Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PTBP1
  • Mouse genes Ptbp1
  • Rat genes Ptbp1
  • Zfish genes ptbp1a,ptbp1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ptbp1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	PTBP1	EXP		Human	PMID:10856256
Molecular Function	GO:0003729	mRNA binding	Ptbp1	IDA		Rat	PMID:19273590|RGD:9999430
Molecular Function	GO:0036002	pre-mRNA binding	PTBP1	IDA		Human	PMID:16260624
Molecular Function	GO:0005515	protein binding	PTBP1	IPI	UniProtKB:P23246	Human	PMID:10653975
Molecular Function	GO:0005515	protein binding	PTBP1	IPI	UniProtKB:P23246	Human	PMID:11514619
Molecular Function	GO:0005515	protein binding	PTBP1	IPI	UniProtKB:P09012	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	PTBP1	IPI	UniProtKB:Q7ZYE9	Human	PMID:16373488
Molecular Function	GO:0005515	protein binding	PTBP1	IPI	UniProtKB:Q15365	Human	PMID:16713569
Molecular Function	GO:0005515	protein binding	PTBP1	IPI	UniProtKB:Q96PU8	Human	PMID:16713569
Molecular Function	GO:0005515	protein binding	PTBP1	IPI	UniProtKB:P29991:PRO_0000037940	Human	PMID:21911577
Molecular Function	GO:0005515	protein binding	PTBP1	IPI	UniProtKB:P29991:PRO_0000308465	Human	PMID:21911577
Molecular Function	GO:0005515	protein binding	PTBP1	IPI	UniProtKB:P09012	Human	PMID:22365833
Molecular Function	GO:0005515	protein binding	PTBP1	IPI	UniProtKB:P98175	Human	PMID:22365833
Molecular Function	GO:0005515	protein binding	PTBP1	IPI	UniProtKB:Q96PU8	Human	PMID:22365833
Molecular Function	GO:0005515	protein binding	PTBP1	IPI	UniProtKB:P09012	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PTBP1	IPI	UniProtKB:P98175	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	PTBP1	IPI	UniProtKB:P09012	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	Ptbp1	IPI	PR:Q7TPD6	Mouse	PMID:16051233
Molecular Function	GO:0001069	regulatory region RNA binding	Ptbp1	IDA		Rat	PMID:23511971|RGD:10041054
Molecular Function	GO:0003723	RNA binding	PTBP1	HDA		Human	PMID:22658674
Molecular Function	GO:0003723	RNA binding	PTBP1	HDA		Human	PMID:22681889
Molecular Function	GO:0003723	RNA binding	Ptbp1	IPI	MGI:MGI:5589890	Mouse	PMID:25800779
Molecular Function	GO:0043565	sequence-specific DNA binding	Ptbp1	IDA		Rat	PMID:1561080|RGD:10045981
Molecular Function	GO:0003697	single-stranded DNA binding	Ptbp1	IDA		Rat	PMID:1561080|RGD:10045981
Molecular Function	GO:0000014	single-stranded DNA endodeoxyribonuclease activity	Ptbp1	IDA		Rat	PMID:12269805|RGD:633791
Cellular Component	GO:0005737	cytoplasm	Ptbp1	IDA		Rat	PMID:17400307|RGD:10045957
Cellular Component	GO:0005737	cytoplasm	Ptbp1	IDA		Rat	PMID:19273590|RGD:9999430
Cellular Component	GO:0070062	extracellular exosome	PTBP1	HDA		Human	PMID:20458337
Cellular Component	GO:0016020	membrane	PTBP1	HDA		Human	PMID:19946888
Cellular Component	GO:0044306	neuron projection terminus	Ptbp1	IDA		Rat	PMID:17400307|RGD:10045957
Cellular Component	GO:0005634	nucleus	Ptbp1	IPI	MGI:MGI:5589890	Mouse	PMID:25800779
Cellular Component	GO:0005634	nucleus	Ptbp1	IDA		Mouse	PMID:10716735
Cellular Component	GO:0005634	nucleus	Ptbp1	IDA		Rat	PMID:19273590|RGD:9999430
Cellular Component	GO:0005634	nucleus	Ptbp1	IDA		Rat	PMID:23511971|RGD:10041054
Biological Process	GO:0070935	3'-UTR-mediated mRNA stabilization	Ptbp1	IDA		Rat	PMID:11696543|RGD:10045987
Biological Process	GO:0003231	cardiac ventricle development	Ptbp1	IEP		Rat	PMID:19590510|RGD:10045962
Biological Process	GO:0009953	dorsal/ventral pattern formation	ptbp1a	IMP	ZFIN:ZDB-GENO-090914-5	Zfish	PMID:19666827
Biological Process	GO:0010467	gene expression	Ptbp1	IGI	MGI:MGI:5589890	Mouse	PMID:25800779
Biological Process	GO:0010467	gene expression	Ptbp1	IMP		Mouse	PMID:25800779
Biological Process	GO:0060729	intestinal epithelial structure maintenance	ptbp1a	IMP	ZFIN:ZDB-GENO-091211-6	Zfish	PMID:19197356
Biological Process	GO:0060729	intestinal epithelial structure maintenance	ptbp1a	IMP	ZFIN:ZDB-GENO-091211-4	Zfish	PMID:19197356
Biological Process	GO:0075522	IRES-dependent viral translational initiation	PTBP1	IDA		Human	PMID:17947529
Biological Process	GO:0075522	IRES-dependent viral translational initiation	PTBP1	IMP		Human	PMID:21518806
Biological Process	GO:0006397	mRNA processing	Ptbp1	IMP		Rat	PMID:16177139|RGD:10045980
Biological Process	GO:0048025	negative regulation of mRNA splicing, via spliceosome	PTBP1	IDA		Human	PMID:15009664
Biological Process	GO:0048025	negative regulation of mRNA splicing, via spliceosome	Ptbp1	IDA		Mouse	MGI:MGI:6271441|PMID:17679093
Biological Process	GO:0048025	negative regulation of mRNA splicing, via spliceosome	Ptbp1	IMP		Mouse	PMID:23636947
Biological Process	GO:0051148	negative regulation of muscle cell differentiation	PTBP1	IDA		Human	PMID:21518792
Biological Process	GO:0045665	negative regulation of neuron differentiation	Ptbp1	IDA		Mouse	MGI:MGI:6271441|PMID:17679093
Biological Process	GO:0045746	negative regulation of Notch signaling pathway	ptbp1a	IMP		Zfish	PMID:19197356
Biological Process	GO:0033119	negative regulation of RNA splicing	PTBP1	IDA		Human	PMID:18335065
Biological Process	GO:0022008	neurogenesis	Ptbp1	IMP		Mouse	PMID:25800779
Biological Process	GO:0000956	nuclear-transcribed mRNA catabolic process	Ptbp1	IMP		Rat	PMID:15039777|RGD:10045958
Biological Process	GO:0070886	positive regulation of calcineurin-NFAT signaling cascade	PTBP1	IMP		Human	PMID:23853098
Biological Process	GO:0060472	positive regulation of cortical granule exocytosis by positive regulation of cytosolic calcium ion concentration	ptbp1a	IMP	ZFIN:ZDB-GENO-090914-5	Zfish	PMID:19666827
Biological Process	GO:0032024	positive regulation of insulin secretion	Ptbp1	IMP		Rat	PMID:15039777|RGD:10045958
Biological Process	GO:0010976	positive regulation of neuron projection development	Ptbp1	IMP		Rat	PMID:17400307|RGD:10045957
Biological Process	GO:0035307	positive regulation of protein dephosphorylation	PTBP1	IMP		Human	PMID:23853098
Biological Process	GO:1904411	positive regulation of secretory granule organization	Ptbp1	IMP		Rat	PMID:15039777|RGD:10045958
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Ptbp1	IGI	MGI:MGI:1917202,MGI:MGI:97286,MGI:MGI:99894	Mouse	PMID:24530304
Biological Process	GO:0045727	positive regulation of translation	Ptbp1	IMP		Rat	PMID:19273590|RGD:9999430
Biological Process	GO:0000381	regulation of alternative mRNA splicing, via spliceosome	PTBP1	IDA		Human	PMID:16260624
Biological Process	GO:0000381	regulation of alternative mRNA splicing, via spliceosome	PTBP1	IDA		Human	PMID:21518792

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern