Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PRPF8
  • Mouse genes Prpf8
  • Rat genes Prpf8
  • Zfish genes prpf8
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Prpf8

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0070530	K63-linked polyubiquitin modification-dependent protein binding	PRPF8	IDA		Human	PMID:20595234
Molecular Function	GO:0005515	protein binding	PRPF8	IPI	UniProtKB:O75643	Human	PMID:16723661
Molecular Function	GO:0005515	protein binding	PRPF8	IPI	UniProtKB:O94906	Human	PMID:16723661
Molecular Function	GO:0005515	protein binding	PRPF8	IPI	UniProtKB:Q15029	Human	PMID:16723661
Molecular Function	GO:0005515	protein binding	PRPF8	IPI	UniProtKB:P52756	Human	PMID:18951082
Molecular Function	GO:0005515	protein binding	PRPF8	IPI	UniProtKB:Q6Y7W6	Human	PMID:20696395
Molecular Function	GO:0005515	protein binding	PRPF8	IPI	UniProtKB:O75934	Human	PMID:22365833
Molecular Function	GO:0005515	protein binding	PRPF8	IPI	UniProtKB:O95391	Human	PMID:22365833
Molecular Function	GO:0005515	protein binding	PRPF8	IPI	UniProtKB:Q13435	Human	PMID:22365833
Molecular Function	GO:0005515	protein binding	PRPF8	IPI	UniProtKB:Q15365	Human	PMID:22365833
Molecular Function	GO:0005515	protein binding	PRPF8	IPI	UniProtKB:Q15427	Human	PMID:22365833
Molecular Function	GO:0005515	protein binding	PRPF8	IPI	UniProtKB:Q92917	Human	PMID:22365833
Molecular Function	GO:0005515	protein binding	PRPF8	IPI	UniProtKB:Q96NB3	Human	PMID:22365833
Molecular Function	GO:0005515	protein binding	PRPF8	IPI	UniProtKB:Q9BRX9	Human	PMID:22365833
Molecular Function	GO:0005515	protein binding	PRPF8	IPI	UniProtKB:Q9UMS4	Human	PMID:22365833
Molecular Function	GO:0005515	protein binding	PRPF8	IPI	UniProtKB:Q8IWS0	Human	PMID:22720776
Molecular Function	GO:0005515	protein binding	PRPF8	IPI	UniProtKB:O75643-1	Human	PMID:23704370
Molecular Function	GO:0005515	protein binding	PRPF8	IPI	UniProtKB:P52298,UniProtKB:Q09161	Human	PMID:23793891
Molecular Function	GO:0005515	protein binding	PRPF8	IPI	UniProtKB:O95905	Human	PMID:26711270
Molecular Function	GO:0005515	protein binding	PRPF8	IPI	UniProtKB:O94906	Human	PMID:27173435
Molecular Function	GO:0005515	protein binding	PRPF8	IPI	UniProtKB:O95905	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	PRPF8	IPI	UniProtKB:Q96DI7	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	PRPF8	IPI	UniProtKB:P54253	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PRPF8	IPI	UniProtKB:Q13148	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PRPF8	IPI	UniProtKB:O75643	Human	PMID:9774689
Molecular Function	GO:0005515	protein binding	PRPF8	IPI	UniProtKB:Q15029	Human	PMID:9774689
Molecular Function	GO:0005515	protein binding	PRPF8	IPI	UniProtKB:Q96DI7	Human	PMID:9774689
Molecular Function	GO:0005515	protein binding	Prpf8	IPI	RGD:1310194	Rat	PMID:1707521|RGD:10045883
Molecular Function	GO:0003723	RNA binding	PRPF8	HDA		Human	PMID:22658674
Molecular Function	GO:0003723	RNA binding	PRPF8	HDA		Human	PMID:22681889
Cellular Component	GO:0071013	catalytic step 2 spliceosome	PRPF8	IDA		Human	PMID:11991638
Cellular Component	GO:0016020	membrane	PRPF8	HDA		Human	PMID:19946888
Cellular Component	GO:0005634	nucleus	PRPF8	IDA		Human	PMID:22720776
Cellular Component	GO:0005634	nucleus	PRPF8	IDA		Human	PMID:28781166
Cellular Component	GO:0005634	nucleus	PRPF8	IDA		Human	PMID:29301961
Cellular Component	GO:0030532	small nuclear ribonucleoprotein complex	Prpf8	IDA		Rat	PMID:1707521|RGD:10045883
Cellular Component	GO:0071006	U2-type catalytic step 1 spliceosome	PRPF8	IDA		Human	PMID:29301961
Cellular Component	GO:0071007	U2-type catalytic step 2 spliceosome	PRPF8	IDA		Human	PMID:28076346
Cellular Component	GO:0071005	U2-type precatalytic spliceosome	PRPF8	IDA		Human	PMID:28781166
Cellular Component	GO:0071005	U2-type precatalytic spliceosome	PRPF8	IDA		Human	PMID:29361316
Cellular Component	GO:0071005	U2-type precatalytic spliceosome	PRPF8	IDA		Human	PMID:30315277
Cellular Component	GO:0046540	U4/U6 x U5 tri-snRNP complex	PRPF8	IPI		Human	PMID:30975767
Cellular Component	GO:0046540	U4/U6 x U5 tri-snRNP complex	PRPF8	IDA		Human	PMID:23793891
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Prpf8	IDA		Rat	PMID:1345341|RGD:10045884
Biological Process	GO:0071356	cellular response to tumor necrosis factor	Prpf8	IDA		Rat	PMID:1345341|RGD:10045884
Biological Process	GO:0000398	mRNA splicing, via spliceosome	PRPF8	IDA		Human	PMID:28781166
Biological Process	GO:0000398	mRNA splicing, via spliceosome	PRPF8	IDA		Human	PMID:29301961
Biological Process	GO:0000244	spliceosomal tri-snRNP complex assembly	PRPF8	IDA		Human	PMID:20595234
Biological Process	GO:0000244	spliceosomal tri-snRNP complex assembly	prpf8	IMP	ZFIN:ZDB-GENO-130925-17	Zfish	PMID:23714367

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern