Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PSEN2
  • Mouse genes Psen2
  • Rat genes Psen2
  • Zfish genes psen2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Psen2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042500	aspartic endopeptidase activity, intramembrane cleaving	Psen2	IMP	MGI:MGI:1930939	Mouse	PMID:12684521
Molecular Function	GO:0042500	aspartic endopeptidase activity, intramembrane cleaving	Psen2	IGI	MGI:MGI:1202717	Mouse	PMID:21206757
Molecular Function	GO:0042500	aspartic endopeptidase activity, intramembrane cleaving	Psen2	IMP		Mouse	PMID:21206757
Molecular Function	GO:0004175	endopeptidase activity	Psen2	IMP		Mouse	PMID:17556541
Molecular Function	GO:0004175	endopeptidase activity	Psen2	IGI	MGI:MGI:1202717	Mouse	PMID:17920016
Molecular Function	GO:0005515	protein binding	PSEN2	IPI	UniProtKB:Q99828	Human	PMID:10366599
Molecular Function	GO:0005515	protein binding	PSEN2	IPI	UniProtKB:P30626	Human	PMID:10748169
Molecular Function	GO:0005515	protein binding	PSEN2	IPI	UniProtKB:Q8WW43	Human	PMID:12297508
Molecular Function	GO:0005515	protein binding	PSEN2	IPI	UniProtKB:Q92542	Human	PMID:12297508
Molecular Function	GO:0005515	protein binding	PSEN2	IPI	UniProtKB:Q96BI3	Human	PMID:12297508
Molecular Function	GO:0005515	protein binding	PSEN2	IPI	UniProtKB:Q14204	Human	PMID:21163940
Molecular Function	GO:0005515	protein binding	PSEN2	IPI	UniProtKB:Q53EL6	Human	PMID:21163940
Molecular Function	GO:0005515	protein binding	PSEN2	IPI	UniProtKB:Q9BQ95	Human	PMID:21163940
Molecular Function	GO:0005515	protein binding	PSEN2	IPI	UniProtKB:A4FUJ8	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PSEN2	IPI	UniProtKB:O00472	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PSEN2	IPI	UniProtKB:O76041	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PSEN2	IPI	UniProtKB:O94851	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PSEN2	IPI	UniProtKB:O95416	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PSEN2	IPI	UniProtKB:P02792	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PSEN2	IPI	UniProtKB:P05067	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PSEN2	IPI	UniProtKB:P27986-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PSEN2	IPI	UniProtKB:P29466-3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PSEN2	IPI	UniProtKB:P41218	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PSEN2	IPI	UniProtKB:P54819	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PSEN2	IPI	UniProtKB:P68431	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PSEN2	IPI	UniProtKB:Q0P5N6	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PSEN2	IPI	UniProtKB:Q13113	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PSEN2	IPI	UniProtKB:Q16611	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PSEN2	IPI	UniProtKB:Q2NKQ1-4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PSEN2	IPI	UniProtKB:Q2QGD7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PSEN2	IPI	UniProtKB:Q3SY56	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PSEN2	IPI	UniProtKB:Q3SYB3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PSEN2	IPI	UniProtKB:Q86WV2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PSEN2	IPI	UniProtKB:Q8N488	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PSEN2	IPI	UniProtKB:Q8N895	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PSEN2	IPI	UniProtKB:Q8NBB4-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PSEN2	IPI	UniProtKB:Q8TDB4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PSEN2	IPI	UniProtKB:Q8WVV9-3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PSEN2	IPI	UniProtKB:Q96HT8	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PSEN2	IPI	UniProtKB:Q96NC0	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PSEN2	IPI	UniProtKB:Q99496	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PSEN2	IPI	UniProtKB:Q9BSL1	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PSEN2	IPI	UniProtKB:Q9GZS3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PSEN2	IPI	UniProtKB:Q9NSD5-3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PSEN2	IPI	UniProtKB:P05067	Human	PMID:9223340
Molecular Function	GO:0005515	protein binding	Psen2	IPI	PR:P57716	Mouse	PMID:15474363
Molecular Function	GO:0005515	protein binding	Psen2	IPI	PR:Q6P069	Mouse	PMID:16204356
Molecular Function	GO:0005515	protein binding	Psen2	IPI	PR:Q60625	Mouse	PMID:11719200
Molecular Function	GO:0005515	protein binding	Psen2	IPI	PR:Q9CQR7	Mouse	PMID:15474363
Molecular Function	GO:0005515	protein binding	Psen2	IPI	PR:Q8BVF7	Mouse	PMID:15474363
Molecular Function	GO:0005515	protein binding	Psen2	IPI	PR:E9Q401	Mouse	PMID:16204356
Cellular Component	GO:0005813	centrosome	PSEN2	IDA		Human	PMID:9298903
Cellular Component	GO:0036064	ciliary basal body	Psen2	IDA		Mouse	PMID:21703454
Cellular Component	GO:0005829	cytosol	Psen2	IDA		Mouse	PMID:9535056
Cellular Component	GO:0005769	early endosome	Psen2	IDA		Rat	PMID:20126630|RGD:13702254
Cellular Component	GO:0005783	endoplasmic reticulum	PSEN2	IDA		Human	PMID:15274632
Cellular Component	GO:0070765	gamma-secretase complex	PSEN2	IDA		Human	PMID:12297508
Cellular Component	GO:0070765	gamma-secretase complex	Psen2	IDA		Mouse	PMID:12684521
Cellular Component	GO:0098978	glutamatergic synapse	Psen2	IDA		Mouse	PMID:23083742
Cellular Component	GO:0098978	glutamatergic synapse	Psen2	IMP		Mouse	PMID:23083742
Cellular Component	GO:0098978	glutamatergic synapse	Psen2	IEP		Mouse	PMID:23083742
Cellular Component	GO:0005794	Golgi apparatus	PSEN2	IDA		Human	PMID:15274632
Cellular Component	GO:0000776	kinetochore	PSEN2	IDA		Human	PMID:9298903
Cellular Component	GO:0016020	membrane	PSEN2	HDA		Human	PMID:19946888
Cellular Component	GO:0016020	membrane	Psen2	IDA		Mouse	PMID:9535056
Cellular Component	GO:0016020	membrane	Psen2	IDA		Mouse	PMID:12684521
Cellular Component	GO:0016020	membrane	Psen2	IDA		Mouse	PMID:9950750
Cellular Component	GO:0016020	membrane	Psen2	IDA		Mouse	PMID:15886206
Cellular Component	GO:0043025	neuronal cell body	Psen2	IDA		Mouse	PMID:9203550
Cellular Component	GO:0005637	nuclear inner membrane	PSEN2	IDA		Human	PMID:9298903
Cellular Component	GO:0005886	plasma membrane	PSEN2	IDA		Human	PMID:15274632
Cellular Component	GO:0005886	plasma membrane	Psen2	IDA		Rat	PMID:20126630|RGD:13702254
Cellular Component	GO:0042734	presynaptic membrane	Psen2	IDA		Rat	PMID:20126630|RGD:13702254
Cellular Component	GO:0032991	protein-containing complex	PSEN2	IDA		Human	PMID:9632714
Cellular Component	GO:0097060	synaptic membrane	Psen2	IDA		Rat	PMID:20126630|RGD:13702254
Cellular Component	GO:0008021	synaptic vesicle	Psen2	IDA		Rat	PMID:20126630|RGD:13702254
Cellular Component	GO:0030018	Z disc	Psen2	IDA		Mouse	PMID:16204356
Biological Process	GO:0042987	amyloid precursor protein catabolic process	PSEN2	IDA		Human	PMID:27608597
Biological Process	GO:0034205	amyloid-beta formation	PSEN2	IDA		Human	PMID:27608597
Biological Process	GO:0034205	amyloid-beta formation	psen2	IMP	ZFIN:ZDB-MRPHLNO-080421-2	Zfish	PMID:23666177
Biological Process	GO:0050435	amyloid-beta metabolic process	Psen2	IMP	MGI:MGI:1930939	Mouse	PMID:12684521
Biological Process	GO:0050435	amyloid-beta metabolic process	Psen2	IDA		Mouse	PMID:10846187
Biological Process	GO:0042640	anagen	Psen2	IGI	MGI:MGI:1202717	Mouse	PMID:15525534
Biological Process	GO:0097190	apoptotic signaling pathway	Psen2	IGI	MGI:MGI:1202717	Mouse	PMID:15148382
Biological Process	GO:0007420	brain development	psen2	IMP	ZFIN:ZDB-MRPHLNO-060331-5	Zfish	PMID:19563801
Biological Process	GO:0007420	brain development	psen2	IMP	ZFIN:ZDB-MRPHLNO-080421-2	Zfish	PMID:19563801
Biological Process	GO:0048854	brain morphogenesis	Psen2	IGI	MGI:MGI:1202717	Mouse	PMID:17614943
Biological Process	GO:0006816	calcium ion transport	Psen2	IPI	PR:Q6P069	Mouse	PMID:16204356
Biological Process	GO:0006816	calcium ion transport	Psen2	IPI	UniProtKB:Q9ERN6	Mouse	PMID:16204356
Biological Process	GO:0060048	cardiac muscle contraction	Psen2	IMP	MGI:MGI:1930939	Mouse	PMID:16204356
Biological Process	GO:0001708	cell fate specification	Psen2	IGI	MGI:MGI:1202717	Mouse	PMID:15525534
Biological Process	GO:0021904	dorsal/ventral neural tube patterning	Psen2	IGI	MGI:MGI:1202717	Mouse	PMID:10557208
Biological Process	GO:0009790	embryo development	Psen2	IGI	MGI:MGI:1202717	Mouse	PMID:10557208
Biological Process	GO:0009790	embryo development	Psen2	IGI	MGI:MGI:1202717	Mouse	PMID:10518543
Biological Process	GO:0030326	embryonic limb morphogenesis	Psen2	IGI	MGI:MGI:1202717	Mouse	PMID:16169548
Biological Process	GO:0032469	endoplasmic reticulum calcium ion homeostasis	Psen2	IGI	MGI:MGI:1202717	Mouse	PMID:12460542
Biological Process	GO:0030900	forebrain development	Psen2	IGI	MGI:MGI:1202717	Mouse	PMID:15148382
Biological Process	GO:0001942	hair follicle development	Psen2	IGI	MGI:MGI:1202717	Mouse	PMID:10557208
Biological Process	GO:0002244	hematopoietic progenitor cell differentiation	Psen2	IGI	MGI:MGI:1202717	Mouse	PMID:15122901
Biological Process	GO:0032635	interleukin-6 production	Psen2	IGI	MGI:MGI:1202717	Mouse	PMID:21206757
Biological Process	GO:0032635	interleukin-6 production	Psen2	IMP		Mouse	PMID:21206757
Biological Process	GO:0007611	learning or memory	Psen2	IGI	MGI:MGI:1202717	Mouse	PMID:15066262
Biological Process	GO:0040011	locomotion	Psen2	IGI	MGI:MGI:1202717	Mouse	PMID:15148382
Biological Process	GO:0048286	lung alveolus development	Psen2	IMP	MGI:MGI:2149117	Mouse	PMID:10518543
Biological Process	GO:0010934	macrophage cytokine production	Psen2	IMP		Mouse	PMID:21206757
Biological Process	GO:0010934	macrophage cytokine production	Psen2	IGI	MGI:MGI:1202717	Mouse	PMID:21206757
Biological Process	GO:0030318	melanocyte differentiation	psen2	IMP	ZFIN:ZDB-MRPHLNO-060331-5	Zfish	PMID:19563801
Biological Process	GO:0030318	melanocyte differentiation	psen2	IMP	ZFIN:ZDB-MRPHLNO-080421-2	Zfish	PMID:19563801
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	PSEN2	IDA		Human	PMID:15274632
Biological Process	GO:0007613	memory	Psen2	IGI	MGI:MGI:1202717	Mouse	PMID:15148382
Biological Process	GO:0007613	memory	Psen2	IGI	MGI:MGI:1202717	Mouse	PMID:17614943
Biological Process	GO:1990456	mitochondrion-endoplasmic reticulum membrane tethering	PSEN2	IMP		Human	PMID:21285369
Biological Process	GO:0002573	myeloid leukocyte differentiation	Psen2	IGI	MGI:MGI:1202717	Mouse	PMID:15122901
Biological Process	GO:2001234	negative regulation of apoptotic signaling pathway	Psen2	IGI	MGI:MGI:1202717	Mouse	PMID:15148382
Biological Process	GO:0007175	negative regulation of epidermal growth factor-activated receptor activity	Psen2	IMP		Mouse	MGI:MGI:4887523|PMID:20208556
Biological Process	GO:0001933	negative regulation of protein phosphorylation	Psen2	IGI	MGI:MGI:1202717	Mouse	PMID:15148382
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Psen2	IMP		Mouse	MGI:MGI:4887523|PMID:20208556
Biological Process	GO:2000059	negative regulation of ubiquitin-dependent protein catabolic process	Psen2	IMP		Mouse	MGI:MGI:4887523|PMID:20208556
Biological Process	GO:0051444	negative regulation of ubiquitin-protein transferase activity	Psen2	IMP		Mouse	MGI:MGI:4887523|PMID:20208556
Biological Process	GO:0022008	neurogenesis	psen2	IMP	ZFIN:ZDB-MRPHLNO-080421-2	Zfish	PMID:19563801
Biological Process	GO:0150076	neuroinflammatory response	Psen2	IMP		Mouse	PMID:21206757
Biological Process	GO:0150076	neuroinflammatory response	Psen2	IGI	MGI:MGI:1202717	Mouse	PMID:21206757
Biological Process	GO:0070050	neuron cellular homeostasis	Psen2	IGI	UniProtKB:P49769	Mouse	MGI:MGI:5616965|PMID:25429133
Biological Process	GO:0007219	Notch signaling pathway	Psen2	IGI	MGI:MGI:1202717	Mouse	PMID:17698590
Biological Process	GO:0007219	Notch signaling pathway	psen2	IMP	ZFIN:ZDB-MRPHLNO-080421-2	Zfish	PMID:19563801
Biological Process	GO:0043065	positive regulation of apoptotic process	Psen2	IGI	MGI:MGI:1202717	Mouse	PMID:16169548
Biological Process	GO:0043085	positive regulation of catalytic activity	PSEN2	IDA		Human	PMID:15274632
Biological Process	GO:0050820	positive regulation of coagulation	Psen2	IMP	MGI:MGI:2664242	Mouse	PMID:12646573
Biological Process	GO:1902043	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors	Psen2	IDA		Mouse	PMID:8940094
Biological Process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	Psen2	IMP		Mouse	MGI:MGI:4887523|PMID:20208556
Biological Process	GO:0001921	positive regulation of receptor recycling	Psen2	IMP		Mouse	MGI:MGI:4887523|PMID:20208556
Biological Process	GO:0140249	protein catabolic process at postsynapse	Psen2	IDA		Mouse	PMID:23083742
Biological Process	GO:0140249	protein catabolic process at postsynapse	Psen2	IMP		Mouse	PMID:23083742
Biological Process	GO:0140249	protein catabolic process at postsynapse	Psen2	IEP		Mouse	PMID:23083742
Biological Process	GO:0051604	protein maturation	Psen2	IGI	MGI:MGI:1202717	Mouse	PMID:11943765
Biological Process	GO:0019538	protein metabolic process	Psen2	IGI	MGI:MGI:1202717	Mouse	PMID:17097608
Biological Process	GO:0016485	protein processing	PSEN2	IDA		Human	PMID:15274632
Biological Process	GO:0016485	protein processing	PSEN2	IDA		Human	PMID:27608597
Biological Process	GO:0016485	protein processing	Psen2	IGI	MGI:MGI:1202717	Mouse	PMID:15280425
Biological Process	GO:0015031	protein transport	Psen2	IGI	MGI:MGI:1202717	Mouse	PMID:11943765
Biological Process	GO:0110097	regulation of calcium import into the mitochondrion	PSEN2	IMP		Human	PMID:21285369
Biological Process	GO:0007176	regulation of epidermal growth factor-activated receptor activity	Psen2	IGI	MGI:MGI:1202717	Mouse	PMID:17556541
Biological Process	GO:0099175	regulation of postsynapse organization	Psen2	IDA		Mouse	PMID:23083742
Biological Process	GO:0099175	regulation of postsynapse organization	Psen2	IEP		Mouse	PMID:23083742
Biological Process	GO:0099175	regulation of postsynapse organization	Psen2	IMP		Mouse	PMID:23083742
Biological Process	GO:0043393	regulation of protein binding	Psen2	IGI	MGI:MGI:1202717	Mouse	PMID:17920016
Biological Process	GO:0048167	regulation of synaptic plasticity	Psen2	IGI	MGI:MGI:1202717	Mouse	PMID:15066262
Biological Process	GO:0001666	response to hypoxia	Psen2	IEP		Rat	PMID:12468103|RGD:1304261
Biological Process	GO:0043589	skin morphogenesis	Psen2	IMP		Mouse	MGI:MGI:4887523|PMID:20208556
Biological Process	GO:0061053	somite development	psen2	IMP	ZFIN:ZDB-MRPHLNO-080421-2	Zfish	PMID:19563801
Biological Process	GO:0001756	somitogenesis	Psen2	IGI	MGI:MGI:1202717	Mouse	PMID:19779553
Biological Process	GO:0001756	somitogenesis	Psen2	IGI	MGI:MGI:1202717	Mouse	PMID:10557208
Biological Process	GO:0002286	T cell activation involved in immune response	Psen2	IGI	MGI:MGI:1202717	Mouse	PMID:17698590
Biological Process	GO:0050852	T cell receptor signaling pathway	Psen2	IGI	MGI:MGI:1202717	Mouse	PMID:17698590
Biological Process	GO:0048538	thymus development	Psen2	IGI	MGI:MGI:1202717	Mouse	PMID:17698590
Biological Process	GO:0032640	tumor necrosis factor production	Psen2	IMP		Mouse	PMID:21206757
Biological Process	GO:0032640	tumor necrosis factor production	Psen2	IGI	MGI:MGI:1202717	Mouse	PMID:21206757

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern