PRMT5	IPI	UniProtKB:P40337-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PRMT5	IPI	UniProtKB:P62993	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PRMT5	IPI	UniProtKB:P78371	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PRMT5	IPI	UniProtKB:Q00613	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PRMT5	IPI	UniProtKB:Q8WUW1	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PRMT5	IPI	UniProtKB:Q6ZV65	Human	PMID:33376131
Molecular Function	GO:0005515	protein binding	Prmt5	IPI	UniProtKB:P97784	Mouse	MGI:MGI:5464222\|PMID:23133559
Molecular Function	GO:0005515	protein binding	Prmt5	IPI	UniProtKB:P97784\|UniProtKB:Q16526	Mouse	MGI:MGI:5464222\|PMID:23133559
Molecular Function	GO:0005515	protein binding	Prmt5	IPI	UniProtKB:Q9CY57	Mouse	MGI:MGI:4420157\|PMID:19858291
Molecular Function	GO:0005515	protein binding	Prmt5	IPI	UniProtKB:Q80V63	Mouse	MGI:MGI:5645199\|PMID:23048031
Molecular Function	GO:0005515	protein binding	Prmt5	IPI	UniProtKB:Q9CQ13	Mouse	MGI:MGI:5487512\|PMID:22193545
Molecular Function	GO:0005515	protein binding	Prmt5	IPI	UniProtKB:P25322	Mouse	MGI:MGI:4837754\|PMID:20951943
Molecular Function	GO:0005515	protein binding	Prmt5	IPI	UniProtKB:Q60636	Mouse	PMID:16699504
Molecular Function	GO:0046982	protein heterodimerization activity	PRMT5	IDA		Human	PMID:18495660
Molecular Function	GO:0016274	protein-arginine N-methyltransferase activity	PRMT5	IDA		Human	PMID:20421892
Molecular Function	GO:0016274	protein-arginine N-methyltransferase activity	PRMT5	IDA		Human	PMID:26554819
Molecular Function	GO:0035243	protein-arginine omega-N symmetric methyltransferase activity	PRMT5	IMP		Human	PMID:17709427
Molecular Function	GO:0035243	protein-arginine omega-N symmetric methyltransferase activity	PRMT5	EXP		Human	PMID:19011621
Molecular Function	GO:0035243	protein-arginine omega-N symmetric methyltransferase activity	PRMT5	IDA		Human	PMID:22143770
Molecular Function	GO:0035243	protein-arginine omega-N symmetric methyltransferase activity	prmt5	IDA		Zfish	PMID:31533925
Molecular Function	GO:0035243	protein-arginine omega-N symmetric methyltransferase activity	prmt5	IMP	ZFIN:ZDB-GENO-200922-4	Zfish	PMID:31533925
Molecular Function	GO:0044877	protein-containing complex binding	Prmt5	IDA		Rat	PMID:15837430\|RGD:2299961
Molecular Function	GO:0043021	ribonucleoprotein complex binding	PRMT5	IPI	UniProtKB:P62318	Human	PMID:17709427
Molecular Function	GO:0003714	transcription corepressor activity	Prmt5	IMP		Mouse	MGI:MGI:5464222\|PMID:23133559
Cellular Component	GO:0000785	chromatin	PRMT5	IDA		Human	PMID:33376131
Cellular Component	GO:0005737	cytoplasm	PRMT5	IDA		Human	PMID:22952863
Cellular Component	GO:0005737	cytoplasm	Prmt5	IDA		Mouse	MGI:MGI:5645199\|PMID:23048031
Cellular Component	GO:0005737	cytoplasm	Prmt5	IDA		Mouse	PMID:16699504
Cellular Component	GO:0005829	cytosol	PRMT5	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	PRMT5	IDA		Human	PMID:18984161
Cellular Component	GO:0005829	cytosol	PRMT5	IDA		Human	PMID:21081503
Cellular Component	GO:0005794	Golgi apparatus	PRMT5	IDA		Human	PMID:20421892
Cellular Component	GO:0035097	histone methyltransferase complex	PRMT5	IDA		Human	PMID:23048031
Cellular Component	GO:0035097	histone methyltransferase complex	Prmt5	IDA		Mouse	MGI:MGI:5645199\|PMID:23048031
Cellular Component	GO:0001673	male germ cell nucleus	Prmt5	IDA		Mouse	PMID:16787967
Cellular Component	GO:0034709	methylosome	PRMT5	IDA		Human	PMID:11756452
Cellular Component	GO:0034709	methylosome	PRMT5	IDA		Human	PMID:18984161
Cellular Component	GO:0034709	methylosome	PRMT5	IDA		Human	PMID:25284789
Cellular Component	GO:0005654	nucleoplasm	PRMT5	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	PRMT5	IDA		Human	PMID:21081503
Cellular Component	GO:0005634	nucleus	Prmt5	IDA		Mouse	MGI:MGI:3655410\|PMID:16787967
Cellular Component	GO:0005634	nucleus	Prmt5	IDA		Mouse	MGI:MGI:5645199\|PMID:23048031
Cellular Component	GO:0005634	nucleus	Prmt5	IDA		Mouse	PMID:16699504
Cellular Component	GO:0032991	protein-containing complex	Prmt5	IDA		Rat	PMID:12101096\|RGD:9491828
Cellular Component	GO:0032991	protein-containing complex	Prmt5	IDA		Rat	PMID:15837430\|RGD:2299961
Biological Process	GO:0032922	circadian regulation of gene expression	Prmt5	IMP		Mouse	MGI:MGI:5464222\|PMID:23133559
Biological Process	GO:0006353	DNA-templated transcription termination	PRMT5	IMP		Human	PMID:26700805
Biological Process	GO:0042118	endothelial cell activation	PRMT5	IMP		Human	PMID:22269951
Biological Process	GO:0010467	gene expression	Prmt5	IDA		Mouse	PMID:16699504
Biological Process	GO:0090161	Golgi ribbon formation	PRMT5	IMP		Human	PMID:20421892
Biological Process	GO:0097421	liver regeneration	Prmt5	IEP		Rat	PMID:15837430\|RGD:2299961
Biological Process	GO:0045596	negative regulation of cell differentiation	Prmt5	IMP		Rat	PMID:21917714\|RGD:9491825
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Prmt5	IMP		Mouse	PMID:18347060
Biological Process	GO:0018216	peptidyl-arginine methylation	PRMT5	IMP		Human	PMID:17709427
Biological Process	GO:0019918	peptidyl-arginine methylation, to symmetrical-dimethyl arginine	prmt5	IMP	ZFIN:ZDB-GENO-200922-4	Zfish	PMID:31533925
Biological Process	GO:0019918	peptidyl-arginine methylation, to symmetrical-dimethyl arginine	prmt5	IDA		Zfish	PMID:31533925
Biological Process	GO:0035246	peptidyl-arginine N-methylation	PRMT5	IDA		Human	PMID:15369763
Biological Process	GO:0035246	peptidyl-arginine N-methylation	PRMT5	IDA		Human	PMID:26554819
Biological Process	GO:1904992	positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway	PRMT5	IGI	UniProtKB:P14416	Human	PMID:26554819
Biological Process	GO:0048714	positive regulation of oligodendrocyte differentiation	Prmt5	IMP		Rat	PMID:22041901\|RGD:9491827
Biological Process	GO:0006479	protein methylation	Prmt5	IMP		Rat	PMID:21917714\|RGD:9491825
Biological Process	GO:0044030	regulation of DNA methylation	Prmt5	IMP		Rat	PMID:22041901\|RGD:9491827
Biological Process	GO:0070372	regulation of ERK1 and ERK2 cascade	Prmt5	IMP		Rat	PMID:21917714\|RGD:9491825
Biological Process	GO:0048742	regulation of skeletal muscle fiber development	prmt5	IMP	ZFIN:ZDB-MRPHLNO-111103-3	Zfish	PMID:22016767
Biological Process	GO:0000387	spliceosomal snRNP assembly	PRMT5	IMP		Human	PMID:17709427

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/29/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.