Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PROC
  • Mouse genes Proc
  • Rat genes Proc
  • Zfish genes proca
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Proc

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0070012	oligopeptidase activity	Proc	IDA		Rat	PMID:1440533|RGD:11100042
Molecular Function	GO:0008233	peptidase activity	Proc	IDA		Mouse	PMID:9616155
Molecular Function	GO:0005515	protein binding	PROC	IPI	UniProtKB:P51511	Human	PMID:15248212
Molecular Function	GO:0005515	protein binding	PROC	IPI	UniProtKB:A8MQ03	Human	PMID:32296183
Molecular Function	GO:0043621	protein self-association	Proc	IDA		Rat	PMID:1440533|RGD:11100042
Molecular Function	GO:0004252	serine-type endopeptidase activity	PROC	IMP		Human	PMID:25748729
Cellular Component	GO:0005783	endoplasmic reticulum	PROC	IDA		Human	PMID:25748729
Cellular Component	GO:0005615	extracellular space	Proc	IDA		Rat	PMID:16522789|RGD:1601502
Cellular Component	GO:0005794	Golgi apparatus	PROC	IDA		Human	PMID:25748729
Biological Process	GO:0001889	liver development	Proc	IMP	MGI:MGI:2183063	Mouse	PMID:9788960
Biological Process	GO:0001889	liver development	Proc	IEP		Rat	PMID:7660357|RGD:1299299
Biological Process	GO:0043066	negative regulation of apoptotic process	PROC	IMP		Human	PMID:12563316
Biological Process	GO:0030195	negative regulation of blood coagulation	Proc	IDA		Mouse	PMID:9616155
Biological Process	GO:0030195	negative regulation of blood coagulation	Proc	IMP	MGI:MGI:2183063	Mouse	PMID:9788960
Biological Process	GO:0030195	negative regulation of blood coagulation	Proc	IDA		Rat	PMID:1440533|RGD:11100042
Biological Process	GO:0050819	negative regulation of coagulation	PROC	IMP		Human	PMID:25651845
Biological Process	GO:0050728	negative regulation of inflammatory response	PROC	IMP		Human	PMID:25651845
Biological Process	GO:1903142	positive regulation of establishment of endothelial barrier	PROC	IMP		Human	PMID:25651845
Biological Process	GO:0030163	protein catabolic process	Proc	IDA		Rat	PMID:1440533|RGD:11100042
Biological Process	GO:0044537	regulation of circulating fibrinogen levels	Proc	IMP	MGI:MGI:2183063	Mouse	PMID:9788960

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern