Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PROK2
  • Mouse genes Prok2
  • Rat genes Prok2
  • Zfish genes prok2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Prok2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001664	G protein-coupled receptor binding	Prok2	IDA		Rat	PMID:12054613|RGD:632409
Molecular Function	GO:0005515	protein binding	PROK2	IPI	UniProtKB:Q969X1	Human	PMID:32296183
Biological Process	GO:0001525	angiogenesis	PROK2	IDA		Human	PMID:12604792
Biological Process	GO:0001525	angiogenesis	prok2	IMP	ZFIN:ZDB-MRPHLNO-190405-4	Zfish	PMID:29545372
Biological Process	GO:0001525	angiogenesis	prok2	IMP	ZFIN:ZDB-GENO-190808-3	Zfish	PMID:29545372
Biological Process	GO:0006935	chemotaxis	PROK2	IDA		Human	PMID:12604792
Biological Process	GO:0007623	circadian rhythm	Prok2	IDA		Mouse	PMID:12024206
Biological Process	GO:0001935	endothelial cell proliferation	PROK2	IDA		Human	PMID:12604792
Biological Process	GO:0043066	negative regulation of apoptotic process	PROK2	IDA		Human	PMID:12604792
Biological Process	GO:0045987	positive regulation of smooth muscle contraction	PROK2	IDA		Human	PMID:11259612
Biological Process	GO:0009416	response to light stimulus	prok2	IMP	ZFIN:ZDB-GENO-171106-10	Zfish	PMID:28648499
Biological Process	GO:0009416	response to light stimulus	prok2	IGI	ZFIN:ZDB-GENE-111117-2	Zfish	PMID:28648499
Biological Process	GO:0009416	response to light stimulus	prok2	IGI	ZFIN:ZDB-GENE-081113-2	Zfish	PMID:28648499
Biological Process	GO:0009416	response to light stimulus	prok2	IMP	ZFIN:ZDB-GENO-080514-1	Zfish	PMID:28648499
Biological Process	GO:0030431	sleep	prok2	IGI	ZFIN:ZDB-GENE-111117-2	Zfish	PMID:28648499
Biological Process	GO:0030431	sleep	prok2	IMP	ZFIN:ZDB-GENO-080514-1	Zfish	PMID:28648499
Biological Process	GO:0030431	sleep	prok2	IMP	ZFIN:ZDB-GENO-171106-10	Zfish	PMID:28648499
Biological Process	GO:0030431	sleep	prok2	IGI	ZFIN:ZDB-GENE-081113-2	Zfish	PMID:28648499
Biological Process	GO:0007283	spermatogenesis	PROK2	IMP		Human	PMID:10580115

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern