Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PROX1
  • Mouse genes Prox1
  • Rat genes Prox1
  • Zfish genes prox1a
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Prox1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	PROX1	IMP		Human	PMID:18815287
Molecular Function	GO:0050692	DNA binding domain binding	PROX1	IPI	UniProtKB:O00482	Human	PMID:15205472
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Prox1	IDA		Mouse	MGI:MGI:3830437|PMID:19091769
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Prox1	IDA		Mouse	PMID:16291864
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	PROX1	IDA		Human	PMID:15143342
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	PROX1	IDA		Human	PMID:15205472
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	PROX1	IDA		Human	PMID:16488887
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	PROX1	IDA		Human	PMID:19264593
Molecular Function	GO:0050693	LBD domain binding	PROX1	IPI	UniProtKB:O00482	Human	PMID:15143342
Molecular Function	GO:0050693	LBD domain binding	PROX1	IPI	UniProtKB:O00482	Human	PMID:15205472
Molecular Function	GO:0016922	nuclear receptor binding	PROX1	IPI	UniProtKB:O00482	Human	PMID:15143342
Molecular Function	GO:0016922	nuclear receptor binding	PROX1	IPI	UniProtKB:O00482	Human	PMID:15205472
Molecular Function	GO:0016922	nuclear receptor binding	PROX1	IPI	UniProtKB:P41235	Human	PMID:16488887
Molecular Function	GO:0005515	protein binding	PROX1	IPI	UniProtKB:O00482-2	Human	PMID:15205472
Molecular Function	GO:0005515	protein binding	PROX1	IPI	UniProtKB:P41235	Human	PMID:16488887
Molecular Function	GO:0005515	protein binding	PROX1	IPI	UniProtKB:P24468	Human	PMID:18815287
Molecular Function	GO:0005515	protein binding	PROX1	IPI	UniProtKB:P24468	Human	PMID:19210544
Molecular Function	GO:0005515	protein binding	PROX1	IPI	UniProtKB:O00482	Human	PMID:19264593
Molecular Function	GO:0005515	protein binding	PROX1	IPI	UniProtKB:P20823	Human	PMID:19264593
Molecular Function	GO:0005515	protein binding	PROX1	IPI	UniProtKB:P56545	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	Prox1	IPI	UniProtKB:P51448|UniProtKB:P51450	Mouse	MGI:MGI:5582866|PMID:23723244
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Prox1	IDA		Mouse	MGI:MGI:5582866|PMID:23723244
Molecular Function	GO:0043565	sequence-specific DNA binding	Prox1	IDA		Mouse	PMID:21040746
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	PROX1	IDA		Human	PMID:28473536
Molecular Function	GO:0000976	transcription cis-regulatory region binding	PROX1	IDA		Human	PMID:19210544
Cellular Component	GO:0005737	cytoplasm	PROX1	IDA		Human	PMID:11850194
Cellular Component	GO:0005737	cytoplasm	Prox1	IDA		Mouse	MGI:MGI:3836138|PMID:11850194
Cellular Component	GO:0005829	cytosol	PROX1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	PROX1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	PROX1	IDA		Human	PMID:11850194
Cellular Component	GO:0005634	nucleus	PROX1	IDA		Human	PMID:15143342
Cellular Component	GO:0005634	nucleus	PROX1	IDA		Human	PMID:15205472
Cellular Component	GO:0005634	nucleus	PROX1	IDA		Human	PMID:19210544
Cellular Component	GO:0005634	nucleus	Prox1	IDA		Mouse	MGI:MGI:5582866|PMID:23723244
Cellular Component	GO:0005634	nucleus	Prox1	IDA		Mouse	MGI:MGI:3836138|PMID:11850194
Cellular Component	GO:0005634	nucleus	Prox1	IDA		Mouse	MGI:MGI:3830437|PMID:19091769
Cellular Component	GO:0005634	nucleus	Prox1	IDA		Mouse	PMID:19023449
Cellular Component	GO:0005634	nucleus	Prox1	IDA		Mouse	PMID:21300049
Cellular Component	GO:0005634	nucleus	Prox1	IDA		Mouse	PMID:21040746
Cellular Component	GO:0005634	nucleus	Prox1	IDA		Rat	PMID:18663461|RGD:5133271
Cellular Component	GO:0005634	nucleus	prox1a	IDA		Zfish	PMID:11410536
Cellular Component	GO:0005634	nucleus	prox1a	IDA		Zfish	PMID:15647323
Biological Process	GO:0090425	acinar cell differentiation	Prox1	IMP	MGI:MGI:3609548	Mouse	PMID:22178591
Biological Process	GO:0060414	aorta smooth muscle tissue morphogenesis	Prox1	IMP		Mouse	MGI:MGI:3830437|PMID:19091769
Biological Process	GO:0055009	atrial cardiac muscle tissue morphogenesis	Prox1	IMP		Mouse	MGI:MGI:3830437|PMID:19091769
Biological Process	GO:0060837	blood vessel endothelial cell differentiation	Prox1	IMP	MGI:MGI:2386336	Mouse	PMID:11927535
Biological Process	GO:0007420	brain development	PROX1	IEP		Human	PMID:8812486
Biological Process	GO:0007420	brain development	Prox1	IEP		Rat	PMID:17368742|RGD:5133272
Biological Process	GO:0061114	branching involved in pancreas morphogenesis	Prox1	IMP	MGI:MGI:3609548	Mouse	PMID:22178591
Biological Process	GO:0008283	cell population proliferation	Prox1	IMP	MGI:MGI:2386336	Mouse	PMID:12692551
Biological Process	GO:0021707	cerebellar granule cell differentiation	Prox1	IMP		Mouse	MGI:MGI:4849596|PMID:20808958
Biological Process	GO:0007623	circadian rhythm	Prox1	IEP		Mouse	MGI:MGI:5582866|PMID:23723244
Biological Process	GO:0021542	dentate gyrus development	Prox1	IMP		Mouse	MGI:MGI:4849596|PMID:20808958
Biological Process	GO:0060059	embryonic retina morphogenesis in camera-type eye	PROX1	IEP		Human	PMID:12692551
Biological Process	GO:0060059	embryonic retina morphogenesis in camera-type eye	Prox1	IEP		Mouse	MGI:MGI:2658694|PMID:12692551
Biological Process	GO:0060214	endocardium formation	Prox1	IMP		Mouse	MGI:MGI:3830437|PMID:19091769
Biological Process	GO:0010631	epithelial cell migration	Prox1	IMP	MGI:MGI:2386336	Mouse	PMID:10888866
Biological Process	GO:0021884	forebrain neuron development	prox1a	IMP	ZFIN:ZDB-MRPHLNO-050225-3	Zfish	PMID:18331627
Biological Process	GO:0002194	hepatocyte cell migration	Prox1	IMP	MGI:MGI:2386336	Mouse	PMID:10888866
Biological Process	GO:0070365	hepatocyte differentiation	PROX1	IEP		Human	PMID:15232737
Biological Process	GO:0070365	hepatocyte differentiation	Prox1	IEP		Mouse	MGI:MGI:4367343|PMID:15232737
Biological Process	GO:0072574	hepatocyte proliferation	Prox1	IMP	MGI:MGI:2386336	Mouse	PMID:10888866
Biological Process	GO:0048839	inner ear development	Prox1	IMP	MGI:MGI:2386336	Mouse	PMID:20186345
Biological Process	GO:0001822	kidney development	PROX1	IEP		Human	PMID:8812486
Biological Process	GO:0002088	lens development in camera-type eye	PROX1	IEP		Human	PMID:8812486
Biological Process	GO:0070309	lens fiber cell morphogenesis	PROX1	IEP		Human	PMID:11850194
Biological Process	GO:0070309	lens fiber cell morphogenesis	Prox1	IMP		Mouse	MGI:MGI:1332720|PMID:10080188
Biological Process	GO:0002089	lens morphogenesis in camera-type eye	Prox1	IMP		Mouse	MGI:MGI:1332720|PMID:10080188
Biological Process	GO:0046619	lens placode formation involved in camera-type eye formation	Prox1	IEP		Mouse	MGI:MGI:3836138|PMID:11850194
Biological Process	GO:0001889	liver development	PROX1	IEP		Human	PMID:11789987
Biological Process	GO:0001889	liver development	Prox1	IEP		Rat	PMID:16770575|RGD:5133274
Biological Process	GO:0030324	lung development	PROX1	IEP		Human	PMID:8812486
Biological Process	GO:0001945	lymph vessel development	Prox1	IMP	MGI:MGI:2450311,MGI:MGI:3609548	Mouse	PMID:16170315
Biological Process	GO:0001946	lymphangiogenesis	PROX1	IDA		Human	PMID:12412020
Biological Process	GO:0001946	lymphangiogenesis	prox1a	IGI	ZFIN:ZDB-MRPHLNO-050225-3,ZFIN:ZDB-MRPHLNO-051212-3	Zfish	PMID:18300419
Biological Process	GO:0001946	lymphangiogenesis	prox1a	IGI	ZFIN:ZDB-MRPHLNO-101105-7	Zfish	PMID:20976189
Biological Process	GO:0001946	lymphangiogenesis	prox1a	IMP	ZFIN:ZDB-MRPHLNO-050225-3	Zfish	PMID:20549745
Biological Process	GO:0060836	lymphatic endothelial cell differentiation	PROX1	IDA		Human	PMID:12198161
Biological Process	GO:0060836	lymphatic endothelial cell differentiation	Prox1	IMP	MGI:MGI:2182767,MGI:MGI:3609548	Mouse	PMID:19056883
Biological Process	GO:0060838	lymphatic endothelial cell fate commitment	PROX1	IMP		Human	PMID:18815287
Biological Process	GO:0030239	myofibril assembly	prox1a	IMP		Zfish	PMID:11410536
Biological Process	GO:0070858	negative regulation of bile acid biosynthetic process	PROX1	IMP		Human	PMID:16488887
Biological Process	GO:0008285	negative regulation of cell population proliferation	PROX1	IMP		Human	PMID:17062673
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	PROX1	IDA		Human	PMID:15205472
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	PROX1	IDA		Human	PMID:16488887
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	prox1a	IDA		Zfish	PMID:14517294
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	PROX1	IDA		Human	PMID:15143342
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	PROX1	IDA		Human	PMID:15205472
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	PROX1	IMP		Human	PMID:16488887
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	PROX1	IMP		Human	PMID:23723244
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Prox1	IDA		Mouse	MGI:MGI:5582866|PMID:23723244
Biological Process	GO:0007406	negative regulation of neuroblast proliferation	Prox1	IMP	MGI:MGI:2386336	Mouse	PMID:12692551
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	PROX1	IDA		Human	PMID:15205472
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Prox1	IDA		Mouse	PMID:21040746
Biological Process	GO:0045071	negative regulation of viral genome replication	PROX1	IDA		Human	PMID:19264593
Biological Process	GO:0007405	neuroblast proliferation	Prox1	IMP	MGI:MGI:2386336	Mouse	PMID:12692551
Biological Process	GO:0048885	neuromast deposition	prox1a	IMP	ZFIN:ZDB-MRPHLNO-050225-3	Zfish	PMID:19948062
Biological Process	GO:0048886	neuromast hair cell differentiation	prox1a	IMP	ZFIN:ZDB-MRPHLNO-050225-3	Zfish	PMID:19948062
Biological Process	GO:0048664	neuron fate determination	Prox1	IMP	MGI:MGI:2386336	Mouse	PMID:12692551
Biological Process	GO:0097150	neuronal stem cell population maintenance	Prox1	IMP		Mouse	MGI:MGI:4849596|PMID:20808958
Biological Process	GO:0031016	pancreas development	PROX1	IEP		Human	PMID:11789987
Biological Process	GO:0045787	positive regulation of cell cycle	Prox1	IMP		Mouse	MGI:MGI:1332720|PMID:10080188
Biological Process	GO:1901978	positive regulation of cell cycle checkpoint	Prox1	IMP		Mouse	PMID:21040746
Biological Process	GO:0008284	positive regulation of cell population proliferation	PROX1	IDA		Human	PMID:12198161
Biological Process	GO:0008284	positive regulation of cell population proliferation	Prox1	IMP		Mouse	MGI:MGI:2658694|PMID:12692551
Biological Process	GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity	PROX1	IDA		Human	PMID:19210544
Biological Process	GO:0010595	positive regulation of endothelial cell migration	PROX1	IDA		Human	PMID:19210544
Biological Process	GO:0001938	positive regulation of endothelial cell proliferation	PROX1	IDA		Human	PMID:19210544
Biological Process	GO:2000979	positive regulation of forebrain neuron differentiation	Prox1	IMP		Mouse	MGI:MGI:4849596|PMID:20808958
Biological Process	GO:0060421	positive regulation of heart growth	Prox1	IMP		Mouse	MGI:MGI:3830437|PMID:19091769
Biological Process	GO:2000179	positive regulation of neural precursor cell proliferation	Prox1	IMP		Mouse	MGI:MGI:4849596|PMID:20808958
Biological Process	GO:0060298	positive regulation of sarcomere organization	Prox1	IMP		Mouse	MGI:MGI:3830437|PMID:19091769
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	PROX1	IMP		Human	PMID:18815287
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Prox1	IDA		Mouse	PMID:16291864
Biological Process	GO:0042752	regulation of circadian rhythm	PROX1	IMP		Human	PMID:23723244
Biological Process	GO:0010468	regulation of gene expression	PROX1	IDA		Human	PMID:12198161
Biological Process	GO:0010468	regulation of gene expression	Prox1	IMP		Mouse	MGI:MGI:1332720|PMID:10080188
Biological Process	GO:0031667	response to nutrient levels	Prox1	IEP		Rat	PMID:15827236|RGD:5133275
Biological Process	GO:0030240	skeletal muscle thin filament assembly	Prox1	IMP		Mouse	MGI:MGI:3830437|PMID:19091769
Biological Process	GO:0006366	transcription by RNA polymerase II	Prox1	IDA		Mouse	PMID:16291864
Biological Process	GO:0048845	venous blood vessel morphogenesis	Prox1	IMP		Mouse	MGI:MGI:3830437|PMID:19091769
Biological Process	GO:0055010	ventricular cardiac muscle tissue morphogenesis	Prox1	IMP		Mouse	MGI:MGI:3830437|PMID:19091769
Biological Process	GO:0055005	ventricular cardiac myofibril assembly	Prox1	IMP		Mouse	MGI:MGI:3830437|PMID:19091769
Biological Process	GO:0060412	ventricular septum morphogenesis	Prox1	IMP		Mouse	MGI:MGI:3830437|PMID:19091769

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern