Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PRRX1
  • Mouse genes Prrx1
  • Rat genes Prrx1
  • Zfish genes prrx1a,prrx1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Prrx1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	Prrx1	IDA		Mouse	PMID:15459107
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PRRX1	IDA		Human	PMID:9334314
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Prrx1	IDA		Mouse	PMID:23447615
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Prrx1	IDA		Mouse	MGI:MGI:5304254|PMID:20683885
Molecular Function	GO:0071837	HMG box domain binding	Prrx1	IPI	UniProtKB:Q04886	Mouse	MGI:MGI:5284787|PMID:16582099
Molecular Function	GO:0005515	protein binding	PRRX1	IPI	UniProtKB:P51687	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PRRX1	IPI	UniProtKB:Q9BW66	Human	PMID:32296183
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	PRRX1	IDA		Human	PMID:1509260
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Prrx1	IDA		Mouse	MGI:MGI:5304254|PMID:20683885
Molecular Function	GO:0016251	RNA polymerase II general transcription initiation factor activity	Prrx1	IDA		Mouse	PMID:32188878
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	PRRX1	IPI	UniProtKB:P78347	Human	PMID:9334314
Cellular Component	GO:0005829	cytosol	PRRX1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	PRRX1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Prrx1	IDA		Mouse	PMID:23447615
Cellular Component	GO:0005634	nucleus	Prrx1	IDA		Mouse	PMID:11748565
Biological Process	GO:0048844	artery morphogenesis	Prrx1	IGI	MGI:MGI:98218	Mouse	PMID:10664157
Biological Process	GO:0048844	artery morphogenesis	Prrx1	IMP	MGI:MGI:1857640	Mouse	PMID:10664157
Biological Process	GO:0086014	atrial cardiac muscle cell action potential	prrx1a	IMP	ZFIN:ZDB-MRPHLNO-181025-3	Zfish	PMID:28974514
Biological Process	GO:0086014	atrial cardiac muscle cell action potential	prrx1a	IMP	ZFIN:ZDB-MRPHLNO-161010-3	Zfish	PMID:28974514
Biological Process	GO:0051216	cartilage development	Prrx1	IMP	MGI:MGI:1857640	Mouse	PMID:7758948
Biological Process	GO:0051216	cartilage development	Prrx1	IGI	MGI:MGI:98218	Mouse	PMID:9876178
Biological Process	GO:1904888	cranial skeletal system development	prrx1a	IMP	ZFIN:ZDB-GENO-170623-1	Zfish	PMID:27058748
Biological Process	GO:1904888	cranial skeletal system development	prrx1b	IMP	ZFIN:ZDB-GENO-170623-1	Zfish	PMID:27058748
Biological Process	GO:0048701	embryonic cranial skeleton morphogenesis	Prrx1	IGI	MGI:MGI:98218	Mouse	PMID:9729491
Biological Process	GO:0048701	embryonic cranial skeleton morphogenesis	Prrx1	IMP	MGI:MGI:1857640	Mouse	PMID:7758948
Biological Process	GO:0030326	embryonic limb morphogenesis	Prrx1	IGI	MGI:MGI:98218	Mouse	PMID:9882503
Biological Process	GO:0030326	embryonic limb morphogenesis	Prrx1	IGI	MGI:MGI:98218	Mouse	PMID:9729491
Biological Process	GO:0048704	embryonic skeletal system morphogenesis	Prrx1	IMP	MGI:MGI:1857640	Mouse	PMID:7758948
Biological Process	GO:0048704	embryonic skeletal system morphogenesis	Prrx1	IGI	MGI:MGI:98218	Mouse	PMID:9729491
Biological Process	GO:0048704	embryonic skeletal system morphogenesis	Prrx1	IGI	MGI:MGI:98218	Mouse	PMID:9876178
Biological Process	GO:0048704	embryonic skeletal system morphogenesis	Prrx1	IGI	MGI:MGI:98218	Mouse	PMID:11532916
Biological Process	GO:0001837	epithelial to mesenchymal transition	prrx1a	IMP	ZFIN:ZDB-MRPHLNO-161010-3	Zfish	PMID:23201163
Biological Process	GO:0001947	heart looping	prrx1a	IMP	ZFIN:ZDB-CRISPR-171102-2	Zfish	PMID:28880281
Biological Process	GO:0001947	heart looping	prrx1a	IMP	ZFIN:ZDB-MRPHLNO-161010-3	Zfish	PMID:28880281
Biological Process	GO:0001947	heart looping	prrx1a	IMP	ZFIN:ZDB-CRISPR-171102-1	Zfish	PMID:28880281
Biological Process	GO:0001947	heart looping	prrx1a	IMP	ZFIN:ZDB-MRPHLNO-161010-4	Zfish	PMID:28880281
Biological Process	GO:0042472	inner ear morphogenesis	Prrx1	IGI	MGI:MGI:98218	Mouse	PMID:9729491
Biological Process	GO:0010463	mesenchymal cell proliferation	Prrx1	IGI	MGI:MGI:98218	Mouse	PMID:11532916
Biological Process	GO:0042474	middle ear morphogenesis	Prrx1	IMP	MGI:MGI:1857640	Mouse	PMID:7758948
Biological Process	GO:0042474	middle ear morphogenesis	Prrx1	IGI	MGI:MGI:98218	Mouse	PMID:9729491
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Prrx1	IDA		Mouse	MGI:MGI:5304254|PMID:20683885
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Prrx1	IDA		Rat	PMID:8749718|RGD:729501
Biological Process	GO:0048664	neuron fate determination	Prrx1	IDA		Mouse	PMID:23447615
Biological Process	GO:0097150	neuronal stem cell population maintenance	Prrx1	IDA		Mouse	PMID:23447615
Biological Process	GO:0010628	positive regulation of gene expression	prrx1b	IMP	ZFIN:ZDB-MRPHLNO-100506-3	Zfish	PMID:19517572
Biological Process	GO:0002053	positive regulation of mesenchymal cell proliferation	Prrx1	IGI	MGI:MGI:98218	Mouse	PMID:11532916
Biological Process	GO:0045880	positive regulation of smoothened signaling pathway	Prrx1	IGI	MGI:MGI:98218	Mouse	PMID:11532916
Biological Process	GO:2000648	positive regulation of stem cell proliferation	Prrx1	IGI	MGI:MGI:98218	Mouse	PMID:11532916
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	PRRX1	IDA		Human	PMID:9334314
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Prrx1	IDA		Mouse	PMID:23447615
Biological Process	GO:0070570	regulation of neuron projection regeneration	Prrx1	IMP		Mouse	PMID:23447615
Biological Process	GO:0060021	roof of mouth development	Prrx1	IMP	MGI:MGI:1857640	Mouse	PMID:7758948
Biological Process	GO:0007224	smoothened signaling pathway	Prrx1	IGI	MGI:MGI:98218	Mouse	PMID:11532916
Biological Process	GO:0072089	stem cell proliferation	Prrx1	IGI	MGI:MGI:98218	Mouse	PMID:11532916

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern