Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PRPF19
  • Mouse genes Prpf19
  • Rat genes Prpf19
  • Zfish genes prpf19
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Prpf19

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	PRPF19	IPI	UniProtKB:Q9UMS4	Human	PMID:16332694
Molecular Function	GO:0005515	protein binding	PRPF19	IPI	UniProtKB:P27695	Human	PMID:19188445
Molecular Function	GO:0005515	protein binding	PRPF19	IPI	UniProtKB:Q99459	Human	PMID:19633697
Molecular Function	GO:0005515	protein binding	PRPF19	IPI	UniProtKB:Q7Z7F0	Human	PMID:19641227
Molecular Function	GO:0005515	protein binding	PRPF19	IPI	UniProtKB:O43660	Human	PMID:20176811
Molecular Function	GO:0005515	protein binding	PRPF19	IPI	UniProtKB:O75934	Human	PMID:20176811
Molecular Function	GO:0005515	protein binding	PRPF19	IPI	UniProtKB:Q99459	Human	PMID:20176811
Molecular Function	GO:0005515	protein binding	PRPF19	IPI	UniProtKB:Q99459	Human	PMID:20467437
Molecular Function	GO:0005515	protein binding	PRPF19	IPI	UniProtKB:O43395	Human	PMID:20595234
Molecular Function	GO:0005515	protein binding	PRPF19	IPI	UniProtKB:P26368	Human	PMID:21536736
Molecular Function	GO:0005515	protein binding	PRPF19	IPI	UniProtKB:O60508	Human	PMID:22365833
Molecular Function	GO:0005515	protein binding	PRPF19	IPI	UniProtKB:O75934	Human	PMID:22365833
Molecular Function	GO:0005515	protein binding	PRPF19	IPI	UniProtKB:P52756	Human	PMID:22365833
Molecular Function	GO:0005515	protein binding	PRPF19	IPI	UniProtKB:P98175	Human	PMID:22365833
Molecular Function	GO:0005515	protein binding	PRPF19	IPI	UniProtKB:Q6P2Q9	Human	PMID:22365833
Molecular Function	GO:0005515	protein binding	PRPF19	IPI	UniProtKB:P52756	Human	PMID:22569250
Molecular Function	GO:0005515	protein binding	PRPF19	IPI	UniProtKB:Q9HCG8	Human	PMID:22961380
Molecular Function	GO:0005515	protein binding	PRPF19	IPI	UniProtKB:Q9BQ65	Human	PMID:23022480
Molecular Function	GO:0005515	protein binding	PRPF19	IPI	UniProtKB:O60508	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	PRPF19	IPI	UniProtKB:O75934	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	PRPF19	IPI	UniProtKB:Q99459	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	Prpf19	IPI	UniProtKB:P62196	Mouse	MGI:MGI:5586800|PMID:17349974
Molecular Function	GO:0005515	protein binding	Prpf19	IPI	UniProtKB:O08837	Rat	PMID:16352598|RGD:10047232
Molecular Function	GO:0061630	ubiquitin protein ligase activity	PRPF19	IDA		Human	PMID:11435423
Molecular Function	GO:0061630	ubiquitin protein ligase activity	PRPF19	IMP		Human	PMID:20595234
Molecular Function	GO:0034450	ubiquitin-ubiquitin ligase activity	PRPF19	IDA		Human	PMID:11435423
Cellular Component	GO:0071013	catalytic step 2 spliceosome	PRPF19	IDA		Human	PMID:11991638
Cellular Component	GO:0005737	cytoplasm	PRPF19	IDA		Human	PMID:11435423
Cellular Component	GO:0016020	membrane	PRPF19	HDA		Human	PMID:19946888
Cellular Component	GO:0016607	nuclear speck	PRPF19	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016607	nuclear speck	PRPF19	IDA		Human	PMID:16332694
Cellular Component	GO:0016607	nuclear speck	PRPF19	IDA		Human	PMID:24332808
Cellular Component	GO:0005634	nucleus	PRPF19	IDA		Human	PMID:11435423
Cellular Component	GO:0005634	nucleus	PRPF19	IDA		Human	PMID:19188445
Cellular Component	GO:0005634	nucleus	Prpf19	IDA		Mouse	PMID:18480465
Cellular Component	GO:0005634	nucleus	Prpf19	IDA		Rat	PMID:16352598|RGD:10047232
Cellular Component	GO:0000974	Prp19 complex	PRPF19	IPI		Human	PMID:20176811
Cellular Component	GO:0000974	Prp19 complex	PRPF19	IDA		Human	PMID:20176811
Cellular Component	GO:0035861	site of double-strand break	PRPF19	IDA		Human	PMID:18263876
Cellular Component	GO:0005681	spliceosomal complex	PRPF19	IPI		Human	PMID:20176811
Cellular Component	GO:0071007	U2-type catalytic step 2 spliceosome	PRPF19	IDA		Human	PMID:28076346
Biological Process	GO:0000077	DNA damage checkpoint signaling	PRPF19	IMP		Human	PMID:24332808
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	PRPF19	IMP		Human	PMID:18263876
Biological Process	GO:0008610	lipid biosynthetic process	Prpf19	IDA		Mouse	PMID:17118936
Biological Process	GO:0000398	mRNA splicing, via spliceosome	PRPF19	IDA		Human	PMID:20176811
Biological Process	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator	prpf19	IGI	ZFIN:ZDB-MRPHLNO-090610-4,ZFIN:ZDB-MRPHLNO-120919-1	Zfish	PMID:22952453
Biological Process	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator	prpf19	IMP	ZFIN:ZDB-MRPHLNO-120919-2	Zfish	PMID:22952453
Biological Process	GO:0048711	positive regulation of astrocyte differentiation	Prpf19	IMP		Rat	PMID:23769735|RGD:10045891
Biological Process	GO:0048026	positive regulation of mRNA splicing, via spliceosome	Prpf19	IMP		Mouse	PMID:18480465
Biological Process	GO:0045666	positive regulation of neuron differentiation	Prpf19	IDA		Rat	PMID:16352598|RGD:10047232
Biological Process	GO:0010498	proteasomal protein catabolic process	PRPF19	IMP		Human	PMID:17349974
Biological Process	GO:0010498	proteasomal protein catabolic process	Prpf19	IMP		Mouse	MGI:MGI:5586800|PMID:17349974
Biological Process	GO:0070534	protein K63-linked ubiquitination	PRPF19	IMP		Human	PMID:20595234
Biological Process	GO:0070534	protein K63-linked ubiquitination	PRPF19	IMP		Human	PMID:24332808
Biological Process	GO:0008104	protein localization	PRPF19	IMP		Human	PMID:18263876
Biological Process	GO:0000209	protein polyubiquitination	PRPF19	IDA		Human	PMID:11435423
Biological Process	GO:0000245	spliceosomal complex assembly	PRPF19	IMP		Human	PMID:16332694
Biological Process	GO:0000244	spliceosomal tri-snRNP complex assembly	PRPF19	IDA		Human	PMID:20595234

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern